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Page 1
Did you mean asthma a pai (158 results)?
CRYPTID-exon: streamlined detection of cryptic exons from RNA-seq data.
Khokhar ES, Brokaw K, Kartje ZJ, Krykbaeva M, Calvo-Roitberg E, Hedger AK, Lee J, Wagh A, Watts JK, Pai AA. Khokhar ES, et al. Among authors: pai aa. bioRxiv [Preprint]. 2025 Dec 19:2025.12.17.694983. doi: 10.64898/2025.12.17.694983. bioRxiv. 2025. PMID: 41446134 Free PMC article. Preprint.
mRNA initiation and termination are spatially coordinated.
Calvo-Roitberg E, Carroll CL, Kim G, Sanabria V, Venev SV, Mick ST, Paquette JD, Uriostegui-Arcos M, Dekker J, Fiszbein A, Pai AA. Calvo-Roitberg E, et al. Among authors: pai aa. Science. 2025 Oct 9;390(6769):eado8279. doi: 10.1126/science.ado8279. Epub 2025 Oct 9. Science. 2025. PMID: 41066574 Free PMC article.
Pervasive noise in human splice site selection.
Khokhar ES, Brokaw K, Kartje ZJ, Sanabria V, Javeed N, Kumar A, Watts JK, Pai AA. Khokhar ES, et al. Among authors: pai aa. bioRxiv [Preprint]. 2025 Jul 20:2025.07.16.665169. doi: 10.1101/2025.07.16.665169. bioRxiv. 2025. PMID: 40791517 Free PMC article. Preprint.
Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.
Davis SM, Hildebrand S, MacMillan HJ, Monopoli KR, Buchwald J, Sousa J, Cooper D, Ly S, Echeverria D, McHugh N, Ferguson C, Coles A, Hariharan VN, O'Reilly D, Tang Q, Furgal R, Yamada K, Alterman JF, Gilbert JW, Knox E, Pineda Y, Weston CN, Baer CE, Pai AA, Khvorova A. Davis SM, et al. Among authors: pai aa. Nucleic Acids Res. 2025 Jun 20;53(12):gkaf479. doi: 10.1093/nar/gkaf479. Nucleic Acids Res. 2025. PMID: 40548938 Free PMC article.
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.
Zhang B, Orning P, Lehman JW, Dinis A, Torres-Ulloa L, Elling R, Kelliher MA, Bertin J, Proulx MK, Goguen JD, Ryan L, Kandasamy RK, Espevik T, Pai AA, Fitzgerald KA, Lien E. Zhang B, et al. Among authors: pai aa. Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2420802122. doi: 10.1073/pnas.2420802122. Epub 2025 Feb 13. Proc Natl Acad Sci U S A. 2025. PMID: 39946533 Free PMC article.
High-resolution profiling reveals coupled transcriptional and translational regulation of transgenes.
Peterman EL, Ploessl DS, Love KS, Sanabria V, Daniels RF, Johnstone CP, Godavarti DR, Kabaria SR, Oakes CG, Pai AA, Galloway KE. Peterman EL, et al. Among authors: pai aa. bioRxiv [Preprint]. 2024 Dec 3:2024.11.26.625483. doi: 10.1101/2024.11.26.625483. bioRxiv. 2024. Update in: Nucleic Acids Res. 2025 Jun 6;53(11):gkaf528. doi: 10.1093/nar/gkaf528. PMID: 39651241 Free PMC article. Updated. Preprint.
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.
Zhang B, Orning P, Lehman JW, Dinis A, Torres-Ulloa L, Elling R, Kelliher MA, Bertin J, Proulx MK, Ryan L, Kandasamy R, Espevik T, Pai AA, Fitzgerald KA, Lien E. Zhang B, et al. Among authors: pai aa. bioRxiv [Preprint]. 2024 Nov 29:2024.11.27.625707. doi: 10.1101/2024.11.27.625707. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2420802122. doi: 10.1073/pnas.2420802122. PMID: 39651143 Free PMC article. Updated. Preprint.
A cohesin traffic pattern genetically linked to gene regulation.
Valton AL, Venev SV, Mair B, Khokhar ES, Tong AHY, Usaj M, Chan K, Pai AA, Moffat J, Dekker J. Valton AL, et al. Among authors: pai aa. Nat Struct Mol Biol. 2022 Dec;29(12):1239-1251. doi: 10.1038/s41594-022-00890-9. Epub 2022 Dec 8. Nat Struct Mol Biol. 2022. PMID: 36482254 Free PMC article.
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo.
Ibraheim R, Tai PWL, Mir A, Javeed N, Wang J, Rodríguez TC, Namkung S, Nelson S, Khokhar ES, Mintzer E, Maitland S, Chen Z, Cao Y, Tsagkaraki E, Wolfe SA, Wang D, Pai AA, Xue W, Gao G, Sontheimer EJ. Ibraheim R, et al. Among authors: pai aa. Nat Commun. 2021 Nov 1;12(1):6267. doi: 10.1038/s41467-021-26518-y. Nat Commun. 2021. PMID: 34725353 Free PMC article.
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, Sena-Esteves M, Pai AA, DiFiglia M, Aronin N, Khvorova A. Alterman JF, et al. Among authors: pai aa. Nat Biotechnol. 2019 Aug;37(8):884-894. doi: 10.1038/s41587-019-0205-0. Epub 2019 Aug 2. Nat Biotechnol. 2019. PMID: 31375812 Free PMC article.
Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.
Didiot MC, Ferguson CM, Ly S, Coles AH, Smith AO, Bicknell AA, Hall LM, Sapp E, Echeverria D, Pai AA, DiFiglia M, Moore MJ, Hayward LJ, Aronin N, Khvorova A. Didiot MC, et al. Among authors: pai aa. Cell Rep. 2018 Sep 4;24(10):2553-2560.e5. doi: 10.1016/j.celrep.2018.07.106. Cell Rep. 2018. PMID: 30184490 Free PMC article.
Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection.
Pai AA, Baharian G, Pagé Sabourin A, Brinkworth JF, Nédélec Y, Foley JW, Grenier JC, Siddle KJ, Dumaine A, Yotova V, Johnson ZP, Lanford RE, Burge CB, Barreiro LB. Pai AA, et al. PLoS Genet. 2016 Sep 30;12(9):e1006338. doi: 10.1371/journal.pgen.1006338. eCollection 2016 Sep. PLoS Genet. 2016. PMID: 27690314 Free PMC article.
Comparative studies of gene regulatory mechanisms.
Pai AA, Gilad Y. Pai AA, et al. Curr Opin Genet Dev. 2014 Dec;29:68-74. doi: 10.1016/j.gde.2014.08.010. Epub 2014 Sep 16. Curr Opin Genet Dev. 2014. PMID: 25215415 Free PMC article. Review.
Controls of nucleosome positioning in the human genome.
Gaffney DJ, McVicker G, Pai AA, Fondufe-Mittendorf YN, Lewellen N, Michelini K, Widom J, Gilad Y, Pritchard JK. Gaffney DJ, et al. Among authors: pai aa. PLoS Genet. 2012;8(11):e1003036. doi: 10.1371/journal.pgen.1003036. Epub 2012 Nov 15. PLoS Genet. 2012. PMID: 23166509 Free PMC article.
Regulatory element copy number differences shape primate expression profiles.
Iskow RC, Gokcumen O, Abyzov A, Malukiewicz J, Zhu Q, Sukumar AT, Pai AA, Mills RE, Habegger L, Cusanovich DA, Rubel MA, Perry GH, Gerstein M, Stone AC, Gilad Y, Lee C. Iskow RC, et al. Among authors: pai aa. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12656-61. doi: 10.1073/pnas.1205199109. Epub 2012 Jul 13. Proc Natl Acad Sci U S A. 2012. PMID: 22797897 Free PMC article.
DNase I sensitivity QTLs are a major determinant of human expression variation.
Degner JF, Pai AA, Pique-Regi R, Veyrieras JB, Gaffney DJ, Pickrell JK, De Leon S, Michelini K, Lewellen N, Crawford GE, Stephens M, Gilad Y, Pritchard JK. Degner JF, et al. Among authors: pai aa. Nature. 2012 Feb 5;482(7385):390-4. doi: 10.1038/nature10808. Nature. 2012. PMID: 22307276 Free PMC article.
Dissecting the regulatory architecture of gene expression QTLs.
Gaffney DJ, Veyrieras JB, Degner JF, Pique-Regi R, Pai AA, Crawford GE, Stephens M, Gilad Y, Pritchard JK. Gaffney DJ, et al. Among authors: pai aa. Genome Biol. 2012 Jan 31;13(1):R7. doi: 10.1186/gb-2012-13-1-r7. Genome Biol. 2012. PMID: 22293038 Free PMC article.