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Arctium lappa leaves based on network pharmacology and experimental validation attenuate atherosclerosis by targeting the AMPK-mediated PPARG/LXRalpha pathway.
Wang M, Cui B, Gong M, Liu Q, Zhuo X, Lv J, Yang L, Liu X, Wang Z, Dai L. Wang M, et al. Biomed Pharmacother. 2022 Sep;153:113503. doi: 10.1016/j.biopha.2022.113503. Epub 2022 Aug 16. Biomed Pharmacother. 2022. PMID: 36076592 Free article.
Arctium lappa (A. lappa) leaves are widely used in various traditional Chinese herbal formulae to ameliorate atherosclerosis (AS) and its complications such as stroke; however, there is no literature reporting the anti-atherosclerotic effect and mechanism of A. lapp
Arctium lappa (A. lappa) leaves are widely used in various traditional Chinese herbal formulae to ameliorate atherosclerosis (
An ethanolic extract of Arctium lappa L. leaves ameliorates experimental atherosclerosis by modulating lipid metabolism and inflammatory responses through PI3K/Akt and NF-kappaB singnaling pathways.
Guo H, Cui BD, Gong M, Li QX, Zhang LX, Chen JL, Chi J, Zhu LL, Xu EP, Wang ZM, Dai LP. Guo H, et al. J Ethnopharmacol. 2024 May 10;325:117768. doi: 10.1016/j.jep.2024.117768. Epub 2024 Jan 20. J Ethnopharmacol. 2024. PMID: 38253275
ETHNOPHARMACOLOGICAL RELEVANCE: Atherosclerosis (AS), a lipid-induced inflammatory condition of the arteries, is a primary contributor to atherosclerotic cardiovascular diseases including stroke. Arctium lappa L. leaf (ALL), an edible and medicinal herb in China, ha …
ETHNOPHARMACOLOGICAL RELEVANCE: Atherosclerosis (AS), a lipid-induced inflammatory condition of the arteries, is a primary contributo …
Arctium lappa root extract containing L-arginine prevents TNF-alpha-induced early atherosclerosis in vitro and in vivo.
Lee J, Ha SJ, Park J, Kim YH, Lee NH, Kim YE, Hong YS, Song KM. Lee J, et al. Nutr Res. 2020 May;77:85-96. doi: 10.1016/j.nutres.2020.03.003. Epub 2020 Mar 21. Nutr Res. 2020. PMID: 32388084
Atherosclerosis is a chronic inflammatory disease affecting the aorta and is a major cause of cardiovascular disease. Arctium lappa root is a plant widely used in traditional Chinese medicine (TCM), and Arctium lappa root extract (ALE) has been reported to ex
Atherosclerosis is a chronic inflammatory disease affecting the aorta and is a major cause of cardiovascular disease. Arctium
Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves.
Liang H, Feng Q, Guo H, Lv J, Zhang L, Li Q, Chi J, Liu Q, Wang Z, Dai L. Liang H, et al. Bioorg Chem. 2022 Oct;127:105940. doi: 10.1016/j.bioorg.2022.105940. Epub 2022 Jun 10. Bioorg Chem. 2022. PMID: 35749853 Review.
Nine new cadinane-type sesquiterpenoids (1-9) and three new eucalyptane -type sesquiterpenes (10-12) were isolated from the ethyl acetate extract of Burdock leaves, which were commonly used for preventing or treating atherosclerosis in China. Their structures were confirme …
Nine new cadinane-type sesquiterpenoids (1-9) and three new eucalyptane -type sesquiterpenes (10-12) were isolated from the ethyl acetate ex …
Arctium lappa L. polysaccharide can regulate lipid metabolism in type 2 diabetic rats through the SREBP-1/SCD-1 axis.
Chen M, Xu J, Wang Y, Wang Z, Guo L, Li X, Huang L. Chen M, et al. Carbohydr Res. 2020 Aug;494:108055. doi: 10.1016/j.carres.2020.108055. Epub 2020 Jun 7. Carbohydr Res. 2020. PMID: 32535406
In the analysis of risk factors of diabetes mellitus with coronary heart disease, dyslipidemia is the most important. Previous studies have found that Arctium lappa L. polysaccharide (ALP) can regulate lipid metabolism in type 1 diabetic rats, but it has not been studied i …
In the analysis of risk factors of diabetes mellitus with coronary heart disease, dyslipidemia is the most important. Previous studies have …
Protective effects of Arctium lappa L. root extracts (AREs) on high fat diet induced quail atherosclerosis.
Wang Z, Li P, Wang C, Jiang Q, Zhang L, Cao Y, Zhong W, Wang C. Wang Z, et al. BMC Complement Altern Med. 2016 Jan 8;16:6. doi: 10.1186/s12906-016-0987-2. BMC Complement Altern Med. 2016. PMID: 26746431 Free PMC article.
BACKGROUND: This study was designed to evaluate the protective effects of Arctium lappa L. root extracts (AREs) from different extraction methods (aqueous, ethanol, chloroform and flavone) on atherosclerosis. ...
BACKGROUND: This study was designed to evaluate the protective effects of Arctium lappa L. root extracts (AREs) from different extrac …
Endovascular Therapy with Interwoven Nitinol Stent Placement after Predilation for Heavily Calcified Femoropopliteal Artery Disease: Results of the BURDOCK Study.
Fujihara M, Takahara M, Iida O, Kawasaki D, Soga Y, Tobita K, Horie K, Takagi T, Okamoto S, Nakama T, Sasaki S, Tsubakimoto Y, Suematsu N. Fujihara M, et al. J Vasc Interv Radiol. 2023 Nov;34(11):1929-1937. doi: 10.1016/j.jvir.2023.07.023. Epub 2023 Jul 30. J Vasc Interv Radiol. 2023. PMID: 37527768
Arctigenin promotes cholesterol efflux from THP-1 macrophages through PPAR-γ/LXR-α signaling pathway.
Xu X, Li Q, Pang L, Huang G, Huang J, Shi M, Sun X, Wang Y. Xu X, et al. Biochem Biophys Res Commun. 2013 Nov 15;441(2):321-6. doi: 10.1016/j.bbrc.2013.10.050. Epub 2013 Oct 17. Biochem Biophys Res Commun. 2013. PMID: 24140409
Cholesterol efflux from macrophages is a critical mechanism to prevent the development of atherosclerosis. Here, we sought to investigate the effects of arctigenin, a bioactive component of Arctium lappa, on the cholesterol efflux in oxidized low-density lipoprotein …
Cholesterol efflux from macrophages is a critical mechanism to prevent the development of atherosclerosis. Here, we sought to investi …