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Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress.
Zhang Q, Liu J, Duan H, Li R, Peng W, Wu C. Zhang Q, et al. J Adv Res. 2021 Jul 6;34:43-63. doi: 10.1016/j.jare.2021.06.023. eCollection 2021 Dec. J Adv Res. 2021. PMID: 35024180 Free PMC article. Review.
OBJECTIVES: This paper aimed to summarized the natural monomers/extracts that potentially exert protective effects against oxidative stress in ECs. METHODS: A literature search was carried out regarding our topic with the keywords of "atherosclerosis" or "Nrf2/HO-1" …
OBJECTIVES: This paper aimed to summarized the natural monomers/extracts that potentially exert protective effects against oxidative …
Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE(-/-) mice.
Ma C, Xia R, Yang S, Liu L, Zhang J, Feng K, Shang Y, Qu J, Li L, Chen N, Xu S, Zhang W, Mao J, Han J, Chen Y, Yang X, Duan Y, Fan G. Ma C, et al. Theranostics. 2020 Jan 1;10(3):1090-1106. doi: 10.7150/thno.38115. eCollection 2020. Theranostics. 2020. PMID: 31938053 Free PMC article.
Background and Purpose: Atherosclerosis is an underlying cause of coronary heart disease. Foam cell, a hallmark of atherosclerosis, is prominently derived from monocyte-differentiated macrophage, and vascular smooth muscle cells (VSMCs) through unlimitedly phagocyti …
Background and Purpose: Atherosclerosis is an underlying cause of coronary heart disease. Foam cell, a hallmark of atherosclerosis …
Formononetin protects against ox-LDL-induced endothelial dysfunction by activating PPAR-gamma signaling based on network pharmacology and experimental validation.
Zhang B, Hao Z, Zhou W, Zhang S, Sun M, Li H, Hou N, Jing C, Zhao M. Zhang B, et al. Bioengineered. 2021 Dec;12(1):4887-4898. doi: 10.1080/21655979.2021.1959493. Bioengineered. 2021. PMID: 34369277 Free PMC article.
Protein-protein interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were applied to explore the potential targets and signaling pathways involved in FMNT against atherosclerosis. Human umbilical vein endothelial cell …
Protein-protein interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were applied to …
Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE(-/-) Mice Fed High-Fat Diet.
Yang M, Jiao H, Li Y, Zhang L, Zhang J, Zhong X, Xue Y. Yang M, et al. Drug Des Devel Ther. 2022 Sep 16;16:3145-3168. doi: 10.2147/DDDT.S372143. eCollection 2022. Drug Des Devel Ther. 2022. PMID: 36148321 Free PMC article.
BACKGROUND: Atherosclerosis (AS) is the leading cause of cardiovascular diseases, such as myocardial infarction and stroke. ...GMTG could decrease serum triglycerides, total cholesterol, low-density lipoprotein-cholesterol, and oxidized low-density …
BACKGROUND: Atherosclerosis (AS) is the leading cause of cardiovascular diseases, such as myocardial infarction and stroke. ...GMTG c …
Suppression of low-density lipoprotein oxidation, vascular smooth muscle cell proliferation and migration by a herbal extract of Radix Astragali, Radix Codonopsis and Cortex Lycii.
Chan JY, Koon JC, Leung PC, Che CT, Fung KP. Chan JY, et al. BMC Complement Altern Med. 2011 Apr 22;11:32. doi: 10.1186/1472-6882-11-32. BMC Complement Altern Med. 2011. PMID: 21513503 Free PMC article.
BACKGROUND: Atherosclerosis is a major cause of death in developed world. Atherosclerosis is characterized by low-density lipoprotein deposition in the arterial wall which ultimately begets the formation of lesions. ...In this study, we want to further investigate t …
BACKGROUND: Atherosclerosis is a major cause of death in developed world. Atherosclerosis is characterized by low-density lipo …
Astragalus Polysaccharide Alleviates Hyperlipidemia via the miR-128-3p/NRF2/Antioxidant Pathway.
Yuan Q, Zhang C, Yang Z. Yuan Q, et al. J Food Sci. 2026 Apr;91(4):e71035. doi: 10.1111/1750-3841.71035. J Food Sci. 2026. PMID: 41964290
Hyperlipidemia, a common metabolic disorder marked by elevated serum lipids like total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), raises risks for cardiovascular diseases, atherosclerosis, nonalcoholic fatty liver disease, …
Hyperlipidemia, a common metabolic disorder marked by elevated serum lipids like total cholesterol (TC), triglycerides (TG), and low-density …
Astragaloside IV protects against C/EBP homologous protein-mediated apoptosis in oxidized low-density lipoprotein-treated macrophages by promoting autophagy.
Tian H, Wang T, Zhang Y, Pan T, Yao S, Yu H, Ma K, Wang S. Tian H, et al. Eur J Pharmacol. 2022 May 15;923:174912. doi: 10.1016/j.ejphar.2022.174912. Epub 2022 Mar 23. Eur J Pharmacol. 2022. PMID: 35339476 Free article.
Astragaloside (AS- ) is one of the main active components extracted from Astragalus membranaceus that exerts an antiatherosclerotic effect. Our study explored the underlying anti-apoptotic effects and the mechanisms of action of AS- in oxidized low-dens …
Astragaloside (AS- ) is one of the main active components extracted from Astragalus membranaceus that exerts an antiatherosclerotic …
Effects of Astragalus injection and Salvia Miltiorrhiza injection on serum inflammatory markers in patients with stable coronary heart disease: a randomized controlled trial protocol.
Luo Z, Liu Y, Zhao Z, Yan X, Wang D, Liu Q. Luo Z, et al. Trials. 2020 Mar 17;21(1):267. doi: 10.1186/s13063-020-4109-6. Trials. 2020. PMID: 32178701 Free PMC article.
BACKGROUND: Coronary heart disease (CHD) is a clinical syndrome caused by coronary atherosclerosis (AS) or functional changes in coronary arteries. We have previously reported that astragaloside IV (in astragalus) and tanshinone IIA (in Salvia miltiorrhiza) improve …
BACKGROUND: Coronary heart disease (CHD) is a clinical syndrome caused by coronary atherosclerosis (AS) or functional changes in coro …
Astragaloside IV Mediates the PI3K/Akt/mTOR Pathway to Alleviate Injury and Modulate the Composition of Intestinal Flora in ApoE(-/-) Atherosclerosis Model Rats.
Sun D, Wang Y, Pang B, Jiang L. Sun D, et al. Discov Med. 2024 May;36(184):1070-1079. doi: 10.24976/Discov.Med.202436184.99. Discov Med. 2024. PMID: 38798265 Free article.
BACKGROUND: Atherosclerosis (AS) is a chronic inflammatory vascular disease with a complex pathogenesis. ...AST IV administration reduced serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), endothelin-1 (ET-1) and angiotens …
BACKGROUND: Atherosclerosis (AS) is a chronic inflammatory vascular disease with a complex pathogenesis. ...AST IV administration red …