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Human endogenous retrovirus-K contributes to motor neuron disease.
Li W, Lee MH, Henderson L, Tyagi R, Bachani M, Steiner J, Campanac E, Hoffman DA, von Geldern G, Johnson K, Maric D, Morris HD, Lentz M, Pak K, Mammen A, Ostrow L, Rothstein J, Nath A. Li W, et al. Sci Transl Med. 2015 Sep 30;7(307):307ra153. doi: 10.1126/scitranslmed.aac8201. Sci Transl Med. 2015. PMID: 26424568 Free PMC article.
The virus was expressed in cortical and spinal neurons of ALS patients, but not in neurons from control healthy individuals. Expression of HERV-K or its env protein in human neurons caused retraction and beading of neurites. ...Thus, HERV-K expression …
The virus was expressed in cortical and spinal neurons of ALS patients, but not in neurons from control healthy individuals. Expression of …
Identification of a HERV-K env surface peptide highly recognized in Rheumatoid Arthritis (RA) patients: a cross-sectional case-control study.
Mameli G, Erre GL, Caggiu E, Mura S, Cossu D, Bo M, Cadoni ML, Piras A, Mundula N, Colombo E, Buscetta G, Passiu G, Sechi LA. Mameli G, et al. Clin Exp Immunol. 2017 Jul;189(1):127-131. doi: 10.1111/cei.12964. Epub 2017 May 9. Clin Exp Immunol. 2017. PMID: 28324619 Free PMC article.
Among them, HERV-K viruses have been reported recently to be involved in the pathogenesis of rheumatoid arthritis (RA). ...Serum from RA patients in our series reacted significantly against HERV-K env-su(19-37) peptide in comparison to the gener …
Among them, HERV-K viruses have been reported recently to be involved in the pathogenesis of rheumatoid arthritis (RA). …
Human endogenous retrovirus HERV-K(HML-2) Rec expression and transcriptional activities in normal and rheumatoid arthritis synovia.
Ehlhardt S, Seifert M, Schneider J, Ojak A, Zang KD, Mehraein Y. Ehlhardt S, et al. J Rheumatol. 2006 Jan;33(1):16-23. J Rheumatol. 2006. PMID: 16395745
We investigated expression of HERV-K(HML-2) env-derived transcripts in normal and RA synovia. METHODS: We analyzed HERV-K(HML-2) expression on the mRNA and protein level by RT-PCR analysis and immunofluorescence labeling of the HERV-K(HML …
We investigated expression of HERV-K(HML-2) env-derived transcripts in normal and RA synovia. METHODS: We analyzed HERV
Increase in human endogenous retrovirus HERV-K (HML-2) viral load in active rheumatoid arthritis.
Reynier F, Verjat T, Turrel F, Imbert PE, Marotte H, Mougin B, Miossec P. Reynier F, et al. Scand J Immunol. 2009 Sep;70(3):295-9. doi: 10.1111/j.1365-3083.2009.02271.x. Scand J Immunol. 2009. PMID: 19703019 Free article.
To study the viral loads of human endogenous retrovirus HERV-K (HML-2) type 1 and type 2 in rheumatoid arthritis (RA), we measured the viral loads of HERV-K (HML-2) type 1 and type 2 using nucleic acid sequence-based amplification (NASBA) techno …
To study the viral loads of human endogenous retrovirus HERV-K (HML-2) type 1 and type 2 in rheumatoid arthritis (RA), …
A role for human endogenous retrovirus-K (HML-2) in rheumatoid arthritis: investigating mechanisms of pathogenesis.
Freimanis G, Hooley P, Ejtehadi HD, Ali HA, Veitch A, Rylance PB, Alawi A, Axford J, Nevill A, Murray PG, Nelson PN. Freimanis G, et al. Clin Exp Immunol. 2010 Jun;160(3):340-7. doi: 10.1111/j.1365-2249.2010.04110.x. Epub 2010 Mar 16. Clin Exp Immunol. 2010. PMID: 20345981 Free PMC article.
These molecular fossils draw parallels with present-day exogenous retroviruses and have been linked previously with immunopathology within rheumatoid arthritis (RA). Mechanisms of pathogenesis for HERV-K in RA such as molecular mimicry were investigated. ...E …
These molecular fossils draw parallels with present-day exogenous retroviruses and have been linked previously with immunopathology within r …
Autoantibodies Against Unmodified and Citrullinated Human Endogenous Retrovirus K Envelope Protein in Patients With Rheumatoid Arthritis.
Wang X, Hefton A, Ni K, Ukadike KC, Bowen MA, Eckert M, Stevens A, Lood C, Mustelin T. Wang X, et al. J Rheumatol. 2022 Jan;49(1):26-35. doi: 10.3899/jrheum.201492. Epub 2021 Aug 1. J Rheumatol. 2022. PMID: 34334364
OBJECTIVE: Autoantibodies against proteins encoded by human endogenous retrovirus K (HERV-K) have been reported in patients with rheumatoid arthritis (RA), but their relevance, if any, has remained unresolved. ...RESULTS: We replicated and expanded upo …
OBJECTIVE: Autoantibodies against proteins encoded by human endogenous retrovirus K (HERV-K) have been reported in pati …
Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome.
Jia L, Liu M, Yang C, Li H, Liu Y, Han J, Zhai X, Wang X, Li T, Li J, Zhang B, Yu C, Li L. Jia L, et al. Retrovirology. 2022 Jun 8;19(1):11. doi: 10.1186/s12977-022-00596-2. Retrovirology. 2022. PMID: 35676699 Free PMC article.
HERVs can be transmitted vertically in a Mendelian fashion and be stably maintained in the human genome, of which they are estimated to comprise approximately 8%. HERV-K (HML1-10) transcription has been confirmed to be associated with a variety of diseases, such as …
HERVs can be transmitted vertically in a Mendelian fashion and be stably maintained in the human genome, of which they are estimated to comp …
Autoantibodies against the envelope proteins of endogenous retroviruses K102 and K108 in patients with systemic lupus erythematosus correlate with active disease.
Khadjinova AI, Wang X, Laine A, Ukadike K, Eckert M, Stevens A, Bengtsson AA, Lood C, Mustelin T. Khadjinova AI, et al. Clin Exp Rheumatol. 2021 Oct 13. doi: 10.55563/clinexprheumatol/2kg1d8. Online ahead of print. Clin Exp Rheumatol. 2021. PMID: 34665695
Transcripts from only two HERV-K loci capable of producing Env, HERV-K102 and -K108, were detected among the 10 expressed loci in SLE patients. CONCLUSIONS: Our data reveal that HERV-K proviruses are expressed in SLE and that the HERV- …
Transcripts from only two HERV-K loci capable of producing Env, HERV-K102 and -K108, were detected among the 10 express …
Posttranscriptional regulation of human endogenous retroviruses by RNA-binding motif protein 4, RBM4.
Foroushani AK, Chim B, Wong M, Rastegar A, Smith PT, Wang S, Barbian K, Martens C, Hafner M, Muljo SA. Foroushani AK, et al. Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26520-26530. doi: 10.1073/pnas.2005237117. Epub 2020 Oct 5. Proc Natl Acad Sci U S A. 2020. PMID: 33020268 Free PMC article.
Loss of RBM4 resulted in an elevated transcript level of bound ERVs of the HERV-K and -H families, as well as increased expression of HERV-K envelope protein. We pinpointed RBM4 regulation of HERV-K to a CGG-containing element that is con …
Loss of RBM4 resulted in an elevated transcript level of bound ERVs of the HERV-K and -H families, as well as increased expres …
The role of molecular mimicry and other factors in the association of Human Endogenous Retroviruses and autoimmunity.
Trela M, Nelson PN, Rylance PB. Trela M, et al. APMIS. 2016 Jan-Feb;124(1-2):88-104. doi: 10.1111/apm.12487. APMIS. 2016. PMID: 26818264 Review.
The most convincing evidence for molecular mimicry is in rheumatoid arthritis, where HERV K-10 shares amino acid sequences with IgG1Fc, a target for rheumatoid factor. ...
The most convincing evidence for molecular mimicry is in rheumatoid arthritis, where HERV K-10 shares amino acid sequen …
16 results