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Year Number of Results
1976 1
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2000 2
2001 1
2002 1
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2008 5
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2011 3
2012 3
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153 results

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Page 1
The β-Secretase BACE1 in Alzheimer's Disease.
Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R, Vanmechelen E, De Vos A, Nisticò R, Corbo M, Imbimbo BP, Streffer J, Voytyuk I, Timmers M, Tahami Monfared AA, Irizarry M, Albala B, Koyama A, Watanabe N, Kimura T, Yarenis L, Lista S, Kramer L, Vergallo A. Hampel H, et al. Biol Psychiatry. 2021 Apr 15;89(8):745-756. doi: 10.1016/j.biopsych.2020.02.001. Epub 2020 Feb 13. Biol Psychiatry. 2021. PMID: 32223911 Free PMC article. Review.
It is required for the generation of all monomeric forms of amyloid-beta (Abeta), including Abeta(42), which aggregates into bioactive conformational species and likely initiates toxicity in Alzheimer's disease (AD). BACE1 concentrations and rates of activity are increased …
It is required for the generation of all monomeric forms of amyloid-beta (Abeta), including Abeta(42), which aggregates into bioactive confo …
Aspartame and ischemic stroke: unraveling the molecular link through network toxicology and molecular docking analysis.
Zhang T, Wang T, Yu K, Huang C, Bao K. Zhang T, et al. Sci Rep. 2025 Jul 4;15(1):23871. doi: 10.1038/s41598-025-08898-z. Sci Rep. 2025. PMID: 40615604 Free PMC article.
Aspartame, a widely used artificial sweetener, remains controversial due to neurotoxic risks from its metabolites-phenylalanine, aspartic acid, and methanol. While epidemiological studies link artificial sweeteners to cerebrovascular disease, the molecular mechanism …
Aspartame, a widely used artificial sweetener, remains controversial due to neurotoxic risks from its metabolites-phenylalanine, aspartic …
Absorption, utilization, and safety of aspartic acid.
Stegink LD. Stegink LD. J Toxicol Environ Health. 1976 Sep;2(1):215-42. doi: 10.1080/15287397609529428. J Toxicol Environ Health. 1976. PMID: 11355 Review.
However, there is no doubt that these amino acids are toxic to the neonatal mouse at high dose levels....
However, there is no doubt that these amino acids are toxic to the neonatal mouse at high dose levels....
Revisiting the safety of aspartame.
Choudhary AK, Pretorius E. Choudhary AK, et al. Nutr Rev. 2017 Sep 1;75(9):718-730. doi: 10.1093/nutrit/nux035. Nutr Rev. 2017. PMID: 28938797 Review.
Since aspartame consumption is on the rise, the safety of this sweetener should be revisited. Most of the literature available on the safety of aspartame is included in this review. Safety studies are based primarily on animal models, as data from human studi …
Since aspartame consumption is on the rise, the safety of this sweetener should be revisited. Most of the literature available on the …
Biodistribution and toxicity assessment of intratumorally injected arginine-glycine-aspartic acid peptide conjugated to CdSe/ZnS quantum dots in mice bearing pancreatic neoplasm.
Li MM, Cao J, Yang JC, Shen YJ, Cai XL, Chen YW, Qu CY, Zhang Y, Shen F, Zhou M, Xu LM. Li MM, et al. Chem Biol Interact. 2018 Aug 1;291:103-110. doi: 10.1016/j.cbi.2018.06.014. Epub 2018 Jun 14. Chem Biol Interact. 2018. PMID: 29908985
Quantum dots (QDs) conjugated with arginine-glycine-aspartic acid (RGD) peptides (which are integrin antagonists) are novel nanomaterials with the unique optical property of high molar extinction coefficient, and they have potential utility as photosensitizers in ph …
Quantum dots (QDs) conjugated with arginine-glycine-aspartic acid (RGD) peptides (which are integrin antagonists) are novel na …
Safety assessment of a novel active ingredient, acetyl aspartic acid, according to the EU Cosmetics Regulation and the Scientific Committee on Consumer Safety guidelines.
Daly P, Moran G. Daly P, et al. Int J Cosmet Sci. 2015 Oct;37 Suppl 1:21-7. doi: 10.1111/ics.12257. Int J Cosmet Sci. 2015. PMID: 26114401
OBJECTIVE: Acetyl aspartic acid (A-A-A) was proposed as a new novel active ingredient for use in cosmetics. ...The MoS for A-A-A was 351, at a level of 5%, for all cosmetic product types, indicating no systemic safety toxicity concern. A-A-A at 5% unde …
OBJECTIVE: Acetyl aspartic acid (A-A-A) was proposed as a new novel active ingredient for use in cosmetics. ...The MoS for A-A …
Formation of metastable disinfection byproducts during free and combined aspartic acid chlorination: Effect of peptide bonds and impact on toxicity.
Yu Y, Reckhow DA. Yu Y, et al. Water Res. 2020 Jan 1;168:115131. doi: 10.1016/j.watres.2019.115131. Epub 2019 Sep 27. Water Res. 2020. PMID: 31622913
In order to clarify the reactivity of combined amino acids with chlorine to form HANs, dichloroacetonitrile (DCAN) formation kinetics was compared between free aspartic acid and two aspartyl-containing tetrapeptides (i.e., Asp-Asp-Asp-Asp and Arg-Gly-Asp-Ser). Resul …
In order to clarify the reactivity of combined amino acids with chlorine to form HANs, dichloroacetonitrile (DCAN) formation kinetics was co …
A novel multifunctional and low toxicity Tb-MOF used for extremely sensitive detection of aspartic acid, ethyl maltol and rotenone in complex matrices.
Zhu J, Jing B, Jia Y, Zhang W, Sun C. Zhu J, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2026 Sep 5;357:127815. doi: 10.1016/j.saa.2026.127815. Epub 2026 Mar 28. Spectrochim Acta A Mol Biomol Spectrosc. 2026. PMID: 41916204
It can achieve highly sensitive detection of three key target substances - aspartic acid, ethyl maltol, and rotenone in complex matrices, with detection limits as low as 16.0, 14.5, and 48.0 nM respectively. ...It is worth noting that the cytotoxicity experiment fur …
It can achieve highly sensitive detection of three key target substances - aspartic acid, ethyl maltol, and rotenone in comple …
L-Asparaginase delivery systems targeted to minimize its side-effects.
Talluri VP, Mutaliyeva B, Sharipova A, Ulaganathan V, Lanka SS, Aidarova S, Suigenbayeva A, Tleuova A. Talluri VP, et al. Adv Colloid Interface Sci. 2023 Jun;316:102915. doi: 10.1016/j.cis.2023.102915. Epub 2023 May 3. Adv Colloid Interface Sci. 2023. PMID: 37159987 Review.
L-ASP catalyzes the deamination process of L-asparagine amino-acid into aspartic acid and ammonia, depriving leukemic cells of asparagine. This leads to decreased protein synthesis and cell division in tumor cells. ...This strategy offers the same benefits as …
L-ASP catalyzes the deamination process of L-asparagine amino-acid into aspartic acid and ammonia, depriving leukemic c …
Green modification of biochar with poly(aspartic acid) enhances the remediation of Cd and Pb in water and soil.
Zhu X, Wang Z, Teng Y, Sun Y, Wang W, Zhang H, Chu H, Zhang J, Liu R, Zhang L. Zhu X, et al. J Environ Manage. 2024 Nov;370:122642. doi: 10.1016/j.jenvman.2024.122642. Epub 2024 Sep 24. J Environ Manage. 2024. PMID: 39321681
The results showed that poly(aspartic acid)-modified biochar (PASP-BC) was more effective in removing Cd(II) from water compared to biochar modified with poly(glutamic acid) (PGA-BC), aspartic acid (ASP-BC), and glutamic acid (GA-BC). ... …
The results showed that poly(aspartic acid)-modified biochar (PASP-BC) was more effective in removing Cd(II) from water compar …
153 results