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Page 1
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis.
Chen GQ, Benthani FA, Wu J, Liang D, Bian ZX, Jiang X. Chen GQ, et al. Cell Death Differ. 2020 Jan;27(1):242-254. doi: 10.1038/s41418-019-0352-3. Epub 2019 May 21. Cell Death Differ. 2020. PMID: 31114026 Free PMC article.
In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of programmed cell death driven by iron-dependent lipid peroxidation. ...Our findings can be exploited clinically to enhance the effect of future ferroptosis-ind …
In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of programmed cell de …
Artemisinin and its derivatives: a promising cancer therapy.
Kiani BH, Kayani WK, Khayam AU, Dilshad E, Ismail H, Mirza B. Kiani BH, et al. Mol Biol Rep. 2020 Aug;47(8):6321-6336. doi: 10.1007/s11033-020-05669-z. Epub 2020 Jul 24. Mol Biol Rep. 2020. PMID: 32710388 Review.
Artemisinin produces highly reactive free radicals by the breakdown of two oxygen atoms that kill cancerous cells. ...This review aims to highlight these achievements and propose potential strategies to develop artemisinin and its derivatives as a new class o
Artemisinin produces highly reactive free radicals by the breakdown of two oxygen atoms that kill cancerous cells. ...This rev
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.
Efferth T. Efferth T. Semin Cancer Biol. 2017 Oct;46:65-83. doi: 10.1016/j.semcancer.2017.02.009. Epub 2017 Feb 28. Semin Cancer Biol. 2017. PMID: 28254675 Review.
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been developed as antimalarial drug and is used worldwide. ...The cellular response of ARS and …
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria and related symptomes (fever, chills). Its act …
Cancer combination therapies with artemisinin-type drugs.
Efferth T. Efferth T. Biochem Pharmacol. 2017 Sep 1;139:56-70. doi: 10.1016/j.bcp.2017.03.019. Epub 2017 Mar 31. Biochem Pharmacol. 2017. PMID: 28366726 Review.
Artemisia annua L. is a Chinese medicinal plant, which is used throughout Asia and Africa as tea or press juice to treat malaria. The bioactivity of its chemical constituent, artemisinin is, however, much broader. We and others found that artemisinin and its derivat …
Artemisia annua L. is a Chinese medicinal plant, which is used throughout Asia and Africa as tea or press juice to treat malaria. The bioact …
Discovery and repurposing of artemisinin.
Shi Q, Xia F, Wang Q, Liao F, Guo Q, Xu C, Wang J. Shi Q, et al. Front Med. 2022 Feb;16(1):1-9. doi: 10.1007/s11684-021-0898-6. Epub 2022 Mar 15. Front Med. 2022. PMID: 35290595 Free PMC article. Review.
We will then discuss how artemisinin and its derivatives could be repurposed to treat cancer, inflammation, immunoregulation-related diseases, and COVID-19. ...We believe that artemisinin is just a starting point and TCM will play an even bigger role in healt …
We will then discuss how artemisinin and its derivatives could be repurposed to treat cancer, inflammation, immunoregulation-r …
Development of artemisinin compounds for cancer treatment.
Lai HC, Singh NP, Sasaki T. Lai HC, et al. Invest New Drugs. 2013 Feb;31(1):230-46. doi: 10.1007/s10637-012-9873-z. Epub 2012 Aug 31. Invest New Drugs. 2013. PMID: 22935909 Review.
Cancer cells contain significantly more intracellular free iron than normal cells and it has been shown that artemisinin and its analogs selectively cause apoptosis in many cancer cell lines. ...These properties make artemisinin compounds attractive
Cancer cells contain significantly more intracellular free iron than normal cells and it has been shown that artemisinin and i
Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of action, and future perspectives.
Bhaw-Luximon A, Jhurry D. Bhaw-Luximon A, et al. Cancer Chemother Pharmacol. 2017 Mar;79(3):451-466. doi: 10.1007/s00280-017-3251-7. Epub 2017 Feb 16. Cancer Chemother Pharmacol. 2017. PMID: 28210763 Review.
Since the late 1990s, there has been rapid multiplication of data on the anti-cancer properties of artemisinins. This article reviews the status of progress of artemisinin and its derivatives as anti-cancer agents in clinical trials, case reports, and …
Since the late 1990s, there has been rapid multiplication of data on the anti-cancer properties of artemisinins. This article …
Combination Therapies of Artemisinin and its Derivatives as a Viable Approach for Future Cancer Treatment.
Kumar MS, Yadav TT, Khair RR, Peters GJ, Yergeri MC. Kumar MS, et al. Curr Pharm Des. 2019;25(31):3323-3338. doi: 10.2174/1381612825666190902155957. Curr Pharm Des. 2019. PMID: 31475891 Review.
RESULT: Literature shows changes at 9, 10 position in the artemisinin structure produces anticancer activity. Artemisinin shows anticancer activity in leukemia, hepatocellular carcinoma, colorectal and breast cancer cell lines. ...Various reports and clinical …
RESULT: Literature shows changes at 9, 10 position in the artemisinin structure produces anticancer activity. Artemisinin show …
Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds.
Lai H, Sasaki T, Singh NP. Lai H, et al. Expert Opin Ther Targets. 2005 Oct;9(5):995-1007. doi: 10.1517/14728222.9.5.995. Expert Opin Ther Targets. 2005. PMID: 16185154 Review.
By covalently tagging artemisinin to transferrin, artemisinin could be selectively picked up and concentrated by cancer cells. ...Formation of free radicals kills the cancer cell. The authors have found that artemisinin-tagged transferrin is hig …
By covalently tagging artemisinin to transferrin, artemisinin could be selectively picked up and concentrated by cancer
Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs.
Carqueijeiro I, Langley C, Grzech D, Koudounas K, Papon N, O'Connor SE, Courdavault V. Carqueijeiro I, et al. Curr Opin Biotechnol. 2020 Oct;65:17-24. doi: 10.1016/j.copbio.2019.11.017. Epub 2019 Dec 13. Curr Opin Biotechnol. 2020. PMID: 31841858 Free article. Review.
The discovery and supply of plant-derived anti-cancer compounds remain challenging given their low bioavailability and structural complexity. ...This review describes the current strategies and recent advancements in the production of these valuable therapeutic compounds, …
The discovery and supply of plant-derived anti-cancer compounds remain challenging given their low bioavailability and structural com …
1,304 results