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Table representation of search results timeline featuring number of search results per year.

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2006 3
2007 3
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2012 5
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113 results
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Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells.
Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, Yang C, Zhai J, Tian R, Chen H, Luo J, Liu N, Deng Z, Lin X, Li N, Fang J, Sun J, Wang C, Zhou Z, Li Z. Zhao L, et al. Nat Commun. 2020 Nov 10;11(1):5683. doi: 10.1038/s41467-020-19414-4. Nat Commun. 2020. PMID: 33173058 Free PMC article.
Here, we profile >80,000 human testicular single-cell transcriptomes from 10 healthy donors spanning the range from infant to adult and 7 NOA patients. ...Furthermore, we find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from i …
Here, we profile >80,000 human testicular single-cell transcriptomes from 10 healthy donors spanning the range from infant …
Biological therapy for non-obstructive azoospermia.
Vij SC, Sabanegh E Jr, Agarwal A. Vij SC, et al. Expert Opin Biol Ther. 2018 Jan;18(1):19-23. doi: 10.1080/14712598.2018.1380622. Epub 2017 Sep 19. Expert Opin Biol Ther. 2018. PMID: 28927307 Review.
AREAS COVERED: This review discusses three of the experimental techniques for restoring fertility in men with NOA: spermatogonial stem cell transplantation, the use of adult and embryonic stem cells to develop mature gametes and gene therapy. .. …
AREAS COVERED: This review discusses three of the experimental techniques for restoring fertility in men with NOA: spermatogonial stem …
Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia.
Xie C, Wang W, Tu C, Meng L, Lu G, Lin G, Lu LY, Tan YQ. Xie C, et al. Hum Reprod Update. 2022 Nov 2;28(6):763-797. doi: 10.1093/humupd/dmac024. Hum Reprod Update. 2022. PMID: 35613017 Review.
Aberrant meiotic recombination often leads to gametogenic failure or produces aneuploid gametes resulting in subfertility or infertility, miscarriage or birth defects. OBJECTIVE AND RATIONALE: The goal of this review was to characterize the molecular mechanisms of meiotic …
Aberrant meiotic recombination often leads to gametogenic failure or produces aneuploid gametes resulting in subfertility or infertility …
The role of leptin and obesity on male infertility.
Khodamoradi K, Parmar M, Khosravizadeh Z, Kuchakulla M, Manoharan M, Arora H. Khodamoradi K, et al. Curr Opin Urol. 2020 May;30(3):334-339. doi: 10.1097/MOU.0000000000000762. Curr Opin Urol. 2020. PMID: 32205811 Review.
PURPOSE OF REVIEW: Several studies suggest a strong association between leptin, obesity, and infertility with respect to the hypothalamic-pituitary-gonadal (HPG) axis, androgen regulation, and sperm production, but the direct mechanistic association between these is …
PURPOSE OF REVIEW: Several studies suggest a strong association between leptin, obesity, and infertility with respect to the hypothal …
Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly.
Lu S, Gu Y, Wu Y, Yang S, Li C, Meng L, Yuan W, Jiang T, Zhang X, Li Y, Wang C, Liu M, Ye L, Guo X, Shen H, Yang X, Tan Y, Hu Z. Lu S, et al. Cell Discov. 2021 Nov 16;7(1):110. doi: 10.1038/s41421-021-00327-5. Cell Discov. 2021. PMID: 34782613 Free PMC article.
We next generated Wdr63-knockout (Wdr63-KO) mice through the CRISPR-Cas9 technology. Remarkably, Wdr63-KO induced decreased sperm number, abnormal flagellar morphology and male infertility. ...Furthermore, WDR63-associated male infertility in human and …
We next generated Wdr63-knockout (Wdr63-KO) mice through the CRISPR-Cas9 technology. Remarkably, Wdr63-KO induced decreased sperm num …
[Stem cell therapy for non-obstructive azoospermia].
Deng CC, Liu GH. Deng CC, et al. Zhonghua Nan Ke Xue. 2020 Apr;26(4):351-356. Zhonghua Nan Ke Xue. 2020. PMID: 33351304 Review. Chinese.
Spermatogonial stem cells can produce haploid gametes by differentiation but human spermatogonial stem cells are difficult to be cultured in vitro. ...Some progress has been achieved in the treatment of NOA by stem cell t …
Spermatogonial stem cells can produce haploid gametes by differentiation but human spermatogonial stem cells …
Spermatogonial stem cell transplantation and male infertility: Current status and future directions.
Forbes CM, Flannigan R, Schlegel PN. Forbes CM, et al. Arab J Urol. 2017 Dec 27;16(1):171-180. doi: 10.1016/j.aju.2017.11.015. eCollection 2018 Mar. Arab J Urol. 2017. PMID: 29713548 Free PMC article. Review.
OBJECTIVE: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future directions, as SSCs show promise as a source for preserving or initiating fertility in otherwise infertile men. MATERIALS AND METHODS: W …
OBJECTIVE: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future dir …
Human induced pluripotent stem cells and male infertility: an overview of current progress and perspectives.
Fang F, Li Z, Zhao Q, Li H, Xiong C. Fang F, et al. Hum Reprod. 2018 Feb 1;33(2):188-195. doi: 10.1093/humrep/dex369. Hum Reprod. 2018. PMID: 29315416 Free PMC article. Review.
Recently, significant progress has been made in ART for the treatment of male infertility. However, current ART has failed to help infertile patients with non-obstructive azoospermia, unless donor sperm is used. In fact, most couples wish to hav …
Recently, significant progress has been made in ART for the treatment of male infertility. However, current ART has failed to …
Germ Cell Derivation from Pluripotent Stem Cells for Understanding In Vitro Gametogenesis.
Hong TK, Song JH, Lee SB, Do JT. Hong TK, et al. Cells. 2021 Jul 26;10(8):1889. doi: 10.3390/cells10081889. Cells. 2021. PMID: 34440657 Free PMC article. Review.
Assisted reproductive technologies (ARTs) have developed considerably in recent years; however, they cannot rectify germ cell aplasia, such as non-obstructive azoospermia (NOA) and oocyte maturation failure syndrome. In vitro gametogenesis is a promising technology …
Assisted reproductive technologies (ARTs) have developed considerably in recent years; however, they cannot rectify germ cell aplasia …
Potential use of stem cells for fertility preservation.
Gauthier-Fisher A, Kauffman A, Librach CL. Gauthier-Fisher A, et al. Andrology. 2020 Jul;8(4):862-878. doi: 10.1111/andr.12713. Epub 2019 Oct 29. Andrology. 2020. PMID: 31560823 Free article. Review.
In men, non-obstructive azoospermia (NOA) results from defects in the spermatogenic process that can be attributed to spermatogonial stem cells (SSC) or their niche, or both. ...OBJECTIVE: Here, we review the benefits and challenges for three types of stem …
In men, non-obstructive azoospermia (NOA) results from defects in the spermatogenic process that can be attributed to spermatogonial …
113 results