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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
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1989 3
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1991 2
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1997 1
2000 1
2001 2
2002 1
2003 3
2005 1
2006 1
2007 6
2008 7
2009 1
2010 2
2011 8
2012 5
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176 results

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Page 1
Aspartame-True or False? Narrative Review of Safety Analysis of General Use in Products.
Czarnecka K, Pilarz A, Rogut A, Maj P, Szymańska J, Olejnik Ł, Szymański P. Czarnecka K, et al. Nutrients. 2021 Jun 7;13(6):1957. doi: 10.3390/nu13061957. Nutrients. 2021. PMID: 34200310 Free PMC article. Review.
It is mainly used as a sweetener for soft drinks, confectionery, and medicines. Despite its widespread use, its safety remains controversial. This narrative review investigates the existing literature on the use of aspartame and its possible effects on the human bod …
It is mainly used as a sweetener for soft drinks, confectionery, and medicines. Despite its widespread use, its safety remains contro …
Revisiting the safety of aspartame.
Choudhary AK, Pretorius E. Choudhary AK, et al. Nutr Rev. 2017 Sep 1;75(9):718-730. doi: 10.1093/nutrit/nux035. Nutr Rev. 2017. PMID: 28938797 Review.
Since aspartame consumption is on the rise, the safety of this sweetener should be revisited. Most of the literature available on the safety of aspartame is included in this review. Safety studies are based primarily on animal models, as data fr …
Since aspartame consumption is on the rise, the safety of this sweetener should be revisited. Most of the literature available …
Aspartame Safety as a Food Sweetener and Related Health Hazards.
Shaher SAA, Mihailescu DF, Amuzescu B. Shaher SAA, et al. Nutrients. 2023 Aug 18;15(16):3627. doi: 10.3390/nu15163627. Nutrients. 2023. PMID: 37630817 Free PMC article. Review.
Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. Over time, it has become a very popular artificial sweetener. ...Within this review, we critically evaluate reports concerning the safety of aspartame. Some studies evidenced subtle mood …
Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. Over time, it has become a very popular artificial sweetener. …
Aspartame: review of safety.
Butchko HH, Stargel WW, Comer CP, Mayhew DA, Benninger C, Blackburn GL, de Sonneville LM, Geha RS, Hertelendy Z, Koestner A, Leon AS, Liepa GU, McMartin KE, Mendenhall CL, Munro IC, Novotny EJ, Renwick AG, Schiffman SS, Schomer DL, Shaywitz BA, Spiers PA, Tephly TR, Thomas JA, Trefz FK. Butchko HH, et al. Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 2):S1-93. doi: 10.1006/rtph.2002.1542. Regul Toxicol Pharmacol. 2002. PMID: 12180494 Review.
These findings are reviewed here. The safety testing of aspartame has gone well beyond that required to evaluate the safety of a food additive. When all the research on aspartame, including evaluations in both the premarketing and postmarketing periods …
These findings are reviewed here. The safety testing of aspartame has gone well beyond that required to evaluate the safety …
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M. Debras C, et al. PLoS Med. 2022 Mar 24;19(3):e1003950. doi: 10.1371/journal.pmed.1003950. eCollection 2022 Mar. PLoS Med. 2022. PMID: 35324894 Free PMC article.
Higher risks were also observed for breast cancer (n = 979 cases, HR = 1.22 [95% CI 1.01 to 1.48], P = 0.036, for aspartame) and obesity-related cancers (n = 2,023 cases, HR = 1.13 [95% CI 1.00 to 1.28], P = 0.036, for total artificial sweeteners, and HR = 1.15 [95% CI 1.0 …
Higher risks were also observed for breast cancer (n = 979 cases, HR = 1.22 [95% CI 1.01 to 1.48], P = 0.036, for aspartame) and obes …
Understanding the link between aspartame and cancer.
Soffritti M. Soffritti M. Expert Rev Anticancer Ther. 2024 Sep;24(9):793-802. doi: 10.1080/14737140.2024.2383675. Epub 2024 Jul 31. Expert Rev Anticancer Ther. 2024. PMID: 39041328 Review.
Aspartame (APM) was submitted for pre-marketing safety evaluation in early 1980. The studies, performed by GD-Searle, produced controversial results. AREAS COVERED: Because of the great commercial diffusion of aspartame, in 1997 the Ramazzini Institute (RI) s …
Aspartame (APM) was submitted for pre-marketing safety evaluation in early 1980. The studies, performed by GD-Searle, produced …
Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies.
Magnuson BA, Burdock GA, Doull J, Kroes RM, Marsh GM, Pariza MW, Spencer PS, Waddell WJ, Walker R, Williams GM. Magnuson BA, et al. Crit Rev Toxicol. 2007;37(8):629-727. doi: 10.1080/10408440701516184. Crit Rev Toxicol. 2007. PMID: 17828671 Review.
Critical review of all carcinogenicity studies conducted on aspartame found no credible evidence that aspartame is carcinogenic. The data from the extensive investigations into the possibility of neurotoxic effects of aspartame, in general, do not support the …
Critical review of all carcinogenicity studies conducted on aspartame found no credible evidence that aspartame is carcinogeni …
Biological fate of low-calorie sweeteners.
Magnuson BA, Carakostas MC, Moore NH, Poulos SP, Renwick AG. Magnuson BA, et al. Nutr Rev. 2016 Nov;74(11):670-689. doi: 10.1093/nutrit/nuw032. Nutr Rev. 2016. PMID: 27753624 Review.
With continued efforts to find solutions to rising rates of obesity and diabetes, there is increased interest in the potential health benefits of the use of low- and no-calorie sweeteners (LNCSs). Concerns about safety often deter the use of LNCSs as a tool in helping cont …
With continued efforts to find solutions to rising rates of obesity and diabetes, there is increased interest in the potential health benefi …
Effect of Non-Nutritive Sweeteners on the Gut Microbiota.
Conz A, Salmona M, Diomede L. Conz A, et al. Nutrients. 2023 Apr 13;15(8):1869. doi: 10.3390/nu15081869. Nutrients. 2023. PMID: 37111090 Free PMC article. Review.
We summarized the results from pre-clinical and clinical studies published over the last ten years that examined the single effects of the most consumed NNS: aspartame, acesulfame-K, sucralose, and saccharin. Pre-clinical studies have given conflicting results for various …
We summarized the results from pre-clinical and clinical studies published over the last ten years that examined the single effects of the m …
Aspartame carcinogenic potential revealed through network toxicology and molecular docking insights.
Chen D, Hou X. Chen D, et al. Sci Rep. 2024 May 20;14(1):11492. doi: 10.1038/s41598-024-62461-w. Sci Rep. 2024. PMID: 38769413 Free PMC article.
The research employed network toxicology and molecular docking techniques to systematically examine the potential carcinogenic effects and mechanisms of aspartame (L-alpha-aspartyl-L-phenylalanine methyl ester). Aspartame, a commonly used synthetic sweetener, is wid …
The research employed network toxicology and molecular docking techniques to systematically examine the potential carcinogenic effects and m …
176 results