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2009 2
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Page 1
Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis.
Rogdaki M, McCutcheon RA, D'Ambrosio E, Mancini V, Watson CJ, Fanshawe JB, Carr R, Telesia L, Martini MG, Philip A, Gilbert BJ, Salazar-de-Pablo G, Kyriakopoulos M, Siskind D, Correll CU, Cipriani A, Efthimiou O, Howes OD, Pillinger T. Rogdaki M, et al. Lancet Child Adolesc Health. 2024 Jul;8(7):510-521. doi: 10.1016/S2352-4642(24)00098-1. Lancet Child Adolesc Health. 2024. PMID: 38897716 Free PMC article.
Primary outcomes were mean change from baseline to end of acute treatment in bodyweight, BMI, fasting glucose, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, prolactin, heart rate, systolic blood pressure (SBP), and QT interval corrected for heart rate …
Primary outcomes were mean change from baseline to end of acute treatment in bodyweight, BMI, fasting glucose, total cholesterol, LDL choles …
Asenapine for schizophrenia and bipolar disorder: a review of the efficacy and safety profile for this newly approved sublingually absorbed second-generation antipsychotic.
Citrome L. Citrome L. Int J Clin Pract. 2009 Dec;63(12):1762-84. doi: 10.1111/j.1742-1241.2009.02228.x. Epub 2009 Oct 14. Int J Clin Pract. 2009. PMID: 19840150 Review.
Similar to other second-generation antipsychotics, asenapine's binding profile includes 5-HT2A and D2 antagonism. Binding at the alpha-1 adrenergic and histamine H1 receptors predicts asenapine's propensity to cause orthostasis and sedation in some pat …
Similar to other second-generation antipsychotics, asenapine's binding profile includes 5-HT2A and D2 antagonism. Binding at t …
First- and Second-Generation Antipsychotics in Children and Young Adults: Systematic Review Update [Internet].
Pillay J, Boylan K, Carrey N, Newton A, Vandermeer B, Nuspl M, MacGregor T, Jafri SHA, Featherstone R, Hartling L. Pillay J, et al. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 Mar. Report No.: 17-EHC001-EF. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 Mar. Report No.: 17-EHC001-EF. PMID: 28749632 Free Books & Documents. Review.
Findings from pairwise meta-analysis between different SGAs were similar, except for showing longer term benefit for quetiapine and risperidone versus olanzapine, and little or no short-term differences between risperidone and quetiapine, or between different doses of aripiprazol …
Findings from pairwise meta-analysis between different SGAs were similar, except for showing longer term benefit for quetiapine and risperid …
Clinically relevant interactions between newer antidepressants and second-generation antipsychotics.
Spina E, de Leon J. Spina E, et al. Expert Opin Drug Metab Toxicol. 2014 May;10(5):721-46. doi: 10.1517/17425255.2014.885504. Epub 2014 Feb 5. Expert Opin Drug Metab Toxicol. 2014. PMID: 24494611 Review.
Further PK DI studies and case reports are also needed to better establish the need for dose correction factors after adding i) fluoxetine to clozapine, lurasidone, quetiapine and olanzapine; ii) paroxetine to olanzapine; iii) fluvoxamine to asenapine, aripiprazole, iloper …
Further PK DI studies and case reports are also needed to better establish the need for dose correction factors after adding i) fluoxetine t …
Comparison of QTc data analysis methods recommended by the ICH E14 guidance and exposure-response analysis: case study of a thorough QT study of asenapine.
Chapel S, Hutmacher MM, Bockbrader H, de Greef R, Lalonde RL. Chapel S, et al. Clin Pharmacol Ther. 2011 Jan;89(1):75-80. doi: 10.1038/clpt.2010.220. Epub 2010 Nov 24. Clin Pharmacol Ther. 2011. PMID: 21107314 Clinical Trial.
An assessment of the effects of asenapine on QTc interval in patients with schizophrenia revealed a discrepancy between the results obtained by two different methods: an intersection-union test (IUT) (as recommended in the International Conference on Harmonisation E14 guid …
An assessment of the effects of asenapine on QTc interval in patients with schizophrenia revealed a discrepancy between the results o …
A review of the pharmacology, efficacy and tolerability of recently approved and upcoming oral antipsychotics: an evidence-based medicine approach.
Citrome L. Citrome L. CNS Drugs. 2013 Nov;27(11):879-911. doi: 10.1007/s40263-013-0105-7. CNS Drugs. 2013. PMID: 24062193
Using the framework and philosophy of EBM, this systematic review summarizes the pharmacology, efficacy, and tolerability of newly approved oral antipsychotics, including iloperidone, asenapine, and lurasidone, and outlines what is known about agents that are in late-stage …
Using the framework and philosophy of EBM, this systematic review summarizes the pharmacology, efficacy, and tolerability of newly approved …
Effects of Antipsychotics on Arrhythmogenic Parameters in Schizophrenia Patients: Beyond Corrected QT Interval.
Okayasu H, Shinozaki T, Takano Y, Sugawara N, Fujii K, Yasui-Furukori N, Ozeki Y, Shimoda K. Okayasu H, et al. Neuropsychiatr Dis Treat. 2021 Jan 27;17:239-249. doi: 10.2147/NDT.S287042. eCollection 2021. Neuropsychiatr Dis Treat. 2021. PMID: 33542628 Free PMC article.
PURPOSE: Antipsychotic drugs have been implicated as risk factors for QT prolongation, which is a predictor of sudden cardiac death. However, the QT interval is considered an imperfect marker for proarrhythmic risk. Recently, improved methods, namely, QT disp …
PURPOSE: Antipsychotic drugs have been implicated as risk factors for QT prolongation, which is a predictor of sudden cardiac death. …
QTc Prolongation and Ventricular Trigemini with Asenapine: A Case Report.
Gıll JS, Sulaıman AH. Gıll JS, et al. Turk Psikiyatri Derg. 2018 Spring;29(1):67-68. Turk Psikiyatri Derg. 2018. PMID: 29730876 Free article. English.
Asenapine is one of the newer atypical antipsychotics on the market. It is a sublingually administered drug that is indicated for the treatment of both schizophrenia and bipolar disorder, and is considered to be safe and well tolerated. Herein, we report a 71-year-old fema …
Asenapine is one of the newer atypical antipsychotics on the market. It is a sublingually administered drug that is indicated for the …
QTc prolongation with asenapine.
Kotasek F, Tibrewal P, Dhillon R. Kotasek F, et al. Aust N Z J Psychiatry. 2014 Oct;48(10):961. doi: 10.1177/0004867414531832. Epub 2014 Apr 16. Aust N Z J Psychiatry. 2014. PMID: 24740249 No abstract available.
Exposure-response analysis in patients with schizophrenia to assess the effect of asenapine on QTc prolongation.
Chapel S, Hutmacher MM, Haig G, Bockbrader H, de Greef R, Preskorn SH, Lalonde RL. Chapel S, et al. J Clin Pharmacol. 2009 Nov;49(11):1297-308. doi: 10.1177/0091270009344855. J Clin Pharmacol. 2009. PMID: 19843656 Clinical Trial.
An exposure-response (E-R) analysis using linear mixed effects modeling was conducted on data from a thorough QTc trial for asenapine in 148 patients with schizophrenia. In a parallel design, patients received asenapine 5 mg twice daily (BID) for 10 days (10d) follo …
An exposure-response (E-R) analysis using linear mixed effects modeling was conducted on data from a thorough QTc trial for asenapine …