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86 results
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Biological therapy for non-obstructive azoospermia.
Vij SC, Sabanegh E Jr, Agarwal A. Vij SC, et al. Expert Opin Biol Ther. 2018 Jan;18(1):19-23. doi: 10.1080/14712598.2018.1380622. Epub 2017 Sep 19. Expert Opin Biol Ther. 2018. PMID: 28927307 Review.
AREAS COVERED: This review discusses three of the experimental techniques for restoring fertility in men with NOA: spermatogonial stem cell transplantation, the use of adult and embryonic stem cells to develop mature gametes and gene therapy. .. …
AREAS COVERED: This review discusses three of the experimental techniques for restoring fertility in men with NOA: spermatogonial stem
Human induced pluripotent stem cells and male infertility: an overview of current progress and perspectives.
Fang F, Li Z, Zhao Q, Li H, Xiong C. Fang F, et al. Hum Reprod. 2018 Feb 1;33(2):188-195. doi: 10.1093/humrep/dex369. Hum Reprod. 2018. PMID: 29315416 Free PMC article. Review.
Recently, significant progress has been made in ART for the treatment of male infertility. However, current ART has failed to help infertile patients with non-obstructive azoospermia, unless donor sperm is used. In fact, most couples wish to hav …
Recently, significant progress has been made in ART for the treatment of male infertility. However, current ART has failed to …
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells.
Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, Yang C, Zhai J, Tian R, Chen H, Luo J, Liu N, Deng Z, Lin X, Li N, Fang J, Sun J, Wang C, Zhou Z, Li Z. Zhao L, et al. Nat Commun. 2020 Nov 10;11(1):5683. doi: 10.1038/s41467-020-19414-4. Nat Commun. 2020. PMID: 33173058 Free PMC article.
Here, we profile >80,000 human testicular single-cell transcriptomes from 10 healthy donors spanning the range from infant to adult and 7 NOA patients. ...Furthermore, we find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from i …
Here, we profile >80,000 human testicular single-cell transcriptomes from 10 healthy donors spanning the range from infant …
[Stem cell therapy for non-obstructive azoospermia].
Deng CC, Liu GH. Deng CC, et al. Zhonghua Nan Ke Xue. 2020 Apr;26(4):351-356. Zhonghua Nan Ke Xue. 2020. PMID: 33351304 Review. Chinese.
Spermatogonial stem cells can produce haploid gametes by differentiation but human spermatogonial stem cells are difficult to be cultured in vitro. ...Some progress has been achieved in the treatment of NOA by stem cell t
Spermatogonial stem cells can produce haploid gametes by differentiation but human spermatogonial stem cells
The role of leptin and obesity on male infertility.
Khodamoradi K, Parmar M, Khosravizadeh Z, Kuchakulla M, Manoharan M, Arora H. Khodamoradi K, et al. Curr Opin Urol. 2020 May;30(3):334-339. doi: 10.1097/MOU.0000000000000762. Curr Opin Urol. 2020. PMID: 32205811 Review.
PURPOSE OF REVIEW: Several studies suggest a strong association between leptin, obesity, and infertility with respect to the hypothalamic-pituitary-gonadal (HPG) axis, androgen regulation, and sperm production, but the direct mechanistic association between these is …
PURPOSE OF REVIEW: Several studies suggest a strong association between leptin, obesity, and infertility with respect to the hypothal …
Transcriptome Analysis to Identify Human Spermatogonial Cells from Sertoli Cell-Only Testes.
Shiraishi K, Tabara M, Matsuyama H. Shiraishi K, et al. J Urol. 2020 Apr;203(4):809-816. doi: 10.1097/JU.0000000000000682. Epub 2019 Nov 19. J Urol. 2020. PMID: 31742474
MATERIALS AND METHODS: This study enrolled 20 men with nonobstructive azoospermia with a histological diagnosis of Sertoli cell-only and no germ cells on in vitro fertilization analysis and 5 with obstructive azoospermia and histologically normal sperm …
MATERIALS AND METHODS: This study enrolled 20 men with nonobstructive azoospermia with a histological diagnosis of Sertoli cell
Novel micro-straw for freezing small quantities of human spermatozoa.
Huang C, Gan RX, Zhang H, Zhou WJ, Huang ZH, Jiang SH, Ji XR, Gong F, Fan LQ, Zhu WB. Huang C, et al. Fertil Steril. 2020 Aug;114(2):301-310. doi: 10.1016/j.fertnstert.2020.03.032. Epub 2020 Jul 2. Fertil Steril. 2020. PMID: 32624215
SETTING: Sperm bank. PATIENT(S): Men with severe oligozoospermia or azoospermia undergoing a total of 143 ICSI cycles at the CITIC-Xiangya Hospital of Reproduction and Genetics from June 1, 2015, to June 31, 2019, and 20 donors at the Hunan Province Human
SETTING: Sperm bank. PATIENT(S): Men with severe oligozoospermia or azoospermia undergoing a total of 143 ICSI cycles a …
Germ cell apoptosis and survival in testicular inflammation.
Theas MS. Theas MS. Andrologia. 2018 Dec;50(11):e13083. doi: 10.1111/and.13083. Andrologia. 2018. PMID: 30569649 Review.
Azoospermia is linked to local testicular microenvironment deregulation, with inflammatory cells present in the 15% of testicular biopsies of infertile patients. ...However, clinical implementation is uncertain in cases with a prolonged inflammatory state of
Azoospermia is linked to local testicular microenvironment deregulation, with inflammatory cells present in the 15% of testicu
Spermatogonial stem cell transplantation and male infertility: Current status and future directions.
Forbes CM, Flannigan R, Schlegel PN. Forbes CM, et al. Arab J Urol. 2017 Dec 27;16(1):171-180. doi: 10.1016/j.aju.2017.11.015. eCollection 2018 Mar. Arab J Urol. 2017. PMID: 29713548 Free PMC article. Review.
OBJECTIVE: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future directions, as SSCs show promise as a source for preserving or initiating fertility in otherwise infertile men. MATERIALS AND METHODS: W …
OBJECTIVE: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future dir …
Treatment options for impaired spermatogenesis: germ cell transplantation and stem-cell based therapy.
Neri QV, Takeuchi T, Rosenwaks Z, Palermo GD. Neri QV, et al. Minerva Ginecol. 2009 Aug;61(4):253-9. Minerva Ginecol. 2009. PMID: 19745793 Review.
Fourteen years later, intracytoplasmic sperm injection has been introduced for the treatment of male factor infertility. ...In the past several years, we have attempted to manufacture gametes by inducing haploidization of somatic cells and more recentl …
Fourteen years later, intracytoplasmic sperm injection has been introduced for the treatment of male factor infertility
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