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Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis.
Chen GQ, Benthani FA, Wu J, Liang D, Bian ZX, Jiang X. Chen GQ, et al. Cell Death Differ. 2020 Jan;27(1):242-254. doi: 10.1038/s41418-019-0352-3. Epub 2019 May 21. Cell Death Differ. 2020. PMID: 31114026 Free PMC article.
In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of programmed cell death driven by iron-dependent lipid peroxidation. ...Our findings can be exploited clinically to enhance the effect of future ferroptosis-ind …
In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of programmed cell de …
Artemisinin and its derivatives: a promising cancer therapy.
Kiani BH, Kayani WK, Khayam AU, Dilshad E, Ismail H, Mirza B. Kiani BH, et al. Mol Biol Rep. 2020 Aug;47(8):6321-6336. doi: 10.1007/s11033-020-05669-z. Epub 2020 Jul 24. Mol Biol Rep. 2020. PMID: 32710388 Review.
Artemisinin produces highly reactive free radicals by the breakdown of two oxygen atoms that kill cancerous cells. ...This review aims to highlight these achievements and propose potential strategies to develop artemisinin and its derivatives as a new class o
Artemisinin produces highly reactive free radicals by the breakdown of two oxygen atoms that kill cancerous cells. ...This rev
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.
Efferth T. Efferth T. Semin Cancer Biol. 2017 Oct;46:65-83. doi: 10.1016/j.semcancer.2017.02.009. Epub 2017 Feb 28. Semin Cancer Biol. 2017. PMID: 28254675 Review.
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been developed as antimalarial drug and is used worldwide. ...The cellular response of ARS and …
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria and related symptomes (fever, chills). Its act …
The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer.
Hu Y, Guo N, Yang T, Yan J, Wang W, Li X. Hu Y, et al. Oxid Med Cell Longev. 2022 Jan 4;2022:1458143. doi: 10.1155/2022/1458143. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35028002 Free PMC article. Review.
Artemisinin (ART) is a bioactive molecule derived from the Chinese medicinal plant Artemisia annua (Asteraceae). ART and artemisinin derivatives (ARTs) have been effectively used for antimalaria treatment. ...
Artemisinin (ART) is a bioactive molecule derived from the Chinese medicinal plant Artemisia annua (Asteraceae). ART and artemisin
Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy.
Zhu S, Yu Q, Huo C, Li Y, He L, Ran B, Chen J, Li Y, Liu W. Zhu S, et al. Curr Med Chem. 2021;28(2):329-345. doi: 10.2174/0929867327666200121124404. Curr Med Chem. 2021. PMID: 31965935
BACKGROUND: Artemisinin is a sesquiterpene lactone compound with a special peroxide bridge that is tightly linked to the cytotoxicity involved in fighting malaria and cancer. Artemisinin and its derivatives (ARTs) are considered to be potential anticancer dru …
BACKGROUND: Artemisinin is a sesquiterpene lactone compound with a special peroxide bridge that is tightly linked to the cytotoxicity …
Discovery and repurposing of artemisinin.
Shi Q, Xia F, Wang Q, Liao F, Guo Q, Xu C, Wang J. Shi Q, et al. Front Med. 2022 Feb;16(1):1-9. doi: 10.1007/s11684-021-0898-6. Epub 2022 Mar 15. Front Med. 2022. PMID: 35290595 Free PMC article. Review.
We will then discuss how artemisinin and its derivatives could be repurposed to treat cancer, inflammation, immunoregulation-related diseases, and COVID-19. ...We believe that artemisinin is just a starting point and TCM will play an even bigger role in healt …
We will then discuss how artemisinin and its derivatives could be repurposed to treat cancer, inflammation, immunoregulation-r …
Anticancer Activity of Artemisinin and its Derivatives.
Slezakova S, Ruda-Kucerova J. Slezakova S, et al. Anticancer Res. 2017 Nov;37(11):5995-6003. doi: 10.21873/anticanres.12046. Anticancer Res. 2017. PMID: 29061778 Review.
Artemisinin is an extract from the plant Artemisia annua. With its semi-synthetic derivatives, they form a group of well-known and efficacious antimalarial drugs. ...Dihydroartemisinin and artesunate exhibit chemosensitising effects in vivo in breast, lung, pancreas and gl
Artemisinin is an extract from the plant Artemisia annua. With its semi-synthetic derivatives, they form a group of well-known and ef
Development of artemisinin compounds for cancer treatment.
Lai HC, Singh NP, Sasaki T. Lai HC, et al. Invest New Drugs. 2013 Feb;31(1):230-46. doi: 10.1007/s10637-012-9873-z. Epub 2012 Aug 31. Invest New Drugs. 2013. PMID: 22935909 Review.
Cancer cells contain significantly more intracellular free iron than normal cells and it has been shown that artemisinin and its analogs selectively cause apoptosis in many cancer cell lines. ...These properties make artemisinin compounds attractive
Cancer cells contain significantly more intracellular free iron than normal cells and it has been shown that artemisinin and i
Cancer combination therapies with artemisinin-type drugs.
Efferth T. Efferth T. Biochem Pharmacol. 2017 Sep 1;139:56-70. doi: 10.1016/j.bcp.2017.03.019. Epub 2017 Mar 31. Biochem Pharmacol. 2017. PMID: 28366726 Review.
Artemisia annua L. is a Chinese medicinal plant, which is used throughout Asia and Africa as tea or press juice to treat malaria. The bioactivity of its chemical constituent, artemisinin is, however, much broader. We and others found that artemisinin and its derivat …
Artemisia annua L. is a Chinese medicinal plant, which is used throughout Asia and Africa as tea or press juice to treat malaria. The bioact …
Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs.
Carqueijeiro I, Langley C, Grzech D, Koudounas K, Papon N, O'Connor SE, Courdavault V. Carqueijeiro I, et al. Curr Opin Biotechnol. 2020 Oct;65:17-24. doi: 10.1016/j.copbio.2019.11.017. Epub 2019 Dec 13. Curr Opin Biotechnol. 2020. PMID: 31841858 Free article. Review.
The discovery and supply of plant-derived anti-cancer compounds remain challenging given their low bioavailability and structural complexity. ...This review describes the current strategies and recent advancements in the production of these valuable therapeutic compounds, …
The discovery and supply of plant-derived anti-cancer compounds remain challenging given their low bioavailability and structural com …
1,184 results