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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1979 6
1980 1
1981 4
1982 3
1983 1
1984 4
1985 4
1986 1
1987 6
1989 10
1990 5
1991 2
1992 4
1993 1
1994 2
1995 2
1996 5
1997 9
1998 5
1999 5
2000 12
2001 18
2002 23
2003 26
2004 43
2005 73
2006 163
2007 170
2008 276
2009 334
2010 476
2011 526
2012 629
2013 749
2014 961
2015 1016
2016 1137
2017 1322
2018 1347
2019 1571
2020 2090
2021 2363
2022 2205
2023 2073
2024 721

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17,919 results

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Page 1
Autophagy and autophagy-related pathways in cancer.
Debnath J, Gammoh N, Ryan KM. Debnath J, et al. Nat Rev Mol Cell Biol. 2023 Aug;24(8):560-575. doi: 10.1038/s41580-023-00585-z. Epub 2023 Mar 2. Nat Rev Mol Cell Biol. 2023. PMID: 36864290 Free PMC article. Review.
Recent studies have addressed not only the tumour cell intrinsic functions of autophagy, but also the roles of autophagy in the tumour microenvironment and associated immune cells. ...In this Review, we discuss and dissect these different functions of autophagy …
Recent studies have addressed not only the tumour cell intrinsic functions of autophagy, but also the roles of autophagy in th …
Autophagy in major human diseases.
Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, Lopez-Otin C, Macleod KF, Madeo F, Martinez J, Meléndez A, Mizushima N, Münz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon HU, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F. Klionsky DJ, et al. EMBO J. 2021 Oct 1;40(19):e108863. doi: 10.15252/embj.2021108863. Epub 2021 Aug 30. EMBO J. 2021. PMID: 34459017 Free PMC article. Review.
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. ...
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interv …
Targeting autophagy in cancer.
Levy JMM, Towers CG, Thorburn A. Levy JMM, et al. Nat Rev Cancer. 2017 Sep;17(9):528-542. doi: 10.1038/nrc.2017.53. Epub 2017 Jul 28. Nat Rev Cancer. 2017. PMID: 28751651 Free PMC article. Review.
Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has led to the therapeutic targeting of autophagy in cancer to be sometimes viewed as controversi …
Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been …
Targeting autophagy in cancer.
Onorati AV, Dyczynski M, Ojha R, Amaravadi RK. Onorati AV, et al. Cancer. 2018 Aug;124(16):3307-3318. doi: 10.1002/cncr.31335. Epub 2018 Apr 19. Cancer. 2018. PMID: 29671878 Free PMC article. Review.
Dysregulated autophagy has implications in health and disease. Specifically, in cancer, autophagy plays a dichotomous role by inhibiting tumor initiation but supporting tumor progression. ...In this review of the literature, the authors present fundamental advances …
Dysregulated autophagy has implications in health and disease. Specifically, in cancer, autophagy plays a dichotomous role by …
Autophagy: renovation of cells and tissues.
Mizushima N, Komatsu M. Mizushima N, et al. Cell. 2011 Nov 11;147(4):728-41. doi: 10.1016/j.cell.2011.10.026. Cell. 2011. PMID: 22078875 Free article. Review.
However, the purpose of autophagy is not the simple elimination of materials, but instead, autophagy serves as a dynamic recycling system that produces new building blocks and energy for cellular renovation and homeostasis. Here we provide a multidisciplinary review …
However, the purpose of autophagy is not the simple elimination of materials, but instead, autophagy serves as a dynamic recyc …
Autophagy: cellular and molecular mechanisms.
Glick D, Barth S, Macleod KF. Glick D, et al. J Pathol. 2010 May;221(1):3-12. doi: 10.1002/path.2697. J Pathol. 2010. PMID: 20225336 Free PMC article. Review.
Thus, autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Autophagy can be either non-selective or selective in the removal of specific organelles, ribosomes and protein aggregates, althou …
Thus, autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell deat …
Autophagy and organelle homeostasis in cancer.
Miller DR, Thorburn A. Miller DR, et al. Dev Cell. 2021 Apr 5;56(7):906-918. doi: 10.1016/j.devcel.2021.02.010. Epub 2021 Mar 8. Dev Cell. 2021. PMID: 33689692 Free PMC article. Review.
Beginning with the earliest studies of autophagy in cancer, there have been indications that autophagy can both promote and inhibit cancer growth and progression; autophagy regulation of organelle homeostasis is similarly complicated. ...Typically, the remova …
Beginning with the earliest studies of autophagy in cancer, there have been indications that autophagy can both promote and in …
Autophagy: Regulator of cell death.
Liu S, Yao S, Yang H, Liu S, Wang Y. Liu S, et al. Cell Death Dis. 2023 Oct 4;14(10):648. doi: 10.1038/s41419-023-06154-8. Cell Death Dis. 2023. PMID: 37794028 Free PMC article. Review.
What are the fine-tuned regulatory mechanisms underlying autophagy-dependent cell death (ADCD) and autophagy-mediated cell death (AMCD)? ...Finally, we discuss autophagy enhancement in the treatment of diseases and offer a new perspective based on the use of …
What are the fine-tuned regulatory mechanisms underlying autophagy-dependent cell death (ADCD) and autophagy-mediated cell dea …
An overview of autophagy: morphology, mechanism, and regulation.
Parzych KR, Klionsky DJ. Parzych KR, et al. Antioxid Redox Signal. 2014 Jan 20;20(3):460-73. doi: 10.1089/ars.2013.5371. Epub 2013 Aug 2. Antioxid Redox Signal. 2014. PMID: 23725295 Free PMC article. Review.
SIGNIFICANCE: Autophagy is a highly conserved eukaryotic cellular recycling process. ...RECENT ADVANCES: Extensive research is currently being done to better understand the process of autophagy. In this review, we describe current knowledge of the morphology, molecu …
SIGNIFICANCE: Autophagy is a highly conserved eukaryotic cellular recycling process. ...RECENT ADVANCES: Extensive research is curren …
Biological Functions of Autophagy Genes: A Disease Perspective.
Levine B, Kroemer G. Levine B, et al. Cell. 2019 Jan 10;176(1-2):11-42. doi: 10.1016/j.cell.2018.09.048. Cell. 2019. PMID: 30633901 Free PMC article. Review.
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes. ...Autophagy selectively targets dysfunctional organelles, intra …
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediat …
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Searches related to "autophagy"