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Identification of a HERV-K env surface peptide highly recognized in Rheumatoid Arthritis (RA) patients: a cross-sectional case-control study.
Mameli G, Erre GL, Caggiu E, Mura S, Cossu D, Bo M, Cadoni ML, Piras A, Mundula N, Colombo E, Buscetta G, Passiu G, Sechi LA. Mameli G, et al. Clin Exp Immunol. 2017 Jul;189(1):127-131. doi: 10.1111/cei.12964. Epub 2017 May 9. Clin Exp Immunol. 2017. PMID: 28324619 Free PMC article.
Endogenous retroviruses (HERV) are believed to be pathogenic in several autoimmune diseases. Among them, HERV-K viruses have been reported recently to be involved in the pathogenesis of rheumatoid arthritis (RA). ...Serum from RA patients in our series …
Endogenous retroviruses (HERV) are believed to be pathogenic in several autoimmune diseases. Among them, HERV-K viruses …
Human endogenous retrovirus-K contributes to motor neuron disease.
Li W, Lee MH, Henderson L, Tyagi R, Bachani M, Steiner J, Campanac E, Hoffman DA, von Geldern G, Johnson K, Maric D, Morris HD, Lentz M, Pak K, Mammen A, Ostrow L, Rothstein J, Nath A. Li W, et al. Sci Transl Med. 2015 Sep 30;7(307):307ra153. doi: 10.1126/scitranslmed.aac8201. Sci Transl Med. 2015. PMID: 26424568 Free PMC article.
Expression of HERV-K was regulated by TAR (trans-activation responsive) DNA binding protein 43, which binds to the long terminal repeat region of the virus. Thus, HERV-K expression within neurons of patients with ALS may contribute to neurodegeneration …
Expression of HERV-K was regulated by TAR (trans-activation responsive) DNA binding protein 43, which binds to the long termin …
Human endogenous retrovirus HERV-K(HML-2) Rec expression and transcriptional activities in normal and rheumatoid arthritis synovia.
Ehlhardt S, Seifert M, Schneider J, Ojak A, Zang KD, Mehraein Y. Ehlhardt S, et al. J Rheumatol. 2006 Jan;33(1):16-23. J Rheumatol. 2006. PMID: 16395745
The involvement of HERV in various disease conditions, such as germ cell tumors or autoimmune diseases like rheumatoid arthritis (RA), has been suggested. We investigated expression of HERV-K(HML-2) env-derived transcripts in normal and RA synovia. MET …
The involvement of HERV in various disease conditions, such as germ cell tumors or autoimmune diseases like rheumatoid arthritis …
Increase in human endogenous retrovirus HERV-K (HML-2) viral load in active rheumatoid arthritis.
Reynier F, Verjat T, Turrel F, Imbert PE, Marotte H, Mougin B, Miossec P. Reynier F, et al. Scand J Immunol. 2009 Sep;70(3):295-9. doi: 10.1111/j.1365-3083.2009.02271.x. Scand J Immunol. 2009. PMID: 19703019 Free article.
To study the viral loads of human endogenous retrovirus HERV-K (HML-2) type 1 and type 2 in rheumatoid arthritis (RA), we measured the viral loads of HERV-K (HML-2) type 1 and type 2 using nucleic acid sequence-based amplification (NASBA) techno …
To study the viral loads of human endogenous retrovirus HERV-K (HML-2) type 1 and type 2 in rheumatoid arthritis (RA), …
Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses.
Subramanian RP, Wildschutte JH, Russo C, Coffin JM. Subramanian RP, et al. Retrovirology. 2011 Nov 8;8:90. doi: 10.1186/1742-4690-8-90. Retrovirology. 2011. PMID: 22067224 Free PMC article.
The most recently active retroviruses that integrated into the human germ line are members of the Betaretrovirus-like HERV-K (HML-2) group, many of which contain intact open reading frames (ORFs) in some or all genes, sometimes encoding functional proteins that are …
The most recently active retroviruses that integrated into the human germ line are members of the Betaretrovirus-like HERV-K ( …
A role for human endogenous retrovirus-K (HML-2) in rheumatoid arthritis: investigating mechanisms of pathogenesis.
Freimanis G, Hooley P, Ejtehadi HD, Ali HA, Veitch A, Rylance PB, Alawi A, Axford J, Nevill A, Murray PG, Nelson PN. Freimanis G, et al. Clin Exp Immunol. 2010 Jun;160(3):340-7. doi: 10.1111/j.1365-2249.2010.04110.x. Epub 2010 Mar 16. Clin Exp Immunol. 2010. PMID: 20345981 Free PMC article.
Both serological and molecular assays showed significant increases in HERV-K (HML-2) gag activity in RA patients, compared to disease controls. ...Exogenous viral protein expression and proinflammatory cytokines were also shown to exert modulatory effects over HE …
Both serological and molecular assays showed significant increases in HERV-K (HML-2) gag activity in RA patients, compared to …
The role of molecular mimicry and other factors in the association of Human Endogenous Retroviruses and autoimmunity.
Trela M, Nelson PN, Rylance PB. Trela M, et al. APMIS. 2016 Jan-Feb;124(1-2):88-104. doi: 10.1111/apm.12487. APMIS. 2016. PMID: 26818264 Review.
The most convincing evidence for molecular mimicry is in rheumatoid arthritis, where HERV K-10 shares amino acid sequences with IgG1Fc, a target for rheumatoid factor. ...
The most convincing evidence for molecular mimicry is in rheumatoid arthritis, where HERV K-10 shares amino acid sequen …
Rheumatoid arthritis patient antibodies highly recognize IL-2 in the immune response pathway involving IRF5 and EBV antigens.
Bo M, Niegowska M, Erre GL, Piras M, Longu MG, Manchia P, Manca M, Passiu G, Sechi LA. Bo M, et al. Sci Rep. 2018 Jan 29;8(1):1789. doi: 10.1038/s41598-018-19957-z. Sci Rep. 2018. PMID: 29379122 Free PMC article.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a progressive joint damage due to largely unknown environmental factors acting in concert with risk alleles conferring genetic susceptibility. A major role has been attributed to viral infections th …
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a progressive joint damage due to largely unknown environm …
Posttranscriptional regulation of human endogenous retroviruses by RNA-binding motif protein 4, RBM4.
Foroushani AK, Chim B, Wong M, Rastegar A, Smith PT, Wang S, Barbian K, Martens C, Hafner M, Muljo SA. Foroushani AK, et al. Proc Natl Acad Sci U S A. 2020 Oct 5:202005237. doi: 10.1073/pnas.2005237117. Online ahead of print. Proc Natl Acad Sci U S A. 2020. PMID: 33020268
Loss of RBM4 resulted in an elevated transcript level of bound ERVs of the HERV-K and -H families, as well as increased expression of HERV-K envelope protein. We pinpointed RBM4 regulation of HERV-K to a CGG-containing element that is con …
Loss of RBM4 resulted in an elevated transcript level of bound ERVs of the HERV-K and -H families, as well as increased expres …
Long PCR detection of the C4A null allele in B8-C4AQ0-C4B1-DR3.
Grant SF, Kristjánsdóttir H, Steinsson K, Blöndal T, Yuryev A, Stefansson K, Gulcher JR. Grant SF, et al. J Immunol Methods. 2000 Oct 20;244(1-2):41-7. doi: 10.1016/s0022-1759(00)00251-9. J Immunol Methods. 2000. PMID: 11033017
Several studies have shown that deficiency of C4A is associated with systemic lupus erythematosus (SLE), rheumatoid arthritis and scleroderma. ...The methodology makes use of the unique sequence of the G11 gene upstream of C4A and the sequence of a 6.4 kb retrotransposon, …
Several studies have shown that deficiency of C4A is associated with systemic lupus erythematosus (SLE), rheumatoid arthritis and scl …
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