PEGylated-liposomal astaxanthin ameliorates Abeta neurotoxicity and Alzheimer-related phenotypes by scavenging formaldehyde.
Gu Z, Zhao H, Song Y, Kou Y, Yang W, Li Y, Li X, Ding L, Sun Z, Lin J, Wang Q, Li X, Yang X, Huang X, Yang C, Tong Z.
Gu Z, et al.
J Control Release. 2024 Feb;366:783-797. doi: 10.1016/j.jconrel.2024.01.019. Epub 2024 Jan 20.
J Control Release. 2024.
PMID: 38242211
Free article.
Amyloid-beta (Abeta) has been found to induce endogenous formaldehyde (FA) accumulation by inactivating FA dehydrogenase (FDH); in turn, excessive FA triggers Abeta aggregation that eventually leads to AD onset. Hence, scavenging FA by astaxanthin (ATX, a strong exogenous …
Amyloid-beta (Abeta) has been found to induce endogenous formaldehyde (FA) accumulation by inactivating FA dehydrogenase (FDH); in turn, exc …