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Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review.
Bandopadhyay S, Mandal S, Ghorai M, Jha NK, Kumar M, Radha, Ghosh A, Proćków J, Pérez de la Lastra JM, Dey A. Bandopadhyay S, et al. J Cell Mol Med. 2023 Mar;27(5):593-608. doi: 10.1111/jcmm.17635. Epub 2023 Feb 8. J Cell Mol Med. 2023. PMID: 36756687 Free PMC article. Review.
Asiaticoside and madecassoside have been identified as the marker compounds of C. asiatica in the Chinese Pharmacopoeia and these triterpene compounds offer a wide range of pharmacological properties, including neuroprotective, cardioprotective, hepatoprotective, wound hea …
Asiaticoside and madecassoside have been identified as the marker compounds of C. asiatica in the Chinese Pharmacopoeia and these tri …
Anxiolytic-like effect of asiaticoside in mice.
Chen SW, Wang WJ, Li WJ, Wang R, Li YL, Huang YN, Liang X. Chen SW, et al. Pharmacol Biochem Behav. 2006 Oct;85(2):339-44. doi: 10.1016/j.pbb.2006.08.017. Epub 2006 Oct 23. Pharmacol Biochem Behav. 2006. PMID: 17059844
The putative anxiolytic activity of asiaticoside was examined in male mice by using a number of experimental paradigms of anxiety, with diazepam being as a positive anxiolytic control. ...Thus, these findings indicated that asiaticoside exhibited an …
The putative anxiolytic activity of asiaticoside was examined in male mice by using a number of experimental paradigms of anxi …
Neuroprotective effects of Asiaticoside.
Qi FY, Yang L, Tian Z, Zhao MG, Liu SB, An JZ. Qi FY, et al. Neural Regen Res. 2014 Jul 1;9(13):1275-82. doi: 10.4103/1673-5374.137574. Neural Regen Res. 2014. PMID: 25221579 Free PMC article.
In the central nervous system, Asiaticoside has been shown to attenuate in vitro neuronal damage caused by exposure to beta-amyloid. ...In addition, Asiaticoside showed anxiolytic effects in acute and chronic stress animals. However, its potential neuroprotec …
In the central nervous system, Asiaticoside has been shown to attenuate in vitro neuronal damage caused by exposure to beta-amyloid. …
Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-beta1/SMAD7/TIMP3 signaling pathway.
Liu Y, Zhao J, Mu X, Deng J, Wu X, He W, Liu Y, Gu R, Han F, Nie X. Liu Y, et al. J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117266. doi: 10.1016/j.jep.2023.117266. Epub 2023 Sep 30. J Ethnopharmacol. 2024. PMID: 37783408
The main bioactive components of Centella asiatica are pentacyclic triterpenoid glycosides, namely asiaticoside and hydroxyasiaticoside. Asiaticoside possess a diverse array of pharmacological properties, such as wound-healing, anti-inflammatory, antioxidant, anti-a …
The main bioactive components of Centella asiatica are pentacyclic triterpenoid glycosides, namely asiaticoside and hydroxyasiaticosi …
Evaluation of anxiolytic properties of Gotukola--(Centella asiatica) extracts and asiaticoside in rat behavioral models.
Wijeweera P, Arnason JT, Koszycki D, Merali Z. Wijeweera P, et al. Phytomedicine. 2006 Nov;13(9-10):668-76. doi: 10.1016/j.phymed.2006.01.011. Epub 2006 Feb 20. Phytomedicine. 2006. PMID: 16488124
The ayurvedic medicinal plant Gotukola (Centella asiatica) was evaluated for its anxiolytic properties. Specifically, this study assessed the effects of: Gotukola plant materials of different genotypic origin; hexane, ethyl acetate and methanol extracts of Gotukola; and …
The ayurvedic medicinal plant Gotukola (Centella asiatica) was evaluated for its anxiolytic properties. Specifically, this study asse …
Anxiolytic effects of standardized extract of Centella asiatica (ECa 233) after chronic immobilization stress in mice.
Wanasuntronwong A, Tantisira MH, Tantisira B, Watanabe H. Wanasuntronwong A, et al. J Ethnopharmacol. 2012 Sep 28;143(2):579-85. doi: 10.1016/j.jep.2012.07.010. Epub 2012 Jul 24. J Ethnopharmacol. 2012. PMID: 22841896
In addition, ameliorating effect of ECa 233 was observed on the body weight and serum corticosterone which were adversely affected by immobilization stress. Madecassoside and asiaticoside, equal to their respective contents of the effective doses of ECa 233, exclusively pr …
In addition, ameliorating effect of ECa 233 was observed on the body weight and serum corticosterone which were adversely affected by immobi …
Centella asiatica - Phytochemistry and mechanisms of neuroprotection and cognitive enhancement.
Gray NE, Alcazar Magana A, Lak P, Wright KM, Quinn J, Stevens JF, Maier CS, Soumyanath A. Gray NE, et al. Phytochem Rev. 2018 Feb;17(1):161-194. doi: 10.1007/s11101-017-9528-y. Epub 2017 Sep 20. Phytochem Rev. 2018. PMID: 31736679 Free PMC article.
Multiple studies in rodent models, and a limited number of human studies support C. asiatica's traditional reputation as a cognitive enhancer, as well as its anxiolytic and anticonvulsant effects. Neuroprotective effects of C.asiatica are seen in several in vitro models, f …
Multiple studies in rodent models, and a limited number of human studies support C. asiatica's traditional reputation as a cognitive enhance …