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Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response.

Wilson DM 3rd, Deacon AM, Duncton MAJ, Pellicena P, Georgiadis MM, Yeh AP, Arvai AS, Moiani D, Tainer JA, Das D. Wilson DM 3rd, et al. Among authors: deacon am. Prog Biophys Mol Biol. 2021 Aug;163:130-142. doi: 10.1016/j.pbiomolbio.2020.10.005. Epub 2020 Oct 25. Prog Biophys Mol Biol. 2021. PMID: 33115610 Free PMC article.

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Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH).

Wilson DM, Duncton MAJ, Chang C, Lee Luo C, Georgiadis TM, Pellicena P, Deacon AM, Gao Y, Das D. Wilson DM, et al. Among authors: deacon am. Front Oncol. 2021 Nov 19;11:778925. doi: 10.3389/fonc.2021.778925. eCollection 2021. Front Oncol. 2021. PMID: 34900730 Free PMC article.

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Structures of single-layer β-sheet proteins evolved from β-hairpin repeats.

Xu Q, Biancalana M, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA. Xu Q, et al. Among authors: deacon am. Protein Sci. 2019 Sep;28(9):1676-1689. doi: 10.1002/pro.3683. Epub 2019 Aug 2. Protein Sci. 2019. PMID: 31306512 Free PMC article.

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A Distinct Type of Pilus from the Human Microbiome.

Xu Q, Shoji M, Shibata S, Naito M, Sato K, Elsliger MA, Grant JC, Axelrod HL, Chiu HJ, Farr CL, Jaroszewski L, Knuth MW, Deacon AM, Godzik A, Lesley SA, Curtis MA, Nakayama K, Wilson IA. Xu Q, et al. Among authors: deacon am. Cell. 2016 Apr 21;165(3):690-703. doi: 10.1016/j.cell.2016.03.016. Epub 2016 Apr 7. Cell. 2016. PMID: 27062925 Free PMC article.

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UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex.

Stepanyuk GA, Serrano P, Peralta E, Farr CL, Axelrod HL, Geralt M, Das D, Chiu HJ, Jaroszewski L, Deacon AM, Lesley SA, Elsliger MA, Godzik A, Wilson IA, Wüthrich K, Salomon DR, Williamson JR. Stepanyuk GA, et al. Among authors: deacon am. Acta Crystallogr D Struct Biol. 2016 Apr;72(Pt 4):497-511. doi: 10.1107/S2059798316001248. Epub 2016 Mar 24. Acta Crystallogr D Struct Biol. 2016. PMID: 27050129 Free PMC article.

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Cofactor-induced reversible folding of Flavodoxin-4 from Lactobacillus acidophilus.

Dutta SK, Serrano P, Geralt M, Axelrod HL, Xu Q, Lesley SA, Godzik A, Deacon AM, Elsliger MA, Wilson IA, Wüthrich K. Dutta SK, et al. Among authors: deacon am. Protein Sci. 2015 Oct;24(10):1600-8. doi: 10.1002/pro.2743. Epub 2015 Jul 30. Protein Sci. 2015. PMID: 26177955 Free PMC article.

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The JCSG high-throughput structural biology pipeline.

Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wooley J, Wüthrich K, Wilson IA. Elsliger MA, et al. Among authors: deacon am. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1137-42. doi: 10.1107/S1744309110038212. Epub 2010 Sep 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20944202 Free PMC article.

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Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin.

Xu Q, Deller MC, Nielsen TK, Grant JC, Lesley SA, Elsliger MA, Deacon AM, Wilson IA. Xu Q, et al. Among authors: deacon am. PLoS One. 2014 Sep 8;9(9):e107309. doi: 10.1371/journal.pone.0107309. eCollection 2014. PLoS One. 2014. PMID: 25197798 Free PMC article.

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Structure of a novel winged-helix like domain from human NFRKB protein.

Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA. Kumar A, et al. Among authors: deacon am. PLoS One. 2012;7(9):e43761. doi: 10.1371/journal.pone.0043761. Epub 2012 Sep 11. PLoS One. 2012. PMID: 22984442 Free PMC article.

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Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling.

Das D, Hervé M, Elsliger MA, Kadam RU, Grant JC, Chiu HJ, Knuth MW, Klock HE, Miller MD, Godzik A, Lesley SA, Deacon AM, Mengin-Lecreulx D, Wilson IA. Das D, et al. Among authors: deacon am. J Bacteriol. 2013 Dec;195(24):5555-66. doi: 10.1128/JB.00900-13. Epub 2013 Oct 11. J Bacteriol. 2013. PMID: 24123814 Free PMC article.

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