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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1981 1
1983 2
1984 2
1986 4
1987 3
1988 3
1989 4
1990 2
1991 7
1992 13
1993 7
1994 18
1995 18
1996 23
1997 10
1998 17
1999 19
2000 22
2001 32
2002 25
2003 36
2004 34
2005 30
2006 25
2007 38
2008 29
2009 42
2010 37
2011 44
2012 54
2013 58
2014 59
2015 75
2016 82
2017 68
2018 87
2019 93
2020 98
2021 74
2022 34
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1,172 results
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Page 1
A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis.
Amaral EP, Costa DL, Namasivayam S, Riteau N, Kamenyeva O, Mittereder L, Mayer-Barber KD, Andrade BB, Sher A. Amaral EP, et al. J Exp Med. 2019 Mar 4;216(3):556-570. doi: 10.1084/jem.20181776. Epub 2019 Feb 20. J Exp Med. 2019. PMID: 30787033 Free PMC article.
We observed that Mtb-induced macrophage necrosis is associated with reduced levels of glutathione and glutathione peroxidase-4 (Gpx4), along with increased free iron, mitochondrial superoxide, and lipid peroxidation, all of which are important hallmarks of fe …
We observed that Mtb-induced macrophage necrosis is associated with reduced levels of glutathione and glutathione perox …
Role of Glutathione in Cancer: From Mechanisms to Therapies.
Kennedy L, Sandhu JK, Harper ME, Cuperlovic-Culf M. Kennedy L, et al. Biomolecules. 2020 Oct 9;10(10):1429. doi: 10.3390/biom10101429. Biomolecules. 2020. PMID: 33050144 Free PMC article. Review.
Glutathione (GSH) is the most abundant non-protein thiol present at millimolar concentrations in mammalian tissues. ...Although in healthy cells it is crucial for the removal and detoxification of carcinogens, elevated GSH levels in tumor cells are associated with t …
Glutathione (GSH) is the most abundant non-protein thiol present at millimolar concentrations in mammalian tissues. ...Although in he …
Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial.
Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M, Jafari P, Akbari H, Taghizadeh M, Memarzadeh MR, Asemi Z, Esmaillzadeh A. Akkasheh G, et al. Nutrition. 2016 Mar;32(3):315-20. doi: 10.1016/j.nut.2015.09.003. Epub 2015 Sep 28. Nutrition. 2016. PMID: 26706022 Clinical Trial.
Additionally, taking probiotics resulted in a significant rise in plasma total glutathione levels (1.8 83.1 vs. -106.8 190.7 mumol/L, P = 0.02) compared with the placebo. We did not find any significant change in fasting plasma glucose, homeostatic model assessment …
Additionally, taking probiotics resulted in a significant rise in plasma total glutathione levels (1.8 83.1 vs. -106.8 190.7 m …
Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis.
Cao L, Wu G, Zhu J, Tan Z, Shi D, Wu X, Tang M, Li Z, Hu Y, Zhang S, Yu R, Mo S, Wu J, Song E, Li M, Song L, Li J. Cao L, et al. Nat Commun. 2019 Aug 21;10(1):3761. doi: 10.1038/s41467-019-11696-7. Nat Commun. 2019. PMID: 31434880 Free PMC article.
Treatment with OICR-9429, a small-molecule antagonist of the WDR5-MLL interaction, inhibits the beta-catenin/JDP2/PRMT5 complex-reestablished GSH metabolism, leading to a lethal increase in the already-elevated levels of ROS in the genotoxic-agent treated cancer cells. The …
Treatment with OICR-9429, a small-molecule antagonist of the WDR5-MLL interaction, inhibits the beta-catenin/JDP2/PRMT5 complex-reestablishe …
Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function.
Sinha R, Sinha I, Calcagnotto A, Trushin N, Haley JS, Schell TD, Richie JP Jr. Sinha R, et al. Eur J Clin Nutr. 2018 Jan;72(1):105-111. doi: 10.1038/ejcn.2017.132. Epub 2017 Aug 30. Eur J Clin Nutr. 2018. PMID: 28853742 Free PMC article.
BACKGROUND/OBJECTIVES: Glutathione (GSH) is the most abundant endogenous antioxidant and a critical regulator of oxidative stress. Maintenance of optimal tissues for GSH levels may be an important strategy for the prevention of oxidative stress-related diseases. ...
BACKGROUND/OBJECTIVES: Glutathione (GSH) is the most abundant endogenous antioxidant and a critical regulator of oxidative stress. Ma …
MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis.
Floros KV, Cai J, Jacob S, Kurupi R, Fairchild CK, Shende M, Coon CM, Powell KM, Belvin BR, Hu B, Puchalapalli M, Ramamoorthy S, Swift K, Lewis JP, Dozmorov MG, Glod J, Koblinski JE, Boikos SA, Faber AC. Floros KV, et al. Cancer Res. 2021 Apr 1;81(7):1896-1908. doi: 10.1158/0008-5472.CAN-20-1641. Epub 2021 Jan 22. Cancer Res. 2021. PMID: 33483374
This dependence creates a marked vulnerability to targeting the system Xc-/glutathione (GSH) pathway with ferroptosis inducers. This reliance can be exploited through therapy with FDA-approved rheumatoid arthritis drugs sulfasalazine (SAS) and auranofin: in MYCN-amplified, …
This dependence creates a marked vulnerability to targeting the system Xc-/glutathione (GSH) pathway with ferroptosis inducers. This …
Pseudomonas aeruginosa in cystic fibrosis: pathogenesis and persistence.
Davies JC. Davies JC. Paediatr Respir Rev. 2002 Jun;3(2):128-34. doi: 10.1016/s1526-0550(02)00003-3. Paediatr Respir Rev. 2002. PMID: 12297059 Review.
These include abnormalities of airway surface liquid leading to impaired mucociliary clearance or malfunction of antibacterial peptides, increased availability of bacterial receptors, reduced ingestion of pathogens by CF cells and impaired defence related to low levels of …
These include abnormalities of airway surface liquid leading to impaired mucociliary clearance or malfunction of antibacterial peptides, inc …
Therapeutic concentrations of calcineurin inhibitors do not deregulate glutathione redox balance in human renal proximal tubule cells.
Ramazani Y, Knops N, Berlingerio SP, Adebayo OC, Lismont C, Kuypers DJ, Levtchenko E, van den Heuvel LP, Fransen M. Ramazani Y, et al. PLoS One. 2021 Apr 30;16(4):e0250996. doi: 10.1371/journal.pone.0250996. eCollection 2021. PLoS One. 2021. PMID: 33930094 Free PMC article.
Several studies have reported oxidative stress as an important mediator of CNI-associated nephrotoxicity in response to CNI exposure in different available proximal tubule cell models. However, former models often made use of supra-therapeutic levels of tissue drug exposur …
Several studies have reported oxidative stress as an important mediator of CNI-associated nephrotoxicity in response to CNI exposure in diff …
Glutathione and infection.
Morris D, Khurasany M, Nguyen T, Kim J, Guilford F, Mehta R, Gray D, Saviola B, Venketaraman V. Morris D, et al. Biochim Biophys Acta. 2013 May;1830(5):3329-49. doi: 10.1016/j.bbagen.2012.10.012. Epub 2012 Oct 23. Biochim Biophys Acta. 2013. PMID: 23089304 Review.
BACKGROUND: The tripeptide gamma-glutamylcysteinylglycine or glutathione (GSH) has demonstrated protective abilities against the detrimental effects of oxidative stress within the human body, as well as protection against infection by exogenous microbial organisms. …
BACKGROUND: The tripeptide gamma-glutamylcysteinylglycine or glutathione (GSH) has demonstrated protective abilities against the detr …
Glutathione catabolism by Treponema denticola impacts its pathogenic potential.
Chu L, Wu Y, Xu X, Phillips L, Kolodrubetz D. Chu L, et al. Anaerobe. 2020 Apr;62:102170. doi: 10.1016/j.anaerobe.2020.102170. Epub 2020 Feb 7. Anaerobe. 2020. PMID: 32044394 Free PMC article.
This bacterium is one of two periodontal pathogens that have been shown to have a complete three step enzymatic pathway (GTSP) that catabolizes glutathione to H(2)S. This pathway may contribute to the tissue pathology seen in periodontitis since diseased periodontal …
This bacterium is one of two periodontal pathogens that have been shown to have a complete three step enzymatic pathway (GTSP) that cataboli …
1,172 results