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Year Number of Results
1963 1
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1966 1
1967 3
1968 2
1969 5
1970 2
1971 7
1972 11
1973 7
1974 7
1975 19
1976 23
1977 26
1978 17
1979 27
1980 38
1981 42
1982 41
1983 35
1984 36
1985 44
1986 32
1987 37
1988 33
1989 22
1990 29
1991 27
1992 29
1993 35
1994 17
1995 30
1996 31
1997 51
1998 32
1999 45
2000 83
2001 105
2002 107
2003 136
2004 181
2005 280
2006 492
2007 730
2008 1075
2009 1442
2010 1874
2011 2316
2012 3023
2013 3687
2014 4338
2015 5017
2016 5511
2017 6529
2018 7274
2019 8272
2020 9652
2021 10623
2022 10529
2023 10101
2024 3806

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86,624 results

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Page 1
Autophagy in major human diseases.
Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, Lopez-Otin C, Macleod KF, Madeo F, Martinez J, Meléndez A, Mizushima N, Münz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon HU, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F. Klionsky DJ, et al. EMBO J. 2021 Oct 1;40(19):e108863. doi: 10.15252/embj.2021108863. Epub 2021 Aug 30. EMBO J. 2021. PMID: 34459017 Free PMC article. Review.
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. ...
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interv …
Targeting autophagy in cancer.
Onorati AV, Dyczynski M, Ojha R, Amaravadi RK. Onorati AV, et al. Cancer. 2018 Aug;124(16):3307-3318. doi: 10.1002/cncr.31335. Epub 2018 Apr 19. Cancer. 2018. PMID: 29671878 Free PMC article. Review.
Dysregulated autophagy has implications in health and disease. Specifically, in cancer, autophagy plays a dichotomous role by inhibiting tumor initiation but supporting tumor progression. ...In this review of the literature, the authors present fundamental advances …
Dysregulated autophagy has implications in health and disease. Specifically, in cancer, autophagy plays a dichotomous role by …
Autophagy: renovation of cells and tissues.
Mizushima N, Komatsu M. Mizushima N, et al. Cell. 2011 Nov 11;147(4):728-41. doi: 10.1016/j.cell.2011.10.026. Cell. 2011. PMID: 22078875 Free article. Review.
However, the purpose of autophagy is not the simple elimination of materials, but instead, autophagy serves as a dynamic recycling system that produces new building blocks and energy for cellular renovation and homeostasis. Here we provide a multidisciplinary review …
However, the purpose of autophagy is not the simple elimination of materials, but instead, autophagy serves as a dynamic recyc …
Autophagy: cellular and molecular mechanisms.
Glick D, Barth S, Macleod KF. Glick D, et al. J Pathol. 2010 May;221(1):3-12. doi: 10.1002/path.2697. J Pathol. 2010. PMID: 20225336 Free PMC article. Review.
Thus, autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Autophagy can be either non-selective or selective in the removal of specific organelles, ribosomes and protein aggregates, althou …
Thus, autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell deat …
Autophagy and organelle homeostasis in cancer.
Miller DR, Thorburn A. Miller DR, et al. Dev Cell. 2021 Apr 5;56(7):906-918. doi: 10.1016/j.devcel.2021.02.010. Epub 2021 Mar 8. Dev Cell. 2021. PMID: 33689692 Free PMC article. Review.
Beginning with the earliest studies of autophagy in cancer, there have been indications that autophagy can both promote and inhibit cancer growth and progression; autophagy regulation of organelle homeostasis is similarly complicated. ...Typically, the remova …
Beginning with the earliest studies of autophagy in cancer, there have been indications that autophagy can both promote and in …
Autophagy: Regulator of cell death.
Liu S, Yao S, Yang H, Liu S, Wang Y. Liu S, et al. Cell Death Dis. 2023 Oct 4;14(10):648. doi: 10.1038/s41419-023-06154-8. Cell Death Dis. 2023. PMID: 37794028 Free PMC article. Review.
What are the fine-tuned regulatory mechanisms underlying autophagy-dependent cell death (ADCD) and autophagy-mediated cell death (AMCD)? ...Finally, we discuss autophagy enhancement in the treatment of diseases and offer a new perspective based on the use of …
What are the fine-tuned regulatory mechanisms underlying autophagy-dependent cell death (ADCD) and autophagy-mediated cell dea …
TMEM164 is a new determinant of autophagy-dependent ferroptosis.
Liu J, Liu Y, Wang Y, Li C, Xie Y, Klionsky DJ, Kang R, Tang D. Liu J, et al. Autophagy. 2023 Mar;19(3):945-956. doi: 10.1080/15548627.2022.2111635. Epub 2022 Aug 22. Autophagy. 2023. PMID: 35947500 Free PMC article.
In addition to autophagy's pro-survival effect during nutrient starvation, excessive activation of autophagy machinery can also cause regulated cell death, especially iron-dependent ferroptosis. ...In contrast, the membrane protein ATG9A (autophagy-rel …
In addition to autophagy's pro-survival effect during nutrient starvation, excessive activation of autophagy machinery …
An overview of autophagy: morphology, mechanism, and regulation.
Parzych KR, Klionsky DJ. Parzych KR, et al. Antioxid Redox Signal. 2014 Jan 20;20(3):460-73. doi: 10.1089/ars.2013.5371. Epub 2013 Aug 2. Antioxid Redox Signal. 2014. PMID: 23725295 Free PMC article. Review.
SIGNIFICANCE: Autophagy is a highly conserved eukaryotic cellular recycling process. ...RECENT ADVANCES: Extensive research is currently being done to better understand the process of autophagy. In this review, we describe current knowledge of the morphology, molecu …
SIGNIFICANCE: Autophagy is a highly conserved eukaryotic cellular recycling process. ...RECENT ADVANCES: Extensive research is curren …
Biological Functions of Autophagy Genes: A Disease Perspective.
Levine B, Kroemer G. Levine B, et al. Cell. 2019 Jan 10;176(1-2):11-42. doi: 10.1016/j.cell.2018.09.048. Cell. 2019. PMID: 30633901 Free PMC article. Review.
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes. ...Autophagy selectively targets dysfunctional organelles, intra …
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediat …
Autophagy--a key player in cellular and body metabolism.
Kim KH, Lee MS. Kim KH, et al. Nat Rev Endocrinol. 2014 Jun;10(6):322-37. doi: 10.1038/nrendo.2014.35. Epub 2014 Mar 25. Nat Rev Endocrinol. 2014. PMID: 24663220 Review.
The authors of this Review highlight research findings on the regulation of cellular autophagy by nutrients. They also describe the role of autophagy in various tissues in the regulation of energy metabolism and the development of diseases related to altered metabol …
The authors of this Review highlight research findings on the regulation of cellular autophagy by nutrients. They also describe the r …
86,624 results
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