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Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis.
Ma Y, Han J, Wang K, Han H, Hu Y, Li H, Wu S, Zhang L. Ma Y, et al. Heliyon. 2024 Jun 19;10(12):e33307. doi: 10.1016/j.heliyon.2024.e33307. eCollection 2024 Jun 30. Heliyon. 2024. PMID: 39022015 Free PMC article. Review.
Atherosclerosis (AS) is a chronic inflammatory disease resulting from dysregulated lipid metabolism, constituting the pathophysiological foundation of cardiovascular and cerebrovascular diseases. ...As such, traditional Chinese medicine (TCM) has been widely used recently
Atherosclerosis (AS) is a chronic inflammatory disease resulting from dysregulated lipid metabolism, constituting the pathophysiologi
GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis.
Zheng G, Zhao Y, Li Z, Hua Y, Zhang J, Miao Y, Guo Y, Li L, Shi J, Dong Z, Yang S, Fan G, Ma C. Zheng G, et al. Theranostics. 2023 Feb 21;13(4):1325-1341. doi: 10.7150/thno.80250. eCollection 2023. Theranostics. 2023. PMID: 36923537 Free PMC article.
Presently, the drug to treat aortic calcification remains not to be available. Ganoderma lucidum spore powder (GLSP) is from Ganoderma lucidum which is a Traditional Chinese Medicine with the homology of medicine and food. ...GLSP may be a potential dr …
Presently, the drug to treat aortic calcification remains not to be available. Ganoderma lucidum spore powder (GLSP) is from …
A network pharmacology analysis on drug-like compounds from Ganoderma lucidum for alleviation of atherosclerosis.
Oh KK, Adnan M, Cho DH. Oh KK, et al. J Food Biochem. 2021 Sep;45(9):e13906. doi: 10.1111/jfbc.13906. Epub 2021 Aug 18. J Food Biochem. 2021. PMID: 34409623
Ganoderma lucidum (GL) is known as a potent alleviator against chronic inflammatory disease like atherosclerosis (AS), but its mechanisms against AS have not been unveiled. ...Overall, we found that the identified 3 DLCs from GL have potent anti-inflammatory
Ganoderma lucidum (GL) is known as a potent alleviator against chronic inflammatory disease like atherosclerosis (AS),
Ganoderma lucidum spore ethanol extract attenuates atherosclerosis by regulating lipid metabolism via upregulation of liver X receptor alpha.
Lai P, Cao X, Xu Q, Liu Y, Li R, Zhang J, Zhang M. Lai P, et al. Pharm Biol. 2020 Dec;58(1):760-770. doi: 10.1080/13880209.2020.1798471. Pharm Biol. 2020. PMID: 32780606 Free PMC article.
CONTEXT: Ganoderma lucidum (Leyss.ex Fr.) Karst (Ganodermataceae) is a fungus that has been used in traditional Chinese medicine. OBJECTIVE: This is the first investigation of the lipid-lowering and anti-atherosclerotic effects of Ganoderma lucidum spo …
CONTEXT: Ganoderma lucidum (Leyss.ex Fr.) Karst (Ganodermataceae) is a fungus that has been used in traditional Chinese medici …
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Cheng Y, Zheng G, Huang H, Ni J, Zhao Y, Sun Y, Chang Y, Liu S, He F, Li D, Guo Y, Miao Y, Xu M, Wang D, Zhang Y, Hua Y, Yang S, Fan G, Ma C. Cheng Y, et al. Theranostics. 2025 Mar 18;15(10):4345-4367. doi: 10.7150/thno.110324. eCollection 2025. Theranostics. 2025. PMID: 40225574 Free PMC article.
Thus, understanding the mechanisms underlying vascular aging and age-related atherosclerosis and vascular calcification is crucial. This study investigates the targets of vascular aging and elucidates the role and mechanisms of Ganoderma lucidum spore powder …
Thus, understanding the mechanisms underlying vascular aging and age-related atherosclerosis and vascular calcification is crucial. T …
Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-alpha/SREBP1 pathway and modulating the gut microbiota in ApoE(-/-) mice fed with HFD.
Zhang Y, Gu Y, Chen Y, Huang Z, Li M, Jiang W, Chen J, Rao W, Luo S, Chen Y, Chen J, Li L, Jia Y, Liu M, Zhou F. Zhang Y, et al. J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1. J Ethnopharmacol. 2021. PMID: 33011372 Free article.
However, the mechanism of DXR IV in atherosclerosis is unclear. AIM OF THE STUDY: This study aimed to illustrate whether DXR IV improve atherosclerosis through modulating the lipid metabolism and gut microbiota in atherosclerosis mice. ...The decroation of DX …
However, the mechanism of DXR IV in atherosclerosis is unclear. AIM OF THE STUDY: This study aimed to illustrate whether DXR IV impro …
Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2.
Wihastuti TA, Amiruddin R, Cesa FY, Alkaf AI, Setiawan M, Heriansyah T. Wihastuti TA, et al. J Basic Clin Physiol Pharmacol. 2020 Feb 7;30(6):/j/jbcpp.2019.30.issue-6/jbcpp-2019-0349/jbcpp-2019-0349.xml. doi: 10.1515/jbcpp-2019-0349. J Basic Clin Physiol Pharmacol. 2020. PMID: 32031980
Background Type 2 diabetes mellitus (T2DM) is a major risk factor of atherosclerosis. Hyperglycemia in T2DM causes advanced formation of glycation end products (AGE) which leads to oxidative stress and chronic inflammation. ...This result indicates that PSP prevents inflam …
Background Type 2 diabetes mellitus (T2DM) is a major risk factor of atherosclerosis. Hyperglycemia in T2DM causes advanced formation …
Ganoderma lucidum triterpenoids and polysaccharides attenuate atherosclerotic plaque in high-fat diet rabbits.
Li Y, Tang J, Gao H, Xu Y, Han Y, Shang H, Lu Y, Qin C. Li Y, et al. Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1929-1938. doi: 10.1016/j.numecd.2021.03.023. Epub 2021 Apr 6. Nutr Metab Cardiovasc Dis. 2021. PMID: 33992512
BACKGROUND AND AIMS: Atherosclerosis is characterized by lipid deposition, oxidative stress, and inflammation in the arterial intima. Ganoderma lucidum triterpenoids (GLTs) and polysaccharides (GLPs) are traditional Chinese medicines with potential cardiovasc …
BACKGROUND AND AIMS: Atherosclerosis is characterized by lipid deposition, oxidative stress, and inflammation in the arterial intima. …
The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients.
Sargowo D, Ovianti N, Susilowati E, Ubaidillah N, Widya Nugraha A, Vitriyaturrida, Siwi Proboretno K, Failasufi M, Ramadhan F, Wulandari H, Waranugraha Y, Hayuning Putri D. Sargowo D, et al. Indian Heart J. 2018 Sep-Oct;70(5):608-614. doi: 10.1016/j.ihj.2017.12.007. Epub 2017 Dec 14. Indian Heart J. 2018. PMID: 30392496 Free PMC article. Clinical Trial.
Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of beta-glucan. Previous studies have proven the PsP of Ganoderma lucidum as an effective antioxidant in atherosclerotic rats and shows no toxicity in anima …
Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of beta-glucan. Previous studi …
Health benefits of Ganoderma lucidum polysaccharides: A review of potential cardiovascular protective effects.
Wang Y, Zuo Y, Weng J, Peng X. Wang Y, et al. Int J Biol Macromol. 2025 Nov;330(Pt 1):148001. doi: 10.1016/j.ijbiomac.2025.148001. Epub 2025 Sep 29. Int J Biol Macromol. 2025. PMID: 41033521 Review.
Ganoderma lucidum polysaccharides (GLPs) are a diverse class of bioactive compounds abundantly present in the mycelia, fruiting bodies, and spores of Ganoderma lucidum (G. lucidum). ...Additionally, GLPs have demonstrated therapeutic potential i
Ganoderma lucidum polysaccharides (GLPs) are a diverse class of bioactive compounds abundantly present in the mycelia, fruitin
30 results