Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
1984 1
1985 1
1986 3
1987 3
1988 4
1989 2
1990 3
1991 6
1992 11
1993 7
1994 8
1995 4
1996 15
1997 15
1998 13
1999 7
2000 15
2001 14
2002 22
2003 23
2004 25
2005 32
2006 35
2007 36
2008 36
2009 27
2010 30
2011 30
2012 26
2013 35
2014 35
2015 31
2016 22
2017 29
2018 31
2019 27
2020 26
2021 11
2022 23
2023 10
2024 11
2025 12
2026 6

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

677 results

Results by year

Filters applied: . Clear all
Page 1
TRPV4.
Plant TD, Strotmann R. Plant TD, et al. Handb Exp Pharmacol. 2007;(179):189-205. doi: 10.1007/978-3-540-34891-7_11. Handb Exp Pharmacol. 2007. PMID: 17217058 Review.
These channels have a characteristic outwardly rectifying current-voltage relation, and are 5-10 times more permeable for Ca2+ than for Na+. TRPV4 can be activated by a wide range of stimuli including physical (cell swelling, heat, mechanical stimulation) and chemical stim …
These channels have a characteristic outwardly rectifying current-voltage relation, and are 5-10 times more permeable for Ca2+ than for Na+. …
Arachidonic acid cytochrome P450 epoxygenase pathway.
Spector AA. Spector AA. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S52-6. doi: 10.1194/jlr.R800038-JLR200. Epub 2008 Oct 23. J Lipid Res. 2009. PMID: 18952572 Free PMC article. Review.
Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acid (EET) regioisomers, 5,6-, 8,9-, 11,12-, and 14,15-EET, that function as autacrine and paracrine mediators. EETs produce vascular relaxation by activating …
Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acid (EET) regioisomers, …
Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading.
Capdevila JH, Wei S, Yan J, Karara A, Jacobson HR, Falck JR, Guengerich FP, DuBois RN. Capdevila JH, et al. J Biol Chem. 1992 Oct 25;267(30):21720-6. J Biol Chem. 1992. PMID: 1400482 Free article.
Inhibition studies utilizing a panel of polyclonal antibodies to several rat liver cytochrome P-450 isoforms, indicated that the renal epoxygenase(s) belongs to the cytochrome P-450 2C gene family. ...The in vivo significance of di …
Inhibition studies utilizing a panel of polyclonal antibodies to several rat liver cytochrome P-450 isoforms, indicated …
Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis.
Chen JK, Capdevila J, Harris RC. Chen JK, et al. Mol Cell Biol. 2001 Sep;21(18):6322-31. doi: 10.1128/MCB.21.18.6322-6331.2001. Mol Cell Biol. 2001. PMID: 11509673 Free PMC article.
However, other than established roles in cholesterol catabolism and steroid hormone biosynthesis, their cellular and/or organ physiological functions remain to be fully characterized. Here we show that the cytochrome P450 epoxygenase arachidonic acid m …
However, other than established roles in cholesterol catabolism and steroid hormone biosynthesis, their cellular and/or organ physiological …
Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes.
Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, Harder DR. Alkayed NJ, et al. Stroke. 1996 May;27(5):971-9. doi: 10.1161/01.str.27.5.971. Stroke. 1996. PMID: 8623121
BACKGROUND AND PURPOSE: Brain parenchymal tissue metabolizes arachidonic acid (AA) via the cytochrome P450 (P450) epoxygenase to epoxyeicosatrienoic acids (EETs). ...Because of the close association between astrocytes and the cerebral microcirculation, …
BACKGROUND AND PURPOSE: Brain parenchymal tissue metabolizes arachidonic acid (AA) via the cytochrome P450 (P450) ep …
[Endogenous protective effects of arachidonic acid epoxygenase metabolites, epoxyeicosatrienoic acids, in cardiovascular system].
He ZW, Wang B, Chen C, Shi ZQ, Wang DW. He ZW, et al. Sheng Li Xue Bao. 2021 Aug 25;73(4):617-630. Sheng Li Xue Bao. 2021. PMID: 34405218 Free article. Review. Chinese.
Recent studies have shown that epoxyeicosatrienoic acids (EETs), endogenous metabolites of arachidonic acid (AA) via CYP450 epoxygenase, possess a spectrum of protective properties in cardiovascular system. ...Meanwhile, various studies have demonstrated that …
Recent studies have shown that epoxyeicosatrienoic acids (EETs), endogenous metabolites of arachidonic acid (AA) via CYP450 …
Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism.
Spector AA, Kim HY. Spector AA, et al. Biochim Biophys Acta. 2015 Apr;1851(4):356-65. doi: 10.1016/j.bbalip.2014.07.020. Epub 2014 Aug 2. Biochim Biophys Acta. 2015. PMID: 25093613 Free PMC article. Review.
The epoxyeicosatrienoic acids (EETs) synthesized from arachidonic acid produce vasodilation, stimulate angiogenesis, have anti-inflammatory actions, and protect the heart against ischemia-reperfusion injury. EETs produce these functional effects by activating …
The epoxyeicosatrienoic acids (EETs) synthesized from arachidonic acid produce vasodilation, stimulate angiogenesis, have anti …
Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage.
Li J, Stier CT, Chander PN, Manthati VL, Falck JR, Carroll MA. Li J, et al. Front Pharmacol. 2014 Aug 15;5:187. doi: 10.3389/fphar.2014.00187. eCollection 2014. Front Pharmacol. 2014. PMID: 25177296 Free PMC article.
Epoxyeicosatrienoic acids (EETs) are epoxygenase products of arachidonic acid which possess vasodepressor, natriuretic, and anti-inflammatory activities. ...In contrast, 2 weeks of treatment with the selective epoxygenase inhibitor, MS-PPOH, inc …
Epoxyeicosatrienoic acids (EETs) are epoxygenase products of arachidonic acid which possess vasodepressor, natriuretic, …
Epoxygenase metabolites of arachidonic acid affect electrophysiologic properties of rat tracheal epithelial cells1.
Pascual JM, McKenzie A, Yankaskas JR, Falck JR, Zeldin DC. Pascual JM, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):772-9. J Pharmacol Exp Ther. 1998. PMID: 9694933
Epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids, products of the cytochrome P450 arachidonic acid epoxygenase pathway, have been shown to affect electrolyte transport in the kidney; however, the effects of these compounds on airway e …
Epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids, products of the cytochrome P450 arachidonic acid …
Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid.
Yu Z, Ng VY, Su P, Engler MM, Engler MB, Huang Y, Lin E, Kroetz DL. Yu Z, et al. J Pharmacol Exp Ther. 2006 May;317(2):732-8. doi: 10.1124/jpet.105.098558. Epub 2006 Jan 18. J Pharmacol Exp Ther. 2006. PMID: 16421287
GLA is converted into arachidonic acid (AA) by elongation and desaturation steps. Epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) are cytochrome P450 (P450)-derived AA eicosanoids with important roles in regulating blood …
GLA is converted into arachidonic acid (AA) by elongation and desaturation steps. Epoxyeicosatrienoic acids (EETs) and 20-hydr …
677 results