A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis.
J Exp Med. 2019 Mar 4;216(3):556-570. doi: 10.1084/jem.20181776. Epub 2019 Feb 20.
J Exp Med. 2019.
PMID: 30787033
Free PMC article.
We observed that Mtb-induced macrophage necrosis is associated with reduced levels of glutathione and glutathione peroxidase-4 (Gpx4), along with increased free iron, mitochondrial superoxide, and lipid peroxidation, all of which are important hallmarks of fe …
We observed that Mtb-induced macrophage necrosis is associated with reduced levels of glutathione and glutathione perox …