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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1982 1
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1986 1
1992 2
1993 4
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1995 4
1996 5
1997 6
1998 6
1999 9
2000 5
2001 10
2002 12
2003 15
2004 14
2005 19
2006 16
2007 21
2008 32
2009 17
2010 17
2011 20
2012 21
2013 21
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593 results

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Page 1
Hyponatremia Demystified: Integrating Physiology to Shape Clinical Practice.
Workeneh BT, Meena P, Christ-Crain M, Rondon-Berrios H. Workeneh BT, et al. Adv Kidney Dis Health. 2023 Mar;30(2):85-101. doi: 10.1053/j.akdh.2022.11.004. Epub 2022 Dec 14. Adv Kidney Dis Health. 2023. PMID: 36868737 Free PMC article. Review.
Plasma osmolality, urine osmolality, and urine sodium can help to differentiate among the different etiologies. Brain adaptation to plasma hypotonicity consisting of solute extrusion to mitigate further water influx into brain cells best explains the clinical …
Plasma osmolality, urine osmolality, and urine sodium can help to differentiate among the different etiologies. Brain adaptation to …
Diagnostic and Therapeutic Strategies to Severe Hyponatremia in the Intensive Care Unit.
Rondon-Berrios H. Rondon-Berrios H. J Intensive Care Med. 2024 Nov;39(11):1039-1054. doi: 10.1177/08850666231207334. Epub 2023 Oct 11. J Intensive Care Med. 2024. PMID: 37822230 Review.
However, its causal role in these poor outcomes and the impact of treatment remain unclear. Plasma sodium is the main determinant of plasma tonicity; consequently, hyponatremia commonly indicates hypotonicity but can also occur in conjunction with isotonicity …
However, its causal role in these poor outcomes and the impact of treatment remain unclear. Plasma sodium is the main determin …
A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.
Fenske W, Refardt J, Chifu I, Schnyder I, Winzeler B, Drummond J, Ribeiro-Oliveira A Jr, Drescher T, Bilz S, Vogt DR, Malzahn U, Kroiss M, Christ E, Henzen C, Fischli S, Tönjes A, Mueller B, Schopohl J, Flitsch J, Brabant G, Fassnacht M, Christ-Crain M. Fenske W, et al. N Engl J Med. 2018 Aug 2;379(5):428-439. doi: 10.1056/NEJMoa1803760. N Engl J Med. 2018. PMID: 30067922 Free article.
The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. METHODS: From 2013 to 2017, we recruited 156 patients with hypotonic polyuria at 11 medical centers to und …
The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogat …
Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome.
Camacho J, Rioseco-Camacho N. Camacho J, et al. 2012 May 31 [updated 2025 Apr 10]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 2012 May 31 [updated 2025 Apr 10]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. PMID: 22649802 Free Books & Documents. Review.
Clinical manifestations and age of onset vary among individuals even in the same family. ...However, the identification of familial SLC25A15 pathogenic variants cannot predict clinical outcome because of significant intrafamilial phenotypic variability....
Clinical manifestations and age of onset vary among individuals even in the same family. ...However, the identification of familial S …
Plasma arginine as a predictive biomarker for outcomes with immune checkpoint inhibition in metastatic colorectal cancer: a correlative analysis of the CCTG CO.26 trial.
Ma LX, Titmuss E, Loree JM, Jonker DJ, Kennecke HF, Berry S, Couture F, Ahmad CE, Goffin JR, Kavan P, Harb M, Colwell B, Samimi S, Samson B, Abbas T, Aucoin N, Aubin F, Koski S, Tu D, O'Callaghan C, Chen EX. Ma LX, et al. J Immunother Cancer. 2024 Dec 4;12(12):e010094. doi: 10.1136/jitc-2024-010094. J Immunother Cancer. 2024. PMID: 39631846 Free PMC article. Clinical Trial.
METHODS: CO.26 randomized patients with refractory mCRC to durvalumab plus tremelimumab (D+T) versus best supportive care (BSC). Plasma ARG concentrations were determined from pretreatment blood samples using high-performance liquid chromatography-tandem mass spectr …
METHODS: CO.26 randomized patients with refractory mCRC to durvalumab plus tremelimumab (D+T) versus best supportive care (BSC). P …
Argininosuccinate lyase deficiency.
Nagamani SC, Erez A, Lee B. Nagamani SC, et al. Genet Med. 2012 May;14(5):501-7. doi: 10.1038/gim.2011.1. Epub 2012 Jan 5. Genet Med. 2012. PMID: 22241104 Free PMC article. Review.
The biochemical diagnosis of ASLD is typically established with elevation of plasma citrulline together with elevated argininosuccinic acid in the plasma or urine. ...However, there is no correlation between the genotype or enzyme activity and clinical out …
The biochemical diagnosis of ASLD is typically established with elevation of plasma citrulline together with elevated argininosuccini …
Arginine therapy in sickle cell disease: A systematic review and meta-analysis of clinical outcomes.
Foncha FML, Bena Nnang JY, Fodop SGJ, Poudjoum BCI, Tcheuko DS, Mekontso JGK. Foncha FML, et al. Clin Nutr ESPEN. 2026 Apr;72:102898. doi: 10.1016/j.clnesp.2025.102898. Epub 2026 Jan 12. Clin Nutr ESPEN. 2026. PMID: 41534622
Pharmacodynamic analysis confirmed increased plasma arginine levels but showed no significant change in the arginine-to-ornithine ratio. CONCLUSION: In summary, this meta-analysis found that l-arginine showed no statistically significant benefit on any …
Pharmacodynamic analysis confirmed increased plasma arginine levels but showed no significant change in the arginine-to …
Neonatal encephalopathy plasma metabolites are associated with neurodevelopmental outcomes.
Friedes BD, Molloy E, Strickland T, Zhu J, Slevin M, Donoghue V, Sweetman D, Kelly L, O'Dea M, Roux A, Harlan R, Ellis G, Manlhiot C, Graham D, Northington F, Everett AD. Friedes BD, et al. Pediatr Res. 2022 Aug;92(2):466-473. doi: 10.1038/s41390-021-01741-x. Epub 2021 Oct 7. Pediatr Res. 2022. PMID: 34621028 Free PMC article.
CONCLUSIONS: Plasma metabolites may help to predict neurological outcomes in neonatal brain injury and enhance current clinical predictors. IMPACT: Plasma metabolites may help to predict neurological outcomes in NE and supplement current clin …
CONCLUSIONS: Plasma metabolites may help to predict neurological outcomes in neonatal brain injury and enhance current clin …
Diagnosis and treatment of hypernatremia.
Tomkins M, Mc Donald D, Green D, O'Reilly MW, Sherlock M. Tomkins M, et al. Best Pract Res Clin Endocrinol Metab. 2026 Jan;40(1):102065. doi: 10.1016/j.beem.2025.102065. Epub 2025 Nov 4. Best Pract Res Clin Endocrinol Metab. 2026. PMID: 41203493 Review.
The reported prevalence of hypernatremia varies depending on the clinical setting with retrospective analyses identifying a prevalence of 0.5-1 % in the community but up to 10 % in intensive care units. ...Hypernatremia is associated with poorer outcomes incl …
The reported prevalence of hypernatremia varies depending on the clinical setting with retrospective analyses identifying a prevalenc …
Arginine:glycine amidinotransferase (AGAT) deficiency: Clinical features and long term outcomes in 16 patients diagnosed worldwide.
Stockler-Ipsiroglu S, Apatean D, Battini R, DeBrosse S, Dessoffy K, Edvardson S, Eichler F, Johnston K, Koeller DM, Nouioua S, Tazir M, Verma A, Dowling MD, Wierenga KJ, Wierenga AM, Zhang V, Wong LJ. Stockler-Ipsiroglu S, et al. Mol Genet Metab. 2015 Dec;116(4):252-9. doi: 10.1016/j.ymgme.2015.10.003. Epub 2015 Oct 17. Mol Genet Metab. 2015. PMID: 26490222 Free article.
BACKGROUND: Arginine:glycine aminotransferase (AGAT) (GATM) deficiency is an autosomal recessive inborn error of creative synthesis. OBJECTIVE: We performed an international survey among physicians known to treat patients with AGAT deficiency, to assess clinical cha …
BACKGROUND: Arginine:glycine aminotransferase (AGAT) (GATM) deficiency is an autosomal recessive inborn error of creative synthesis. …
593 results