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New developments in protein structure-function analysis by MS and use of hydrogen-deuterium exchange microfluidics.
Landreh M, Astorga-Wells J, Johansson J, Bergman T, Jörnvall H. Landreh M, et al. FEBS J. 2011 Oct;278(20):3815-21. doi: 10.1111/j.1742-4658.2011.08215.x. Epub 2011 Jul 5. FEBS J. 2011. PMID: 21668648 Free article. Review.
Ion mobility MS and chemical crosslinking strategies can be applied to probe the architecture of macromolecular assemblies and protein-ligand complexes. MS analysis of hydrogen-deuterium exchange can be used to determine the localization of secondary structure eleme …
Ion mobility MS and chemical crosslinking strategies can be applied to probe the architecture of macromolecular assemblies and protein-ligan …
A membrane cell for on-line hydrogen/deuterium exchange to study protein folding and protein-protein interactions by mass spectrometry.
Astorga-Wells J, Landreh M, Johansson J, Bergman T, Jörnvall H. Astorga-Wells J, et al. Mol Cell Proteomics. 2011 Sep;10(9):M110.006510. doi: 10.1074/mcp.M110.006510. Epub 2011 May 24. Mol Cell Proteomics. 2011. PMID: 21610101 Free PMC article.
A membrane cell for hydrogen and deuterium exchange on-line with mass spectrometry has been developed to monitor protein-protein interactions and protein conformations. ...This cell was validated against three models commonly used in hydrogen-deuterium
A membrane cell for hydrogen and deuterium exchange on-line with mass spectrometry has been developed to monitor protein-prote …
Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies.
Hanke L, Sheward DJ, Pankow A, Vidakovics LP, Karl V, Kim C, Urgard E, Smith NL, Astorga-Wells J, Ekström S, Coquet JM, McInerney GM, Murrell B. Hanke L, et al. Sci Adv. 2022 Mar 25;8(12):eabm0220. doi: 10.1126/sciadv.abm0220. Epub 2022 Mar 25. Sci Adv. 2022. PMID: 35333580 Free PMC article.
We characterize their potency and specificity using neutralization assays and hydrogen/deuterium exchange mass spectrometry (HDX-MS). The most potent nanobodies bind to the receptor binding motif of the receptor binding domain (RBD), and we identify two exceptionall …
We characterize their potency and specificity using neutralization assays and hydrogen/deuterium exchange mass spectrometry (H …
Application of amide hydrogen/deuterium exchange mass spectrometry for epitope mapping in human cystatin C.
Prądzińska M, Behrendt I, Astorga-Wells J, Manoilov A, Zubarev RA, Kołodziejczyk AS, Rodziewicz-Motowidło S, Czaplewska P. Prądzińska M, et al. Amino Acids. 2016 Dec;48(12):2809-2820. doi: 10.1007/s00726-016-2316-y. Epub 2016 Aug 29. Amino Acids. 2016. PMID: 27573935 Free PMC article.
In addition, hCC epitopes in complexes with native polyclonal antibodies extracted from human serum were studied. The results obtained with hydrogen-deuterium exchange mass spectrometry (HDX MS) were compared with the previous findings made using the excision/extrac …
In addition, hCC epitopes in complexes with native polyclonal antibodies extracted from human serum were studied. The results obtained with …
A pH-dependent dimer lock in spider silk protein.
Landreh M, Askarieh G, Nordling K, Hedhammar M, Rising A, Casals C, Astorga-Wells J, Alvelius G, Knight SD, Johansson J, Jörnvall H, Bergman T. Landreh M, et al. J Mol Biol. 2010 Nov 26;404(2):328-36. doi: 10.1016/j.jmb.2010.09.054. Epub 2010 Sep 29. J Mol Biol. 2010. PMID: 20887730
The N-terminal (NT) domain of MaSp1 produced by the nursery web spider Euprosthenops australis acts as a pH-sensitive relay, mediating spidroin assembly at around pH 6.3. Using amide hydrogen/deuterium exchange combined with mass spectrometry (MS), we detected pH-de …
The N-terminal (NT) domain of MaSp1 produced by the nursery web spider Euprosthenops australis acts as a pH-sensitive relay, mediating spidr …
Limited Proteolysis Combined with Stable Isotope Labeling Reveals Conformational Changes in Protein (Pseudo)kinases upon Binding Small Molecules.
Di Michele M, Stes E, Vandermarliere E, Arora R, Astorga-Wells J, Vandenbussche J, van Heerde E, Zubarev R, Bonnet P, Linders JT, Jacoby E, Brehmer D, Martens L, Gevaert K. Di Michele M, et al. J Proteome Res. 2015 Oct 2;14(10):4179-93. doi: 10.1021/acs.jproteome.5b00282. Epub 2015 Aug 25. J Proteome Res. 2015. PMID: 26293246
The ATP-competitive type I B-Raf inhibitor vemurafenib and the type II inhibitor sorafenib stabilized the kinase domain (KD) but had distinct effects on the Ras-binding domain. Stabilization of the B-Raf(WT) KD was confirmed by hydrogen/deuterium exchange MS and mol …
The ATP-competitive type I B-Raf inhibitor vemurafenib and the type II inhibitor sorafenib stabilized the kinase domain (KD) but had distinc …
Biochemical Characterization of the Split Class II Ribonucleotide Reductase from Pseudomonas aeruginosa.
Crona M, Hofer A, Astorga-Wells J, Sjöberg BM, Tholander F. Crona M, et al. PLoS One. 2015 Jul 30;10(7):e0134293. doi: 10.1371/journal.pone.0134293. eCollection 2015. PLoS One. 2015. PMID: 26225432 Free PMC article.
A combination of activity assays and activity-independent methods like surface plasmon resonance and gas phase electrophoretic macromolecule analysis suggests that the enzymatically active form of the enzyme is a (NrdJa-NrdJb)2 homodimer of heterodimers, and a combination of h
A combination of activity assays and activity-independent methods like surface plasmon resonance and gas phase electrophoretic macromolecule …
The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain.
Jung T, Shin B, Tamo G, Kim H, Vijayvargia R, Leitner A, Marcaida MJ, Astorga-Wells J, Jung R, Aebersold R, Peraro MD, Hebert H, Seong IS, Song JJ. Jung T, et al. Structure. 2020 Sep 1;28(9):1035-1050.e8. doi: 10.1016/j.str.2020.06.008. Epub 2020 Jul 14. Structure. 2020. PMID: 32668197 Free PMC article.