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2020 1
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2022 717
2023 234

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Page 1
Computational redesign of Beta-27 Fab with substantially better predicted binding affinity to the SARS-CoV-2 Omicron variant than human ACE2 receptor.
Treewattanawong W, Sitthiyotha T, Chunsrivirot S. Treewattanawong W, et al. Sci Rep. 2023 Sep 19;13(1):15476. doi: 10.1038/s41598-023-42442-1. Sci Rep. 2023. PMID: 37726329 Free PMC article.
During the COVID-19 pandemic, SARS-CoV-2 has caused large numbers of morbidity and mortality, and the Omicron variant (B.1.1.529) was an important variant of concern. To enter human cells, the receptor-binding domain (RBD) of the S1 subunit of SARS-CoV …
During the COVID-19 pandemic, SARS-CoV-2 has caused large numbers of morbidity and mortality, and the Omicron variant (B.1. …
Efficacy of a bivalent (D614 + B.1.351) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, parallel, randomised, modified double-blind, placebo-controlled trial.
Dayan GH, Rouphael N, Walsh SR, Chen A, Grunenberg N, Allen M, Antony J, Asante KP, Bhate AS, Beresnev T, Bonaparte MI, Celle M, Ceregido MA, Corey L, Dobrianskyi D, Fu B, Grillet MH, Keshtkar-Jahromi M, Juraska M, Kee JJ, Kibuuka H, Koutsoukos M, Masotti R, Michael NL, Neuzil KM, Reynales H, Robb ML, Villagómez Martínez SM, Sawe F, Schuerman L, Tong T, Treanor J, Wartel TA, Diazgranados CA, Chicz RM, Gurunathan S, Savarino S, Sridhar S; VAT00008 Study Team. Dayan GH, et al. Lancet Respir Med. 2023 Sep 13:S2213-2600(23)00263-1. doi: 10.1016/S2213-2600(23)00263-1. Online ahead of print. Lancet Respir Med. 2023. PMID: 37716365
This study aimed to describe the clinical efficacy and safety of a bivalent SARS-CoV-2 recombinant protein vaccine as a two-injection primary series during a period of circulation of the omicron (B.1.1.529) variant. METHODS: We conducted a phase 3, par …
This study aimed to describe the clinical efficacy and safety of a bivalent SARS-CoV-2 recombinant protein vaccine as a two-injection primar …
A disintegrin and metalloproteinase domain 9 facilitates SARS-CoV-2 entry into cells with low ACE2 expression.
Melano I, Cheng WC, Kuo LL, Liu YM, Chou YC, Hung MC, Lai MMC, Sher YP, Su WC. Melano I, et al. Microbiol Spectr. 2023 Sep 15:e0385422. doi: 10.1128/spectrum.03854-22. Online ahead of print. Microbiol Spectr. 2023. PMID: 37713503 Free article.
The knockdown of ADAM9 decreased the infectivity of the variants of concern tested-B.1.1.7 (alpha), B.1.617.2 (delta), and B.1.1.529 (omicron). Furthermore, mechanistic studies indicated that ADAM9 is involved in the …
The knockdown of ADAM9 decreased the infectivity of the variants of concern tested-B.1.1.7 (alpha), B.1.6 …
Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice.
Rizvi ZA, Dandotiya J, Sadhu S, Khatri R, Singh J, Singh V, Adhikari N, Sharma K, Das V, Pandey AK, Das B, Medigeshi G, Mani S, Bhatnagar S, Samal S, Pandey AK, Garg PK, Awasthi A. Rizvi ZA, et al. Commun Biol. 2023 Sep 13;6(1):935. doi: 10.1038/s42003-023-05263-6. Commun Biol. 2023. PMID: 37704701 Free PMC article.
Our data show that intranasal infection of BA.5 in hACE2.Tg mice resulted in attenuated pulmonary infection and pathology with diminished COVID-19-induced clinical and pathological manifestations. BA.5, similar to Omicron (B.1.1.529), infection led to …
Our data show that intranasal infection of BA.5 in hACE2.Tg mice resulted in attenuated pulmonary infection and pathology with diminished CO …
Antibody correlates of protection against Delta infection after vaccination: A nested case-control within the UK-based SIREN study.
Atti A, Insalata F, Carr EJ, Otter AD, Foulkes S, Wu MY; Crick COVID Immunity Pipeline; Cole MJ, Linley E, Semper A, Brooks T, Hopkins S, Charlett A, Beale R, Hall V; SIREN Study Group. Atti A, et al. J Infect. 2023 Sep 7:S0163-4453(23)00380-8. doi: 10.1016/j.jinf.2023.07.007. Online ahead of print. J Infect. 2023. PMID: 37689394 Free article.
OBJECTIVES: To investigate serological correlates of protection against SARS-CoV-2 B.1.617.2 (Delta) infection after two vaccinations. METHODS: We performed a case-control study, where cases were Delta infections after the second vaccine dose and controls were vacci …
OBJECTIVES: To investigate serological correlates of protection against SARS-CoV-2 B.1.617.2 (Delta) infection after two vacci …
Efficacy and safety of Huashi Baidu granule plus Nirmatrelvir-Ritonavir combination therapy in patients with high-risk factors infected with Omicron (B.1.1.529): A multi-arm single-center, open-label, randomized controlled trial.
Yu Z, Zheng Y, Chen B, Lv J, Zhu X, Shang B, Xv Y, Tao R, Yang Y, Cong J, Li D, Wu H, Qv W, Zhang X, Xv C, Feng H, Yuan W, Gao Y. Yu Z, et al. Phytomedicine. 2023 Aug 16;120:155025. doi: 10.1016/j.phymed.2023.155025. Online ahead of print. Phytomedicine. 2023. PMID: 37639813
RESULTS: Of 312 participants, 85 (82%) of 104 in combination therapy, 71 (68%) of 105 in HSBD monotherapy, and 73 (71%) of 103 in Paxlovid monotherapy had a primary outcome event. The hazard ratios of primary outcome were 1.37 (95% CI 1.03 - 1.84, p = 0.012) …
RESULTS: Of 312 participants, 85 (82%) of 104 in combination therapy, 71 (68%) of 105 in HSBD monotherapy, and 73 (71%) of 103 in Paxlovid m …
The effect of SARS-CoV-2 variants on the plasma oxylipins and PUFAs of COVID-19 patients.
Biagini D, Oliveri P, Baj A, Gasperina DD, Ferrante FD, Lomonaco T, Ghimenti S, Lenzi A, Bonini A, Vivaldi F, Oger C, Galano JM, Balas L, Durand T, Maggi F, Di Francesco F. Biagini D, et al. Prostaglandins Other Lipid Mediat. 2023 Aug 24;169:106770. doi: 10.1016/j.prostaglandins.2023.106770. Online ahead of print. Prostaglandins Other Lipid Mediat. 2023. PMID: 37633481 Review.
Here, we compare the plasma profiles of thirty-seven oxylipins and four PUFAs in subjects infected with Wild-type, Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) variants. ...
Here, we compare the plasma profiles of thirty-seven oxylipins and four PUFAs in subjects infected with Wild-type, Alpha (B.1. …
Efficacy, Pharmacokinetics, and Toxicity Profiles of a Broad Anti-SARS-CoV-2 Neutralizing Antibody.
Godínez-Palma S, González-González E, Ramírez-Villedas F, Garzón-Guzmán C, Vallejo-Castillo L, Carballo-Uicab G, Marcelín-Jiménez G, Batista D, Pérez-Tapia SM, Almagro JC. Godínez-Palma S, et al. Viruses. 2023 Aug 14;15(8):1733. doi: 10.3390/v15081733. Viruses. 2023. PMID: 37632075 Free PMC article.
We show here that IgG-A7 protected 100% of the transgenic mice infected with Delta (B.1.617.2) and Omicron (B.1.1.529) at doses of 0.5 and 5 mg/kg, respectively. In addition, we studied the pharmacokinetic (PK) profile and toxicology (Tox …
We show here that IgG-A7 protected 100% of the transgenic mice infected with Delta (B.1.617.2) and Omicron (B.1. …
A study on the effect of natural products against the transmission of B.1.1.529 Omicron.
Alkafaas SS, Abdallah AM, Hussien AM, Bedair H, Abdo M, Ghosh S, Elkafas SS, Apollon W, Saki M, Loutfy SA, Onyeaka H, Hessien M. Alkafaas SS, et al. Virol J. 2023 Aug 25;20(1):191. doi: 10.1186/s12985-023-02160-6. Virol J. 2023. PMID: 37626376 Free PMC article. Review.
However, a large population is still unvaccinated, leading to the emergence of mutated strains like alpha, beta, delta, and B.1.1.529 (Omicron). Recent reports from the World Health Organization raised concerns about the Omicron variant, which emerged …
However, a large population is still unvaccinated, leading to the emergence of mutated strains like alpha, beta, delta, and B.1 …
Profiling humoral responses to COVID-19 immunization in Kawasaki disease using SARS-CoV-2 variant protein microarrays.
Keskin BB, Liu SF, Du PX, Tsai PS, Ho TS, Su WY, Lin PC, Shih HC, Weng KP, Yang KD, Huang YH, Kuo KC, Syu GD, Kuo HC. Keskin BB, et al. Analyst. 2023 Aug 23. doi: 10.1039/d3an00802a. Online ahead of print. Analyst. 2023. PMID: 37610260
Binding antibodies against spikes were lower in the KD subjects with 1-dose of BNT162b2, and mean differences were significant for the P.1 S-protein (non-KD-KD, 3401; 95% CI, 289.0 to 6512; P = 0.0252), B.1.617.2 S-protein (non-KD-KD, 4652; 95% CI, 215 …
Binding antibodies against spikes were lower in the KD subjects with 1-dose of BNT162b2, and mean differences were significant for th …
936 results