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Year Number of Results
1990 1
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1997 3
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2001 3
2002 2
2003 3
2004 3
2005 1
2006 3
2007 7
2008 7
2009 4
2010 5
2011 6
2012 4
2013 4
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2017 9
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284 results

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Page 1
Dietary glycation compounds - implications for human health.
Hellwig M, Diel P, Eisenbrand G, Grune T, Guth S, Henle T, Humpf HU, Joost HG, Marko D, Raupbach J, Roth A, Vieths S, Mally A. Hellwig M, et al. Crit Rev Toxicol. 2024 Sep;54(8):485-617. doi: 10.1080/10408444.2024.2362985. Epub 2024 Aug 16. Crit Rev Toxicol. 2024. PMID: 39150724 Free article.
In this work, the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) summarized data on formation, occurrence, exposure and toxicity of glycation compounds (Part A) and systematically assessed potential associations between dietary intak …
In this work, the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) summarized data on formation, occur …
First-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP-deleted solid tumors: results from phase I dose exploration.
Rodon J, Prenen H, Sacher A, Villalona-Calero M, Penel N, El Helali A, Rottey S, Yamamoto N, Ghiringhelli F, Goebeler ME, Doi T, Postel-Vinay S, Lin CC, Liu C, Chuang CH, Keyvanjah K, Eggert T, O'Neil BH. Rodon J, et al. Ann Oncol. 2024 Dec;35(12):1138-1147. doi: 10.1016/j.annonc.2024.08.2339. Epub 2024 Sep 16. Ann Oncol. 2024. PMID: 39293516 Free article. Clinical Trial.
AMG 193, a CNS-penetrant methylthioadenosine-cooperative protein arginine methyltransferase 5 (PRMT5) inhibitor, selectively induces synthetic lethality in MTAP-deleted tumor cells. ...PATIENTS AND METHODS: In this first-in-human, multicenter, open-label, phase I study, pa …
AMG 193, a CNS-penetrant methylthioadenosine-cooperative protein arginine methyltransferase 5 (PRMT5) inhibitor, selectively induces …
Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice.
Yao K, Kang Q, Liu W, Chen D, Wang L, Li S. Yao K, et al. J Hazard Mater. 2024 May 15;470:134165. doi: 10.1016/j.jhazmat.2024.134165. Epub 2024 Mar 28. J Hazard Mater. 2024. PMID: 38574660
It has been reported that N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-Q), a derivative of the tire antioxidant, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), exhibits acute toxicity towards organisms. However, the possible reproductive …
It has been reported that N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-Q), a derivative of the tire antioxidant, N-(1,3- …
A 90-day toxicity study of tripeptide, arginine-alanine-lysine.
Dunn M, Glávits R, Murbach TS, Modica V, Endres JR, Hirka G, Pasics Szakonyiné I. Dunn M, et al. J Appl Toxicol. 2023 Sep;43(9):1332-1346. doi: 10.1002/jat.4468. Epub 2023 Apr 2. J Appl Toxicol. 2023. PMID: 36946007
Although there is a growing level of interest in the use of peptides in the health and wellness industry, there is a lack of literature pertaining to a specific tripeptide derived from arginine, alanine, and lysine (RAK) that is of interest for human dietary use. Therefore …
Although there is a growing level of interest in the use of peptides in the health and wellness industry, there is a lack of literature pert …
Pegargiminase Plus First-Line Chemotherapy in Patients With Nonepithelioid Pleural Mesothelioma: The ATOMIC-Meso Randomized Clinical Trial.
Szlosarek PW, Creelan BC, Sarkodie T, Nolan L, Taylor P, Olevsky O, Grosso F, Cortinovis D, Chitnis M, Roy A, Gilligan D, Kindler H, Papadatos-Pastos D, Ceresoli GL, Mansfield AS, Tsao A, O'Byrne KJ, Nowak AK, Steele J, Sheaff M, Shiu CF, Kuo CL, Johnston A, Bomalaski J, Zauderer MG, Fennell DA; ATOMIC-Meso Study Group. Szlosarek PW, et al. JAMA Oncol. 2024 Apr 1;10(4):475-483. doi: 10.1001/jamaoncol.2023.6789. JAMA Oncol. 2024. PMID: 38358753 Free PMC article. Clinical Trial.
Pegargiminase or placebo was continued until progression, toxicity, or 24 months. MAIN OUTCOMES AND MEASURES: The primary end point was overall survival, and secondary end points were progression-free survival and safety. ...CONCLUSIONS AND RELEVANCE: In this random …
Pegargiminase or placebo was continued until progression, toxicity, or 24 months. MAIN OUTCOMES AND MEASURES: The primary end point w …
Targeting PRMT5 through PROTAC for the treatment of triple-negative breast cancer.
Guo Y, Li Y, Zhou Z, Hou L, Liu W, Ren W, Mi D, Sun J, Dai X, Wu Y, Cheng Z, Wu T, Luo Q, Tian C, Li F, Yu Z, Chen Y, Chen C. Guo Y, et al. J Exp Clin Cancer Res. 2024 Nov 30;43(1):314. doi: 10.1186/s13046-024-03237-y. J Exp Clin Cancer Res. 2024. PMID: 39614393 Free PMC article.
BACKGROUND: Triple-negative breast cancer (TNBC) is currently the most aggressive subtype of breast cancer, characterized by high heterogeneity and strong invasiveness, and currently lacks effective therapies. PRMT5, a type II protein arginine methyltransferase, is upregul …
BACKGROUND: Triple-negative breast cancer (TNBC) is currently the most aggressive subtype of breast cancer, characterized by high heterogene …
Citrullinemia Type I.
Quinonez SC, Lee KN. Quinonez SC, et al. 2004 Jul 7 [updated 2022 Aug 18]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 2004 Jul 7 [updated 2022 Aug 18]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. PMID: 20301631 Free Books & Documents. Review.
Without prompt intervention, hyperammonemia and the accumulation of other toxic metabolites (e.g., glutamine) result in increased ICP, increased neuromuscular tone, spasticity, ankle clonus, seizures, loss of consciousness, and death. ...Measurement of growth parameters; e …
Without prompt intervention, hyperammonemia and the accumulation of other toxic metabolites (e.g., glutamine) result in increased ICP …
Acquired inhibitors.
Cohen AJ, Kessler CM. Cohen AJ, et al. Baillieres Clin Haematol. 1996 Jun;9(2):331-54. doi: 10.1016/s0950-3536(96)80067-9. Baillieres Clin Haematol. 1996. PMID: 8800509 Review.
The selection of the appropriate treatment depends upon the associated medical condition, likelihood of spontaneous remission, risk of toxicities of therapy and cost. Determining the efficacy and safety of new treatment modalities for factor VIII auto-antibodies and …
The selection of the appropriate treatment depends upon the associated medical condition, likelihood of spontaneous remission, risk of to …
Pharmacokinetics and safety of arginine supplementation in animals.
Wu G, Bazer FW, Cudd TA, Jobgen WS, Kim SW, Lassala A, Li P, Matis JH, Meininger CJ, Spencer TE. Wu G, et al. J Nutr. 2007 Jun;137(6 Suppl 2):1673S-1680S. doi: 10.1093/jn/137.6.1673S. J Nutr. 2007. PMID: 17513446 Free article.
Anticipating the future use of arginine to enhance fetal and neonatal growth as well as to treat diabetes and obesity, we performed studies in pigs, rats, and sheep to determine the pharmacokinetics of orally or i.v. administered arginine and the safety of it …
Anticipating the future use of arginine to enhance fetal and neonatal growth as well as to treat diabetes and obesity, we performed s …
Current Treatment Modalities for Urea Cycle Disorders.
Ah Mew N, Lichter-Konecki U. Ah Mew N, et al. Paediatr Drugs. 2025 Nov;27(6):723-734. doi: 10.1007/s40272-025-00719-0. Epub 2025 Sep 22. Paediatr Drugs. 2025. PMID: 40976841 Review.
A deficiency of any of these components disrupts this process, leading to the accumulation of nitrogen in the form of ammonia, which is especially toxic to the brain. For decades, treatment of urea cycle disorders has consisted of nitrogen scavengers, dietary protein restr …
A deficiency of any of these components disrupts this process, leading to the accumulation of nitrogen in the form of ammonia, which is espe …
284 results