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1982 34
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2012 323
2013 335
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A colorimetric assay developed for the evaluation of tumor cell-platelet interaction and drug intervention.
Wang X, Fang X, Li X, Cheng H, Jiang H, Zheng J. Wang X, et al. Talanta. 2026 Feb 1;298(Pt A):128836. doi: 10.1016/j.talanta.2025.128836. Epub 2025 Sep 9. Talanta. 2026. PMID: 40946479
Moreover, we investigated the intervention of drugs and found that aspirin pretreatment could significantly reduce platelet binding in three cell lines. Among them, the inhibition of PC9R was most pronounced, followed by A549, and the weakest effect in PC9. ...This study h …
Moreover, we investigated the intervention of drugs and found that aspirin pretreatment could significantly reduce platelet binding i …
Association of aspirin and ibuprofen use with endometrial cancer risk in the PLCO dataset.
Zhao Y, Wang Y, Zhang Y, Han Q, Hu Y, Zhang Y, Tang L, Wang S, Kong B, Li X. Zhao Y, et al. Int J Cancer. 2026 Feb 1;158(3):656-665. doi: 10.1002/ijc.70101. Epub 2025 Aug 21. Int J Cancer. 2026. PMID: 40838337
Studies on aspirin's effect on EC risk have been controversial; research on ibuprofen remains limited. We therefore aimed to investigate the relationship between aspirin and ibuprofen use and risk of EC through a cohort study. This analysis was based on the P …
Studies on aspirin's effect on EC risk have been controversial; research on ibuprofen remains limited. We therefore aimed to i …
Chemoprevention in Barrett's Esophagus: An Updated Review.
Samnani S, Jankowski JA, Moayyedi P. Samnani S, et al. Gastrointest Endosc Clin N Am. 2026 Jan;36(1):171-193. doi: 10.1016/j.giec.2025.05.004. Epub 2025 Jul 22. Gastrointest Endosc Clin N Am. 2026. PMID: 41260766 Review.
Barrett's esophagus is a premalignant condition that significantly increases the risk of esophageal Adenocarcinoma (EAC), a rapidly rising cancer in developed countries. Given the limitations of surveillance in preventing EAC-related mortality, chemoprevention has emerged …
Barrett's esophagus is a premalignant condition that significantly increases the risk of esophageal Adenocarcinoma (EAC), a rapidly rising …
Esophageal embolization for hemostasis in cancer patients presenting with upper gastrointestinal bleeding in the setting of antiplatelet therapy: A case report.
Anh NT, Khoa TD, Thanh TTT, Dat LH, Mai TTN, Dung LT, Vu LT, Loc TQ. Anh NT, et al. Radiol Case Rep. 2025 Oct 31;21(1):372-375. doi: 10.1016/j.radcr.2025.09.073. eCollection 2026 Jan. Radiol Case Rep. 2025. PMID: 41245059 Free PMC article.
Risk factors for developing UGIB include advanced age, Helicobacter pylori infection, medication use (NSAIDs, aspirin, P2Y12 inhibitors, anticoagulants, and steroids), and esophageal cancer, which, although less common, is an important cause in clinical practice. .. …
Risk factors for developing UGIB include advanced age, Helicobacter pylori infection, medication use (NSAIDs, aspirin, P2Y12 inhibito …
Clinical and biological determinants of multimodal metronomic chemotherapy efficacy in chemo-refractory gastrointestinal cancers.
Spehner L, Bouard A, El Kaddissi A, Kroemer M, Kim S, Nguyen T, Klajer E, Fein F, Abdeljaoued S, Loyon R, Borg C, Vienot A. Spehner L, et al. Int J Cancer. 2026 Jan 1;158(1):182-192. doi: 10.1002/ijc.70095. Epub 2025 Aug 16. Int J Cancer. 2026. PMID: 40817820 Clinical Trial.
However, the efficacy of metronomic chemotherapy (MC) in chemo-refractory gastrointestinal cancers and its mode of action remain elusive. Multimodal MC was administered continuously, combining low doses of capecitabine, cyclophosphamide, and aspirin. ...Multimodal M …
However, the efficacy of metronomic chemotherapy (MC) in chemo-refractory gastrointestinal cancers and its mode of action remain elus …
JAK2 wild-type erythrocytosis: concept, differential diagnosis, diagnostic steps, and treatment approaches.
Szuber N, Tefferi A, Gangat N. Szuber N, et al. Hematology Am Soc Hematol Educ Program. 2025 Dec 5;2025(1):183-190. doi: 10.1182/hematology.2025000704. Hematology Am Soc Hematol Educ Program. 2025. PMID: 41347984 Review.
There are currently no evidence-based treatment guidelines. Low-dose aspirin and/or phlebotomy (with frequency determined by symptom relief) might be considered on an individualized basis in the presence of hyperviscosity symptoms, cardiovascular comorbidities, and/or a hi …
There are currently no evidence-based treatment guidelines. Low-dose aspirin and/or phlebotomy (with frequency determined by symptom …
Predictive Role of Circulating Tumor DNA in Stage III Colon Cancer Treated With Celecoxib: A Post Hoc Analysis of the CALGB (Alliance)/SWOG 80702 Phase 3 Randomized Clinical Trial.
Zhang GQ, Meyerhardt JA, Shi Q, Twombly T, Pederson L, Ma C, Väyrynen JP, Zhao M, Takashima Y, Shergill A, Kumar P, Couture F, Kuebler P, Krishnamurthi S, Tan B, O'Reilly EM, Giannakis M, Ogino S, Jurdi A, Sharma S, Aleshin A, Shields AF, Nowak JA. Zhang GQ, et al. JAMA Oncol. 2025 Dec 4:e255144. doi: 10.1001/jamaoncol.2025.5144. Online ahead of print. JAMA Oncol. 2025. PMID: 41343176
IMPORTANCE: Observational studies have associated use of aspirin and selective cyclooxygenase inhibitors with decreased recurrence and improved survival in patients with colon cancer. ...OBJECTIVE: To investigate the predictive value of postoperative ctDNA for survi …
IMPORTANCE: Observational studies have associated use of aspirin and selective cyclooxygenase inhibitors with decreased recurrence an …
Decoding the interplay between COVID-19 and diabetic nephropathy through bioinformatics and systems biology techniques.
Chen X, Zeng Q, Xia M, Chen Y. Chen X, et al. Biochem Biophys Rep. 2025 Nov 17;44:102366. doi: 10.1016/j.bbrep.2025.102366. eCollection 2025 Dec. Biochem Biophys Rep. 2025. PMID: 41332907 Free PMC article.
Based on transcriptomic signatures, drug repurposing candidates, such as alpha-d-mannose, aspirin, and methotrexate, were identified. Additionally, hub genes showed a high diagnostic potential (area under the curve >0.80 for COVID-19 and DN). ...
Based on transcriptomic signatures, drug repurposing candidates, such as alpha-d-mannose, aspirin, and methotrexate, were identified. …
Association of aspirin use alone with mortality and liver-related events in MASLD: a multi-institutional three-year study.
Huang CH, Wang CL, Wu VC, Hsieh YC, Wu CL, Zeng ZF, Huang YT, Hsu CW, Chien RN, Chang SH. Huang CH, et al. Ann Med. 2025 Dec;57(1):2573146. doi: 10.1080/07853890.2025.2573146. Epub 2025 Oct 17. Ann Med. 2025. PMID: 41103259 Free PMC article.
METHODS: This retrospective, multi-institutional cohort study included 48,722 MASLD patients from 2008 to 2020, divided into aspirin users and non-users. Exclusion criteria included significant cardiac disease unrelated to aspirin, alcoholic liver disease, incomplet …
METHODS: This retrospective, multi-institutional cohort study included 48,722 MASLD patients from 2008 to 2020, divided into aspirin …
Aspirin use is associated with attenuated risk of severe acute kidney injury in septic patients: a dual-center retrospective analysis from MIMIC-IV and eICU cohorts.
Luo Y, Li H, Li J, Li D, Qiu Z, Lei S, Fu Q, Xia Z. Luo Y, et al. Ren Fail. 2025 Dec;47(1):2568650. doi: 10.1080/0886022X.2025.2568650. Epub 2025 Oct 12. Ren Fail. 2025. PMID: 41077850 Free PMC article.
Sepsis is a systemic inflammatory response syndrome caused by infection, and sepsis-associated acute kidney injury (AKI) markedly increases mortality. Although aspirin's anti-inflammatory properties show therapeutic promise in sepsis, its specific renal protective e …
Sepsis is a systemic inflammatory response syndrome caused by infection, and sepsis-associated acute kidney injury (AKI) markedly increases …
Aspirin Use and Risk of Breast Cancer Recurrence in Chinese Patients.
Wang X, Yang X, Chen R, Liu W, Zhao X, Wu Y, Chen J. Wang X, et al. Cancer Epidemiol Biomarkers Prev. 2025 Dec 1;34(12):2144-2149. doi: 10.1158/1055-9965.EPI-25-0842. Cancer Epidemiol Biomarkers Prev. 2025. PMID: 40986335
BACKGROUND: Observational studies have suggested a potential role for aspirin in reducing breast cancer recurrence, but data from Asian populations remain limited. We aimed to evaluate the association between long-term aspirin use and invasive disease-free su …
BACKGROUND: Observational studies have suggested a potential role for aspirin in reducing breast cancer recurrence, but data f …
Adjuvant Anti-Inflammatory Therapy in Postoperative Colorectal Cancer: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Lenz G, Pereira RA, Valagni G, Biachi de Castria T. Lenz G, et al. Clin Colorectal Cancer. 2025 Dec;24(4):415-424.e2. doi: 10.1016/j.clcc.2025.08.003. Epub 2025 Aug 21. Clin Colorectal Cancer. 2025. PMID: 40940200 Review.
Colorectal cancer (CRC) recurrence remains a major challenge in postsurgery. Chronic inflammation driven by cyclooxygenase (COX-2) and prostaglandin pathways promotes tumor recurrence, encouraging interest in nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin …
Colorectal cancer (CRC) recurrence remains a major challenge in postsurgery. Chronic inflammation driven by cyclooxygenase (COX-2) an …
Impact of Atherosclerotic Conditions and Cardiovascular Medications on Abdominal Aortic Aneurysm Growth.
Alkhalfan F, Hariri E, Aggarwal A, Burton R, Rajasekar B, Scalise A, Chaudhury P, Fendrikova Mahlay N, Owens AP 3rd, Cameron SJ. Alkhalfan F, et al. Am J Med. 2025 Dec;138(12):1689-1696.e3. doi: 10.1016/j.amjmed.2025.06.040. Epub 2025 Jun 25. Am J Med. 2025. PMID: 40578465 Free PMC article.
We further stratified by medication use, including aspirin. RESULTS: Coronary artery disease, carotid artery stenosis, and renal artery stenosis were associated with reduced odds of fast aortic aneurysm growth, likely due to medications for treating these conditions. As …
We further stratified by medication use, including aspirin. RESULTS: Coronary artery disease, carotid artery stenosis, and renal arte …
A validated predictive model for mid- and long-term mortality risk assessment after elective endovascular repair in abdominal aortic aneurysm patients.
Li R, Xue J, Sun H, Jiang J, Liu Y. Li R, et al. Ann Med. 2025 Dec;57(1):2519685. doi: 10.1080/07853890.2025.2519685. Epub 2025 Jun 22. Ann Med. 2025. PMID: 40544476 Free article.
A prediction model was established, including age, gender, aneurysm diameter, American Society of Anesthetists score, chronic obstructive pulmonary disease, cardiac disease, renal disease, cerebrovascular disease, diabetes, peripheral vascular disease, statins, aspirin, an …
A prediction model was established, including age, gender, aneurysm diameter, American Society of Anesthetists score, chronic obstructive pu …
Visceral Organ Malignancy in Patients Undergoing Primary Total Hip Arthroplasty: Is There a Role for Aspirin Prophylaxis?
Tarabichi S, Verhey JT, Brinkman JC, Hall RP, Lebens R, Deckey DG, Spangehl MJ, Bingham JS. Tarabichi S, et al. J Arthroplasty. 2025 Dec;40(12):3221-3226.e2. doi: 10.1016/j.arth.2025.05.105. Epub 2025 Jun 3. J Arthroplasty. 2025. PMID: 40473051
BACKGROUND: Although aspirin has become the prophylactic agent of choice for venous thromboembolism prevention in low-risk patients undergoing primary total hip arthroplasty (THA), there remains a paucity of data in the literature on the efficacy of aspirin as a mod …
BACKGROUND: Although aspirin has become the prophylactic agent of choice for venous thromboembolism prevention in low-risk patients u …
Risk factors for hepatocellular carcinoma: an umbrella review of systematic review and meta-analysis.
Wang J, Qiu K, Zhou S, Gan Y, Jiang K, Wang D, Wang H. Wang J, et al. Ann Med. 2025 Dec;57(1):2455539. doi: 10.1080/07853890.2025.2455539. Epub 2025 Jan 20. Ann Med. 2025. PMID: 39834076 Free PMC article.
Medications like metformin, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), aspirin, statins, and selective serotonin reuptake inhibitors reduce HCC risk, while acid suppressive agents, particularly proton pump inhibitors, elevate it. ...Lifestyle habits such as smo …
Medications like metformin, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), aspirin, statins, and selective serotonin reuptake …
Aspirin and HCC risk in MASLD: Nationwide cohort study with genetic risk analysis.
Ahn J, Hur MH, Shin H, Park MK, Won S, Park J, Ko Y, Park Y, Lee YB, Cho EJ, Lee JH, Yu SJ, Yoon JH, Kim YJ. Ahn J, et al. Clin Mol Hepatol. 2025 Nov 25. doi: 10.3350/cmh.2025.0528. Online ahead of print. Clin Mol Hepatol. 2025. PMID: 41287437 Free article.
Additionally, Mendelian randomization (MR) analysis was performed in the UKB cohort using a genomic risk score (GRS) for salicylic acid, based on genetic variants related to aspirin metabolism, as a proxy for aspirin use. RESULTS: In the NHIS cohort, 6,584,155 eligi …
Additionally, Mendelian randomization (MR) analysis was performed in the UKB cohort using a genomic risk score (GRS) for salicylic acid, bas …
Drug Repurposing in Oncology: A Strategic Pathway to Unlocking New Therapeutic Potential.
Shaik R, Laddika SG, Unnisa M, Hamza A, Begum S, Sarwar SF. Shaik R, et al. Ther Innov Regul Sci. 2025 Nov 19. doi: 10.1007/s43441-025-00895-8. Online ahead of print. Ther Innov Regul Sci. 2025. PMID: 41258978 Review.
The growing number of cancer cases and deaths highlights the urgent need for innovative treatment approaches. ...Future developments in personalized medicine and artificial intelligence may increase the efficacy of drug repurposing in cancer treatment. To fully real …
The growing number of cancer cases and deaths highlights the urgent need for innovative treatment approaches. ...Future developments …
European Code Against Cancer, 5th edition - hormone replacement therapy, other common medical therapies and cancer.
Thorat MA, Arbyn M, Baldwin D, Castells X, Hofvind S, Ivanus U, Senore C, Toes-Zoutendijk E, van der Aalst C, Canelo-Aybar C, Fernández-Sáenz FK, Feliu A, Zeeb H, Carvalho AL, D'Souza E, Ritchie D, Espina C, Lansdorp-Vogelaar I, DeCensi A. Thorat MA, et al. Mol Oncol. 2025 Nov 18. doi: 10.1002/1878-0261.70158. Online ahead of print. Mol Oncol. 2025. PMID: 41250966 Free article.
Several medical therapies modify the risk of developing certain cancers in an individual. The aim of this paper was to provide the scientific justification for the 5th edition of the European Code Against Cancer (ECAC5) recommendation on the use of hormone replaceme …
Several medical therapies modify the risk of developing certain cancers in an individual. The aim of this paper was to provide the sc …
A Clinical Analysis of the Association Between Nifedipine and Insulin Usage and the Increased Incidence of Colonic Polyps.
Wang XL, Tian T, Zhang D, Li YN, Li CZ. Wang XL, et al. JGH Open. 2025 Nov 14;9(11):e70269. doi: 10.1002/jgh3.70269. eCollection 2025 Nov. JGH Open. 2025. PMID: 41245742 Free PMC article.
OBJECTIVE: To investigate the association between the incidence of colon polyps and colon cancer and the use of clinical medications, including nifedipine and insulin, thereby providing a scientific basis for the development of chemoprevention strategies for colorectal …
OBJECTIVE: To investigate the association between the incidence of colon polyps and colon cancer and the use of clinical medications, …
Exploring the nexus: Clinical and physiological correlation between cardiovascular disease and colorectal cancer.
Bashir M, Murtada A, Jubouri M, Awad W, Williams I, Bailey DM. Bashir M, et al. Exp Physiol. 2025 Nov 14. doi: 10.1113/EP092898. Online ahead of print. Exp Physiol. 2025. PMID: 41235913 Review.
Colorectal cancer (CRC) and cardiovascular disease (CVD) are leading causes of morbidity and mortality worldwide, traditionally studied as distinct pathologies. ...Furthermore, it considers the implications of commonly used therapies, such as aspirin and statins, wh …
Colorectal cancer (CRC) and cardiovascular disease (CVD) are leading causes of morbidity and mortality worldwide, traditionally studi …
Major Bleeding With Apixaban vs Aspirin: A Subanalysis of the ARTESiA Randomized Clinical Trial.
Siegal DM, Sticherling C, Healey JS, McIntyre WF, Christensen LS, Parkash R, Vanassche T, Conen D, Gold M, Granger CB, Nielsen JC, Carrier M, Wojdyla DM, Erath JW, Rivard L, Kutyifa V, Wright DJ, Lopes RD. Siegal DM, et al. JAMA Cardiol. 2025 Nov 12:e254151. doi: 10.1001/jamacardio.2025.4151. Online ahead of print. JAMA Cardiol. 2025. PMID: 41222953
After a mean (SD) follow-up of 3.5 (1.8) years, 1 or more major bleeding episodes occurred in 133 patients, 86 of 1989 taking apixaban and 47 of 1972 taking aspirin (1.71 vs 0.94 per 100-patient-years; hazard ratio [HR], 1.80; 95% CI, 1.26-2.57). ...NSAID use, cancer …
After a mean (SD) follow-up of 3.5 (1.8) years, 1 or more major bleeding episodes occurred in 133 patients, 86 of 1989 taking apixaban and 4 …
Gross tumor assessment is not a reliable measure of the efficacy of chemo-preventive agents for breast cancer in preclinical mouse models.
Bhardwaj A, Koh A, Embury MD, Sandhu J, Rojo RD, Albarracin CT, Bedrosian I. Bhardwaj A, et al. Sci Rep. 2025 Nov 11;15(1):39402. doi: 10.1038/s41598-025-19423-7. Sci Rep. 2025. PMID: 41219225 Free PMC article.
Despite success in preclinical animal models, most cancer prevention drugs fail to show efficacy in clinical trials. One potential reason could be that study end points in animal models are not sufficiently robust. ...SV40C3TAg mice that spontaneously develop TNBC-like tum …
Despite success in preclinical animal models, most cancer prevention drugs fail to show efficacy in clinical trials. One potential re …
Risks and Benefits of Nonsteroidal Anti-inflammatory Drugs in the Hemostatic System.
Cignarella A, Campello E, Ramaschi GE, Simion C, Simioni P. Cignarella A, et al. Semin Thromb Hemost. 2025 Nov 10. doi: 10.1055/a-2725-6989. Online ahead of print. Semin Thromb Hemost. 2025. PMID: 41130453
For instance, preclinical studies suggest that the antiplatelet action of low-dose aspirin enhances immune system activity against cancer cells, resulting in metastasis prevention. ...In the context of polypharmacotherapy, attenuation of aspirin antiplatelet …
For instance, preclinical studies suggest that the antiplatelet action of low-dose aspirin enhances immune system activity against …
Bulk and surface engineered drug delivery system of repurposed drug enhances low-dose gemcitabine efficacy in pancreatic cancer.
Thrivikraman S, Kamalasanan K, Umar K P A, K P, R Unni A, M S S. Thrivikraman S, et al. Int J Pharm. 2025 Nov 10;684:126152. doi: 10.1016/j.ijpharm.2025.126152. Epub 2025 Sep 6. Int J Pharm. 2025. PMID: 40921292
The clinical use of gemcitabine (GEM), a frontline chemotherapeutic agent for pancreatic ductal adenocarcinoma (PDAC), is limited by its short half-life, rapid systemic clearance, associated dose-limiting toxicities and a faster development of resistance in pancreatic cancer …
The clinical use of gemcitabine (GEM), a frontline chemotherapeutic agent for pancreatic ductal adenocarcinoma (PDAC), is limited by its sho …
Chemopreventive Effects of Statins and Aspirin on Colorectal Cancer Among Patients with Inflammatory Bowel Disease: Evidence of a Synergistic Association from a Large Cohort.
Sleiman J, Khouri C, Lee UJ, Dimachkie R, Abureesh O, Njeim R, Deeb L. Sleiman J, et al. Clin Exp Gastroenterol. 2025 Nov 7;18:277-290. doi: 10.2147/CEG.S545373. eCollection 2025. Clin Exp Gastroenterol. 2025. PMID: 41230252 Free PMC article.
It was, however, significantly associated with a reduced risk of any cancer (OR: 0.630, p<0.0001). Furthermore, combining statins and aspirin significantly reduced the risk of CRC (OR: 0.163, p=0.0028) and any cancer (OR: 0.367, p<0.0001) compared to no …
It was, however, significantly associated with a reduced risk of any cancer (OR: 0.630, p<0.0001). Furthermore, combining statins …
The role of metaorganismal lipid metabolism in human health and disease.
Massey WJ, Brown JM. Massey WJ, et al. Immunometabolism (Cobham). 2025 Nov 7;7(4):e00074. doi: 10.1097/IN9.0000000000000074. eCollection 2025 Oct. Immunometabolism (Cobham). 2025. PMID: 41209147 Free PMC article.
Most chronic diseases including coronary heart disease, obesity, diabetes, cancer, and multiple neurodegenerative diseases are driven by dysregulated lipid metabolism. In fact, many common drugs taken by millions including aspirin, statins, fibrates, and others impr …
Most chronic diseases including coronary heart disease, obesity, diabetes, cancer, and multiple neurodegenerative diseases are driven …
Kawasaki disease shock syndrome with extreme leukemoid reaction mimicking hematologic malignancy in an IVIG-resistant child: A case report.
Liu L, Xuan W, Wang Y, Tu N, Wang X, Pan B. Liu L, et al. Medicine (Baltimore). 2025 Nov 7;104(45):e45845. doi: 10.1097/MD.0000000000045845. Medicine (Baltimore). 2025. PMID: 41204570 Free PMC article.
High-dose methylprednisolone was initiated, followed by tapering corticosteroids and low-dose aspirin. Short-term anticoagulation with dipyridamole and low-molecular-weight heparin was introduced as thromboprophylaxis, given the extreme inflammatory burden, hypoalbuminemia …
High-dose methylprednisolone was initiated, followed by tapering corticosteroids and low-dose aspirin. Short-term anticoagulation wit …
Portal hypertension caused by essential thrombocythemia: A case report.
Fang Y, Xiang K, Liu Y, Tao L, Shi L, Chen D. Fang Y, et al. Medicine (Baltimore). 2025 Nov 7;104(45):e45855. doi: 10.1097/MD.0000000000045855. Medicine (Baltimore). 2025. PMID: 41204533 Free PMC article.
OUTCOMES: Post-discharge, oral antitumor agents and aspirin for antiplatelet therapy were prescribed, with outpatient follow-up. LESSONS: ET can also lead to PHT, portal vein thrombosis, and esophageal varices. ...
OUTCOMES: Post-discharge, oral antitumor agents and aspirin for antiplatelet therapy were prescribed, with outpatient follow-up. LESS …
Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial.
Wolfe R, Broder JC, Zhou Z, Murray AM, Ryan J, Chan AT, Nelson MR, Woods RL, Ernst ME, Orchard SG, Kirpach B, Reid CM, Shah RC, Stocks N, Margolis KL, Neumann JT, Wilson M, Fitzgerald S, Mahady SE, Wood EM, Ket S, Eaton CB, Hand P, Malik M, Abhayaratna WP, Venkataraman P, Chan P, Cloud GC, Donnan GA, Williamson JD, Tonkin AM. Wolfe R, et al. Eur Heart J. 2025 Nov 7;46(42):4410-4422. doi: 10.1093/eurheartj/ehaf514. Eur Heart J. 2025. PMID: 40796244 Free PMC article. Clinical Trial.
However, during the post-trial period (median 4.3 years), there was a higher rate of MACE (HR 1.17, 95% CI 1.01, 1.36) in those randomized to aspirin compared with placebo. Over the entire period, a higher rate of major haemorrhage was observed in the randomized aspirin …
However, during the post-trial period (median 4.3 years), there was a higher rate of MACE (HR 1.17, 95% CI 1.01, 1.36) in those randomized t …
Network Controllability Reveals Key Mitigation Points for Tumor-Promoting Signaling in Tumor-Educated Platelets.
Osmanoglu Ö, Özer E, Gupta SK, Heinze KG, Schulze H, Dandekar T. Osmanoglu Ö, et al. Int J Mol Sci. 2025 Nov 5;26(21):10780. doi: 10.3390/ijms262110780. Int J Mol Sci. 2025. PMID: 41226816 Free PMC article.
Therapeutic strategies targeting "tumor-educated platelets" (TEPs) and platelet-tumor interactions by key signaling pathways (ITAM, P2Y12) may reduce metastasis and cancer. Using a TEP gene expression dataset originally created to study swarm intelligence-enhanced detectio …
Therapeutic strategies targeting "tumor-educated platelets" (TEPs) and platelet-tumor interactions by key signaling pathways (ITAM, P2Y12) m …
Use of non-prescription analgesic medications and survival among Black women with ovarian cancer.
Colin-Leitzinger C, Aranzabal O, Johnson CE, Alberg AJ, Bandera EV, Bondy M, Cote ML, Hastert TA, Haller K, Lawson A, Marks JR, Peters ES, Terry PD, Schildkraut JM, Peres LC. Colin-Leitzinger C, et al. Br J Cancer. 2025 Nov 5. doi: 10.1038/s41416-025-03254-4. Online ahead of print. Br J Cancer. 2025. PMID: 41193853
METHODS: Leveraging data from the African American Cancer Epidemiology Study, we examined the association of pre-diagnostic analgesic medication use (aspirin, non-aspirin non-steroidal anti-inflammatory drugs [naNSAIDs], and acetaminophen) with survival among …
METHODS: Leveraging data from the African American Cancer Epidemiology Study, we examined the association of pre-diagnostic analgesic …
Platelet inhibition delays time to neurosurgical intervention for cerebral metastasis in non-small cell lung cancer.
Wasilewski D, Onken J, Won SY, Rafaelian A, Hempelmann A, Bernstock J, Maletzki C, Freiman T, Vajkoczy P, Gessler F, Dubinski D. Wasilewski D, et al. Sci Rep. 2025 Nov 4;15(1):38467. doi: 10.1038/s41598-025-25708-8. Sci Rep. 2025. PMID: 41188518 Free PMC article.
An inverse association between the use of platelet inhibitors and the risk of cancer has been reported by numerous epidemiological studies in the past. The effects of antiplatelet agents on the cerebral metastasis formation of non-small cell lung cancer (NSCLC) are …
An inverse association between the use of platelet inhibitors and the risk of cancer has been reported by numerous epidemiological st …
History of Venous Thromboembolism Is Not a Contraindication to Aspirin Prophylaxis in Patients Undergoing Total Joint Arthroplasty.
Verhey JT, Tarabichi S, Brinkman JC, Hall RP, Deckey DG, Christopher ZK, Clarke HD, Spangehl MJ, Bingham JS. Verhey JT, et al. J Arthroplasty. 2025 Nov 3:S0883-5403(25)01372-5. doi: 10.1016/j.arth.2025.10.069. Online ahead of print. J Arthroplasty. 2025. PMID: 41192530
BACKGROUND: Although aspirin has become the prophylactic agent of choice for venous thromboembolism (VTE) prevention in low VTE risk patients undergoing primary total joint arthroplasty (TJA), there remains a paucity of data in the literature on the efficacy of aspirin …
BACKGROUND: Although aspirin has become the prophylactic agent of choice for venous thromboembolism (VTE) prevention in low VTE risk …
Antiatherosclerotic effects of a novel aspirin-anthraquinone derivative through the induction of macrophage apoptosis.
Lin S, Li Y, Zhang Y, Wang Q, Qu X, Wang N, Zhong X, Zhang S, Zhang D, Wang Z, Li S. Lin S, et al. J Thromb Thrombolysis. 2025 Nov 2. doi: 10.1007/s11239-025-03197-w. Online ahead of print. J Thromb Thrombolysis. 2025. PMID: 41177818
ASA-X(3) has anticancer effects by inducing significant apoptosis in gastric cancer cells. We conducted a preliminary experiment and reported that ASA-X(3) promotes macrophage apoptosis. ...
ASA-X(3) has anticancer effects by inducing significant apoptosis in gastric cancer cells. We conducted a preliminary experiment and …
Photothermal Therapy Combined with Chemotherapy and Anti-Inflammation Therapy Weakens the Immunosuppression of Cervical Cancer.
Yang X, Fu J, Xu Y, Li D, Ren H. Yang X, et al. Pharmaceuticals (Basel). 2025 Nov 1;18(11):1657. doi: 10.3390/ph18111657. Pharmaceuticals (Basel). 2025. PMID: 41304902 Free PMC article.
Methods: In this study, the chemotherapeutic drug cisplatin (DDP) and the anti-inflammatory drug Aspirin-DL-Lysine (ADL) were loaded into a hollow porous nanomaterial zeolitic imidazolate framework-8 (ZIF-8), which was then coated with polydopamine, in order to form near-i …
Methods: In this study, the chemotherapeutic drug cisplatin (DDP) and the anti-inflammatory drug Aspirin-DL-Lysine (ADL) were loaded …
Understanding mechanisms of colorectal cancer chemoprevention using seAFOod polyp prevention trial outcomes and its Biobank: STOP-ADENOMA synopsis.
Sun G, Fenton H, Fuller H, Race A, Mell T, Burke L, Downing A, Rees C, Brown L, Loadman P, Williams E, Hull M. Sun G, et al. Southampton (UK): National Institute for Health and Care Research; 2025 Nov. Southampton (UK): National Institute for Health and Care Research; 2025 Nov. PMID: 41289414 Free Books & Documents. Review.
BACKGROUND: The 2 2 factorial seAFOod trial demonstrated that aspirin and omega-3 polyunsaturated fatty acid eicosapentaenoic acid reduce colorectal polyp number (a biomarker of colorectal cancer risk) during colonoscopy surveillance in the Bowel Cancer Scree …
BACKGROUND: The 2 2 factorial seAFOod trial demonstrated that aspirin and omega-3 polyunsaturated fatty acid eicosapentaenoic acid re …
Effect of the Combination of Concomitant Drugs on Efficacy of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer.
Saiki M, Takusagawa K, Takahashi N, Homma K, Satoh T, Furuya S, Shimamura S, Omori C, Ohkoshi H, Hoshino Y, Uchida Y, Ikemura S, Soejima K. Saiki M, et al. Cancer Rep (Hoboken). 2025 Nov;8(11):e70399. doi: 10.1002/cnr2.70399. Cancer Rep (Hoboken). 2025. PMID: 41195639 Free PMC article.
Drug exposure at treatment initiation was assessed for proton pump inhibitors (PPIs), low-dose aspirin, non-steroidal anti-inflammatory drugs, statins, biguanides, antibiotics, and probiotics. ...RESULTS: PPI use was independently associated with shorter PFS (HR: 2.44, p & …
Drug exposure at treatment initiation was assessed for proton pump inhibitors (PPIs), low-dose aspirin, non-steroidal anti-inflammato …
Chemoprevention of hepatocellular carcinoma.
Schwenk S, Kaplan DE. Schwenk S, et al. Hepatol Commun. 2025 Oct 31;9(11):e0836. doi: 10.1097/HC9.0000000000000836. eCollection 2025 Nov 1. Hepatol Commun. 2025. PMID: 41171441 Free PMC article. Review.
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and a leading cause of cancer-related deaths globally. Chronic liver disease (CLD), primarily due to viral hepatitis, alcohol use, and metabolic dysfunction-associated steatotic liver dis …
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and a leading cause of cancer-related deaths gl …
Genomic Risk Prediction of Incident Atrial Fibrillation in Older Individuals Without Prior Cardiovascular Disease.
Fransquet PD, Yu C, Tran C, Hussain SM, Neumann JT, Ball J, Lin T, Beilin L, Nelson MR, Polkinghorne KR, Zhou Z, Fatkin D, Brodtmann A, Tonkin A, McNeil JJ, Lacaze P. Fransquet PD, et al. JACC Adv. 2025 Nov;4(11 Pt 1):102245. doi: 10.1016/j.jacadv.2025.102245. Epub 2025 Oct 21. JACC Adv. 2025. PMID: 41124989 Free PMC article.
METHODS: AF-PRS was calculated in 12,906 individuals aged 65 years without prior cardiovascular disease or AF at enrollment into the ASPREE (Aspirin in Reducing Events in the Elderly) trial. Cox proportional hazards models assessed HRs) per SD of AF-PRS, alone and with cli …
METHODS: AF-PRS was calculated in 12,906 individuals aged 65 years without prior cardiovascular disease or AF at enrollment into the ASPREE …
High-sensitivity C-reactive protein, LDL cholesterol, lipoprotein(a) and 30-year risk of stroke in healthy women: a prospective, longitudinal cohort study.
Nordestgaard AT, Moorthy MV, Cook NR, Rifai N, Lee IM, Buring JE, Ridker PM. Nordestgaard AT, et al. Lancet Neurol. 2025 Nov;24(11):920-930. doi: 10.1016/S1474-4422(25)00306-0. Lancet Neurol. 2025. PMID: 41109233
METHODS: In this prospective, longitudinal cohort study, participants who were enrolled in the Women's Health Study (a randomised controlled trial of aspirin and vitamin E for the prevention of cardiovascular disease and cancer in women in the USA that completed in …
METHODS: In this prospective, longitudinal cohort study, participants who were enrolled in the Women's Health Study (a randomised controlled …
Low-dose aspirin use is associated with reduced 30- and 90-day mortality and overall improved outcomes in patients with acute pancreatitis: A multinational multicenter analysis.
Kim DH, Ko D, Elizondo Alatorre C, Lukens FJ, Porres JA, Palacios Argueta P, Raimondo M, Ji B, Bi Y, Kröner PT. Kim DH, et al. Pancreatology. 2025 Nov;25(7):1080-1085. doi: 10.1016/j.pan.2025.09.022. Epub 2025 Sep 24. Pancreatology. 2025. PMID: 41087237
INTRODUCTION: Studies regarding outcomes in patients with acute pancreatitis (AP) on aspirin (ASA) have shown conflicting results. This study aims to evaluate the association between low-dose ASA and clinical outcomes in patients with AP at 30 and 90 days. ...
INTRODUCTION: Studies regarding outcomes in patients with acute pancreatitis (AP) on aspirin (ASA) have shown conflicting results. Th …
Aspirin Use and Risk of HCC and Gastrointestinal Bleeding in Patients With HBV-Related Cirrhosis: A Landmark Analysis.
Kim MN, Park GU, You SC, Lee JS, Lee HW, Kim BK, Kim SU, Park JY, Kim DY, Ahn SH. Kim MN, et al. J Gastroenterol Hepatol. 2025 Nov;40(11):2750-2757. doi: 10.1111/jgh.70078. Epub 2025 Oct 1. J Gastroenterol Hepatol. 2025. PMID: 41030108 Free PMC article.
Patients diagnosed with compensated HBV-related cirrhosis in 2005-2017 were included. Patients who were prescribed aspirin for at least 90 days consecutively during the 3-year exposure period were classified as the aspirin-treated group. ...CONCLUSIONS: In patients …
Patients diagnosed with compensated HBV-related cirrhosis in 2005-2017 were included. Patients who were prescribed aspirin for at lea …
Low-Dose Aspirin for Individualized Cancer Prevention in Older Adults: A Secondary Analysis of the ASPREE Randomized Clinical Trial.
Thao LTP, Nguyen TL, Singh J, Byars SG, Bick AG, Ford L, Gibbs P, McNeil JJ, Murray AM, Orchard SG, Phung J, Umar A, Wood EM, Woods RL, Lacaze P, Chan AT, Curtis DJ, McQuilten ZK, Wolfe R. Thao LTP, et al. JAMA Oncol. 2025 Nov 1;11(11):1348-1355. doi: 10.1001/jamaoncol.2025.3593. JAMA Oncol. 2025. PMID: 40996732 Clinical Trial.
IMPORTANCE: The role of low-dose aspirin (LDA) in cancer prevention among older adults is unclear. Identifying individuals likely to experience benefit or harm is crucial for guiding personalized prevention strategies. ...LDA was associated with lower cancer …
IMPORTANCE: The role of low-dose aspirin (LDA) in cancer prevention among older adults is unclear. Identifying individuals lik …
Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy.
Reijnders E, Bossuyt PM, Jukema JW, Ruhaak LR, Romijn FPHTM, Szarek M, Trompet S, Bhatt DL, Bittner VA, Diaz R, Fazio S, Stevanovic I, Goodman SG, Harrington RA, White HD, Steg PG, Schwartz GG, Cobbaert CM. Reijnders E, et al. Arterioscler Thromb Vasc Biol. 2025 Nov;45(11):2111-2123. doi: 10.1161/ATVBAHA.124.322336. Epub 2025 Sep 25. Arterioscler Thromb Vasc Biol. 2025. PMID: 40995631 Free PMC article. Clinical Trial.
Effect of aspirin use on cancer incidence and mortality: An updated systematic review and meta-analysis.
Petrelli F, Ghidini A, Antista M, Meli N, Dottorini L, Rossitto M, Angeli I, Moleri G, Garrone O, Tomasello G, Ghidini M. Petrelli F, et al. Public Health. 2025 Nov;248:105924. doi: 10.1016/j.puhe.2025.105924. Epub 2025 Aug 26. Public Health. 2025. PMID: 40865396 Review.
OBJECTIVES: To evaluate the association between aspirin use and cancer incidence and mortality, and to clarify aspirin's potential role in cancer prevention. ...CONCLUSIONS: This meta-analysis supports the growing body of evidence suggesting …
OBJECTIVES: To evaluate the association between aspirin use and cancer incidence and mortality, and to clarify aspirin' …
Multi-institutional study of outcomes from portal vein reconstruction during pancreatic cancer surgery.
Gondi S, McSpadden M, Schlesselman C, Williams M, Dougherty K, Bennett KM, Gober L, Bath J. Gondi S, et al. J Vasc Surg. 2025 Nov;82(5):1680-1686. doi: 10.1016/j.jvs.2025.07.014. Epub 2025 Jul 15. J Vasc Surg. 2025. PMID: 40675402
OBJECTIVE: Portal vein reconstruction (PVR) is undertaken to enhance resectability during pancreatic cancer surgery. We hypothesize that the type of reconstructions for patients undergoing PVR may not significantly influence overall outcomes. METHODS: Patients undergoing P …
OBJECTIVE: Portal vein reconstruction (PVR) is undertaken to enhance resectability during pancreatic cancer surgery. We hypothesize t …
Co-loaded aspirin and doxorubicin by chondroitin sulphate nanoparticles inhibited metastasis of breast cancer by squelching circulating tumor microemboli.
Ma X, Xiao L, Zhao M, Sun S, Du Y, Xiu Y, Yan K, Li Z, Li W, Wu J. Ma X, et al. Colloids Surf B Biointerfaces. 2025 Nov;255:114942. doi: 10.1016/j.colsurfb.2025.114942. Epub 2025 Jul 9. Colloids Surf B Biointerfaces. 2025. PMID: 40644795
Platelets (PLTs) play a critical role in proliferation and migration of cancers, combination therapy based on chemotherapeutical and anti-PLT agents could inhibit tumor development. ...Moreover, ASP/CS-DOX significantly inhibited tumor metastasis in the breast cancer …
Platelets (PLTs) play a critical role in proliferation and migration of cancers, combination therapy based on chemotherapeutical and …
Inflammatory Biomarkers for Thrombotic Risk Assessment in Multiple Myeloma Patients on IMiD/aCD38-Based Regimens: Insights from a Prospective Observational Study.
Botta C, Corsale AM, Cammarata C, Di Fazio F, Gigliotta E, Rizzuto A, Ingrascì M, Speciale M, Aquilina C, Biondo M, Romano A, Napolitano M, Mattana M, Siragusa S. Botta C, et al. Biomolecules. 2025 Oct 31;15(11):1533. doi: 10.3390/biom15111533. Biomolecules. 2025. PMID: 41301451 Free PMC article.
Most patients (n = 38) received frontline therapy, and all were given thromboprophylaxis according to guidelines, mainly aspirin (73%). Five patients (9.4%) developed VTE after a median of 48 days, managed with short-term low-molecular-weight heparin (LMWH). ...Notably, fo …
Most patients (n = 38) received frontline therapy, and all were given thromboprophylaxis according to guidelines, mainly aspirin (73% …
Impact of Maternal Aspirin Therapy on Neonatal Epigenetic Patterns.
Varotsis D, Betal SGN, Addya S, Aghai ZH, Boelig RC. Varotsis D, et al. Am J Perinatol. 2025 Oct 30. doi: 10.1055/a-2721-5822. Online ahead of print. Am J Perinatol. 2025. PMID: 41167500
Low-dose aspirin (LDA) is an intervention recommended to prevent the development of hypertensive disorders of pregnancy (HDP) in high-risk pregnancies. ...Research on potential protective impact of maternal aspirin on neonatal epigenetics is warranted.....
Low-dose aspirin (LDA) is an intervention recommended to prevent the development of hypertensive disorders of pregnancy (HDP) in high …
Elevated alpha-1 antitrypsin and C-reactive protein: association on all-cause and cause-specific mortality in older adults.
Tran C, Schneider HG, Lam QT, Neumann JT, Cicuttini F, Yu C, Zhou Z, Nelson MR, Tonkin AM, Clayton-Chubb D, Hussain SM, Fransquet PD, Woods RL, Orchard SG, Lacaze P, McNeil JJ. Tran C, et al. Geroscience. 2025 Oct 29. doi: 10.1007/s11357-025-01956-4. Online ahead of print. Geroscience. 2025. PMID: 41160314
Cox proportional hazard models estimated adjusted hazard ratios (aHRs) for all-cause and cause-specific mortality (cancer, cardiovascular and other) over a median follow-up of 10.9 years. AAT and hs-CRP were analyzed in deciles, comparing the highest decile to the middle 8 …
Cox proportional hazard models estimated adjusted hazard ratios (aHRs) for all-cause and cause-specific mortality (cancer, cardiovasc …
Aspirin inhibition and recovery of cyclooxygenase activity and thromboxane biosynthesis in human megakaryocytes: a translational surrogate model.
Mallah ZI, Petrucci G, Ayoub AJ, Farhoud MA, Jelwan JG, Lucchisani S, Fakih AK, Badran B, Hamade E, Patrono C, Rocca B, Habib A. Mallah ZI, et al. J Pharmacol Exp Ther. 2025 Oct 28;392(12):103762. doi: 10.1016/j.jpet.2025.103762. Online ahead of print. J Pharmacol Exp Ther. 2025. PMID: 41265381 Free article.
We studied aspirin pharmacodynamics in human megakaryocytic cell lines as a reliable and feasible surrogate model. ...SIGNIFICANCE STATEMENT: In human megakaryocyte cell lines, once-daily aspirin treatment at low-concentration range time-dependently inhibits COX-1 w …
We studied aspirin pharmacodynamics in human megakaryocytic cell lines as a reliable and feasible surrogate model. ...SIGNIFICANCE ST …
Ropeginterferon alfa-2b vs standard therapy in polycythemia vera: A meta-analysis of efficacy and safety outcomes.
Tom L, Mani S, Rawat A, Nan M, Mundada SM, Al Khatib B, Gopinath A, Taj O, Salahuddin N, Shaju F, Parsa S, Abdurrahman M, Das A, Khawar MMH, Sher A. Tom L, et al. World J Clin Oncol. 2025 Oct 24;16(10):112392. doi: 10.5306/wjco.v16.i10.112392. World J Clin Oncol. 2025. PMID: 41178922 Free PMC article.
Ropeginterferon alfa-2b (RI) offers potential advantages over standard therapy (ST; including phlebotomy, hydroxyurea, and aspirin) by achieving hematologic and molecular responses. However, its comparative efficacy and safety remain understudied. ...
Ropeginterferon alfa-2b (RI) offers potential advantages over standard therapy (ST; including phlebotomy, hydroxyurea, and aspirin) b …
Exploring the potential of artificial intelligence in assessing the risk of gastric neoplastic lesions in patients with corpus atrophic gastritis.
Dilaghi E, Cesaroni E, Ligato I, Silvestri M, Liuzzi G, Annibale B, Lucidi S, Esposito G, Sciandrone M. Dilaghi E, et al. Gastric Cancer. 2025 Oct 22. doi: 10.1007/s10120-025-01679-7. Online ahead of print. Gastric Cancer. 2025. PMID: 41123822
Antral inflammation and age > 60 were linked to epithelial GNL, while anti-thyroperoxidase-antibodies, smoking, and dyspeptic-symptoms were linked to T1gNET. Low-dose aspirin and H. pylori eradication therapy showed inverse associations with epithelial GNL and T1gNET, r …
Antral inflammation and age > 60 were linked to epithelial GNL, while anti-thyroperoxidase-antibodies, smoking, and dyspeptic-symptoms we …
Baseline use of aspirin or statins with oral estrogen and progestogens to prevent incident arterial or venous thrombotic events: a secondary analysis of the Women's Health Initiative trial.
Davis JW, Aragaki AK, Harrington LB, Rossouw JE, Wells G, Shadyab A, Schnatz PF, Shufelt CL, Warsinger-Martin L, Wild RA, Manson JE. Davis JW, et al. Menopause. 2025 Oct 21. doi: 10.1097/GME.0000000000002647. Online ahead of print. Menopause. 2025. PMID: 41117635
CONCLUSIONS: In this secondary randomized clinical trial analysis, neither statins nor aspirin significantly modified effects of oral HT on key arterial or venous thrombotic outcomes at 2 or 5 years. Results, however, may be underpowered given low baseline exposure prevale …
CONCLUSIONS: In this secondary randomized clinical trial analysis, neither statins nor aspirin significantly modified effects of oral …
Training gut and body: physical activity, diet, ASA and microbiota influence the outcome in gastrointestinal cancer survivors.
Oneda E, Noventa S, Libertini M, Cherri S, Manno A, Meriggi F, Martinetti M, Zaniboni A. Oneda E, et al. Front Nutr. 2025 Oct 16;12:1648004. doi: 10.3389/fnut.2025.1648004. eCollection 2025. Front Nutr. 2025. PMID: 41178954 Free PMC article. Review.
Gastrointestinal (GI) cancers remain a significant contributor to global cancer mortality. Recent evidence highlights the crucial role of lifestyle interventions-particularly physical activity and diet-in improving outcomes for GI cancer survivors. ...The rev …
Gastrointestinal (GI) cancers remain a significant contributor to global cancer mortality. Recent evidence highlights the cruc …
Association of cardiometabolic risk burden with gastrointestinal bleeding in aspirin users.
Wei Y, Yan J, Gao Z, Wei H, Qiu Z, Xiao J, Huang W. Wei Y, et al. BMC Gastroenterol. 2025 Oct 15;25(1):736. doi: 10.1186/s12876-025-04347-3. BMC Gastroenterol. 2025. PMID: 41094370 Free PMC article.
INTRODUCTION: Aspirin is widely used in patients with ischemic cardiovascular diseases, most of whom have cardiometabolic disorders. This study aimed to investigate the impact of cardiometabolic risk burden on first gastrointestinal (GI) bleeding in aspirin users. M …
INTRODUCTION: Aspirin is widely used in patients with ischemic cardiovascular diseases, most of whom have cardiometabolic disorders. …
Clonal Hematopoiesis and Cardiovascular Disease and Bleeding Risk and the Effectiveness of Aspirin.
McQuilten ZK, Thao LTP, Bick AG, Byars S, Chan AT, Ford L, Leichter A, McNeil JJ, Murray AM, Murphy AJ, Orchard SG, Phung J, Ramshaw HS, Singh J, Tonkin AM, Umar A, Wolfe R, Wood EM, Woods RL, Lacaze P, Curtis DJ. McQuilten ZK, et al. JAMA Cardiol. 2025 Oct 15:e253756. doi: 10.1001/jamacardio.2025.3756. Online ahead of print. JAMA Cardiol. 2025. PMID: 41091476
OBJECTIVE: To investigate whether low-dose aspirin might benefit older adults with CHIP for the primary prevention of CVD. DESIGN, SETTING, AND PARTICIPANTS: This was a prespecified substudy of the Aspirin in Reducing Events in the Elderly (ASPREE) double-blind, ran …
OBJECTIVE: To investigate whether low-dose aspirin might benefit older adults with CHIP for the primary prevention of CVD. DESIGN, SE …
Green Tea Polyphenols Ameliorate Esophagitis rather than Aspirin in a Non-Randomized Prospective Cohort Study.
Li X, Zhang Q, Zhang H, Li P, Zhu S, Zhang S, Xing J. Li X, et al. Dig Dis. 2025 Oct 13:1-11. doi: 10.1159/000548588. Online ahead of print. Dig Dis. 2025. PMID: 41078050
INTRODUCTION: Green tea polyphenols (GTPs) and aspirin were demonstrated to be novel candidates for cancer chemoprevention. This study aimed to investigate effects of GTPs and aspirin on esophageal diseases. ...RESULTS: A total of 159, 151, 160 participants s …
INTRODUCTION: Green tea polyphenols (GTPs) and aspirin were demonstrated to be novel candidates for cancer chemoprevention. Th …
Optimal Strategy for Thromboprophylaxis in Fontan Circulation: A Systematic Review and Meta-analysis with a Focus on Ethnic Differences.
Oh KJ, Lee JS, Seol JH, Choi HJ, Cho MJ, Choi M, Song JY, Jung JW, Na JY, Kim JA, Kim SJ. Oh KJ, et al. Pediatr Cardiol. 2025 Oct 10. doi: 10.1007/s00246-025-04019-9. Online ahead of print. Pediatr Cardiol. 2025. PMID: 41071335

Thirty reports-four randomized controlled trials and 26 cohort studies-were analyzed. Aspirin (risk ratio [RR], 0.46; 95% confidence interval [CI], 0.2-1.08; p = 0.07), warfarin (RR, 0.40; 95% CI, 0.24-0.65; p < 0.001), and direct oral anticoagulants (DOACs) (RR, 0.22;

…
Thirty reports-four randomized controlled trials and 26 cohort studies-were analyzed. Aspirin (risk ratio [RR], 0.46; 95% confidence …
Screening and eradication of Helicobacter pylori for gastric cancer prevention: Taipei Global Consensus II.
Liou JM, Malfertheiner P, Hong TC, Cheng HC, Sugano K, Shah S, Sheu BS, Chen MJ, Chiang TH, Chen YC, Yamaoka Y, Wong SH, Chen CC, Lee YY, Quach DT, Wu DC, Hsu PI, Wu CY, Wu JY, Luo JC, Chang WL, Lu H, Suzuki H, Jung HY, Mahachai V, Vilaichone RK, Mégraud F, Lin JT, Yeoh KG, Leung WK, El-Omar EM, Lee YC, Wu MS; Asian Pacific Alliance on Helicobacter and Microbiota (APAHAM). Liou JM, et al. Gut. 2025 Oct 8;74(11):1767-1791. doi: 10.1136/gutjnl-2025-336027. Gut. 2025. PMID: 40912906
OBJECTIVE: To convene a global consensus on Helicobacter pylori (H pylori) screening and eradication strategies for gastric cancer prevention, identify key knowledge gaps and outline future research directions. ...Eradication of H pylori, the primary cause of gastric ca …
OBJECTIVE: To convene a global consensus on Helicobacter pylori (H pylori) screening and eradication strategies for gastric cancer pr …
Effect of aspirin on grip strength and gait speed in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly (ASPREE) Study.
Phyo AZZ, Espinoza SE, Orchard SG, Wolfe R, Murray AM, Woods RL, Ryan J. Phyo AZZ, et al. J Gerontol A Biol Sci Med Sci. 2025 Oct 5;80(11):glaf198. doi: 10.1093/gerona/glaf198. J Gerontol A Biol Sci Med Sci. 2025. PMID: 40929147 Free PMC article. Clinical Trial.
This study aimed to examine the effect of low-dose aspirin on handgrip strength and habitual gait speed in relatively healthy older people. METHODS: The ASPREE (ASPirin in Reducing Events in the Elderly) trial randomized 19 114 community-dwelling Australians and US …
This study aimed to examine the effect of low-dose aspirin on handgrip strength and habitual gait speed in relatively healthy older p …
Development of scoring models to predict early pancreatic cancer risk in new-onset diabetes mellitus patients.
Cheung KS, Wan EYF, Zhou J, Lam CLK, Leung WK. Cheung KS, et al. Hepatobiliary Surg Nutr. 2025 Oct 1;14(5):782-794. doi: 10.21037/hbsn-2024-743. Epub 2025 Jul 22. Hepatobiliary Surg Nutr. 2025. PMID: 41104217 Free PMC article.
BACKGROUND: Diabetes mellitus is a risk factor of pancreatic cancer (PC). We aimed to develop risk models to predict PC within 1- and 3-year in new onset diabetes mellitus (NODM). ...Predictors in 1- and 3-year risk models included age, sex, acute pancreatitis history, ins …
BACKGROUND: Diabetes mellitus is a risk factor of pancreatic cancer (PC). We aimed to develop risk models to predict PC within 1- and …
Painful diabetic neuropathy complicated with secondary erythromelalgia in polycythemia vera: A case report.
Zhang H, Qin Z, Feng X. Zhang H, et al. J Int Med Res. 2025 Oct;53(10):3000605251382382. doi: 10.1177/03000605251382382. Epub 2025 Oct 1. J Int Med Res. 2025. PMID: 41034711 Free PMC article.
The patient received a multidisciplinary regimen, including pregabalin, aspirin, and interferon-alpha, resulting in significant symptom relief and improved hematologic parameters. ...
The patient received a multidisciplinary regimen, including pregabalin, aspirin, and interferon-alpha, resulting in significant sympt …
Aspirin's effect on macrophages beyond its chemopreventive role in inflammation and cancer.
Unver N. Unver N. Inflammopharmacology. 2025 Oct;33(10):5735-5743. doi: 10.1007/s10787-025-01945-1. Epub 2025 Sep 24. Inflammopharmacology. 2025. PMID: 40991180 Review.
On the other hand, aspirin's effects on macrophages include inflammation resolution, cytokine regulation, and increased phagocytosis. ...Key factors, such as macrophage infiltration, immunophenotype, and polarization, are required to appropriately evaluate aspiri …
On the other hand, aspirin's effects on macrophages include inflammation resolution, cytokine regulation, and increased phagoc …
Association between low-dose aspirin use and breast cancer recurrence: a Danish nationwide cohort study with up to 23 years of follow-up.
Solmunde E, Pedersen RN, Nørgaard M, Mellemkjær L, Friis S, Ejlertsen B, Ahern TP, Cronin-Fenton DP. Solmunde E, et al. Br J Cancer. 2025 Oct;133(6):865-873. doi: 10.1038/s41416-025-03112-3. Epub 2025 Jul 22. Br J Cancer. 2025. PMID: 40691279 Free PMC article.
BACKGROUND: The anti-cancer potential of low-dose aspirin in long-term breast cancer (BC) survivors remain unknown. ...CONCLUSIONS: The reduced recurrence risk in aspirin users may indicate potential anti-cancer effects of aspirin, though …
BACKGROUND: The anti-cancer potential of low-dose aspirin in long-term breast cancer (BC) survivors remain unknown. ... …
Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy.
Qiao Z, Zhang G, Chen X, Zhang Y, Zhang S, Qin X, Sohail A, Xu X, Liu J, Han B, Wang D, Zhang X, Wang Z. Qiao Z, et al. Apoptosis. 2025 Oct;30(9-10):2254-2268. doi: 10.1007/s10495-025-02139-4. Epub 2025 Jul 5. Apoptosis. 2025. PMID: 40618003
Aspirin, widely recognized for its anti-inflammatory and cardioprotective effects, has also shown potential as a cancer therapeutic. ...In colorectal cancer cells, CM-NAG also suppressed migration and invasion and induced apoptosis more effectively than as …
Aspirin, widely recognized for its anti-inflammatory and cardioprotective effects, has also shown potential as a cancer therap …
Pediatric Extreme Thrombocytosis: Etiology, Management, and Outcomes.
Lashansky A, Grishin E, Budnik I, Efros O, Toren A, Levy-Mendelovich S, Kenet G, Golan H, Barg AA. Lashansky A, et al. Pediatr Blood Cancer. 2025 Oct;72(10):e31893. doi: 10.1002/pbc.31893. Epub 2025 Jul 2. Pediatr Blood Cancer. 2025. PMID: 40605123
Thrombotic events occurred in 10 cases (4.9%), primarily related to central venous lines or other risk factors rather than elevated platelet counts alone. Aspirin prophylaxis was uncommon, administered in 14% of patients, mainly in those with existing comorbidities. ...
Thrombotic events occurred in 10 cases (4.9%), primarily related to central venous lines or other risk factors rather than elevated platelet …
The APROVE (Anti-coagulation/Platelet Treatment in Pancreatic Resections Involving Vascular Reconstruction) Study: Results from a Worldwide Survey.
Marchetti A, Garnier J, Habib JR, Rompen IF, Andel PCM, Salinas CH, Ratner M, De Pastena M, Salvia R, Hewitt DB, Morgan K, Kluger MD, Garg K, Javed AA, Wolfgang CL, Sacks GD. Marchetti A, et al. Ann Surg Oncol. 2025 Oct;32(10):7400-7409. doi: 10.1245/s10434-025-17686-y. Epub 2025 Jun 30. Ann Surg Oncol. 2025. PMID: 40587069
An "aggressive" protocol was defined as the use of any AT protocol other than prophylactic heparin, aspirin, or their combination. RESULTS: The survey was completed by 80 surgeons (59% Europe, 30% USA, 11% Asia). ...Conversely, in the USA, prophylactic heparin + aspirin …
An "aggressive" protocol was defined as the use of any AT protocol other than prophylactic heparin, aspirin, or their combination. RE …
Thromboembolism in transplant-ineligible multiple myeloma patients on triplet/quadruplet therapy: a post hoc analysis of BENEFIT trial.
Chalayer E, Frere C, Daguenet E, Lecompte T, Tardy B, Bounouara I, Sapet M, Bobin A, Harel S, Decaux O, Belhadj K, Touzeau C, Macro M, Mohty M, Moreau P, Corre J, Avet-Loiseau H, Karlin L, Facon T, Perrot A, Hulin C, Manier S, Frenzel L, Leleu X. Chalayer E, et al. J Thromb Haemost. 2025 Oct;23(10):3220-3230. doi: 10.1016/j.jtha.2025.06.012. Epub 2025 Jun 14. J Thromb Haemost. 2025. PMID: 40523501 Clinical Trial.
RESULTS: In the whole cohort, the 6-month cumulative incidence of VTE was 4.8% (95% CI, 2.7%-8.1%), 0.8% (95% CI, 0.1%-5.6%) in patients receiving low-dose direct oral anticoagulants (DOACs) compared with 5.6% (95% CI, 1.9%-16.7%) in those who received prophylactic-dose heparin, …
RESULTS: In the whole cohort, the 6-month cumulative incidence of VTE was 4.8% (95% CI, 2.7%-8.1%), 0.8% (95% CI, 0.1%-5.6%) in patients rec …
Effect of Aspirin on Development of First and Recurrent Primary Cutaneous Keratinocyte Carcinomas in Older Australian Adults: Extended Follow-up of a Large Randomised Controlled Trial.
Hiscutt E, Yan M, Mar V, Wolfe R, Trevaks R, Wilson M, Orchard SG. Hiscutt E, et al. J Cancer Prev. 2025 Sep 30;30(3):177-184. doi: 10.15430/JCP.25.017. J Cancer Prev. 2025. PMID: 41112419 Free PMC article.
Keratinocyte carcinomas (KC) are the most frequent cancers diagnosed in Australia and impart the largest economic cost of all cancers. Predisposed individuals tend to develop multiple KC over their lifetime. Data from the ASPirin in Reducing Events in the Eld …
Keratinocyte carcinomas (KC) are the most frequent cancers diagnosed in Australia and impart the largest economic cost of all canc …
Epidemiology of colonic adenoma and cancer.
Kim DH. Kim DH. Clin Endosc. 2025 Sep 29. doi: 10.5946/ce.2025.189. Online ahead of print. Clin Endosc. 2025. PMID: 41017554 Free article. Review.
Colorectal cancer (CRC) remains a major global health concern, showing significant variation in incidence and trends across different populations and age groups. ...In selected individuals, chemoprevention with low-dose aspirin may also lower CRC incidence. Screenin …
Colorectal cancer (CRC) remains a major global health concern, showing significant variation in incidence and trends across different …
BTK inhibitors potently impair platelet aggregation as a class effect independent of BTK specificity or dose in CLL and MCL.
Kojima K, Watanabe S, Takeuchi A, Kunisawa N, Yoshida S. Kojima K, et al. J Clin Exp Hematop. 2025 Sep 28;65(3):174-179. doi: 10.3960/jslrt.25028. Epub 2025 Jul 30. J Clin Exp Hematop. 2025. PMID: 40738685 Free PMC article.

This inhibitory effect was more potent than that of acetylsalicylic acid (aspirin, 100 mg daily) (P < 0.0001). BTKi did not significantly affect adenosine diphosphate- or ristocetin-induced aggregation. ...Second, in BTKi-treated patients requiring anti-platelet agents,

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This inhibitory effect was more potent than that of acetylsalicylic acid (aspirin, 100 mg daily) (P < 0.0001). BTKi did not signif

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Advances in the Diagnosis and Treatment of Myeloproliferative Neoplasms (MPNs).
Ma X, Zhou Z, Gu S, Guo Y, Zhou T, Shao R, Yan J, Chen W, Shi X. Ma X, et al. Cancers (Basel). 2025 Sep 27;17(19):3142. doi: 10.3390/cancers17193142. Cancers (Basel). 2025. PMID: 41097669 Free PMC article. Review.
Myeloproliferative neoplasms (MPNs) encompass three principal subtypes: polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). ...Treatment methods mainly include bloodletting therapy, low-dose aspirin anticoagulant therapy, cytored …
Myeloproliferative neoplasms (MPNs) encompass three principal subtypes: polycythemia vera (PV), essential thrombocythemia (ET), and p …
Case Report: Synchronous aspirin-induced ileal ulcer and ascending colon adenocarcinoma: diagnostic challenges and pathophysiological insights from an incidental intraoperative finding.
Zhao Z, Xiao Y, Zhao H, Li J, Liu J. Zhao Z, et al. Front Med (Lausanne). 2025 Sep 24;12:1643706. doi: 10.3389/fmed.2025.1643706. eCollection 2025. Front Med (Lausanne). 2025. PMID: 41070071 Free PMC article.
The patient had no history of inflammatory bowel disease and was on regular low-dose aspirin (100 mg/d) for a long time. Colonoscopy showed a mass in the ascending colon, and biopsy confirmed the diagnosis of moderately differentiated carcinoma. ...The combination of the p …
The patient had no history of inflammatory bowel disease and was on regular low-dose aspirin (100 mg/d) for a long time. Colonoscopy …
Practical guide to management after an acute pulmonary embolism.
Alikhan R, Howard LS, Johnson M, Sweeney S, Kiely DG, Pepke-Zaba J. Alikhan R, et al. BMJ Open Respir Res. 2025 Sep 23;12(1):e003028. doi: 10.1136/bmjresp-2024-003028. BMJ Open Respir Res. 2025. PMID: 40992888 Free PMC article. Review.
Dilemmas discussed included: (1) how to manage a breathless patient; (2) what to do if CTEPH is suspected; (3) the difference between CTEPH and post-PE syndrome, (4) testing for thrombophilia, (5) when to investigate for cancer, (6) anticoagulation duration and dose, (7) a …
Dilemmas discussed included: (1) how to manage a breathless patient; (2) what to do if CTEPH is suspected; (3) the difference between CTEPH …
Older research participants are motivated to receive genetic results for the benefit of younger relatives.
Willis AM, Chiew F, Horsley P, Klumsathian S, Ling E, Jacobs C, Lacaze P, Tiller J, Young MA. Willis AM, et al. Eur J Hum Genet. 2025 Sep 22. doi: 10.1038/s41431-025-01940-8. Online ahead of print. Eur J Hum Genet. 2025. PMID: 40983644
Semi-structured interviews were conducted with individuals aged 70 enrolled in the ASPirin in Reducing Events in the Elderly (ASPREE) study. Participants received medically actionable genetic results in Hereditary Breast and Ovarian Cancer, Lynch syndrome or Familia …
Semi-structured interviews were conducted with individuals aged 70 enrolled in the ASPirin in Reducing Events in the Elderly (ASPREE) …
Acute Myeloid Leukemia With RUNX1::RUNX1T1 Fusion Transformed From JAK2V617F-Mutated Polycythemia Vera: A Case Report.
Tsukiji H, Miyazaki S, Iino T, Yoshimoto G, Kubota Y. Tsukiji H, et al. Cureus. 2025 Sep 18;17(9):e92609. doi: 10.7759/cureus.92609. eCollection 2025 Sep. Cureus. 2025. PMID: 41111834 Free PMC article.
Leukemic transformation is an event that significantly affects the prognosis of patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). In acute myeloid leukemia (AML) transformed from MPNs, balanced chromosomal translocations, including t(8;21) …
Leukemic transformation is an event that significantly affects the prognosis of patients with Philadelphia chromosome-negative myeloprolifer …
Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer.
Martling A, Hed Myrberg I, Nilbert M, Grönberg H, Granath F, Eklund M, Öresland T, Iversen LH, Haapamäki C, Janson M, Westberg K, Segelman J, Ersson U, Prytz M, Angenete E, Bergström R, Mayrhofer M, Glimelius B, Lindberg J; ALASCCA Study Group. Martling A, et al. N Engl J Med. 2025 Sep 18;393(11):1051-1064. doi: 10.1056/NEJMoa2504650. N Engl J Med. 2025. PMID: 40961426 Clinical Trial.
BACKGROUND: Aspirin reduces the incidence of colorectal adenoma and colorectal cancer among high-risk persons. ...Severe adverse events occurred in 16.8% of aspirin recipients and 11.6% of placebo recipients. CONCLUSIONS: Aspirin led to a significantly …
BACKGROUND: Aspirin reduces the incidence of colorectal adenoma and colorectal cancer among high-risk persons. ...Severe adver …
Cardiovascular comorbidities and cancer-directed therapies in Hispanic breast cancer patients: a two-center analysis from the Southwestern U.S.
Escobar Gil T, Sherry E, Borja Montes OF, Millhuff AC, Hanson VG, Ayodele V, Baig A, Nemunaitis JM, Mazo Canola M. Escobar Gil T, et al. Front Oncol. 2025 Sep 17;15:1637171. doi: 10.3389/fonc.2025.1637171. eCollection 2025. Front Oncol. 2025. PMID: 41040531 Free PMC article.
Data included demographics, cancer therapy, cardiovascular comorbidities, and medication use. RESULTS: The cohort had a mean age of 59.9 years and a mean BMI of 30.1 kg/m2. ...In contrast, 94.2% of patients with hyperlipidemia were on statins, numerically higher than prior …
Data included demographics, cancer therapy, cardiovascular comorbidities, and medication use. RESULTS: The cohort had a mean age of 5 …
The impact of aspirin on PD-L1 expression and alteration of M2 polarization in non-small cell lung cancer.
Unver N, Uluturk S, Tavukcuoglu E, Duymaz Yilmaz E, Kaymaz Y, Esendagli G. Unver N, et al. Inflamm Res. 2025 Sep 16;74(1):124. doi: 10.1007/s00011-025-02091-8. Inflamm Res. 2025. PMID: 40956358
Transcriptomic profiling was performed after 48 h of culture with differentiated M2-polarized macrophages in the presence of lung cancer cell secretomes. In contrast to the EGFR mutant aspirin-treated HCC827 cell line, the findings revealed that factors produced by …
Transcriptomic profiling was performed after 48 h of culture with differentiated M2-polarized macrophages in the presence of lung cancer …
Apixaban Versus Aspirin to Reduce Cognitive Decline After Cryptogenic Stroke and Atrial Cardiopathy: ARCADIA-Cognition Study.
Lazar RM, Howard G, Brewer MT, Cassarly C, Pauls Q, Kemp S, Tirschwell DL, Sheth KN, Wintermark M, Kamel H, Longstreth WT Jr, Elkind MSV, Broderick JP, Lansberg MG. Lazar RM, et al. J Am Heart Assoc. 2025 Sep 16;14(18):e042147. doi: 10.1161/JAHA.125.042147. Epub 2025 Aug 22. J Am Heart Assoc. 2025. PMID: 40847528 Free PMC article. Clinical Trial.
Baseline characteristics were balanced between the apixaban (n=128) and aspirin (n=121) arms. Mean age was 68 (SD: 10.4) years, median modified Rankin Scale score 1 (interquartile range, 0-2), 52% female, and 19% Black. During median follow-up of 378 (interquartile range, …
Baseline characteristics were balanced between the apixaban (n=128) and aspirin (n=121) arms. Mean age was 68 (SD: 10.4) years, media …
Rutaecarpine alleviates aspirin-induced gastric injury via oxidative stress and ferroptosis inhibition.
Chang L, Wei S, Wang X, Li H, Zhou X, Wu W, Zhu S, Jing M, Zhao Y. Chang L, et al. Eur J Pharmacol. 2025 Sep 15;1003:177969. doi: 10.1016/j.ejphar.2025.177969. Epub 2025 Jul 17. Eur J Pharmacol. 2025. PMID: 40683445
This study aimed to investigate the molecular mechanism of RUT in treating aspirin-induced acute gastric mucosal injury in rats. METHODS: SD rats received RUT for 7 consecutive days before aspirin-induced gastric damage. ...CONCLUSION: These findings demonstrate tha …
This study aimed to investigate the molecular mechanism of RUT in treating aspirin-induced acute gastric mucosal injury in rats. METH …
Reprogramming inflammation: Mechanisms and therapeutic targeting of eicosanoids and pro-resolving mediators.
Kolawole OR, Kashfi K. Kolawole OR, et al. Eur J Pharmacol. 2025 Sep 15;1003:177924. doi: 10.1016/j.ejphar.2025.177924. Epub 2025 Jul 5. Eur J Pharmacol. 2025. PMID: 40623536 Review.
While acute inflammation is typically self-limited and resolves through endogenous mechanisms, persistent or dysregulated inflammation underlies many chronic diseases, including atherosclerosis, arthritis, and cancer. Eicosanoids, lipid mediators derived from polyunsaturat …
While acute inflammation is typically self-limited and resolves through endogenous mechanisms, persistent or dysregulated inflammation under …
Successful Cancer Surgery Without Transfusion Following Early Discontinuation of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention for Acute Myocardial Infarction.
Suh S, Kim N, Kim S. Suh S, et al. J Clin Med. 2025 Sep 13;14(18):6456. doi: 10.3390/jcm14186456. J Clin Med. 2025. PMID: 41010667 Free PMC article.
She was later diagnosed with gallbladder cancer and required urgent surgery but firmly refused allogeneic blood transfusion. This posed a major challenge, as the surgery was expected to cause significant bleeding, and the patient had undergone coronary stenting within the …
She was later diagnosed with gallbladder cancer and required urgent surgery but firmly refused allogeneic blood transfusion. This pos …
Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development.
Richards C, Chen H, O'Rourke M, Bannister A, Owen G, Volkerling A, Ghosh A, Gorrie CA, Gallego-Ortega D, Bottomley AL, Padula MP, McGrath KC, Cole L, Hansbro PM, McClements L. Richards C, et al. Nat Commun. 2025 Sep 12;16(1):8267. doi: 10.1038/s41467-025-62996-0. Nat Commun. 2025. PMID: 40940337 Free PMC article.
Inflammation inhibits proliferation and STBs within bioprinted organoids, which aspirin or metformin (0.5 mM) cannot rescue. We reverse the inside-out architecture of ACH-3P organoids by suspension culture with STBs forming on the outer layer of organoids, reflecting place …
Inflammation inhibits proliferation and STBs within bioprinted organoids, which aspirin or metformin (0.5 mM) cannot rescue. We rever …
Therapeutic potential of the gut commensal bacterium Parabacteroides goldsteinii in human health and disease treatment.
Li Z, Zhang L, Wan Z, Liu H, Zhang T, Li Y. Li Z, et al. Front Microbiol. 2025 Sep 11;16:1618892. doi: 10.3389/fmicb.2025.1618892. eCollection 2025. Front Microbiol. 2025. PMID: 41019532 Free PMC article. Review.
Current evidence shows that therapeutic efficacy against obesity, non-alcoholic fatty liver disease, inflammatory bowel disease, autism spectrum disorder, and colorectal cancer via short-chain fatty acids secretion, bile acid transformation, and host immunity modulation. D …
Current evidence shows that therapeutic efficacy against obesity, non-alcoholic fatty liver disease, inflammatory bowel disease, autism spec …
Genetically predicted causal relationship between aspirin and colorectal cancer in individuals of European ancestry.
Yang S, Zeng T, Jian M, Zhao D, Liu M. Yang S, et al. Medicine (Baltimore). 2025 Sep 5;104(36):e44292. doi: 10.1097/MD.0000000000044292. Medicine (Baltimore). 2025. PMID: 40922335 Free PMC article.
Previous studies have suggested a potential preventive effect of aspirin on colorectal cancer (CRC), but the causal relationship remains unclear. Based on the summary statistics of genome-wide association studies, Mendelian randomization (MR) method was used to asse …
Previous studies have suggested a potential preventive effect of aspirin on colorectal cancer (CRC), but the causal relationsh …
Aspirin and healthy lifespan in older people: main outcome of the ASPREE-XT observational study.
Shah RC, Ryan J, Webb KL, Wolfe R, Chan A, Chong TT, Ernst ME, Espinoza SE, Flynn O, Lee SY, McNeil J, Nelson MR, Orchard SG, Reid CM, Sheets K, Stocks NP, Weerasinghe NS, Wilson ME, Woods RL, Murray AM. Shah RC, et al. Lancet Healthy Longev. 2025 Sep;6(9):100764. doi: 10.1016/j.lanhl.2025.100764. Epub 2025 Sep 30. Lancet Healthy Longev. 2025. PMID: 41043446 Free PMC article. Clinical Trial.
BACKGROUND: In the Aspirin in Reducing Events in the Elderly (ASPREE) clinical trial, low-dose aspirin was not associated with survival free of dementia and persistent physical disability (a measure of a healthy lifespan); however, there was a small increased risk o …
BACKGROUND: In the Aspirin in Reducing Events in the Elderly (ASPREE) clinical trial, low-dose aspirin was not associated with …
Fasciocutaneous Vascularized Lymph Node Transfer for Head and Neck Lymphedema: A Case Report.
Almadani H, Rhyu H, Cantor A, Brazio PS. Almadani H, et al. Microsurgery. 2025 Sep;45(6):e70098. doi: 10.1002/micr.70098. Microsurgery. 2025. PMID: 40736143
Head and neck lymphedema is a common complication of head and neck cancer treatment. Lymphovenous bypass is a promising surgical treatment but may not be an option for all patients after radiotherapy due to the obliteration of local lymphatic targets for bypass. ...The pat …
Head and neck lymphedema is a common complication of head and neck cancer treatment. Lymphovenous bypass is a promising surgical trea …
Spinal Cord Stroke in the Pediatric Population: A Clinical Overview.
Elgehiny A, Wright M, Srivaths L, Mannava S, AlQahtani S, He J, Davila-Williams D, Fraser S. Elgehiny A, et al. Pediatr Neurol. 2025 Sep;170:38-42. doi: 10.1016/j.pediatrneurol.2025.06.002. Epub 2025 Jul 3. Pediatr Neurol. 2025. PMID: 40609286
Treatment was primarily supportive. Four patients received prophylactic aspirin. Follow-up revealed that 3 patients were ambulatory, whereas 3 exhibited persistent motor deficits, and 2 had a neurogenic bladder. ...Treatment was supportive, with steroids used for suspected …
Treatment was primarily supportive. Four patients received prophylactic aspirin. Follow-up revealed that 3 patients were ambulatory, …
The prevalence and associated factors of aspirin resistance in JAK2 V617F-mutated essential thrombocythemia and polycythemia vera.
Phollarp P, Dankai W, Wongtakan O, Niprapan P, Punnachet T, Hantrakun N, Piriyakhuntorn P, Rattanathammethee T, Hantrakool S, Chai-Adisaksopha C, Tantiworawit A, Norasetthada L, Lekawanvijit S, Rattarittamrong E. Phollarp P, et al. Blood Coagul Fibrinolysis. 2025 Sep 1;36(6):261-267. doi: 10.1097/MBC.0000000000001376. Epub 2025 Jun 27. Blood Coagul Fibrinolysis. 2025. PMID: 40574684
The primary aim was to determine the prevalence of aspirin resistance in JAK2 V617F-mutated essential thrombocythemia and polycythemia vera patients. Secondary objectives included analyzing risk factors for aspirin resistance including JAK2 V617F allele burden. This …
The primary aim was to determine the prevalence of aspirin resistance in JAK2 V617F-mutated essential thrombocythemia and polycythemi …
Association of non-steroidal anti-inflammatory medications and aspirin with colorectal cancer incidence in older adults.
Zaman FY, Orchard SG, Polekhina G, Gibbs P, Bernstein WB, Macrae F, Tie J, Millar J, Gately L, Rodríguez LM, van Londen GJ, Mar V, Hiscutt E, Adler N, Kent A, Ong WL, Haydon A, Warner E, Chan AT, Zalcberg J. Zaman FY, et al. J Natl Cancer Inst. 2025 Sep 1;117(9):1875-1882. doi: 10.1093/jnci/djaf145. J Natl Cancer Inst. 2025. PMID: 40515653 Free PMC article. Clinical Trial.
BACKGROUND: The relationship between aspirin, and/or other non-steroidal anti-inflammatory drugs (NSAIDs), and colorectal cancer (CRC) risk in older adults is uncertain. This study investigated the association between non-aspirin NSAIDs (NA-NSAIDs) use, alone …
BACKGROUND: The relationship between aspirin, and/or other non-steroidal anti-inflammatory drugs (NSAIDs), and colorectal cancer …
Repurposing salicylic acid as a versatile inducer of proximity.
Wang T, Liu S, Ke Y, Ali S, Wang R, Hong T, Liu Z, Ma G, Lan TH, Wang F, Zhu MX, Huang Y, Zhou Y. Wang T, et al. Nat Chem Biol. 2025 Sep;21(9):1444-1456. doi: 10.1038/s41589-025-01918-z. Epub 2025 Jun 13. Nat Chem Biol. 2025. PMID: 40514548
Here, we present a salicylic acid (SA)-mediated binary association system (SAMBA), evolved from a tobacco SA receptor, that enables rapid protein-protein heterodimerization in response to SA or aspirin after hydrolysis. We demonstrate the broad applicability of SAMBA in va …
Here, we present a salicylic acid (SA)-mediated binary association system (SAMBA), evolved from a tobacco SA receptor, that enables rapid pr …
Aspirin Use Is Protective Against Gastric Cancer in a High-Incidence Region of Central America.
Rifkin SB, Montalvan-Sanchez EE, Norwood DA, Estevez-Ordonez D, Montalvan-Sanchez D, Rodriguez-Murillo A, Dominguez RL, Morgan DR. Rifkin SB, et al. Dig Dis Sci. 2025 Sep;70(9):3126-3134. doi: 10.1007/s10620-025-09042-7. Epub 2025 Jun 6. Dig Dis Sci. 2025. PMID: 40478405 Free PMC article.
PURPOSE: Gastric cancer is a leading cause of cancer-related deaths in Central America, where Helicobacter pylori infection is highly prevalent. ...METHODS: A case-control study was conducted with 1067 incident cases of gastric cancer and 1745 controls. Helic …
PURPOSE: Gastric cancer is a leading cause of cancer-related deaths in Central America, where Helicobacter pylori infection is …
Aspirin use and cancer risk.
Lai SW. Lai SW. Int J Cancer. 2025 Sep 1;157(5):1020-1021. doi: 10.1002/ijc.35484. Epub 2025 May 19. Int J Cancer. 2025. PMID: 40387036 No abstract available.
Triglyceride-glucose index and its association with depressive symptoms in older adults: a longitudinal analysis.
Forbes M, Mohebbi M, Woods RL, Lotfaliany M, Reynolds CF 3rd, O'Neil A, McNeil JJ, Berk M. Forbes M, et al. J Affect Disord. 2025 Sep 1;384:80-85. doi: 10.1016/j.jad.2025.05.014. Epub 2025 May 5. J Affect Disord. 2025. PMID: 40334858 Free article.
The main model was adjusted for age, gender, ethnicity, living arrangements, education, smoking status, alcohol consumption, body mass index, hypertension, type 2 diabetes, chronic kidney disease, a history of cancer, modified mini-mental state examination score, aspiri …
The main model was adjusted for age, gender, ethnicity, living arrangements, education, smoking status, alcohol consumption, body mass index …
Janus kinase inhibitors enhance prostanoid biosynthesis in human whole blood in vitro: implications for cardiovascular side effects and prevention strategies.
Alabbasi S, Tacconelli S, de Vries M, Gunnarsson I, Oke V, Kvarnström M, De Michele A, Gregorio PD, Patrignani P, Idborg H, Jakobsson PJ. Alabbasi S, et al. Ann Rheum Dis. 2025 Sep;84(9):1549-1560. doi: 10.1016/j.ard.2025.03.014. Epub 2025 May 5. Ann Rheum Dis. 2025. PMID: 40328613 Free article.
Upadacitinib showed a trend towards increased TXB(2) (46% 40%, n = 7), while filgotinib did not (21% 19%, n = 7). Aspirin (100 muM) almost completely reduced serum TXB(2) in the presence of all JAKis. CONCLUSIONS: The enhanced biosynthesis of TXA(2) in platelets, with a mi …
Upadacitinib showed a trend towards increased TXB(2) (46% 40%, n = 7), while filgotinib did not (21% 19%, n = 7). Aspirin (100 muM) a …
Recombinant Activated Factor VIIa Combined With Tranexamic Acid Control Haemostasis in Patients With Severe Factor XI Deficiency Undergoing Urological Procedures.
Sternbach N, Ehrlich Y, Stenevsky A, Saidian D, Elhalim DA, Baniel J, Raanani P, Spectre G. Sternbach N, et al. Haemophilia. 2025 Sep;31(5):1003-1007. doi: 10.1111/hae.70052. Epub 2025 Apr 29. Haemophilia. 2025. PMID: 40298276 Free PMC article.
RESULTS: All procedures were performed without significant bleeding complications, except for one patient who remained on aspirin therapy and experienced manageable bleeding. None of the patients required discontinuation of TXA due to blood clots, nor did they require bloo …
RESULTS: All procedures were performed without significant bleeding complications, except for one patient who remained on aspirin the …
Preconception and antenatal care for women with a history of haematopoietic stem cell transplantation: Results of a UK clinician survey.
Birchenall KA, David AL, Davies M, Grandage V, Griffin M. Birchenall KA, et al. Obstet Med. 2024 Sep 4;18(3):167-173. doi: 10.1177/1753495X241272942. eCollection 2025 Sep. Obstet Med. 2024. PMID: 39553174 Free PMC article.
BACKGROUND: Female childhood cancer survivors with history of bone marrow transplant with or without total body irradiation have increased pregnancy risks. ...RESULTS: Forty responses received between 22 October 2020 and 21 October 2021: 43% reviewed this group monthly, 15 …
BACKGROUND: Female childhood cancer survivors with history of bone marrow transplant with or without total body irradiation have incr …
Multisystem fatal metastasis of large cell lung carcinoma (LCLC) masquerading as acute cerebral infarction: A case report.
Yu TS, Pei BQ, Zhao D. Yu TS, et al. Medicine (Baltimore). 2025 Aug 29;104(35):e44224. doi: 10.1097/MD.0000000000044224. Medicine (Baltimore). 2025. PMID: 40898486 Free PMC article.
INTERVENTIONS: During the initial phase of the illness, the patient received intravenous edaravone (30 mg/d) and enteric-coated oral aspirin tablets (100 mg daily). On May 15, follow-up magnetic resonance imaging revealed acute multifocal infarcts involving the bilateral f …
INTERVENTIONS: During the initial phase of the illness, the patient received intravenous edaravone (30 mg/d) and enteric-coated oral aspi …
Hydroxychloroquine and pregnancy outcomes in patients with anti-phospholipid syndrome: a systematic review and meta-analysis.
Berman A, Kenet G, Lubetsky A, Agmon-Levin N, Soffer S, Barg AA, Levy-Mendelovich S, Cohen O, Waldman-Radinsky L, Lalezari S, Klang E, Efros O. Berman A, et al. RMD Open. 2025 Aug 27;11(3):e005825. doi: 10.1136/rmdopen-2025-005825. RMD Open. 2025. PMID: 40866107 Free PMC article.
BACKGROUND: About 20% of female patients with anti-phospholipid syndrome (APS) experience obstetric complications despite standard treatment with aspirin and heparin. Treatment with hydroxychloroquine (HCQ) was shown to reduce disease flares during pregnancy in patients wi …
BACKGROUND: About 20% of female patients with anti-phospholipid syndrome (APS) experience obstetric complications despite standard treatment …
Antithrombotic strategies and outcomes in neonates and infants with cardiac shunts: a systematic review and meta-analysis.
Kiskaddon AL, Goldenberg NA, Betensky M, Branstetter JW, Ashour D, Williams P, Stock AC, Silvey M, Giglia TM, Do NL; Cardiac Disease Thrombosis and Hemostasis Working Party of the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis. Kiskaddon AL, et al. Res Pract Thromb Haemost. 2025 Aug 26;9(6):103161. doi: 10.1016/j.rpth.2025.103161. eCollection 2025 Aug. Res Pract Thromb Haemost. 2025. PMID: 41050633 Free PMC article.
The most common antithrombotic agents in the acute postoperative setting were unfractionated heparin (UFH; n = 1452, 30.7%) and aspirin (n = 1413, 29.3%). The pooled prevalence of shunt thrombosis was 8.4% (95% CI, 6.5%-10.4%) and varied among antithrombotic agents: asp …
The most common antithrombotic agents in the acute postoperative setting were unfractionated heparin (UFH; n = 1452, 30.7%) and aspirin …
Platelet-Associated microRNAs as Markers of Aspirin Response and Pregnancy Outcome in Pregnancies at High-Risk for Preeclampsia.
Boelig RC, Tawk A, Zhan T, Kraft WK, McKenzie SE, Michael J. Boelig RC, et al. Am J Perinatol. 2025 Aug 26. doi: 10.1055/a-2677-6668. Online ahead of print. Am J Perinatol. 2025. PMID: 40858153
Aspirin is recommended in high-risk pregnancies for the prevention of preeclampsia/preterm birth; it is unclear whether aspirin's antiplatelet or anti-inflammatory (or both) effects drive its efficacy, and there are no established markers of therapeutic effic …
Aspirin is recommended in high-risk pregnancies for the prevention of preeclampsia/preterm birth; it is unclear whether aspirin …
Quantitative MALDI imaging of aspirin metabolites in mouse models of triple-negative breast cancer.
Hahm TH, Brown DR, Tressler CM, Tran T, Ly A, Pathak AP, McMahon MT, Glunde K. Hahm TH, et al. Theranostics. 2025 Aug 22;15(18):9359-9374. doi: 10.7150/thno.116819. eCollection 2025. Theranostics. 2025. PMID: 41041055 Free PMC article.
This study refines and develops quantitative matrix-assisted laser desorption/ionization (QMALDI) imaging to investigate the distribution of aspirin metabolites including SA in triple-negative breast cancer (TNBC) models in mice. ...Conclusion: This newly developed …
This study refines and develops quantitative matrix-assisted laser desorption/ionization (QMALDI) imaging to investigate the distribution of …
Acute myocardial infarction induced by avatrombopag: a case report.
Junqi G, Chaohui L, Mingjian L, Fengyou Y. Junqi G, et al. Front Pharmacol. 2025 Aug 22;16:1618693. doi: 10.3389/fphar.2025.1618693. eCollection 2025. Front Pharmacol. 2025. PMID: 40936593 Free PMC article.
At the 14-day follow-up, thrombocytopenia recurred (platelets 18 10(9)/L), requiring avatrombopag re-initiation alongside aspirin. No further thrombosis occurred. CONCLUSION: Avatrombopag monotherapy may induce rapid coronary thrombosis. ...
At the 14-day follow-up, thrombocytopenia recurred (platelets 18 10(9)/L), requiring avatrombopag re-initiation alongside aspirin. No …
Population Pharmacokinetics of Rifampicin in Plasma and Cerebrospinal Fluid in Adults With Tuberculosis Meningitis.
Abdelgawad N, Wasserman S, Gausi K, Davis A, Stek C, Wiesner L, Meintjes G, Wilkinson RJ, Denti P. Abdelgawad N, et al. J Infect Dis. 2025 Aug 14;232(2):e234-e241. doi: 10.1093/infdis/jiaf178. J Infect Dis. 2025. PMID: 40295169 Free PMC article. Clinical Trial.
METHODS: In a randomized controlled trial, adults with HIV-associated TBM were assigned to experimental arms of high-dose rifampicin (oral, 35 mg/kg; intravenous, 20 mg/kg) plus linezolid, with or without aspirin, or a control arm that received the standard of care with 10 …
METHODS: In a randomized controlled trial, adults with HIV-associated TBM were assigned to experimental arms of high-dose rifampicin (oral, …
Lipoxins as Modulators of Diseases.
Saqib U, Pandey M, Vyas A, Patidar P, Hajela S, Ali A, Tiwari M, Sarkar S, Yadav N, Patel S, Shukla D, Lienemann GN, White FA, García-Perdomo HA, Baig MS, Halade GV, Hajela K, Sharma S, Obukhov AG. Saqib U, et al. Cells. 2025 Aug 12;14(16):1244. doi: 10.3390/cells14161244. Cells. 2025. PMID: 40862723 Free PMC article. Review.
Lipoxins are released during various diseases and conditions, including but not limited to systemic inflammation, infection, asthma, cancer, diabetes, and cardiovascular disorders. Recently, several synthetic lipoxin analogs have been developed that also exhibit potent ant …
Lipoxins are released during various diseases and conditions, including but not limited to systemic inflammation, infection, asthma, canc …
New Approaches and Strategies for the Repurposing of Iron Chelating/Antioxidant Drugs for Diseases of Free Radical Pathology in Medicine.
Kontoghiorghes GJ. Kontoghiorghes GJ. Antioxidants (Basel). 2025 Aug 10;14(8):982. doi: 10.3390/antiox14080982. Antioxidants (Basel). 2025. PMID: 40867878 Free PMC article. Review.
Such efforts should be similar to the fulfilment of orphan or emergency drug regulatory requirements, which, in most cases, involve the treatment or clinical improvement of rare or severe diseases such as neurodegenerative diseases and cancer. Promising results of antioxid …
Such efforts should be similar to the fulfilment of orphan or emergency drug regulatory requirements, which, in most cases, involve the trea …
Postoperative Stroke Through a Patent Foramen Ovale in a Patient With Lung Cancer: A Case Report.
Nakamura M, Shimizu Y, Goto T, Koike T, Tsuchida M. Nakamura M, et al. Cureus. 2025 Aug 8;17(8):e89618. doi: 10.7759/cureus.89618. eCollection 2025 Aug. Cureus. 2025. PMID: 40922849 Free PMC article.
Cerebral infarction is a rare but serious complication after pulmonary resection for lung cancer. A 78-year-old man with hypertension and diabetes underwent video-assisted thoracoscopic right middle lobectomy for stage IA2 adenocarcinoma. ...Evaluation, including Holter mo …
Cerebral infarction is a rare but serious complication after pulmonary resection for lung cancer. A 78-year-old man with hypertension …
Biomedical Prowess of Clitoria mariana (L.) Flower Methanolic Extract: A Comprehensive In Vitro, Ex Vivo, and In Vivo Evaluation.
Rajkumar M, Presley SID, Govindaraj P, Girigoswami K, Meenambigai K, Deepak P, Deepika B, Elbehairi SEI, Alfaifi MY, Shati AA, Menaa F. Rajkumar M, et al. Chem Biodivers. 2025 Aug 7:e01051. doi: 10.1002/cbdv.202501051. Online ahead of print. Chem Biodivers. 2025. PMID: 40773726
Notably, the phytoextract demonstrated marked cytotoxicity against various cancer cell lines, with the highest potency against MCF-7, followed by HeLa, A549, and PC-3, based on IC(50) (concentration required to inhibit 50%) values. Its anti-inflammatory properties, compara …
Notably, the phytoextract demonstrated marked cytotoxicity against various cancer cell lines, with the highest potency against MCF-7, …
MRI findings intracranial hemorrhages in ARCADIA-MRI: an ancillary study to the ARCADIA trial.
Chen H, Lansberg M, Zhu G, Cassarly C, Paula Q, Kemp S, Howard G, Smith EE, Tirschwell D, Sheth KN, Kamel H, Longstreth WT Jr, Elkind MSV, Broderick J, Lazar RM, Wintermark M. Chen H, et al. AJNR Am J Neuroradiol. 2025 Aug 7:ajnr.A8955. doi: 10.3174/ajnr.A8955. Online ahead of print. AJNR Am J Neuroradiol. 2025. PMID: 40769726 Free PMC article.
RESULTS: MRI outcomes were compared between the 79 patients in the apixaban group and 95 in the aspirin group with both baseline and follow-up MRIs available. The treatment groups had similar baseline MRI findings. On the follow-up MRIs, the findings of incident bleeding e …
RESULTS: MRI outcomes were compared between the 79 patients in the apixaban group and 95 in the aspirin group with both baseline and …
Population pharmacokinetics of pyrazinamide and isoniazid in plasma and cerebrospinal fluid from South African adults with tuberculous meningitis.
Calderin JM, Wasserman S, Resendiz-Galvan JE, Abdelgawad N, Davis A, Stek C, Wiesner L, Wilkinson RJ, Denti P. Calderin JM, et al. Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0009925. doi: 10.1128/aac.00099-25. Epub 2025 Jul 1. Antimicrob Agents Chemother. 2025. PMID: 40590723 Free PMC article. Clinical Trial.
Participants were randomized to receive either standard TBM treatment (including rifampicin 10 mg/kg) or high-dose rifampicin (35 mg/kg) plus linezolid, with or without aspirin. Plasma and lumbar CSF samples were collected on days 3 and 28 after study enrollment, and drug …
Participants were randomized to receive either standard TBM treatment (including rifampicin 10 mg/kg) or high-dose rifampicin (35 mg/kg) plu …
[Efficacy Analysis of Stanozolol Combined with Avatrombopag in the Treatment of Chemotherapy-Induced Thrombocytopenia in Relapsed/Refractory Tumors].
He Y, Liu WY, Zhang YY, Lyu Y, Zhang SS, Quan RC. He Y, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2025 Aug;33(4):1127-1130. doi: 10.19746/j.cnki.issn.1009-2137.2025.04.029. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2025. PMID: 40936140 Chinese.
One patient had a PLT increase exceeding 35010(9)/L, and the treatment with avatrombopag was suspended, and aspirin and other drugs were given to prevent thrombosis. No thrombose events or CIT-related bleeding events were observed in all patients. ...
One patient had a PLT increase exceeding 35010(9)/L, and the treatment with avatrombopag was suspended, and aspirin and other drugs w …
Platelet protease-activated receptor 4 genotype and response to aspirin in pregnancy.
Boelig RC, Michael JV, Tawk A, Zhan T, Chan JSY, Kraft WK, McKenzie SE. Boelig RC, et al. Blood Vessel Thromb Hemost. 2025 Jun 30;2(3):100085. doi: 10.1016/j.bvth.2025.100085. eCollection 2025 Aug. Blood Vessel Thromb Hemost. 2025. PMID: 40918740 Free PMC article.
The platelet protease-activated receptor 4 (PAR4) threonine 120 (Thr120) allele is an activating allele associated with reduced aspirin response in vitro. Aspirin is recommended in high-risk pregnancies to prevent preeclampsia and preterm birth. ...We conducted a pr …
The platelet protease-activated receptor 4 (PAR4) threonine 120 (Thr120) allele is an activating allele associated with reduced aspirin …
Safety of direct oral anticoagulants in surgical bioprosthetic heart valves: a paediatric institution's experience.
Barisano D, Nance G, Gleason M, Chai P, Fundora MP, Woods G, Rosenblum JM, Branstetter JW. Barisano D, et al. Cardiol Young. 2025 Aug;35(8):1631-1636. doi: 10.1017/S1047951125101194. Epub 2025 Aug 11. Cardiol Young. 2025. PMID: 40785409
METHODS: This is a single-centre, retrospective study of paediatric patients who underwent surgical pulmonary valve replacement and received a direct oral anticoagulant in addition to aspirin post heart valve insertion. The primary objective was a composite safety score co …
METHODS: This is a single-centre, retrospective study of paediatric patients who underwent surgical pulmonary valve replacement and received …
Optimizing risk-reducing surgery and aspirin decision aids for Lynch syndrome carriers using the person-based approach: A think-aloud interview study.
Kohut K, Morton K, Turner L, Foster R, Bancroft EK, Burn J, Crosbie EJ, Dominguez-Valentin M, Esplen MJ, Hanson H, Hurley K, Moller P, Ryan N, Snape K; CanGene‐CanVar Patient Reference Panel; International Lynch Decision Aid Stakeholder Panel; Eccles D, Foster C. Kohut K, et al. J Genet Couns. 2025 Aug;34(4):e70089. doi: 10.1002/jgc4.70089. J Genet Couns. 2025. PMID: 40772451 Free PMC article.
The first half of interviews focused on the gynecological risk-reducing surgery and the second half on the aspirin decision aid. Twenty carriers (eight men) were interviewed, half of whom had a personal history of cancer. ...Three themes were constructed to guide fu …
The first half of interviews focused on the gynecological risk-reducing surgery and the second half on the aspirin decision aid. Twen …
Plasma Proteomic Analysis Reveals Complement System Changes in Irradiated Female BALB/c Mice during Mammary Carcinogenesis.
Akbarzadeh T, Ma L, Lee J, Moore J, Chou W, Shabani S, Furdui CM, Parvin B, Barcellos-Hoff MH. Akbarzadeh T, et al. Cancer Res Commun. 2025 Aug 1;5(8):1409-1418. doi: 10.1158/2767-9764.CRC-25-0183. Cancer Res Commun. 2025. PMID: 40757647 Free PMC article.
The risk of breast cancer increases decades after ionizing radiation exposure, thereby linking aging intrinsically to the evolution of cancer. ...The specific changes in the complement system, which mediates adaptive immune function, following radiation exposure may …
The risk of breast cancer increases decades after ionizing radiation exposure, thereby linking aging intrinsically to the evolution o …
Metformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Gillessen S, Murphy L, James ND, Sachdeva A, El-Taji O, Abdel-Aty H, Adler AI, Amos C, Attard G, Varughese M, Gale J, Brown S, Srihari N, Birtle AJ, Brown M, Chan K, Chowdhury S, Cross W, Dearnaley DP, Din O, Dutey-Magni P, Gilbert DC, Gilson C, Gray S, Grist E, Hofmann U, Hudson AM, Jain Y, Jeyasangar G, Jones R, Kayani M, Langley RE, Malik Z, Mason MD, Matheson D, McAlpine C, Macnair A, Millman R, Murphy C, Padden-Modi M, Parikh O, Parker C, Rush H, Russell M, Srinivasan R, Sundar S, Tanguay JS, Turco F, Williams P, Sydes MR, Parmar MKB, Brown LC, Clarke NW; STAMPEDE investigators. Gillessen S, et al. Lancet Oncol. 2025 Aug;26(8):1018-1030. doi: 10.1016/S1470-2045(25)00231-1. Epub 2025 Jul 7. Lancet Oncol. 2025. PMID: 40639383 Free PMC article. Clinical Trial.
Several studies have suggested that metformin has anticancer activity in some malignancies, including prostate cancer. Metformin might also mitigate the adverse metabolic effects of androgen-deprivation therapy (ADT). ...Adverse metabolic side-effects of ADT were significa …
Several studies have suggested that metformin has anticancer activity in some malignancies, including prostate cancer. Metformin migh …
Dose-response relationship between aspirin and gastric cancer risk: A systematic review and meta-analysis.
Zhang S, Wang H, Ji J, Chai R, Song S, Shi J, Liu S. Zhang S, et al. Cancer Epidemiol. 2025 Aug;97:102873. doi: 10.1016/j.canep.2025.102873. Epub 2025 Jun 28. Cancer Epidemiol. 2025. PMID: 40582143 Review.
The results demonstrated a significant inverse association between aspirin dose and gastric cancer risk, with a relative risk (RR) of 0.73 (95 % CI: 0.57-0.94) for the highest versus lowest aspirin dose. ...Our results provide strong evidence of the associati …
The results demonstrated a significant inverse association between aspirin dose and gastric cancer risk, with a relative risk …
Gender-Specific Population Attributable Fractions for Cardiovascular Disease and All-Cause Mortality Associated with Living Arrangement in Community-Dwelling Older People.
Teshale AB, Htun HL, Owen AJ, Baker JR, Isaksen I, Freak-Poli R. Teshale AB, et al. J Gen Intern Med. 2025 Aug;40(11):2613-2623. doi: 10.1007/s11606-025-09648-7. Epub 2025 Jun 25. J Gen Intern Med. 2025. PMID: 40562890 Free PMC article.
METHODS: This study used longitudinal data from the Aspirin in Reducing Events in the Elderly (ASPREE) study and its sub-study, the ASPREE Longitudinal Study of Older Persons (ALSOP), which included 5853 men and 6998 women. ...
METHODS: This study used longitudinal data from the Aspirin in Reducing Events in the Elderly (ASPREE) study and its sub-study, the A …
"PIK"ing the Right Patients for Adjuvant Aspirin Therapy for Colorectal Cancer.
Drew DA, Downie JM, Chan AT. Drew DA, et al. Clin Cancer Res. 2025 Aug 1;31(15):3107-3109. doi: 10.1158/1078-0432.CCR-25-0953. Clin Cancer Res. 2025. PMID: 40439583
Observational studies demonstrate that aspirin use after diagnosis of colorectal cancer, particularly tumors with mutated PIK3CA, improves outcomes. ...In this issue, we discuss the SAKK 41/13 adjuvant aspirin randomized controlled trial results in context of …
Observational studies demonstrate that aspirin use after diagnosis of colorectal cancer, particularly tumors with mutated PIK3 …
The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC.
Peduzzi G, Archibugi L, Farinella R, Ponz de Leon Pisani R, Vodickova L, Vodicka P, Kraja B, Sainz J, Bars-Cortina D, Daniel N, Silvestri R, Uysal-Onganer P, Landi S, Dulińska-Litewka J, Comandatore A, Campa D, Hughes DJ, Rizzato C. Peduzzi G, et al. Semin Cancer Biol. 2025 Aug;113:100-129. doi: 10.1016/j.semcancer.2025.05.004. Epub 2025 May 12. Semin Cancer Biol. 2025. PMID: 40368260 Free article. Review.
Pancreatic cancer (PC), particularly pancreatic ductal adenocarcinoma (PDAC), is a significant global health issue with high mortality rates. PDAC, though only 3 % of cancer diagnoses, causes 7 % of cancer deaths due to its severity and asymptomatic early sta …
Pancreatic cancer (PC), particularly pancreatic ductal adenocarcinoma (PDAC), is a significant global health issue with high mortalit …
Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community-Dwelling Older Adults.
Bousman CA, Narang A, Al Bkhetan Z, Woods RL, Orchard SG, Owen AJ, Fravel MA, Gilmartin-Thomas J, Ryan J, Fransquet PD, Wolfe R, Yu C, McNeil JJ, Lacaze P, Ernst ME. Bousman CA, et al. Clin Pharmacol Ther. 2025 Aug;118(2):337-342. doi: 10.1002/cpt.3702. Epub 2025 Apr 30. Clin Pharmacol Ther. 2025. PMID: 40304392 Free PMC article.
This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a change to standard prescribing), the use of cautionary medications (i.e., those associated with an actionable PGx genotype), polypharmacy (i.e., 5 medications simul …
This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a change to standard presc …
Pharmacologic agents for perioperative cardioprotection in noncardiac surgery.
Paula-Garcia WN, De Hert S. Paula-Garcia WN, et al. Curr Opin Anaesthesiol. 2025 Aug 1;38(4):361-368. doi: 10.1097/ACO.0000000000001494. Epub 2025 Apr 11. Curr Opin Anaesthesiol. 2025. PMID: 40241429 Review.
Statins continue to be the cornerstone due to their pleiotropic effect. Continuation of aspirin is supported perioperatively if the bleeding risk due to surgery is low to moderate. ...
Statins continue to be the cornerstone due to their pleiotropic effect. Continuation of aspirin is supported perioperatively if the b …
Adjuvant Aspirin Treatment in PIK3CA-Mutated Colon Cancer Patients: The SAKK 41/13 Prospective Randomized Placebo-Controlled Double-Blind Trial.
Güller U, Hayoz S, Horber D, Jochum W, De Dosso S, Koeberle D, Schacher S, Inauen R, Stahl M, Delaunoit T, Ettrich T, Bodoky G, Michel P, Koessler T, Rothgiesser K, Calmonte S, Joerger M. Güller U, et al. Clin Cancer Res. 2025 Aug 1;31(15):3142-3149. doi: 10.1158/1078-0432.CCR-24-4048. Clin Cancer Res. 2025. PMID: 40067142 Free PMC article. Clinical Trial.
PURPOSE: We assessed the benefit of adjuvant aspirin in patients with resected phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)-mutated colon cancer. ...No patient experienced aspirin-related serious adverse events. CONCLUSIONS: …
PURPOSE: We assessed the benefit of adjuvant aspirin in patients with resected phosphatidylinositol-4,5-bisphosphate 3-kinase catalyt …
Acetylsalicylic acid and cancer: updates on the new potential of a nature-inspired drug.
Rauf A, Olatunde A, Islam MR, Ahmad Z, Hafeez N, Hemeg HA, Imran M, Mubarak MS, Ribaudo G. Rauf A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug;398(8):9387-9403. doi: 10.1007/s00210-025-03959-6. Epub 2025 Mar 1. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 40021514 Review.
The analysis of recent studies highlights the potential of ASA to improve the effectiveness of chemotherapy and its role in cancer inhibition through specific molecular pathways. Mechanistic insights suggest that ASA may influence cellular processes that contribute to c …
The analysis of recent studies highlights the potential of ASA to improve the effectiveness of chemotherapy and its role in cancer in …
DBA Syndrome.
Sieff C. Sieff C. 2009 Jun 25 [updated 2025 Jul 31]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2009 Jun 25 [updated 2025 Jul 31]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 20301769 Free Books & Documents. Review.
Assessment of liver iron for those on chronic red blood cell transfusions. Cancer surveillance includes history, physical examination, and blood counts every four to six months. ...During pregnancy the maternal hemoglobin level must be monitored. Use of low-dose aspirin …
Assessment of liver iron for those on chronic red blood cell transfusions. Cancer surveillance includes history, physical examination …
Adjuvant therapeutic efficacy of low-dose aspirin on short-term outcomes of patients with cancer-associated venous thromboembolism.
Xiong W, Deng Z, Cheng Y, Song X, Yao Q, Qu J, Xu M, Han F, Guo X, Luo Y. Xiong W, et al. BMC Med. 2025 Jul 28;23(1):444. doi: 10.1186/s12916-025-04284-8. BMC Med. 2025. PMID: 40722083 Free PMC article.
BACKGROUND: Although aspirin was reported to have primary thromboprophylactic efficacy on cancer patients, its adjuvant role in the treatment of patients with cancer-associated venous thromboembolism (VTE) has been unclear yet. METHODS: Patients with cance …
BACKGROUND: Although aspirin was reported to have primary thromboprophylactic efficacy on cancer patients, its adjuvant role i …
Unlocking the therapeutic potential of Catharanthus roseus leaves via in-vitro, in-vivo, and in-silico study.
Sarkar BK, Polash MJI, Islam MJ, Hanif MA, Jannat N, Kundu SK, Sarkar BK, Hossain MS. Sarkar BK, et al. Sci Rep. 2025 Jul 17;15(1):25909. doi: 10.1038/s41598-025-96643-x. Sci Rep. 2025. PMID: 40676081 Free PMC article.
(CR), is a perennial flowering herb, has traditionally been used by local populations in South Asia, Africa, China and Malaysia to treat diabetes, cancer and microbial infection. The principal objective of this study was to investigate the antidiabetic, antilipidemic and a …
(CR), is a perennial flowering herb, has traditionally been used by local populations in South Asia, Africa, China and Malaysia to treat dia …
Non-steroidal anti-inflammatory medication use and endometrial cancer survival: A population-based Norwegian cohort study.
Haug AJ, Støer N, Langseth H, Siafarikas F, Botteri E, Fortner RT, Lindemann K. Haug AJ, et al. Int J Cancer. 2025 Jul 15;157(2):277-287. doi: 10.1002/ijc.35363. Epub 2025 Feb 24. Int J Cancer. 2025. PMID: 39992017 Free PMC article.
While nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to improve survival in certain cancers, data in patients with endometrial cancer (EC) is conflicting. This study investigated use of aspirin and nonaspirin NSAIDs (NA-NSAIDs) and EC-specific- …
While nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to improve survival in certain cancers, data in patients with end …
Balancing the risk of major bleeding against vascular disease risk in people without atherosclerotic disease.
Hammami I, Mafham M, Emberson J, Offer A, Hopewell JC, Armitage J, Baigent C, Parish S. Hammami I, et al. Heart. 2025 Jul 14;111(15):716-721. doi: 10.1136/heartjnl-2024-324841. Heart. 2025. PMID: 40010936 Free PMC article.
MB risk was highest among participants with frailty, prior bleeds, cancer, liver disease or renal dysfunction, with a 4.3-fold difference in risk between the highest and lowest fifths of MB risk (HR 4.3, 95% CI 3.87 to 4.77). ...Such models can help identify those with mod …
MB risk was highest among participants with frailty, prior bleeds, cancer, liver disease or renal dysfunction, with a 4.3-fold differ …
Head and Neck Free-Flap Reconstruction in Patients With Pre-Existing Coagulopathies: A Case Series.
Longfellow GA, Matthews M, Adams G, Benaim EH, Hackman T, Sullivan CB. Longfellow GA, et al. Ear Nose Throat J. 2025 Jul 13:1455613251356340. doi: 10.1177/01455613251356340. Online ahead of print. Ear Nose Throat J. 2025. PMID: 40652344 Free article.
Postoperative anticoagulation included SC UFH or low-molecular-weight heparin in 86.7% of patients, with 33.3% also receiving aspirin and 20.0% transitioning to direct oral anticoagulants. Two patients (13.3%) experienced flap loss due to thrombosis; neither received intra …
Postoperative anticoagulation included SC UFH or low-molecular-weight heparin in 86.7% of patients, with 33.3% also receiving aspirin …
Radiation-induced acute pericarditis after palliative spine radiation in a non-small cell lung cancer patient on osimertinib: a case report.
Decha-Umphai C, Prachanukul T, Phattraprayoon N, Ungtrakul T. Decha-Umphai C, et al. Discov Oncol. 2025 Jul 10;16(1):1299. doi: 10.1007/s12672-025-03176-w. Discov Oncol. 2025. PMID: 40637790 Free PMC article.
We report a case of acute pericarditis occurring immediately after palliative spine radiation in a 54-year-old male with non-small cell lung cancer (NSCLC) on Osimertinib. He initially presented with brain, liver, spleen, and bone metastases and was treated with erlotinib …
We report a case of acute pericarditis occurring immediately after palliative spine radiation in a 54-year-old male with non-small cell lung …
Chemoprevention of Barrett's Esophagus: a Systematic Review and Comprehensive Assessment of Bias.
Ko MT, Rizwanullah A, Jafri Z, Fung A, Alexandre L. Ko MT, et al. Dis Esophagus. 2025 Jul 3;38(4):doaf062. doi: 10.1093/dote/doaf062. Dis Esophagus. 2025. PMID: 40794904 Free PMC article. Review.
We conducted a systematic review and meta-analysis to evaluate the assumed causal association between proton-pump inhibitors (PPIs), aspirin and statins, and BE progression, and undertook a comprehensive risk of bias (RoB) assessment. ...The only trial included was at low …
We conducted a systematic review and meta-analysis to evaluate the assumed causal association between proton-pump inhibitors (PPIs), aspi …
Thrombocytosis and bleeding in myeloproliferative neoplasms: exploring clinical diversity and risk of acquired von Willebrand syndrome-insights from a UK center.
Simini G, Innes A, Vinayagam S, Mobayen G, Karawitage N, Claudiani S, Odho Z, Laffan M, Arachchillage DJ. Simini G, et al. Res Pract Thromb Haemost. 2025 Jun 24;9(5):102954. doi: 10.1016/j.rpth.2025.102954. eCollection 2025 Jul. Res Pract Thromb Haemost. 2025. PMID: 40709222 Free PMC article.
BACKGROUND: Myeloproliferative neoplasms (MPNs) represent a group of blood disorders characterized by myeloid cell proliferation and an associated increased risk of thrombosis and bleeding. ...RESULTS: A total of 39 patients were included, majority of whom received aspi …
BACKGROUND: Myeloproliferative neoplasms (MPNs) represent a group of blood disorders characterized by myeloid cell proliferation and …
Acetyl Salicylic Acid, COX-2 Inhibitors and Other NSAIDs and Breast Cancer Survival in a Finnish Population-Based Cohort.
Malin M, Murto M, Arponen O, Jukkola A, Siltari A, Artama M, Visvanathan K, Murtola T. Malin M, et al. Cancer Rep (Hoboken). 2025 Jul;8(7):e70271. doi: 10.1002/cnr2.70271. Cancer Rep (Hoboken). 2025. PMID: 40616422 Free PMC article.
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs), particularly acetylsalicylic acid (ASA), have been associated with reduced breast cancer (BCa) mortality. While overexpression of cyclooxygenase-2 (COX-2) correlates with poorer prognosis in BCa, COX-2 inhibitors …
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs), particularly acetylsalicylic acid (ASA), have been associated with reduced breas …
Biomedical potential of agricultural waste extracts: phytochemicals with antioxidant, anti-inflammatory, anticancer, and anti-parasitic activities.
Alzandi AA, Al Hijab LYA, Elagib SM, Naguib DM. Alzandi AA, et al. 3 Biotech. 2025 Jul;15(7):231. doi: 10.1007/s13205-025-04407-1. Epub 2025 Jul 1. 3 Biotech. 2025. PMID: 40612585
This study evaluated aqueous extracts from six agricultural byproducts-rice straw, wheat straw, maize stalks, sugar cane bagasse, soybean debris, and peanut seed coat-for their phytochemical composition, antioxidant activity, and biological effects against liver flukes (Opisthorc …
This study evaluated aqueous extracts from six agricultural byproducts-rice straw, wheat straw, maize stalks, sugar cane bagasse, soybean de …
Regular aspirin use, breast tumor characteristics and long-term breast cancer survival.
Peng C, Wang T, Holmes MD, Chen WY, Brantley KD, Le PA, J Heng Y, Schedin PJ, Rosner BA, Willett WC, Stampfer MJ, Tamimi RM, Heather Eliassen A. Peng C, et al. NPJ Breast Cancer. 2025 Jul 1;11(1):62. doi: 10.1038/s41523-025-00775-2. NPJ Breast Cancer. 2025. PMID: 40595613 Free PMC article.
Among 10,705 stages I-III breast cancer patients in the Nurses' Health Studies (NHS/NHSII), we examined the associations between post-diagnostic aspirin use and long-term breast cancer survival. During up to 34 years of follow-up, regular post-diagnostic a …
Among 10,705 stages I-III breast cancer patients in the Nurses' Health Studies (NHS/NHSII), we examined the associations between post …
Aspirin improves short and long term survival outcomes of patients with sepsis associated encephalopathy.
Gong QQ, Yuan ZN, She TY, Ge F, Zhang Y. Gong QQ, et al. Sci Rep. 2025 Jul 1;15(1):22242. doi: 10.1038/s41598-025-08075-2. Sci Rep. 2025. PMID: 40595183 Free PMC article.
This study aims to evaluate the effect of aspirin on the prognosis of patients with SAE. A retrospective cohort study using the Medical Information Mart for Intensive Care IV (MIMIC-IV 2.2) database included 5840 patients with SAE: aspirin group (n = 3378) and non- …
This study aims to evaluate the effect of aspirin on the prognosis of patients with SAE. A retrospective cohort study using the Medic …
Helminth-induced prostaglandin signaling and dietary shifts in PUFA metabolism promote colitis-associated cancer.
Smith KA, Reed EK, Guschina I, Tyrrell VJ, Butters C, Darby MG, Katsandegwaza B, Chetty A, Horsnell WGC, O'Donnell VB, Gallimore A. Smith KA, et al. J Lipid Res. 2025 Jul;66(7):100837. doi: 10.1016/j.jlr.2025.100837. Epub 2025 Jun 7. J Lipid Res. 2025. PMID: 40490052 Free PMC article.
Oxylipins derived from dietary polyunsaturated fatty acids (PUFAs) are key determinants of intestinal health, homeostasis, and inflammatory disorders, such as colitis-associated colorectal cancer. Previous research has independently linked a high dietary omega (omega)-6:om …
Oxylipins derived from dietary polyunsaturated fatty acids (PUFAs) are key determinants of intestinal health, homeostasis, and inflammatory …
External validation of a digital pathology-based multimodal artificial intelligence-derived prognostic model in patients with advanced prostate cancer starting long-term androgen deprivation therapy: a post-hoc ancillary biomarker study of four phase 3 randomised controlled trials of the STAMPEDE platform protocol.
Parker CTA, Mendes L, Liu VYT, Grist E, Joun S, Yamashita R, Mitani A, Chen E, Parry MA, Sachdeva A, Murphy L, Huang HC, Griffin J, van der Wal D, Todorovic T, Lall S, Santos Vidal S, Goncalves M, Thakali S, Wingate A, Zakka L, Brown M, Wetterskog D, Amos CL, Atako NB, Jones RJ, Cross WR, Gillessen S, Parker CC; STAMPEDE collaborators; Berney DM, Tran PT, Spratt DE, Sydes MR, Parmar MKB, Clarke NW, Brown LC, Feng FY, Esteva A, James ND, Attard G. Parker CTA, et al. Lancet Digit Health. 2025 Jul;7(7):100885. doi: 10.1016/j.landig.2025.100885. Epub 2025 Jun 3. Lancet Digit Health. 2025. PMID: 40467357 Free article. Clinical Trial.
INTERPRETATION: Diagnostic prostate biopsy samples contain prognostic information in patients with, or at high-risk of, radiologically overt metastatic prostate cancer. MMAI algorithm combined with disease burden improves prognostication of advanced prostate cancer. …
INTERPRETATION: Diagnostic prostate biopsy samples contain prognostic information in patients with, or at high-risk of, radiologically overt …
Aspirin for colorectal cancer chemoprevention: where are we?
Genoud V, Kim F, Koessler T. Genoud V, et al. Curr Opin Oncol. 2025 Jul 1;37(4):383-390. doi: 10.1097/CCO.0000000000001153. Epub 2025 May 16. Curr Opin Oncol. 2025. PMID: 40423235 Review.
PURPOSE OF REVIEW: Aspirin (acetylsalicylic acid, ASA) is gaining recognition as a possible chemopreventive agent for colorectal cancer (CRC). ...
PURPOSE OF REVIEW: Aspirin (acetylsalicylic acid, ASA) is gaining recognition as a possible chemopreventive agent for colorectal c …
Exploring the Protective Role of Aspirin Use in Mitigating Colorectal Cancer (CRC) Metastasis: A Nationwide Analysis (2016 to 2020).
Paladiya R, Khoury N, Shah M, Moond V, Patel N, Bahirwani J, Garg A, Sohal A, Vaziri H. Paladiya R, et al. J Clin Gastroenterol. 2025 Jul 1;59(6):569-575. doi: 10.1097/MCG.0000000000002045. J Clin Gastroenterol. 2025. PMID: 39042482
Despite advancements in treatment strategies, the mortality from colorectal cancer (CRC) remains high. Evidence suggests that aspirin (ASA) may have a protective effect on CRC incidence and metastasis through various mechanisms. ...There was a higher prevalence of D …
Despite advancements in treatment strategies, the mortality from colorectal cancer (CRC) remains high. Evidence suggests that aspi …
Aspirin as a potential drug repurposing candidate targeting estrogen receptor alpha in breast cancer: a molecular dynamics and in-vitro study.
Kaur D, Choudhury C, Yadav R, Kumari L, Bhatia A. Kaur D, et al. J Biomol Struct Dyn. 2025 Jul;43(11):5268-5279. doi: 10.1080/07391102.2024.2308780. Epub 2024 Jan 27. J Biomol Struct Dyn. 2025. PMID: 38279948
Substantial epidemiologic evidence suggests that Aspirin use reduces the risk of different cancers including BC, while its role as an adjuvant or a possible antineoplastic agent in cancer treatment is being investigated. ...In addition, in-vitro assays, qPCR, …
Substantial epidemiologic evidence suggests that Aspirin use reduces the risk of different cancers including BC, while its rol …
Evaluating the efficacy of antiplatelet therapy in spontaneous coronary artery dissection: a scoping review.
Park HE, Cho LS, Fendrikova-Mahlay N, Chaudhury P, Cameron SJ. Park HE, et al. Cardiovasc Diagn Ther. 2025 Jun 30;15(3):705-713. doi: 10.21037/cdt-24-108. Epub 2025 Jun 26. Cardiovasc Diagn Ther. 2025. PMID: 40656783 Free PMC article. Review.
There is no clear consensus regarding the optimum antiplatelet medication regimen and treatment duration for SCAD despite current American Heart Association (AHA) consensus guidelines recommending 12-month regimen of dual antiplatelet therapy (DAPT) consisting of a P2Y12 inhibito …
There is no clear consensus regarding the optimum antiplatelet medication regimen and treatment duration for SCAD despite current American H …
Chemoprevention of Keratinocyte Cancers: Could Aspirin Be the Solution?
Hiscutt E, Orchard S, Wolfe R, Mar V. Hiscutt E, et al. J Cancer Prev. 2025 Jun 30;30(2):59-74. doi: 10.15430/JCP.25.007. J Cancer Prev. 2025. PMID: 40621157 Free PMC article. Review.
This has resulted in an acute, urgent need for efficacious, tolerable, safe chemoprevention agents that could decrease keratinocyte cancer burden. Aspirin has been investigated as a chemopreventive agent for many years in other cancers. In this narrative revi …
This has resulted in an acute, urgent need for efficacious, tolerable, safe chemoprevention agents that could decrease keratinocyte cance …
Targeting DAMPs by Aspirin Inhibits Head and Neck Cancer Stem Cells and Stimulates Radio-Sensitization to Proton Therapy.
Vasiljevic T, Zapletal E, Tarle M, Bozicevic Mihalic I, Gouasmia S, Provatas G, Vukovic Djerfi K, Müller D, Hat K, Luksic I, Matijevic Glavan T. Vasiljevic T, et al. Cancers (Basel). 2025 Jun 26;17(13):2157. doi: 10.3390/cancers17132157. Cancers (Basel). 2025. PMID: 40647457 Free PMC article.
BACKGROUND: Cancer stem cells (CSCs) are a subpopulation of cancer cells known for their self-renewal capacity, tumorigenicity, and resistance to treatment. Toll-like receptor 3 (TLR3) plays a complex role in cancer, exhibiting both pro-apoptotic and pro-tumo …
BACKGROUND: Cancer stem cells (CSCs) are a subpopulation of cancer cells known for their self-renewal capacity, tumorigenicity …
Risk factors for gastric cancer: an umbrella review of systematic reviews and meta-analyses.
Liang JL, Yuan HM, Quan C, Chen JQ. Liang JL, et al. Front Oncol. 2025 Jun 26;15:1564575. doi: 10.3389/fonc.2025.1564575. eCollection 2025. Front Oncol. 2025. PMID: 40641920 Free PMC article.
Risk factors included depression, Helicobacter pylori (Hp) infection, dermatomyositis, and Graves' disease. Class III evidence confirmed that aspirin, non-aspirin NSAIDs, soy food intake, non-fermented soy food intake, physical activity, vitamin A, ginseng, dietary …
Risk factors included depression, Helicobacter pylori (Hp) infection, dermatomyositis, and Graves' disease. Class III evidence confirmed tha …
Efficacy and Safety of Ropeginterferon Alfa-2b in Low-Risk Polycythemia Vera.
Lee JY, Yoon SS, Yang DH, Sohn SK, Yoon SY, Bang SM, Lee GW, Choi CW, Choi EJ, Cheong JW, Park YH, Lee SE. Lee JY, et al. Cancer Res Treat. 2025 Jun 26. doi: 10.4143/crt.2025.552. Online ahead of print. Cancer Res Treat. 2025. PMID: 40575947 Free article.
PURPOSE: Conventional management of low-risk polycythemia vera (PV), consisting of phlebotomy and aspirin, often fails to adequately control symptoms and hematologic parameters. This study evaluated the efficacy and safety of ropeginterferon alfa-2b (Ropeg) in low-risk PV …
PURPOSE: Conventional management of low-risk polycythemia vera (PV), consisting of phlebotomy and aspirin, often fails to adequately …
ETV6-Related Thrombocytopenia and Predisposition to Leukemia.
Pencheva B, Di Paola J, Porter CC. Pencheva B, et al. 2020 Nov 19 [updated 2025 Jun 26]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2020 Nov 19 [updated 2025 Jun 26]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 33226740 Free Books & Documents. Review.
Agents/circumstances to avoid: For those with a history of bleeding, avoidance of medications that decrease platelet function (e.g., aspirin, nonsteroidal anti-inflammatory drugs) and avoidance of participation in contact sports are recommended. ...
Agents/circumstances to avoid: For those with a history of bleeding, avoidance of medications that decrease platelet function (e.g., aspi …
A novel approach to enhance glioblastoma multiforme treatment efficacy: non-coding RNA targeted therapy and adjuvant approaches.
Liu M, Wang Y, Chen X, Zeng Y, Huang W, Yang J, Dai H, Cheng L, Mauro C, Cheung KCP. Liu M, et al. Clin Epigenetics. 2025 Jun 21;17(1):108. doi: 10.1186/s13148-025-01900-5. Clin Epigenetics. 2025. PMID: 40544306 Free PMC article. Review.
MAIN BODY: Recent research has suggested the potential of repurposing FDA-approved drugs such as temozolomide (TMZ), disulfiram (DSF), and aspirin for the treatment of glioblastoma, with encouraging evidence particularly for DSF and aspirin. ...In short, we will exp …
MAIN BODY: Recent research has suggested the potential of repurposing FDA-approved drugs such as temozolomide (TMZ), disulfiram (DSF), and …
Acetylsalicylic Acid and Head and Neck Cancer: Risk, Five-Year Survival, and Recurrence in over 11,000,000 Patients-A Retrospective Case-Control Study.
Wüster J, Heene S, Brandenburg L, Preissner R, Nahles S, Heiland M, Preissner S. Wüster J, et al. Cancers (Basel). 2025 Jun 20;17(13):2065. doi: 10.3390/cancers17132065. Cancers (Basel). 2025. PMID: 40647366 Free PMC article.
Background/Objectives: Acetylsalicylic acid (ASA) medication has been suggested to have a beneficial effect on cancer risk and survival. Therefore, this retrospective case-control study investigated the correlation between ASA and HNC in over 11,000,000 patients to investi …
Background/Objectives: Acetylsalicylic acid (ASA) medication has been suggested to have a beneficial effect on cancer risk and surviv …
Antiplatelet Therapy Mitigates Brain Metastasis Risk in Non-Small Cell Lung Cancer: Insights from a Comprehensive Retrospective Study.
Martín-Abreu C, García-Gil M, Méndez-Monge M, Fariña-Jerónimo H, Plata-Bello J. Martín-Abreu C, et al. Cancers (Basel). 2025 Jun 20;17(13):2059. doi: 10.3390/cancers17132059. Cancers (Basel). 2025. PMID: 40647360 Free PMC article.
BACKGROUND: Brain metastases are a common and devastating complication of non-small cell lung cancer (NSCLC), severely affecting prognosis and quality of life. Despite increasing interest in the role of platelets in tumor progression and dissemination, the potential impact …
BACKGROUND: Brain metastases are a common and devastating complication of non-small cell lung cancer (NSCLC), severely affecting prog …
Evaluating the Impact of Common Non-Oncologic Medication Use During Radiotherapy in Patients with High-Risk Prostate Cancer.
Perlow HK, Khullar K, Kumar R, Sasmal S, Nakamoto K, Gokun Y, Eckstein J, Young R, Diaz DA, Martin D, Collier KA, Meng L, Parikh RR, Clinton S, Wang SJ. Perlow HK, et al. Curr Oncol. 2025 Jun 15;32(6):353. doi: 10.3390/curroncol32060353. Curr Oncol. 2025. PMID: 40558296 Free PMC article.
INTRODUCTION: The treatment efficacy of prostate cancer (PCa) radiotherapy (RT) can be inadvertently affected by the concurrent usage of non-oncologic medications. Many studies have associated the intake of several non-oncologic drugs with cancer specific outcomes. …
INTRODUCTION: The treatment efficacy of prostate cancer (PCa) radiotherapy (RT) can be inadvertently affected by the concurrent usage …
Aspirin Suppresses Aromatase-Mediated Estrogen Biosynthesis to Alleviate Polycystic Ovary Syndrome by the Inhibition of Adenylate Cyclase.
Shi XK, Sheng YW, Cao DY, Shi N, Zhang GL, Wang F. Shi XK, et al. FASEB J. 2025 Jun 15;39(11):e70688. doi: 10.1096/fj.202403152R. FASEB J. 2025. PMID: 40464588
These results revealed that aspirin is a potent inhibitor of ACs and a previously unrecognized role of ACs in estrogen biosynthesis. Therefore, aspirin warrants further investigation as a novel therapeutic agent in PCOS....
These results revealed that aspirin is a potent inhibitor of ACs and a previously unrecognized role of ACs in estrogen biosynthesis. …
Long-term use of low-dose aspirin for cancer prevention: A 20-year longitudinal cohort study of 1,506,525 Hong Kong residents.
Lam A, Hao Z, Yiu K, Chan S, Chan F, Sung J, Tsoi K. Lam A, et al. Int J Cancer. 2025 Jun 15;156(12):2330-2339. doi: 10.1002/ijc.35331. Epub 2025 Jan 18. Int J Cancer. 2025. PMID: 39825684 Free PMC article.
The long-term use of aspirin was associated with a reduced risk of cancer (SHR 0.92, 95% CI 0.91-0.94) and a reduced risk of cancer mortality (SHR 0.80, 95% CI 0.79-0.82). ...Low-dose use of aspirin was associated with lower risk of cancer among …
The long-term use of aspirin was associated with a reduced risk of cancer (SHR 0.92, 95% CI 0.91-0.94) and a reduced risk of …
Escalating doses of intravenous APAC demonstrate antithrombotic effect in pigs.
Bagoly Z, Jouppila A, Orbán-Kálmándi R, Lóczi L, Bomberák D, Kádár ZA, Deák Á, Mátrai Á, Debreceni IB, Kappelmayer J, Németh N, Lassila R. Bagoly Z, et al. Thromb J. 2025 Jun 4;23(1):57. doi: 10.1186/s12959-025-00742-8. Thromb J. 2025. PMID: 40468348 Free PMC article.
METHODS: We studied escalating APAC boluses (0.15-1.5 mg/kg; n = 11) and their reversal in anesthetized pigs for pharmacodynamics using functional coagulation testing. In some experiments, aspirin (500 mg) was co-administered with APAC, and protamine sulfate for reversal. …
METHODS: We studied escalating APAC boluses (0.15-1.5 mg/kg; n = 11) and their reversal in anesthetized pigs for pharmacodynamics using func …
The hydroxamate based HDAC inhibitor WMJ-J-09 induces colorectal cancer cell death by targeting tubulin and downregulating survivin.
Huang YH, Huang YM, Huang WJ, Yu MC, Chuang CH, Hsu YF, Chen HC, Chen LC, Huang SW, Hsu MJ. Huang YH, et al. Sci Rep. 2025 Jun 4;15(1):19590. doi: 10.1038/s41598-025-04714-w. Sci Rep. 2025. PMID: 40467895 Free PMC article.
Aberrant expression of histone deacetylases (HDACs) is associated with cancer drug resistance and tumor progression. While considerable studies and effort have been devoted to developing novel HDAC inhibitors in cancer therapy, hydroxamate-based HDAC inhibitors have …
Aberrant expression of histone deacetylases (HDACs) is associated with cancer drug resistance and tumor progression. While considerab …
Blockade of the PGE2 Pathway Inhibits the Growth of PTEN-Deficient HNSCC Tumors.
Nguyen JP, Na'ara S, Woerner LC, VanLandingham NK, Hoerner M, Santuray RT, Blum K, Kim MO, Johnson DE, Grandis JR. Nguyen JP, et al. Mol Cancer Ther. 2025 Jun 4;24(6):931-941. doi: 10.1158/1535-7163.MCT-24-0604. Mol Cancer Ther. 2025. PMID: 39976130 Free PMC article.
In this study, we assessed PGE2 signaling in PTEN-deficient HNSCC and evaluated the effect of aspirin or TPST-1495, a dual EP2/EP4 antagonist, on the growth of PTEN knockout and PIK3CA-altered HNSCC tumors in immunocompetent mice. Our results demonstrated that aspirin …
In this study, we assessed PGE2 signaling in PTEN-deficient HNSCC and evaluated the effect of aspirin or TPST-1495, a dual EP2/EP4 an …
Bevacizumab, Atezolizumab, and Acetylsalicylic Acid in Recurrent, Platinum-Resistant Ovarian Cancer: The EORTC 1508-GCG Phase II Study.
Banerjee S, Ghisoni E, Wolfer A, Ottevanger PB, Le Scodan R, Sarivalasis A, Montes A, Kroep J, Romeo Marin M, Szturz P, Morotti M, Dagher J, Kandalaft L, Herrera F, Coens C, Dangaj Laniti D, Coukos G. Banerjee S, et al. Clin Cancer Res. 2025 Jun 3;31(11):2145-2153. doi: 10.1158/1078-0432.CCR-24-3368. Clin Cancer Res. 2025. PMID: 40100121 Clinical Trial.
PURPOSE: Treatment options for patients with platinum-resistant ovarian cancer (PROC) are limited, and new therapeutic strategies are urgently needed. This phase II, randomized, multicentre trial evaluated the safety and activity of the anti-PD-L1 antibody atezolizumab (at …
PURPOSE: Treatment options for patients with platinum-resistant ovarian cancer (PROC) are limited, and new therapeutic strategies are …
Carborane-Based Analogs of Celecoxib and Flurbiprofen, their COX Inhibition Potential, and COX Selectivity Index.
Ueberham L, Schädlich J, Schramke K, Braun S, Selg C, Laube M, Lönnecke P, Pietzsch J, Hey-Hawkins E. Ueberham L, et al. ChemMedChem. 2025 Jun 2;20(11):e202500166. doi: 10.1002/cmdc.202500166. Epub 2025 May 4. ChemMedChem. 2025. PMID: 40128115 Free PMC article.
The overexpression of COX-2 under inflammatory conditions, its role in cancer and neurodegenerative diseases necessitates the need to develop and improve nonsteroidal anti-inflammatory drugs. These mainly unselective COX inhibitors, e.g. aspirin, are used to reduce …
The overexpression of COX-2 under inflammatory conditions, its role in cancer and neurodegenerative diseases necessitates the need to …
Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention.
Zhu X, Chen R, Ness RM, Naik RD, Murff HJ, Zhang H, Xu Y, Benante KA, Azcarate-Peril MA, Zheng Y, Wang J, Shrubsole MJ, Su T, Mi X, Kocherginsky M, Rodriguez LM, Della'Zanna G, Richmond E, Hou L, Khan SA, Dai Q. Zhu X, et al. Cancer Prev Res (Phila). 2025 Jun 2;18(6):321-334. doi: 10.1158/1940-6207.CAPR-24-0168. Cancer Prev Res (Phila). 2025. PMID: 40034042 Free PMC article. Clinical Trial.
Aspirin reduces colorectal cancer risk but has a potential for adverse effects. Recent preclinical data suggest that intermittent dosing of aspirin may minimize adverse effects while maintaining efficacy. ...However, compared with intermittent aspirin …
Aspirin reduces colorectal cancer risk but has a potential for adverse effects. Recent preclinical data suggest that intermitt …
Latent JAK2 V617F-Positive Myeloproliferative Neoplasm With Normal Blood Counts and Recurrent Splanchnic Vein Thrombosis in a Young Woman.
Thida AM, Luhrs C, Baral A, Zhonghua L, Brown J. Thida AM, et al. Cureus. 2025 Jun 1;17(6):e85208. doi: 10.7759/cureus.85208. eCollection 2025 Jun. Cureus. 2025. PMID: 40605890 Free PMC article.
Latent myeloproliferative neoplasms are diagnostically challenging clonal hematopoietic disorders characterized by the JAK2 V617F mutation without overt hematologic abnormalities. ...Management included indefinite anticoagulation with apixaban, low-dose aspirin, and …
Latent myeloproliferative neoplasms are diagnostically challenging clonal hematopoietic disorders characterized by the JAK2 V617F mut …
Eflornithine for the Chemoprevention of Luminal Gastrointestinal Neoplasms: A Systematic Review.
Godoy A, Montalvan-Sanchez D, Principe-Meneses FS, Riva-Moscoso A, Sierra L, Erazo G, Avila C, Ramirez-Rojas M, Giron R, Guifarro DA. Godoy A, et al. Gastroenterology Res. 2025 Jun;18(3):93-100. doi: 10.14740/gr1801. Epub 2025 Jun 4. Gastroenterology Res. 2025. PMID: 40503186 Free PMC article. Review.
While aspirin is a well-studied chemopreventive agent for GI neoplasms, its use may be limited due to the underlying bleeding risk. ...Side effects included ototoxicity, reversible upon discontinuation, and mild GI events, both occurring at higher doses. CONCLUSION: …
While aspirin is a well-studied chemopreventive agent for GI neoplasms, its use may be limited due to the underlying bleeding …
Incidence of major health events across metropolitan and regional areas: A 10+ year prospective study of 16,697 older Australians.
Farbotko S, Owen A, Orchard SG, Woods RL, Nelson M, Stocks NP, Tonkin A, Wolfe R, McNeil J, Gibbs P, Zalcberg J, Ryan J. Farbotko S, et al. Australas J Ageing. 2025 Jun;44(2):e70036. doi: 10.1111/ajag.70036. Australas J Ageing. 2025. PMID: 40334009 Free PMC article.
OBJECTIVE: To examine the prevalence of health risk factors by rurality status and the association of rurality and incidence of disability-free survival (DFS), its components (death, dementia and physical disability), cardiovascular disease (CVD), cancer and underlying cau …
OBJECTIVE: To examine the prevalence of health risk factors by rurality status and the association of rurality and incidence of disability-f …
Effects of aspirin at diagnosis on the survival of colorectal cancer patients: a 20-year population-based study.
Agustsson AS, Haraldsdottir S, Birgisson H, Lund SH, Ingason AB, Hreinsson JP, Björnsson ES. Agustsson AS, et al. Scand J Gastroenterol. 2025 Jun;60(6):516-525. doi: 10.1080/00365521.2025.2499126. Epub 2025 May 4. Scand J Gastroenterol. 2025. PMID: 40320718 Free article.
However, cancer-specific survival (CSS) was significantly better for aspirin users (HR: 0.79, 95% CI (0.65-0.95), p = 0.01). This benefit was not observed in patients with stages I-III CRC or those diagnosed due to gastrointestinal bleeding. CONCLUSION: Aspirin …
However, cancer-specific survival (CSS) was significantly better for aspirin users (HR: 0.79, 95% CI (0.65-0.95), p = 0.01). T …
Multimodal evaluation of lipoxygenase-targeting NSAIDs using integrated in vitro, SAR, in silico, cytotoxicity towards MCF-7 cell line, DNA docking and MD simulation approaches.
Iqbal A, Abbas W, Ejaz S, Riaz N, Ashok AK, Hayat MM, Ashraf M. Iqbal A, et al. Int J Biol Macromol. 2025 Jun;314:143665. doi: 10.1016/j.ijbiomac.2025.143665. Epub 2025 Apr 30. Int J Biol Macromol. 2025. PMID: 40316117
Lipoxygenase (LOX) and cyclooxygenase (COX) pathways generate biologically active mediators implicated in inflammatory disorders and several classes of cancer. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the COX pathway by inhibiting the COX-1 and COX-2 enzymes. …
Lipoxygenase (LOX) and cyclooxygenase (COX) pathways generate biologically active mediators implicated in inflammatory disorders and several …
Use of Aspirin Increased the Adenoma Detection Rate and Positive Predictive Value of Fecal Immunochemical Test.
Han Z, Zhou R, Li Y, Li Y. Han Z, et al. J Gastroenterol Hepatol. 2025 Jun;40(6):1461-1471. doi: 10.1111/jgh.16949. Epub 2025 Apr 13. J Gastroenterol Hepatol. 2025. PMID: 40223165
BACKGROUND AND AIM: We aim to evaluate the effect of aspirin on fecal immunochemical test (FIT) performance for advanced colorectal neoplasia (ACRN) including advanced adenoma (AA) and colorectal cancer (CRC). ...CONCLUSIONS: The use of aspirin increased dete …
BACKGROUND AND AIM: We aim to evaluate the effect of aspirin on fecal immunochemical test (FIT) performance for advanced colorectal n …
Vitamin C and D do not increase the chemopreventive effect of aspirin on colon carcinogenesis in a mouse model.
Pereira M, Brandão Ostermann RA, de Fáveri W, Damiani AP, Magenis ML, de Oliveira Monteiro I, Longaretti LM, Zaccaron RP, Lock Silveira PC, Bazo AP, Trevisan Frajacomo FT, Moraes de Andrade V. Pereira M, et al. Food Chem Toxicol. 2025 Jun;200:115400. doi: 10.1016/j.fct.2025.115400. Epub 2025 Mar 19. Food Chem Toxicol. 2025. PMID: 40118136
Adult male and female mice were divided into seven groups: a control group; a group treated with 1,2-dimethylhydrazine (DMH, 40 mg/kg twice per week during weeks 4 and 5); and groups treated with DMH plus the following: aspirin (6 mg/kg in water); Vitamin C (500 mg/L in wa …
Adult male and female mice were divided into seven groups: a control group; a group treated with 1,2-dimethylhydrazine (DMH, 40 mg/kg twice …
Integrating Social Determinants of Health and Established Risk Factors to Predict Cardiovascular Disease Risk Among Healthy Older Adults.
Teshale AB, Htun HL, Vered M, Owen AJ, Ryan J, Polkinghorne KR, Kilkenny MF, Tonkin A, Freak-Poli R. Teshale AB, et al. J Am Geriatr Soc. 2025 Jun;73(6):1797-1807. doi: 10.1111/jgs.19440. Epub 2025 Mar 18. J Am Geriatr Soc. 2025. PMID: 40099367 Free PMC article.
METHODS: The data was sourced from the ASPirin in Reducing Events in the Elderly (ASPREE) longitudinal study, and its sub-study, the ASPREE Longitudinal Study of Older Persons (ALSOP). ...
METHODS: The data was sourced from the ASPirin in Reducing Events in the Elderly (ASPREE) longitudinal study, and its sub-study, the …
Topics of Interest in Women With Myeloproliferative Neoplasms.
Szuber N, Guglielmelli P, Gangat N. Szuber N, et al. Am J Hematol. 2025 Jun;100 Suppl 4(Suppl 4):74-87. doi: 10.1002/ajh.27665. Epub 2025 Mar 14. Am J Hematol. 2025. PMID: 40084464 Free PMC article. Review.
OVERVIEW: Sex and gender have emerged as central modifiers of disease biology, phenotype, and clinical outcomes in myeloproliferative neoplasms (MPNs). This review will uniquely highlight issues affecting women with MPN and articulate their relevant determinants. ...Full d …
OVERVIEW: Sex and gender have emerged as central modifiers of disease biology, phenotype, and clinical outcomes in myeloproliferative neo …
Comparative Dental Pulp Stem Cells (DPSCs) and Periodontal Ligament Stem Cells (PDLSCs): Difference in effect of aspirin on osteoblast potential of PDLSCs and DPSCs.
Abd Rahman F, Azwa FN. Abd Rahman F, et al. Tissue Cell. 2025 Jun;94:102776. doi: 10.1016/j.tice.2025.102776. Epub 2025 Feb 21. Tissue Cell. 2025. PMID: 40022908 Review.
Currently, PDLSCs and DPSCs exhibit a strong ability to undergo osteogenic differentiation when stimulated by factors such as growth factors, chemicals, and paracrine signaling. It has been shown that aspirin (ASA) can enhance the osteoblastic potential of PDLSCs and DPSCs …
Currently, PDLSCs and DPSCs exhibit a strong ability to undergo osteogenic differentiation when stimulated by factors such as growth factors …
Impact of Antibiotics and Chronic Medications on Efficacy of Immune Checkpoint Inhibitors in Patients With Hepatocellular Carcinoma.
Ng KYY, Teo AEK, Tan SH, Tan JJE, Tay DSH, Lee AWX, Ang AJS, Wong LWJ, Choo SP, Toh HC, Lee SY, Lee JJX, Tai DW. Ng KYY, et al. Asia Pac J Clin Oncol. 2025 Jun;21(3):256-265. doi: 10.1111/ajco.14139. Epub 2024 Nov 27. Asia Pac J Clin Oncol. 2025. PMID: 39601254
Sixty-two patients (36.9%) had concomitant antibiotic usage, 26.8% metformin, 30.4% statin, 31.0% beta-blockers, 60.1% PPI, 6.5% NSAIDs, and 11.9% aspirin. Patients with aHCC receiving antibiotics did not have a shorter OS (adjusted HR [aHR] 1.40, 95% CI 0.94-2.09, p = 0.0 …
Sixty-two patients (36.9%) had concomitant antibiotic usage, 26.8% metformin, 30.4% statin, 31.0% beta-blockers, 60.1% PPI, 6.5% NSAIDs, and …
Chemoprevention of Colorectal Cancer-With Emphasis on Low-Dose Aspirin and Anticoagulants.
Agustsson AS, Bjornsson ES. Agustsson AS, et al. Pharmaceuticals (Basel). 2025 May 28;18(6):811. doi: 10.3390/ph18060811. Pharmaceuticals (Basel). 2025. PMID: 40573208 Free PMC article. Review.
Background and Aims: Colorectal cancer (CRC) remains the third most common cancer worldwide and a leading cause of cancer-related death. ...This review summarizes current evidence from observational studies, randomized controlled trials, and meta-analyses on …
Background and Aims: Colorectal cancer (CRC) remains the third most common cancer worldwide and a leading cause of cancer …
Exploring the mechanism of action of aspirin in improving endometrial receptivity in PCOS rats based on uterine lavage fluid metabolomics.
Zhang Y, Wang X, He Y, Liu Q, Yang S. Zhang Y, et al. PLoS One. 2025 May 22;20(5):e0324432. doi: 10.1371/journal.pone.0324432. eCollection 2025. PLoS One. 2025. PMID: 40403007 Free PMC article.
BACKGROUNDS: Aspirin has been shown to enhance endometrial receptivity (ER) during the window of implantation in patients with polycystic ovary syndrome (PCOS). ...Moreover, through ultra-performance liquid chromatography-mass spectrometry, the study of uterine lavage flui …
BACKGROUNDS: Aspirin has been shown to enhance endometrial receptivity (ER) during the window of implantation in patients with polycy …
[Analysis of the efficacy of neoadjuvant immunotherapy combined with chemotherapy in non-small cell lung cancer patients after percutaneous coronary intervention].
Guo L, Ou SL, Zhang SY, Li D, You B, Ma XC. Guo L, et al. Zhonghua Yi Xue Za Zhi. 2025 May 20;105(19):1549-1552. doi: 10.3760/cma.j.cn112137-20241226-02938. Zhonghua Yi Xue Za Zhi. 2025. PMID: 40374341 Chinese.
This study explores the safety and efficacy of neoadjuvant immunotherapy combined with chemotherapy in non-small cell lung cancer (NSCLC) patients undergoing dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). ...A total of 21 patients were inc …
This study explores the safety and efficacy of neoadjuvant immunotherapy combined with chemotherapy in non-small cell lung cancer (NS …
Updates in clinical trial-explored chemopreventive agents for cutaneous melanoma: mechanisms affecting melanocytes.
Ghajar-Rahimi G, Yusuf N. Ghajar-Rahimi G, et al. Melanoma Manag. 2025 May 13;12(1):2505400. doi: 10.1080/20450885.2025.2505400. Epub 2025 May 16. Melanoma Manag. 2025. PMID: 40376946 Free PMC article. Review.
Cutaneous melanoma is a highly aggressive skin cancer with rising incidence, driven by risk factors such as ultraviolet exposure, genetic predisposition, and immunosuppression. ...There is a dearth of clinical trials studying chemoprevention of melanoma, particularly compa …
Cutaneous melanoma is a highly aggressive skin cancer with rising incidence, driven by risk factors such as ultraviolet exposure, gen …
Evaluation of Etiologic Heterogeneity for Risk of Diffuse Large B-Cell Lymphoma Subtype Defined by the Cell of Origin.
Kleinstern G, Robinson DP, Rimsza LM, Larson MC, King RL, Nowakowski GS, Thompson CA, Ansell SM, Maurer MJ, Feldman AL, Slager SL, Novak AJ, Habermann TM, Cerhan JR. Kleinstern G, et al. Cancer Epidemiol Biomarkers Prev. 2025 May 2;34(5):780-787. doi: 10.1158/1055-9965.EPI-24-1610. Cancer Epidemiol Biomarkers Prev. 2025. PMID: 40047811 Free PMC article.
RESULTS: We identified heterogeneity by the COO for low socioeconomic status (SES), which was only associated with non-GCB DLBCL (OR = 1.88 for low vs. average SES; 95% CI, 1.08-3.27); alcohol use, which was only associated with GCB DLBCL (OR = 0.48 for former drinkers; 95% CI, 0 …
RESULTS: We identified heterogeneity by the COO for low socioeconomic status (SES), which was only associated with non-GCB DLBCL (OR = 1.88 …
Dual antiplatelet therapy versus aspirin alone in acute ischemic stroke or transient ischemic attack: A meta-analysis and trial sequential analysis of randomized controlled trials.
Odat RM, Alshwayyat S, Bahdar ZI, Abdelraheem M, Khalefa BB, Jarah O, Obeidat MH, Bani Khalaf ME, Bani Khalaf AJ, Hussein AM, Yasin JA, Hanifa H, Jain H. Odat RM, et al. J Int Med Res. 2025 May;53(5):3000605251337035. doi: 10.1177/03000605251337035. Epub 2025 May 13. J Int Med Res. 2025. PMID: 40364517 Free PMC article.
This study aimed to systematically review and analyze the efficacy and safety of dual antiplatelet therapy compared with aspirin alone in patients with acute ischemic stroke or transient ischemic attack.MethodsWe searched PubMed, Embase, Scopus, Cochrane, and Web of Scienc …
This study aimed to systematically review and analyze the efficacy and safety of dual antiplatelet therapy compared with aspirin alon …
Design, Synthesis, Biological Evaluation, and In Silico Study of Aspirin-Sulfonamide Hybrids as Potential Anticancer Agents.
Duan X, Ma X, Chen M, Zhang T, Sun X, Wei M, Bao X. Duan X, et al. Arch Pharm (Weinheim). 2025 May;358(5):e70001. doi: 10.1002/ardp.70001. Arch Pharm (Weinheim). 2025. PMID: 40347041
Aspirin's potential as a cancer treatment had garnered significant attention over the past 50 years. ...These findings underscore the potential of hybrid 3k as a novel therapeutic agent for non-small-cell lung cancer and its contribution to expanding t …
Aspirin's potential as a cancer treatment had garnered significant attention over the past 50 years. ...These findings …
Chemoprevention of Gastrointestinal Cancers: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials and Cohort Studies.
Chan JE, Shanmugham S, Kumar S, Lee YY, Ching SM, Chaiyakunapruk N, Veettil SK. Chan JE, et al. Clin Transl Sci. 2025 May;18(5):e70235. doi: 10.1111/cts.70235. Clin Transl Sci. 2025. PMID: 40344467 Free PMC article.
Seven inverse associations were graded as either high quality (celecoxib and colorectal adenomas, (N = 4)) or moderate (aspirin and colorectal adenomas, (N = 2) and H-pylori eradication and gastric cancer (N = 1)). ...Despite the limited established evidence, the in …
Seven inverse associations were graded as either high quality (celecoxib and colorectal adenomas, (N = 4)) or moderate (aspirin and c …
Role of Proton Pump Inhibitors in Prevention of Upper Gastrointestinal Bleeding in Patients on Dual Antiplatelet Therapy: Systematic Review and Meta-Analysis.
Saeed A, Haider M, Yousuf S, Ahmad S, Fine M, Yazdani A, Hayat U, Noverati N, Khan MA, Gangwani MK, Aziz M, Farooq U, Kamal F. Saeed A, et al. Am J Ther. 2025 May-Jun 01;32(3):e256-e261. doi: 10.1097/MJT.0000000000001834. Epub 2024 Dec 4. Am J Ther. 2025. PMID: 40338683
BACKGROUND: Dual antiplatelet therapy (DAPT) with oral P2Y12 inhibitors and aspirin is crucial for patients with acute coronary syndrome (ACS) and postpercutaneous coronary interventions (PCI). ...
BACKGROUND: Dual antiplatelet therapy (DAPT) with oral P2Y12 inhibitors and aspirin is crucial for patients with acute coronary syndr …
Determining the optimal use of approved drugs in oncology.
Bouche G, Gilbert D, Quartagno M, Dehbi HM, Merrick S, Barjesteh van Waalwijk van Doorn-Khosrovani S, Stephens R, Parmar M, Langley RE. Bouche G, et al. Lancet Oncol. 2025 May;26(5):e282-e294. doi: 10.1016/S1470-2045(25)00037-3. Lancet Oncol. 2025. PMID: 40318659 Review.
Management of epithelial precancerous conditions and early neoplasia of the stomach (MAPS III): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG) and European Society of Pathology (ESP) Guideline update 2025.
Dinis-Ribeiro M, Libânio D, Uchima H, Spaander MCW, Bornschein J, Matysiak-Budnik T, Tziatzios G, Santos-Antunes J, Areia M, Chapelle N, Esposito G, Fernandez-Esparrach G, Kunovsky L, Garrido M, Tacheci I, Link A, Marcos P, Marcos-Pinto R, Moreira L, Pereira AC, Pimentel-Nunes P, Romanczyk M, Fontes F, Hassan C, Bisschops R, Feakins R, Schulz C, Triantafyllou K, Carneiro F, Kuipers EJ. Dinis-Ribeiro M, et al. Endoscopy. 2025 May;57(5):504-554. doi: 10.1055/a-2529-5025. Epub 2025 Mar 20. Endoscopy. 2025. PMID: 40112834 Free article.
ESGE/EHMSG/ESP suggest that gastric cancer screening or surveillance in asymptomatic individuals over 80 should be discontinued or not started, and that patients' comorbidities should be considered when treatment of superficial lesions is planned.ESGE/EHMSG/ESP recommend t …
ESGE/EHMSG/ESP suggest that gastric cancer screening or surveillance in asymptomatic individuals over 80 should be discontinued or no …
Prescription and Non-prescription Medication Pill Burdens and Their Associations with Health-Related Quality of Life in Older Adults: A Cross-Sectional Study.
Vonderhaar JM, Ernst ME, Fravel MA, Orchard SG, Owen AJ, Woods RL, Wolfe R, Stocks N, Gilmartin-Thomas J. Vonderhaar JM, et al. Drugs Aging. 2025 May;42(5):457-467. doi: 10.1007/s40266-025-01199-0. Epub 2025 Mar 19. Drugs Aging. 2025. PMID: 40106218 Clinical Trial.
METHODS: Data from the final intervention year of the ASPirin in Reducing Events in the Elderly (ASPREE) randomized trial in older adults from Australia and the USA, were analyzed cross-sectionally. ...
METHODS: Data from the final intervention year of the ASPirin in Reducing Events in the Elderly (ASPREE) randomized trial in older ad …
Aspirin-induced acetylation of APE1/Ref-1 enhances RAGE binding and promotes apoptosis in ovarian cancer cells.
Jin H, Lee YR, Kim S, Lee EO, Joo HK, Yoo HJ, Kim CS, Jeon BH. Jin H, et al. Korean J Physiol Pharmacol. 2025 May 1;29(3):293-305. doi: 10.4196/kjpp.24.273. Epub 2025 Mar 7. Korean J Physiol Pharmacol. 2025. PMID: 40051129 Free PMC article.
The role of acetylated apurinic/apyrimidinic endonuclease 1/redox factor 1 (APE1/Ref-1) in ovarian cancer remains poorly understood. Therefore, this study aimed to investigate the combined effect of recombinant human APE1/Ref-1 (rhAPE1/Ref-1) and aspirin (ASA) on tw …
The role of acetylated apurinic/apyrimidinic endonuclease 1/redox factor 1 (APE1/Ref-1) in ovarian cancer remains poorly understood. …
Trends in age and antithrombotic therapy in patients who underwent transurethral resection of bladder tumor and perioperative complications.
Wada N, Hatakeyama T, Takagi H, Tsunekawa R, Kobayashi S, Nagabuchi M, Kitta T, Kakizaki H. Wada N, et al. Int J Urol. 2025 May;32(5):516-523. doi: 10.1111/iju.15684. Epub 2025 Jan 27. Int J Urol. 2025. PMID: 39868806
The usage of warfarin (25.4%, 13%, and 4.2% in periods I, II, and III, respectively) and aspirin (65.1%, 40.3%, and 32.3% in periods I, II, and III, respectively) was decreased, whereas direct oral anticoagulant (1.6%, 18.2%, and 35.4% in periods I, II, and III, respective …
The usage of warfarin (25.4%, 13%, and 4.2% in periods I, II, and III, respectively) and aspirin (65.1%, 40.3%, and 32.3% in periods …
The efficacy of aspirin versus low-molecular-weight heparin for venous thromboembolism prophylaxis after knee and hip arthroplasty: A systematic review and meta-analysis of randomized controlled trials.
Salman LA, Altahtamouni SB, Khatkar H, Al-Ani A, Hameed S, Alvand A. Salman LA, et al. Knee Surg Sports Traumatol Arthrosc. 2025 May;33(5):1605-1616. doi: 10.1002/ksa.12456. Epub 2024 Sep 3. Knee Surg Sports Traumatol Arthrosc. 2025. PMID: 39228215 Free PMC article.
CONCLUSION: This study demonstrated a significantly higher risk of PE among patients receiving aspirin compared to LMWH following hip or knee arthroplasty for osteoarthritis. Aspirin was associated with a significantly higher overall VTE risk among patients undergoi …
CONCLUSION: This study demonstrated a significantly higher risk of PE among patients receiving aspirin compared to LMWH following hip …
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