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85 results

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Page 1
A safety evaluation of aripiprazole in the treatment of schizophrenia.
Preda A, Shapiro BB. Preda A, et al. Expert Opin Drug Saf. 2020 Dec;19(12):1529-1538. doi: 10.1080/14740338.2020.1832990. Epub 2020 Oct 16. Expert Opin Drug Saf. 2020. PMID: 33064050 Review.
AREAS COVERED: We review short-and-long-term clinical trials, meta-analyses of clinical trials and product information pertaining to the safety and efficacy of aripiprazole in adults with schizophrenia. Formulations of aripiprazole reviewed include oral aripipraz …
AREAS COVERED: We review short-and-long-term clinical trials, meta-analyses of clinical trials and product information pertaining to the saf …
Antipsychotics and risk of QT prolongation: a pharmacovigilance study.
Bordet C, Garcia P, Salvo F, Touafchia A, Galinier M, Sommet A, Montastruc F. Bordet C, et al. Psychopharmacology (Berl). 2023 Jan;240(1):199-202. doi: 10.1007/s00213-022-06293-4. Epub 2022 Dec 14. Psychopharmacology (Berl). 2023. PMID: 36515735
CONCLUSIONS: This large study in a real-world setting suggests that sertindole and ziprasidone were the antipsychotics drugs associated with the highest risk of QT prolongation reporting. Our results suggest that lurasidone is less associated with QT interval prolon …
CONCLUSIONS: This large study in a real-world setting suggests that sertindole and ziprasidone were the antipsychotics drugs associated with …
QT Prolongation, Torsades de Pointes, and Psychotropic Medications: A 5-Year Update.
Beach SR, Celano CM, Sugrue AM, Adams C, Ackerman MJ, Noseworthy PA, Huffman JC. Beach SR, et al. Psychosomatics. 2018 Mar-Apr;59(2):105-122. doi: 10.1016/j.psym.2017.10.009. Epub 2017 Nov 3. Psychosomatics. 2018. PMID: 29275963 Review.
BACKGROUND: Some psychotropic medications have been associated with prolongation of the QT interval and QT prolongation, especially in those with medical illness, and are linked to lethal ventricular arrhythmias, such as Torsades de Pointes (TdP). ...Among at …
BACKGROUND: Some psychotropic medications have been associated with prolongation of the QT interval and QT prolongation, espec …
Aripiprazole: a review of its use in the management of mania in adults with bipolar I disorder.
Dhillon S. Dhillon S. Drugs. 2012 Jan 1;72(1):133-62. doi: 10.2165/11208320-000000000-00000. Drugs. 2012. PMID: 22191800 Review.
Aripiprazole was generally well tolerated in these studies and was associated with a low risk of prolactin elevation, corrected QT interval prolongation and metabolic disturbances. ...Further trials comparing aripiprazole with other agents, including atypical …
Aripiprazole was generally well tolerated in these studies and was associated with a low risk of prolactin elevation, corrected QT …
Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder.
Swainston Harrison T, Perry CM. Swainston Harrison T, et al. Drugs. 2004;64(15):1715-36. doi: 10.2165/00003495-200464150-00010. Drugs. 2004. PMID: 15257633 Review.
The mechanism of action of aripiprazole is not yet known, but evidence suggests that its efficacy in the treatment of the positive and negative symptoms of schizophrenia and its lower propensity for extrapyramidal symptoms (EPS) may be attributable to aripiprazole' …
The mechanism of action of aripiprazole is not yet known, but evidence suggests that its efficacy in the treatment of the positive an …
Risk Stratification of QTc Prolongation in Critically Ill Patients Receiving Antipsychotics for the Management of Delirium Symptoms.
Sadlonova M, Beach SR, Funk MC, Rosen JH, Ramirez Gamero AF, Karlson RA, Huffman JC, Celano CM. Sadlonova M, et al. J Intensive Care Med. 2025 Apr;40(4):355-371. doi: 10.1177/08850666231222470. Epub 2023 Dec 21. J Intensive Care Med. 2025. PMID: 38130132 Review.
Among other antipsychotics, those most likely to cause QTc prolongation are iloperidone and ziprasidone, while aripiprazole and lurasidone appear to have minimal risk for QTc prolongation. Genetic vulnerabilities, female sex, older age, pre-existing cardiovascular disease, …
Among other antipsychotics, those most likely to cause QTc prolongation are iloperidone and ziprasidone, while aripiprazole and luras …
Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis.
Rogdaki M, McCutcheon RA, D'Ambrosio E, Mancini V, Watson CJ, Fanshawe JB, Carr R, Telesia L, Martini MG, Philip A, Gilbert BJ, Salazar-de-Pablo G, Kyriakopoulos M, Siskind D, Correll CU, Cipriani A, Efthimiou O, Howes OD, Pillinger T. Rogdaki M, et al. Lancet Child Adolesc Health. 2024 Jul;8(7):510-521. doi: 10.1016/S2352-4642(24)00098-1. Lancet Child Adolesc Health. 2024. PMID: 38897716 Free PMC article.
Primary outcomes were mean change from baseline to end of acute treatment in bodyweight, BMI, fasting glucose, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, prolactin, heart rate, systolic blood pressure (SBP), and QT interval corrected for heart rate …
Primary outcomes were mean change from baseline to end of acute treatment in bodyweight, BMI, fasting glucose, total cholesterol, LDL choles …
The cardiac safety of aripiprazole treatment in patients at high risk for torsade: a systematic review with a meta-analytic approach.
Polcwiartek C, Sneider B, Graff C, Taylor D, Meyer J, Kanters JK, Nielsen J. Polcwiartek C, et al. Psychopharmacology (Berl). 2015 Sep;232(18):3297-308. doi: 10.1007/s00213-015-4024-9. Epub 2015 Aug 1. Psychopharmacology (Berl). 2015. PMID: 26231497
Most SCDs occur in patients with additional cardiac risk factors. OBJECTIVES: Aripiprazole's cardiac safety has not been assessed in patients at high risk for torsade, where QTc prolongation risk is highly increased. ...No clinical studies assessing aripip …
Most SCDs occur in patients with additional cardiac risk factors. OBJECTIVES: Aripiprazole's cardiac safety has not been asses …
Agitated Psychiatric Patient.
Pabst BM, Leung C, Frey JA, Yee J. Pabst BM, et al. J Educ Teach Emerg Med. 2020 Oct 15;5(4):S59-S83. doi: 10.21980/J85352. eCollection 2020 Oct. J Educ Teach Emerg Med. 2020. PMID: 37465334 Free PMC article.
Chemical and/or physical restraints are sometimes necessary to ensure patient and staff safety when verbal de-escalation is ineffective, particularly since agitation is the leading cause of hospital staff injuries.2 Chemical restraints have been shown to be less physically trauma …
Chemical and/or physical restraints are sometimes necessary to ensure patient and staff safety when verbal de-escalation is ineffective, par …
Brexpiprazole: A Review in Schizophrenia.
Frampton JE. Frampton JE. Drugs. 2019 Feb;79(2):189-200. doi: 10.1007/s40265-019-1052-5. Drugs. 2019. PMID: 30671869 Review.
Brexpiprazole (Rxulti( ), Rexulti( )) is an oral atypical antipsychotic agent approved for the treatment of schizophrenia in the EU (in adult patients) and the USA, as well as in some other countries, including Japan. Like aripiprazole, it is a partial agonist at dopamine …
Brexpiprazole (Rxulti( ), Rexulti( )) is an oral atypical antipsychotic agent approved for the treatment of schizophrenia in the EU (in adul …
85 results