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Multi-disciplinary methods to define RNA-protein interactions and regulatory networks.
Ascano M, Gerstberger S, Tuschl T. Ascano M, et al. Curr Opin Genet Dev. 2013 Feb;23(1):20-8. doi: 10.1016/j.gde.2013.01.003. Epub 2013 Feb 28. Curr Opin Genet Dev. 2013. PMID: 23453689 Free PMC article. Review.
The multitude of RNA-binding proteins (RBPs) and their many RNA targets has only been captured experimentally in recent times. In this review, we will examine current multidisciplinary approaches toward elucidating RNA-protein networks and their regulation....
The multitude of RNA-binding proteins (RBPs) and their many RNA targets has only been captured experimentally in recent times. In this re
Identification of RNA-protein interaction networks using PAR-CLIP.
Ascano M, Hafner M, Cekan P, Gerstberger S, Tuschl T. Ascano M, et al. Wiley Interdiscip Rev RNA. 2012 Mar-Apr;3(2):159-77. doi: 10.1002/wrna.1103. Epub 2011 Dec 27. Wiley Interdiscip Rev RNA. 2012. PMID: 22213601 Free PMC article. Review.
The recent introduction of deep-sequencing technologies enabled the development of new methods for broadly mapping interaction sites between RNA-binding proteins (RBPs) and their RNA target sites. In this article, we review crosslinking and immunoprecipitation (CLIP) metho …
The recent introduction of deep-sequencing technologies enabled the development of new methods for broadly mapping interaction sites between …
Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease.
Gerstberger S, Hafner M, Ascano M, Tuschl T. Gerstberger S, et al. Adv Exp Med Biol. 2014;825:1-55. doi: 10.1007/978-1-4939-1221-6_1. Adv Exp Med Biol. 2014. PMID: 25201102 Free PMC article. Review.
This chapter globally discusses human RBPs and provides a brief introduction to their identification and RNA targets. We review RBPs based on common structural RNA-binding domains, study their evolutionary conservation and expression, and summarize disease associations of …
This chapter globally discusses human RBPs and provides a brief introduction to their identification and RNA targets. We review RBPs …