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An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.
Lopresti AL, Smith SJ, Malvi H, Kodgule R. Lopresti AL, et al. Medicine (Baltimore). 2019 Sep;98(37):e17186. doi: 10.1097/MD.0000000000017186. Medicine (Baltimore). 2019. PMID: 31517876 Free PMC article. Clinical Trial.

BACKGROUND: Ashwagandha (Withania somnifera (L.) Dunal) is a herb traditionally used to reduce stress and enhance wellbeing. ...Ashwagandha intake was also associated with greater reductions in morning cortisol (P < .001), and DHEA-S (P = .004) comp

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BACKGROUND: Ashwagandha (Withania somnifera (L.) Dunal) is a herb traditionally used to reduce stress and enhance wellbeing. . …
A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.
Chandrasekhar K, Kapoor J, Anishetty S. Chandrasekhar K, et al. Indian J Psychol Med. 2012 Jul;34(3):255-62. doi: 10.4103/0253-7176.106022. Indian J Psychol Med. 2012. PMID: 23439798 Free PMC article.
These included a measurement of serum cortisol, and assessing their scores on standard stress-assessment questionnaires. They were randomized to either the placebo control group or the study drug treatment group, and were asked to take one capsule twice a day for a …
These included a measurement of serum cortisol, and assessing their scores on standard stress-assessment questionnaires. They were …
A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study.
Majeed M, Nagabhushanam K, Mundkur L. Majeed M, et al. Medicine (Baltimore). 2023 Oct 13;102(41):e35521. doi: 10.1097/MD.0000000000035521. Medicine (Baltimore). 2023. PMID: 37832082 Free PMC article. Clinical Trial.
BACKGROUND: The coronavirus disease-2019 (COVID-19) pandemic has resulted in a surge in stress, anxiety, and depression worldwide. Ashwagandha, an ayurvedic adaptogen has been traditionally used to manage stress, anxiety, and general well-being. ...ARE was also associated …
BACKGROUND: The coronavirus disease-2019 (COVID-19) pandemic has resulted in a surge in stress, anxiety, and depression worldwide. Ashwag …
Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study.
Salve J, Pate S, Debnath K, Langade D. Salve J, et al. Cureus. 2019 Dec 25;11(12):e6466. doi: 10.7759/cureus.6466. Cureus. 2019. PMID: 32021735 Free PMC article.
Sixty male and female participants with a baseline perceived stress scale (PSS) score >20 were randomized to receive capsules of Ashwagandha extract 125 mg, Ashwagandha extract 300 mg or identical placebo twice daily for eight weeks in a 1:1:1 ratio. ...A …
Sixty male and female participants with a baseline perceived stress scale (PSS) score >20 were randomized to receive capsules of …
Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis.
Arumugam V, Vijayakumar V, Balakrishnan A, B Bhandari R, Boopalan D, Ponnurangam R, Sankaralingam Thirupathy V, Kuppusamy M. Arumugam V, et al. Explore (NY). 2024 Nov-Dec;20(6):103062. doi: 10.1016/j.explore.2024.103062. Epub 2024 Sep 21. Explore (NY). 2024. PMID: 39348746
BACKGROUND: Ashwagandha (Withania somnifera) is an adaptogenic herb used to prevent and treat psychosomatic disorders. ...Randomized controlled trials that examined the effects of Ashwagandha on stress and anxiety were included. ...
BACKGROUND: Ashwagandha (Withania somnifera) is an adaptogenic herb used to prevent and treat psychosomatic disorders. ...R …
A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males.
Lopresti AL, Drummond PD, Smith SJ. Lopresti AL, et al. Am J Mens Health. 2019 Mar-Apr;13(2):1557988319835985. doi: 10.1177/1557988319835985. Am J Mens Health. 2019. PMID: 30854916 Free PMC article. Clinical Trial.
Ashwagandha ( Withania somnifera) is a herb commonly used in Ayurvedic medicine to promote youthful vigor, enhance muscle strength and endurance, and improve overall health. ...There were no significant between-group differences in cortisol and estradiol. In …
Ashwagandha ( Withania somnifera) is a herb commonly used in Ayurvedic medicine to promote youthful vigor, enhance muscle stre …
Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial.
Choudhary D, Bhattacharyya S, Joshi K. Choudhary D, et al. J Evid Based Complementary Altern Med. 2017 Jan;22(1):96-106. doi: 10.1177/2156587216641830. Epub 2016 Apr 6. J Evid Based Complementary Altern Med. 2017. PMID: 27055824 Free PMC article. Clinical Trial.
The objective of this study was to evaluate the safety and efficacy of a standardized root extract of Ashwagandha through a double-blind, randomized, placebo-controlled trial. A total of 52 subjects under chronic stress received either Ashwagandha (300 mg) or …
The objective of this study was to evaluate the safety and efficacy of a standardized root extract of Ashwagandha through a double-bl …
Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study.
Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Gopukumar K, et al. Evid Based Complement Alternat Med. 2021 Nov 30;2021:8254344. doi: 10.1155/2021/8254344. eCollection 2021. Evid Based Complement Alternat Med. 2021. PMID: 34858513 Free PMC article.
This double-blind, randomized, placebo-controlled clinical study evaluated the effect of Ashwagandha root extract sustained-release capsule 300 mg (Prolanza ; hereafter Ashwagandha SR) on cognitive functions, stress levels, sleep quality, overall well-being, …
This double-blind, randomized, placebo-controlled clinical study evaluated the effect of Ashwagandha root extract sustained-re …
A New Ashwagandha Formulation (Zenroot ) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
Mahadevan M, Gopukumar K, Gupta R, Morde A, Patni P, Srinivas SS, Bhuvanendran A, Phanindra A. Mahadevan M, et al. Adv Ther. 2025 Oct;42(10):5238-5254. doi: 10.1007/s12325-025-03327-z. Epub 2025 Aug 28. Adv Ther. 2025. PMID: 40875185 Free PMC article. Clinical Trial.
INTRODUCTION: Prolonged exposure to stress may lead to low mood, anxiety, depression, insomnia, and metabolic disorders. Ashwagandha, an established adaptogen, is known to combat stress. We studied the safety and efficacy of Ashwagandha formulation, Zenroot (ZEN), …
INTRODUCTION: Prolonged exposure to stress may lead to low mood, anxiety, depression, insomnia, and metabolic disorders. Ashwagandha, …
Withania somnifera and Trigonella foenum-graecum as ingredients of testosterone-boosting supplements: Possible clinical implications.
Skrzypiec-Spring M, Pokrywka A, Kuliczkowska-Płaksej J, Szeląg A, Bolanowski M. Skrzypiec-Spring M, et al. Adv Clin Exp Med. 2025 Feb;34(2):295-303. doi: 10.17219/acem/185743. Adv Clin Exp Med. 2025. PMID: 38628109 Free article. Review.
Based on the analysis of existing data on substances used to increase endogenous T levels, especially double-blind placebo-controlled randomized clinical trials, we selected 2 herbal extracts with the best documented positive effects on T levels, Withania somnifera …
Based on the analysis of existing data on substances used to increase endogenous T levels, especially double-blind placebo-controlled ran …
25 results