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151 results

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Page 1
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells.
Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, Yang C, Zhai J, Tian R, Chen H, Luo J, Liu N, Deng Z, Lin X, Li N, Fang J, Sun J, Wang C, Zhou Z, Li Z. Zhao L, et al. Nat Commun. 2020 Nov 10;11(1):5683. doi: 10.1038/s41467-020-19414-4. Nat Commun. 2020. PMID: 33173058 Free PMC article.
Here, we profile >80,000 human testicular single-cell transcriptomes from 10 healthy donors spanning the range from infant to adult and 7 NOA patients. ...Furthermore, we find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from i …
Here, we profile >80,000 human testicular single-cell transcriptomes from 10 healthy donors spanning the range from infant …
Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia.
Xie C, Wang W, Tu C, Meng L, Lu G, Lin G, Lu LY, Tan YQ. Xie C, et al. Hum Reprod Update. 2022 Nov 2;28(6):763-797. doi: 10.1093/humupd/dmac024. Hum Reprod Update. 2022. PMID: 35613017 Review.
Aberrant meiotic recombination often leads to gametogenic failure or produces aneuploid gametes resulting in subfertility or infertility, miscarriage or birth defects. OBJECTIVE AND RATIONALE: The goal of this review was to characterize the molecular mechanisms of meiotic …
Aberrant meiotic recombination often leads to gametogenic failure or produces aneuploid gametes resulting in subfertility or infertility …
The Genetics of Female and Male Infertility.
Tüttelmann F, Wyrwoll MJ, Steingröver J, Wieacker P. Tüttelmann F, et al. Dtsch Arztebl Int. 2025 Mar 7;122(5):115-120. doi: 10.3238/arztebl.m2024.0259. Dtsch Arztebl Int. 2025. PMID: 39836465 Free PMC article. Review.
BACKGROUND: An estimated 17% of all couples worldwide are involuntarily childless (infertile). The clinically identifiable causes of infertility can be found in the male or female partner or in both. ...Klinefelter syndrome and deletions of the Y-chromosomal azoo …
BACKGROUND: An estimated 17% of all couples worldwide are involuntarily childless (infertile). The clinically identifiable causes of …
Cell-Based Therapy Approaches in Treatment of Non-obstructive Azoospermia.
Roshandel E, Mehravar M, Nikoonezhad M, Alizadeh AM, Majidi M, Salimi M, Hajifathali A. Roshandel E, et al. Reprod Sci. 2023 May;30(5):1482-1494. doi: 10.1007/s43032-022-01115-6. Epub 2022 Nov 15. Reprod Sci. 2023. PMID: 36380137 Free PMC article. Review.
The rate of infertility has globally increased in recent years for a variety of reasons. One of the main causes of infertility in men is azoospermia that is defined by the absence of sperm in the ejaculate and classified into two categories: obstructiv …
The rate of infertility has globally increased in recent years for a variety of reasons. One of the main causes of infertility …
Biological therapy for non-obstructive azoospermia.
Vij SC, Sabanegh E Jr, Agarwal A. Vij SC, et al. Expert Opin Biol Ther. 2018 Jan;18(1):19-23. doi: 10.1080/14712598.2018.1380622. Epub 2017 Sep 19. Expert Opin Biol Ther. 2018. PMID: 28927307 Review.
AREAS COVERED: This review discusses three of the experimental techniques for restoring fertility in men with NOA: spermatogonial stem cell transplantation, the use of adult and embryonic stem cells to develop mature gametes and gene therapy. .. …
AREAS COVERED: This review discusses three of the experimental techniques for restoring fertility in men with NOA: spermatogonial stem …
Enhancing Spermatogenesis in Non-obstructive Azoospermia Through Mesenchymal Stem Cell Therapy22.
Margiana R. Margiana R. Curr Stem Cell Res Ther. 2024;19(11):1429-1441. doi: 10.2174/011574888X283311231226081845. Curr Stem Cell Res Ther. 2024. PMID: 38243988 Review.
Stem cells hold great promise as novel and encouraging therapeutic tools in the treatment of degenerative disorders due to their differentiation potential while maintaining the capability to self-renewal and their unlimited ability to divide and regenerate ti …
Stem cells hold great promise as novel and encouraging therapeutic tools in the treatment of degenerative disorders due …
[Stem cell therapy for non-obstructive azoospermia].
Deng CC, Liu GH. Deng CC, et al. Zhonghua Nan Ke Xue. 2020 Apr;26(4):351-356. Zhonghua Nan Ke Xue. 2020. PMID: 33351304 Review. Chinese.
Non-obstructive azoospermia (NOA) is an important factor that causes male infertility. Stem cells are a group of cells capable of self-renewal and multi-directional differentiation, and embryonic stem cells and induced pluripotent …
Non-obstructive azoospermia (NOA) is an important factor that causes male infertility. Stem cells are a group of …
Human induced pluripotent stem cells and male infertility: an overview of current progress and perspectives.
Fang F, Li Z, Zhao Q, Li H, Xiong C. Fang F, et al. Hum Reprod. 2018 Feb 1;33(2):188-195. doi: 10.1093/humrep/dex369. Hum Reprod. 2018. PMID: 29315416 Free PMC article. Review.
Recently, significant progress has been made in ART for the treatment of male infertility. However, current ART has failed to help infertile patients with non-obstructive azoospermia, unless donor sperm is used. In fact, most couples wish to hav …
Recently, significant progress has been made in ART for the treatment of male infertility. However, current ART has failed to …
Spermatogonial stem cell transplantation and male infertility: Current status and future directions.
Forbes CM, Flannigan R, Schlegel PN. Forbes CM, et al. Arab J Urol. 2017 Dec 27;16(1):171-180. doi: 10.1016/j.aju.2017.11.015. eCollection 2018 Mar. Arab J Urol. 2017. PMID: 29713548 Free PMC article. Review.
OBJECTIVE: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future directions, as SSCs show promise as a source for preserving or initiating fertility in otherwise infertile men. MATERIALS AND METHODS: W …
OBJECTIVE: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future dir …
[Fertility and fertility preservation in men].
Hoffmann I, Greither T, Behre HM. Hoffmann I, et al. Dermatologie (Heidelb). 2023 Jul;74(7):490-495. doi: 10.1007/s00105-023-05167-w. Epub 2023 Jun 7. Dermatologie (Heidelb). 2023. PMID: 37286872 Review. German.
Fertility preservation is of high importance for patients prior to treatment that can impair fertility. The individual risk of becoming infertile after a fertility-reducing therapy depends on the type and duration of therapy, surgical technique, dose a …
Fertility preservation is of high importance for patients prior to treatment that can impair fertility. The individual risk of becomi …
151 results