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Page 1
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis.
Chen GQ, Benthani FA, Wu J, Liang D, Bian ZX, Jiang X. Chen GQ, et al. Cell Death Differ. 2020 Jan;27(1):242-254. doi: 10.1038/s41418-019-0352-3. Epub 2019 May 21. Cell Death Differ. 2020. PMID: 31114026 Free PMC article.
In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of programmed cell death driven by iron-dependent lipid peroxidation. ...Our findings can be exploited clinically to enhance the effect of future ferroptosis-ind …
In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of programmed cell de …
Artemisinin and its derivatives: a promising cancer therapy.
Kiani BH, Kayani WK, Khayam AU, Dilshad E, Ismail H, Mirza B. Kiani BH, et al. Mol Biol Rep. 2020 Aug;47(8):6321-6336. doi: 10.1007/s11033-020-05669-z. Epub 2020 Jul 24. Mol Biol Rep. 2020. PMID: 32710388 Review.
Artemisinin produces highly reactive free radicals by the breakdown of two oxygen atoms that kill cancerous cells. ...This review aims to highlight these achievements and propose potential strategies to develop artemisinin and its derivatives as a new class o …
Artemisinin produces highly reactive free radicals by the breakdown of two oxygen atoms that kill cancerous cells. ...This rev …
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.
Efferth T. Efferth T. Semin Cancer Biol. 2017 Oct;46:65-83. doi: 10.1016/j.semcancer.2017.02.009. Epub 2017 Feb 28. Semin Cancer Biol. 2017. PMID: 28254675 Review.
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been developed as antimalarial drug and is used worldwide. Interestingly, the bioactivity is n …
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria and related symptomes (fever, chills). Its act …
Cancer combination therapies with artemisinin-type drugs.
Efferth T. Efferth T. Biochem Pharmacol. 2017 Sep 1;139:56-70. doi: 10.1016/j.bcp.2017.03.019. Epub 2017 Mar 31. Biochem Pharmacol. 2017. PMID: 28366726 Review.
The bioactivity of its chemical constituent, artemisinin is, however, much broader. We and others found that artemisinin and its derivatives also exert profound activity against tumor cells in vitro and in vivo. ...I also summarize the activity of artemisinin …
The bioactivity of its chemical constituent, artemisinin is, however, much broader. We and others found that artemisinin and i …
Discovery and repurposing of artemisinin.
Shi Q, Xia F, Wang Q, Liao F, Guo Q, Xu C, Wang J. Shi Q, et al. Front Med. 2022 Feb;16(1):1-9. doi: 10.1007/s11684-021-0898-6. Epub 2022 Mar 15. Front Med. 2022. PMID: 35290595 Free PMC article. Review.
We will then discuss how artemisinin and its derivatives could be repurposed to treat cancer, inflammation, immunoregulation-related diseases, and COVID-19. Finally, we will discuss the implications of the "artemisinin story" and how that can better guide the …
We will then discuss how artemisinin and its derivatives could be repurposed to treat cancer, inflammation, immunoregulation-r …
Artemisinin and Its Derivatives as Potential Anticancer Agents.
Wen L, Chan BC, Qiu MH, Leung PC, Wong CK. Wen L, et al. Molecules. 2024 Aug 16;29(16):3886. doi: 10.3390/molecules29163886. Molecules. 2024. PMID: 39202965 Free PMC article. Review.
Artemisinin is a natural sesquiterpene lactone obtained from the traditional Chinese medicinal herb Artemisia annua L. ...In this review, we focused on the research progress of artemisinin and its derivatives with potential anticancer activities. The pharmacological …
Artemisinin is a natural sesquiterpene lactone obtained from the traditional Chinese medicinal herb Artemisia annua L. ...In this rev …
Artemisinin's molecular symphony: illuminating pathways for cancer therapy.
Jhade SK, Kalidoss K, Pathak PK, Shrivastava R. Jhade SK, et al. Mol Biol Rep. 2024 Dec 31;52(1):95. doi: 10.1007/s11033-024-10202-7. Mol Biol Rep. 2024. PMID: 39739138 Review.
This review delves into the molecular intricacies underlying ART's anticancer effects, elucidating its modulation of cell signaling pathways, induction of apoptosis and autophagy, and inhibition of angiogenesis crucial for cancer progression. Additionally, the review highl …
This review delves into the molecular intricacies underlying ART's anticancer effects, elucidating its modulation of cell signaling pathways …
Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of action, and future perspectives.
Bhaw-Luximon A, Jhurry D. Bhaw-Luximon A, et al. Cancer Chemother Pharmacol. 2017 Mar;79(3):451-466. doi: 10.1007/s00280-017-3251-7. Epub 2017 Feb 16. Cancer Chemother Pharmacol. 2017. PMID: 28210763 Review.
Since the late 1990s, there has been rapid multiplication of data on the anti-cancer properties of artemisinins. This article reviews the status of progress of artemisinin and its derivatives as anti-cancer agents in clinical trials, case reports, and …
Since the late 1990s, there has been rapid multiplication of data on the anti-cancer properties of artemisinins. This article …
Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds.
Lai H, Sasaki T, Singh NP. Lai H, et al. Expert Opin Ther Targets. 2005 Oct;9(5):995-1007. doi: 10.1517/14728222.9.5.995. Expert Opin Ther Targets. 2005. PMID: 16185154 Review.
By covalently tagging artemisinin to transferrin, artemisinin could be selectively picked up and concentrated by cancer cells. ...Formation of free radicals kills the cancer cell. The authors have found that artemisinin-tagged transferrin is hig …
By covalently tagging artemisinin to transferrin, artemisinin could be selectively picked up and concentrated by cancer …
Ferroptosis: A New Research Direction of Artemisinin and Its Derivatives in Anti-Cancer Treatment.
Wang Y, Yuan X, Ren M, Wang Z. Wang Y, et al. Am J Chin Med. 2024;52(1):161-181. doi: 10.1142/S0192415X24500071. Epub 2024 Feb 7. Am J Chin Med. 2024. PMID: 38328829 Review.
Ferroptosis, an iron-dependent cell death mechanism driven by an accumulation of lipid peroxides on cellular membranes, has emerged as a promising strategy to treat various diseases, including cancer. Ferroptosis inducers not only exhibit cytotoxic effects on multiple c …
Ferroptosis, an iron-dependent cell death mechanism driven by an accumulation of lipid peroxides on cellular membranes, has emerged as a pro …
1,523 results