Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1999 1
2000 1
2006 1
2009 1
2010 1
2011 1
2015 1
2016 1
2017 1
2018 1
2019 1
2020 1
2021 3
2022 5
2023 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

19 results

Results by year

Filters applied: . Clear all
Page 1
Human endogenous retrovirus-K contributes to motor neuron disease.
Li W, Lee MH, Henderson L, Tyagi R, Bachani M, Steiner J, Campanac E, Hoffman DA, von Geldern G, Johnson K, Maric D, Morris HD, Lentz M, Pak K, Mammen A, Ostrow L, Rothstein J, Nath A. Li W, et al. Sci Transl Med. 2015 Sep 30;7(307):307ra153. doi: 10.1126/scitranslmed.aac8201. Sci Transl Med. 2015. PMID: 26424568 Free PMC article.
The virus was expressed in cortical and spinal neurons of ALS patients, but not in neurons from control healthy individuals. Expression of HERV-K or its env protein in human neurons caused retraction and beading of neurites. ...Thus, HERV-K expression …
The virus was expressed in cortical and spinal neurons of ALS patients, but not in neurons from control healthy individuals. Expression of …
Identification of a HERV-K env surface peptide highly recognized in Rheumatoid Arthritis (RA) patients: a cross-sectional case-control study.
Mameli G, Erre GL, Caggiu E, Mura S, Cossu D, Bo M, Cadoni ML, Piras A, Mundula N, Colombo E, Buscetta G, Passiu G, Sechi LA. Mameli G, et al. Clin Exp Immunol. 2017 Jul;189(1):127-131. doi: 10.1111/cei.12964. Epub 2017 May 9. Clin Exp Immunol. 2017. PMID: 28324619 Free PMC article.
Endogenous retroviruses (HERV) are believed to be pathogenic in several autoimmune diseases. Among them, HERV-K viruses have been reported recently to be involved in the pathogenesis of rheumatoid arthritis (RA). ...Serum from RA patients in our series reacte …
Endogenous retroviruses (HERV) are believed to be pathogenic in several autoimmune diseases. Among them, HERV-K viruses have b …
Human endogenous retrovirus HERV-K(HML-2) Rec expression and transcriptional activities in normal and rheumatoid arthritis synovia.
Ehlhardt S, Seifert M, Schneider J, Ojak A, Zang KD, Mehraein Y. Ehlhardt S, et al. J Rheumatol. 2006 Jan;33(1):16-23. J Rheumatol. 2006. PMID: 16395745
METHODS: We analyzed HERV-K(HML-2) expression on the mRNA and protein level by RT-PCR analysis and immunofluorescence labeling of the HERV-K(HML-2) Rec (formerly cORF) protein. ...We demonstrate for the first time expression of HERV-K pro …
METHODS: We analyzed HERV-K(HML-2) expression on the mRNA and protein level by RT-PCR analysis and immunofluorescence labeling …
Increase in human endogenous retrovirus HERV-K (HML-2) viral load in active rheumatoid arthritis.
Reynier F, Verjat T, Turrel F, Imbert PE, Marotte H, Mougin B, Miossec P. Reynier F, et al. Scand J Immunol. 2009 Sep;70(3):295-9. doi: 10.1111/j.1365-3083.2009.02271.x. Scand J Immunol. 2009. PMID: 19703019 Free article.
To study the viral loads of human endogenous retrovirus HERV-K (HML-2) type 1 and type 2 in rheumatoid arthritis (RA), we measured the viral loads of HERV-K (HML-2) type 1 and type 2 using nucleic acid sequence-based amplification (NASBA) techno …
To study the viral loads of human endogenous retrovirus HERV-K (HML-2) type 1 and type 2 in rheumatoid arthritis (RA), …
Autoantibodies Against Unmodified and Citrullinated Human Endogenous Retrovirus K Envelope Protein in Patients With Rheumatoid Arthritis.
Wang X, Hefton A, Ni K, Ukadike KC, Bowen MA, Eckert M, Stevens A, Lood C, Mustelin T. Wang X, et al. J Rheumatol. 2022 Jan;49(1):26-35. doi: 10.3899/jrheum.201492. Epub 2021 Aug 1. J Rheumatol. 2022. PMID: 34334364 Free PMC article.
OBJECTIVE: Autoantibodies against proteins encoded by human endogenous retrovirus K (HERV-K) have been reported in patients with rheumatoid arthritis (RA), but their relevance, if any, has remained unresolved. ...RESULTS: We replicated and expanded upon publi …
OBJECTIVE: Autoantibodies against proteins encoded by human endogenous retrovirus K (HERV-K) have been reported in patients wi …
Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome.
Jia L, Liu M, Yang C, Li H, Liu Y, Han J, Zhai X, Wang X, Li T, Li J, Zhang B, Yu C, Li L. Jia L, et al. Retrovirology. 2022 Jun 8;19(1):11. doi: 10.1186/s12977-022-00596-2. Retrovirology. 2022. PMID: 35676699 Free PMC article.
HERVs can be transmitted vertically in a Mendelian fashion and be stably maintained in the human genome, of which they are estimated to comprise approximately 8%. HERV-K (HML1-10) transcription has been confirmed to be associated with a variety of diseases, such as …
HERVs can be transmitted vertically in a Mendelian fashion and be stably maintained in the human genome, of which they are estimated to comp …
A role for human endogenous retrovirus-K (HML-2) in rheumatoid arthritis: investigating mechanisms of pathogenesis.
Freimanis G, Hooley P, Ejtehadi HD, Ali HA, Veitch A, Rylance PB, Alawi A, Axford J, Nevill A, Murray PG, Nelson PN. Freimanis G, et al. Clin Exp Immunol. 2010 Jun;160(3):340-7. doi: 10.1111/j.1365-2249.2010.04110.x. Epub 2010 Mar 16. Clin Exp Immunol. 2010. PMID: 20345981 Free PMC article.
These molecular fossils draw parallels with present-day exogenous retroviruses and have been linked previously with immunopathology within rheumatoid arthritis (RA). Mechanisms of pathogenesis for HERV-K in RA such as molecular mimicry were investigated. ...E …
These molecular fossils draw parallels with present-day exogenous retroviruses and have been linked previously with immunopathology within r …
Expression of Envelope Protein Encoded by Endogenous Retrovirus K102 in Rheumatoid Arthritis Neutrophils.
Laine A, Wang X, Ni K, Smith SEB, Najjar R, Whitmore LS, Yacoub M, Bays A, Gale M Jr, Mustelin T. Laine A, et al. Microorganisms. 2023 May 17;11(5):1310. doi: 10.3390/microorganisms11051310. Microorganisms. 2023. PMID: 37317284 Free PMC article.
One such protein is the transmembrane envelope (Env) protein encoded by human endogenous retrovirus K (HERV-K). We reported recently that patients with rheumatoid arthritis (RA) have IgG autoantibodies that recognize Env. Here, we use RNA sequencing of RA neu …
One such protein is the transmembrane envelope (Env) protein encoded by human endogenous retrovirus K (HERV-K). We reported re …
The role of molecular mimicry and other factors in the association of Human Endogenous Retroviruses and autoimmunity.
Trela M, Nelson PN, Rylance PB. Trela M, et al. APMIS. 2016 Jan-Feb;124(1-2):88-104. doi: 10.1111/apm.12487. APMIS. 2016. PMID: 26818264 Review.
The most convincing evidence for molecular mimicry is in rheumatoid arthritis, where HERV K-10 shares amino acid sequences with IgG1Fc, a target for rheumatoid factor. ...
The most convincing evidence for molecular mimicry is in rheumatoid arthritis, where HERV K-10 shares amino acid sequen …
Autoantibodies against the envelope proteins of endogenous retroviruses K102 and K108 in patients with systemic lupus erythematosus correlate with active disease.
Khadjinova AI, Wang X, Laine A, Ukadike K, Eckert M, Stevens A, Bengtsson AA, Lood C, Mustelin T. Khadjinova AI, et al. Clin Exp Rheumatol. 2022 Jul;40(7):1306-1312. doi: 10.55563/clinexprheumatol/2kg1d8. Epub 2021 Oct 13. Clin Exp Rheumatol. 2022. PMID: 34665695 Free PMC article.
Antibody reactivity was evaluated for correlations with clinical and laboratory parameters of the patients. Expression of HERV-K transcripts were profiled in SLE leukocytes by RNA-Seq. RESULTS: Both adult and paediatric SLE patients had autoantibodies against HER …
Antibody reactivity was evaluated for correlations with clinical and laboratory parameters of the patients. Expression of HERV-K …
19 results