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Page 1
Author Correction: Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.
Sanchez-Garcia MA, Sadiku P, Ortmann BM, Wit N, Negishi Y, Coelho P, Zhang A, Pednekar C, Howden AJM, Griffith DM, Seear R, Kindrick JD, Mengede J, Cooper G, Morrison T, Watts ER, Shimeld BT, Reyes L, Mirchandani AS, Arienti S, Xu X, Thomson A, Brenes AJ, Turton HA, Dowey R, Hull RC, Davidson-Smith H, McLaren A, Deans A, Choudhury G, Doverman K, Hope D, Vick O, Woodhead A, Petrie I, Green S, Rzechorzek NM, Turtle L, Openshaw PJM, Semple MG; PHOSP-COVID Study Collaborative Group; Sproul D, Baillie JK, Thompson AAR, Mole DR, von Kriegsheim A, Whyte MKB, Mhlanga MM, Nathan JA, Walmsley SR. Sanchez-Garcia MA, et al. Among authors: baillie jk. Nat Immunol. 2025 Dec 1. doi: 10.1038/s41590-025-02380-8. Online ahead of print. Nat Immunol. 2025. PMID: 41326670 No abstract available.
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals.
Turnbull ML, Wang Y, Clare S, Lieber G, Williams SL, Noerenberg M, Alexander AJT, Clohisey Hendry S, Stewart DG, Hughes J, Swingler S, Lytras S, Davies EL, Harcourt K, Smollett K, Pinto RM, Lee HM, Gaunt ER, Loney C, Jung JS, Lyons PA, Kapczynski DR, Hutchinson E, da Silva Filipe A, Taubenberger JK, Rihn SJ, Baillie JK, Fodor E, Castello A, Smith KGC, Digard P, Wilson SJ. Turnbull ML, et al. Among authors: baillie jk. Science. 2025 Nov 27;390(6776):eadq4691. doi: 10.1126/science.adq4691. Epub 2025 Nov 27. Science. 2025. PMID: 41308154
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.
Sanchez-Garcia MA, Sadiku P, Ortmann BM, Wit N, Negishi Y, Coelho P, Zhang A, Pednekar C, Howden AJM, Griffith DM, Seear R, Kindrick JD, Mengede J, Cooper G, Morrison T, Watts ER, Shimeld BT, Reyes L, Mirchandani AS, Arienti S, Xu X, Thomson A, Brenes AJ, Turton HA, Dowey R, Hull RC, Davidson-Smith H, McLaren A, Deans A, Choudhury G, Doverman K, Hope D, Vick O, Woodhead A, Petrie I, Green S, Rzechorzek NM, Turtle L, Openshaw PJM, Semple MG; PHOSP-COVID Study Collaborative Group; Sproul D, Baillie JK, Thompson AAR, Mole DR, von Kriegsheim A, Whyte MKB, Mhlanga MM, Nathan JA, Walmsley SR. Sanchez-Garcia MA, et al. Among authors: baillie jk. Nat Immunol. 2025 Nov;26(11):1903-1915. doi: 10.1038/s41590-025-02301-9. Epub 2025 Oct 28. Nat Immunol. 2025. PMID: 41152617 Free PMC article.
Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report [Internet].
Reddy K, Aggarwal N, Alipanah-Lechner N, Annane D, Antcliffe DB, Babalis D, Baillie JK, Beane A, Bos LDJ, Burrell A, Calfee CS, Cano-Gamez K, Cornelius VR, Cross M, Davenport E, del Sorbo L, Esserman L, Fan E, Fanelli V, Ferguson ND, Clark Files D, Fisser C, Fujitani S, Goligher EC, Gordon AC, Grasselli G, Hamilton F, Haniffa R, Haren A, Harvey DJR, Hays LM, Heath A, Heming N, Herold S, Hicks T, Ichihara N, Jaiswal V, Kataoka J, Knight JC, Lawler PR, Liu K, Marshall JC, Maslove DM, Matthay MA, McAuley DF, Meyer NJ, Millar JA, Müller-Redetzky H, Nichol A, Norrie J, Ostermann M, Owen A, O’Kane CM, Parekh D, Phillips R, Richards D, Rochwerg B, Rostron AJ, Saito H, Samanta RJ, Scaravilli V, Self W, Shankar-Hari M, Simpson AJ, Sinha P, Smit MR, Stewart J, Taylor Thompson B, Vadász I, Waddingham E, Webb S, Wheeler G, Martin Witzenrath D, Wurfel MM, Martin TR. Reddy K, et al. Among authors: baillie jk. Southampton (UK): National Institute for Health and Care Research; 2025 Jul 30. Southampton (UK): National Institute for Health and Care Research; 2025 Jul 30. PMID: 40854066 Free Books & Documents. Review.
Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.
Walsh TS, Parker RA, Aitken LM, McKenzie CA, Emerson L, Boyd J, Macdonald A, Beveridge G, Giddings A, Hope D, Irvine S, Tuck S, Lone NI, Kydonaki K, Norrie J, Brealey D, Antcliffe D, Reay M, Williams A, Bewley J, Creagh-Brown B, McAuley DF, Dark P, Wise MP, Gordon AC, Perkins GD, Reade MC, Blackwood B, MacLullich A, Glen R, Page VJ, Weir CJ; A2B Trial Investigators. Walsh TS, et al. JAMA. 2025 Jul 1;334(1):32-45. doi: 10.1001/jama.2025.7200. JAMA. 2025. PMID: 40388916 Free PMC article. Clinical Trial.
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination.
Chen JL, Wang B, Lu Y, Antoun E, Bird O, Drennan PG, Yin Z, Liu G, Yao X, Pidoux M, Bates A, Jayathilaka D, Wang J, Angus B, Beer S, Espinosa A, Baillie JK, Semple MG; ISARIC4C Investigators; Rostron T, Waugh C, Sopp P, Knight JC, Fullerton JN, Coles M, Smith GL, Mentzer AJ, Peng Y, Dong T. Chen JL, et al. Among authors: baillie jk. Nat Commun. 2025 May 10;16(1):4362. doi: 10.1038/s41467-025-59370-5. Nat Commun. 2025. PMID: 40348752 Free PMC article.
The tear production of tecovirimat in a single hospitalized mpox patient: a pharmacokinetic analysis.
Woolley SD, Duru I, Pagano L, Lester R, Devine K, Ahmad S, Huq R, Marshall S, McLaughlan D, Lavery M, Challenger E, Else LJ, Semple MG, Kaye S, Khoo SH, Beadsworth MBJ; Airborne HCID Network and ISARIC4C Investigator. Woolley SD, et al. J Antimicrob Chemother. 2025 May 2;80(5):1455-1457. doi: 10.1093/jac/dkaf071. J Antimicrob Chemother. 2025. PMID: 40111753 Free PMC article. No abstract available.
Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaçao: Observational Cohort Study.
Swets MC, Kerr SR, MacKenna B, Fisher L, van Wijnen M, Brandwagt D, Schenk PW, Fraaij P, Visser LG, Bacon S, Mehrkar A, Nichol A, Twomey P, Matthews PC; ISARIC4C Hepatitis Study Group; Semple MG, Groeneveld GH, Goldacre B, Jones I, Baillie JK. Swets MC, et al. Among authors: baillie jk. JMIR Public Health Surveill. 2024 Dec 23;10:e55376. doi: 10.2196/55376. JMIR Public Health Surveill. 2024. PMID: 39864403 Free PMC article.
Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease.
Chau LF, Lillico S, Opriessnig T, Blake R, Tardy L, Lee CH, Maxwell S, Warren C, Thornton E, Mclaughlin CL, McLachlan G, Tait-Burkard C, Fletcher S, Anderson S, Brown S, Gibbard L, Tzelos T, MacMillan-Christensen D, Baillie JK, Dorward DA, Griffiths DJ, Grey F. Chau LF, et al. Among authors: baillie jk. Nat Commun. 2025 Jan 17;16(1):766. doi: 10.1038/s41467-024-54615-1. Nat Commun. 2025. PMID: 39824810 Free PMC article.
Evaluation of the diagnostic accuracy of Xpert® Mpox and STANDARD™ M10 MPX/OPX for the detection of monkeypox virus.
Romero-Ramirez A, Somasundaran A, Kontogianni K, Parkes J, Hussain Y, Gould S, Williams CT, Wooding D, Body R, Hardwick HE, Baillie JK, Dunning J, Semple MG; CONDOR steering group; ISARIC 4C Investigators; Fletcher TE, Edwards T, Emperador D, Cubas-Atienzar AI. Romero-Ramirez A, et al. Among authors: baillie jk. J Infect. 2025 Feb;90(2):106413. doi: 10.1016/j.jinf.2025.106413. Epub 2025 Jan 15. J Infect. 2025. PMID: 39824291 Free PMC article.
IL-33 is associated with alveolar dysfunction in patients with viral lower respiratory tract disease.
Scott IC, Zuydam NV, Cann JA, Negri VA, Tsafou K, Killick H, Liu Z, McCrae C, Rees DG, England E, Guscott MA, Houslay K, McCormick D, Freeman A, Schofield D, Freeman A, Cohen ES, Thwaites R, Brohawn Z, Platt A, Openshaw PJM, Semple MG, Baillie JK, Wilkinson T; ISARIC4C Investigators. Scott IC, et al. Among authors: baillie jk. Mucosal Immunol. 2025 Apr;18(2):312-325. doi: 10.1016/j.mucimm.2024.12.001. Epub 2024 Dec 9. Mucosal Immunol. 2025. PMID: 39662674 Free PMC article.
Monkeypox virus isolation from longitudinal samples in 11 hospitalised patients.
Callaby H, Olver J, Emery K, Richards KS, Killip M, Groves N, Beadsworth MBJ, Price DA, Cooke GS, Collini P, Cole J, Dunning J, Semple MG, Baillie JK; ISARIC4C Investigators; Rampling T, Houlihan CF. Callaby H, et al. Among authors: baillie jk. Lancet Infect Dis. 2025 Jan;25(1):e4-e5. doi: 10.1016/S1473-3099(24)00735-7. Epub 2024 Nov 29. Lancet Infect Dis. 2025. PMID: 39617024 No abstract available.
Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis.
Baillie JK, Angus D, Burnham K, Calandra T, Calfee C, Gutteridge A, Hacohen N, Khatri P, Langley R, Ma'ayan A, Marshall J, Maslove D, Prescott HC, Rowan K, Scicluna BP, Seymour C, Shankar-Hari M, Shapiro N, Joost Wiersinga W, Singer M, Randolph AG. Baillie JK, et al. Intensive Care Med. 2024 Dec;50(12):2031-2042. doi: 10.1007/s00134-024-07665-4. Epub 2024 Oct 21. Intensive Care Med. 2024. PMID: 39432104 Free PMC article. Review.
Cognitive and psychiatric symptom trajectories 2-3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK.
Taquet M, Skorniewska Z, De Deyn T, Hampshire A, Trender WR, Hellyer PJ, Chalmers JD, Ho LP, Horsley A, Marks M, Poinasamy K, Raman B, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A, Singapuri A, Sereno M, Saunders RM, Harris VC, Rogers N, Houchen-Wolloff L, Greening NJ, Mansoori P, Harrison EM, Docherty AB, Lone NI, Quint J, Brightling CE, Wain LV, Evans RA, Geddes JR, Harrison PJ; PHOSP-COVID Study Collaborative Group. Taquet M, et al. Lancet Psychiatry. 2024 Sep;11(9):696-708. doi: 10.1016/S2215-0366(24)00214-1. Epub 2024 Jul 31. Lancet Psychiatry. 2024. PMID: 39096931 Free article.
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.
Sidhu JK, Siggins MK, Liew F, Russell CD, Uruchurtu ASS, Davis C, Turtle L, Moore SC, Hardwick HE, Oosthuyzen W, Thomson EC, Semple MG, Baillie JK, Openshaw PJM, Thwaites RS; ISARIC4C investigators. Sidhu JK, et al. Among authors: baillie jk. J Infect Dis. 2024 Jul 25;230(1):e17-e29. doi: 10.1093/infdis/jiad590. J Infect Dis. 2024. PMID: 39052740 Free PMC article.
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods.
Mesinovic M, Wong XC, Rajahram GS, Citarella BW, Peariasamy KM, van Someren Greve F, Olliaro P, Merson L, Clifton L, Kartsonaki C; ISARIC Characterisation Group. Mesinovic M, et al. Sci Rep. 2024 Jul 16;14(1):16387. doi: 10.1038/s41598-024-63212-7. Sci Rep. 2024. PMID: 39013928 Free PMC article.
Retrospective analysis of hospital electronic health records reveals unseen cases of acute hepatitis with unknown aetiology in adults in Oxfordshire.
Tan CCS, Kelly G, Cregan J, Wilson JD, James T, Chand M, Hopkins S, Swets M, Baillie JK, Jeffery K, Walker AS, Eyre DW, Stoesser N, Matthews PC. Tan CCS, et al. Among authors: baillie jk. BMC Public Health. 2024 Jul 15;24(1):1890. doi: 10.1186/s12889-024-19292-1. BMC Public Health. 2024. PMID: 39010057 Free PMC article.
Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries.
Battaglini D, Kelly TL, Griffee M, Fanning J, Premraj L, Whitman G, Porto DB, Arora R, Thomson D, Pelosi P, White NM, Bassi GL, Suen J, Fraser JF, Robba C, Cho SM; COVID-19 Critical Care Consortium Investigators. Battaglini D, et al. Heart Lung. 2024 Nov-Dec;68:131-144. doi: 10.1016/j.hrtlng.2024.06.015. Epub 2024 Jul 4. Heart Lung. 2024. PMID: 38968643 Free article.
Stratified analyses refine association between TLR7 rare variants and severe COVID-19.
Boos J, van der Made CI, Ramakrishnan G, Coughlan E, Asselta R, Löscher BS, Valenti LVC, de Cid R, Bujanda L, Julià A, Pairo-Castineira E, Baillie JK, May S, Zametica B, Heggemann J, Albillos A, Banales JM, Barretina J, Blay N, Bonfanti P, Buti M, Fernandez J, Marsal S, Prati D, Ronzoni L, Sacchi N; Spanish/Italian Severe COVID-19 Sequencing group; GenOMICC Investigators; Schultze JL, Riess O, Franke A, Rawlik K, Ellinghaus D, Hoischen A, Schmidt A, Ludwig KU. Boos J, et al. Among authors: baillie jk. HGG Adv. 2024 Oct 10;5(4):100323. doi: 10.1016/j.xhgg.2024.100323. Epub 2024 Jun 28. HGG Adv. 2024. PMID: 38944683 Free PMC article.
Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study.
Turtle L, Elliot S, Drake TM, Thorpe M, Khoury EG, Greenhalf W, Hardwick HE, Leeming G, Law A, Oosthuyzen W, Pius R, Shaw CA, Baillie JK, Openshaw PJM, Docherty AB, Semple MG, Harrison EM, Palmieri C; ISARIC4C Investigators. Turtle L, et al. Among authors: baillie jk. Lancet Oncol. 2024 May;25(5):636-648. doi: 10.1016/S1470-2045(24)00107-4. Epub 2024 Apr 12. Lancet Oncol. 2024. PMID: 38621404 Free article.
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.
Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu JK, Ascough S, Moore SC, Mohamed N, Nunag J, King C, Leavy OC, Elneima O, McAuley HJC, Shikotra A, Singapuri A, Sereno M, Harris VC, Houchen-Wolloff L, Greening NJ, Lone NI, Thorpe M, Thompson AAR, Rowland-Jones SL, Docherty AB, Chalmers JD, Ho LP, Horsley A, Raman B, Poinasamy K, Marks M, Kon OM, Howard LS, Wootton DG, Quint JK, de Silva TI, Ho A, Chiu C, Harrison EM, Greenhalf W, Baillie JK, Semple MG, Turtle L, Evans RA, Wain LV, Brightling C, Thwaites RS, Openshaw PJM; PHOSP-COVID collaborative group; ISARIC investigators. Liew F, et al. Among authors: baillie jk. Nat Immunol. 2024 Apr;25(4):607-621. doi: 10.1038/s41590-024-01778-0. Epub 2024 Apr 8. Nat Immunol. 2024. PMID: 38589621 Free PMC article.
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael BD, Dunai C, Needham EJ, Tharmaratnam K, Williams R, Huang Y, Boardman SA, Clark JJ, Sharma P, Subramaniam K, Wood GK, Collie C, Digby R, Ren A, Norton E, Leibowitz M, Ebrahimi S, Fower A, Fox H, Tato E, Ellul MA, Sunderland G, Held M, Hetherington C, Egbe FN, Palmos A, Stirrups K, Grundmann A, Chiollaz AC, Sanchez JC, Stewart JP, Griffiths M, Solomon T, Breen G, Coles AJ, Kingston N, Bradley JR, Chinnery PF, Cavanagh J, Irani SR, Vincent A, Baillie JK, Openshaw PJ, Semple MG; ISARIC4C Investigators; COVID-CNS Consortium; Taams LS, Menon DK. Michael BD, et al. Among authors: baillie jk. Nat Commun. 2024 Apr 4;15(1):2918. doi: 10.1038/s41467-024-47320-6. Nat Commun. 2024. PMID: 38575615 Free PMC article. No abstract available.
Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.
Cho SM, Premraj L, Battaglini D, Fanning JP, Suen J, Bassi GL, Fraser J, Robba C, Griffee M, Solomon T, Semple MG, Baillie K, Sigfrid L, Scott JT, Citarella BW, Merson L, Arora RC, Whitman G, Thomson D, White N; ISARIC Clinical Characterization Group. Cho SM, et al. Among authors: baillie k. Brain Commun. 2024 Feb 9;6(2):fcae036. doi: 10.1093/braincomms/fcae036. eCollection 2024. Brain Commun. 2024. PMID: 38444907 Free PMC article.
Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies.
Shankar-Hari M, Calandra T, Soares MP, Bauer M, Wiersinga WJ, Prescott HC, Knight JC, Baillie KJ, Bos LDJ, Derde LPG, Finfer S, Hotchkiss RS, Marshall J, Openshaw PJM, Seymour CW, Venet F, Vincent JL, Le Tourneau C, Maitland-van der Zee AH, McInnes IB, van der Poll T. Shankar-Hari M, et al. Among authors: baillie kj. Lancet Respir Med. 2024 Apr;12(4):323-336. doi: 10.1016/S2213-2600(23)00468-X. Epub 2024 Feb 23. Lancet Respir Med. 2024. PMID: 38408467 Free PMC article. Review.
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group; Horby PW, Peto L, Staplin N, Campbell M, Pessoa-Amorim G, Mafham M, Emberson JR, Stewart R, Prudon B, Uriel A, Green CA, Dhasmana DJ, Malein F, Majumdar J, Collini P, Shurmer J, Yates B, Baillie JK, Buch MH, Day J, Faust SN, Jaki T, Jeffery K, Juszczak E, Knight M, Lim WS, Montgomery A, Mumford A, Rowan K, Thwaites G, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. Among authors: baillie jk. Nat Commun. 2024 Jan 31;15(1):924. doi: 10.1038/s41467-023-43644-x. Nat Commun. 2024. PMID: 38296965 Free PMC article. Clinical Trial.
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael BD, Dunai C, Needham EJ, Tharmaratnam K, Williams R, Huang Y, Boardman SA, Clark JJ, Sharma P, Subramaniam K, Wood GK, Collie C, Digby R, Ren A, Norton E, Leibowitz M, Ebrahimi S, Fower A, Fox H, Tato E, Ellul MA, Sunderland G, Held M, Hetherington C, Egbe FN, Palmos A, Stirrups K, Grundmann A, Chiollaz AC, Sanchez JC, Stewart JP, Griffiths M, Solomon T, Breen G, Coles AJ, Kingston N, Bradley JR, Chinnery PF, Cavanagh J, Irani SR, Vincent A, Baillie JK, Openshaw PJ, Semple MG; ISARIC4C Investigators; COVID-CNS Consortium; Taams LS, Menon DK. Michael BD, et al. Among authors: baillie jk. Nat Commun. 2023 Dec 22;14(1):8487. doi: 10.1038/s41467-023-42320-4. Nat Commun. 2023. PMID: 38135686 Free PMC article.
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies.
Costigan D, Fenn J, Yen S, Ilott N, Bullers S, Hale J, Greenhalf W, Conibear E, Koycheva A, Madon K, Jahan I, Huang M, Badhan A, Parker E, Rosadas C, Jones K, McClure M, Tedder R, Taylor G, Baillie KJ, Semple MG, Openshaw PJM, Pearson C, Johnson J; INSTINCT Study Group; ISARIC4C investigators; Lalvani A, Thornton EE. Costigan D, et al. Among authors: baillie kj. Mucosal Immunol. 2024 Feb;17(1):111-123. doi: 10.1016/j.mucimm.2023.11.005. Epub 2023 Nov 22. Mucosal Immunol. 2024. PMID: 37995912 Free PMC article.
Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.
Swets MC, Kerr S, Scott-Brown J, Brown AB, Gupta R, Millar JE, Spata E, McCurrach F, Bretherick AD, Docherty A, Harrison D, Rowan K, Young N; ISARIC4C Investigators; Groeneveld GH, Dunning J, Nguyen-Van-Tam JS, Openshaw P, Horby PW, Harrison E, Staplin N, Semple MG, Lone N, Baillie JK. Swets MC, et al. Among authors: baillie jk. Nat Commun. 2023 Nov 15;14(1):7374. doi: 10.1038/s41467-023-42205-6. Nat Commun. 2023. PMID: 37968269 Free PMC article.
Simvastatin in Critically Ill Patients with Covid-19.
REMAP-CAP Investigators; Hills TE, Lorenzi E, Berry LR, Shyamsundar M, Al-Beidh F, Annane D, Arabi Y, Aryal D, Au C, Beane A, Bhimani Z, Bonten M, Bradbury CA, Brunkhorst FM, Burrell A, Buxton M, Calfee CS, Cecconi M, Cheng AC, Cove ME, Detry MA, Estcourt LJ, Fitzgerald M, Goligher EC, Goossens H, Green C, Haniffa R, Harrison DA, Hashmi M, Higgins AM, Horvat C, Huang DT, Ichihara N, Jayakumar D, Kruger PS, Lamontagne F, Lampro L, Lawler PR, Marshall JC, Mason AJ, McGlothlin A, McGuinness S, McQuilten ZK, McVerry BJ, Mouncey PR, Murthy S, Neal MD, Nichol AD, O'Kane CM, Parke RL, Parker JC, Rabindrarajan E, Reyes LF, Rowan KM, Saito H, Santos M, Saunders CT, Seymour CW, Shankar-Hari M, Sinha P, Thompson BT, Turgeon AF, Turner AM, van de Veerdonk F, Weis S, Young IS, Zarychanski R, Lewis RJ, McArthur CJ, Angus DC, Berry SM, Derde LPG, Webb SA, Gordon AC, McAuley DF. REMAP-CAP Investigators, et al. N Engl J Med. 2023 Dec 21;389(25):2341-2354. doi: 10.1056/NEJMoa2309995. Epub 2023 Oct 25. N Engl J Med. 2023. PMID: 37888913 Free PMC article. Clinical Trial.
Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.
LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators; Adhikari NKJ, Hashmi M, Tirupakuzhi Vijayaraghavan BK, Haniffa R, Beane A, Webb SA, Angus DC, Gordon AC, Cook DJ, Guyatt GH, Berry LR, Lorenzi E, Mouncey PR, Au C, Pinto R, Ménard J, Sprague S, Masse MH, Huang DT, Heyland DK, Nichol AD, McArthur CJ, de Man A, Al-Beidh F, Annane D, Anstey M, Arabi YM, Battista MC, Berry S, Bhimani Z, Bonten MJM, Bradbury CA, Brant EB, Brunkhorst FM, Burrell A, Buxton M, Cecconi M, Cheng AC, Cohen D, Cove ME, Day AG, Derde LPG, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Goossens H, Green C, Higgins AM, Hills TE, Horvat C, Ichihara N, Jayakumar D, Kanji S, Khoso MN, Lawler PR, Lewis RJ, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McQuilten ZK, McVerry BJ, Murthy S, Parke RL, Parker JC, Reyes LF, Rowan KM, Saito H, Salahuddin N, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Tolppa T, Trapani T, Turgeon AF, Turner AM, Udy AA, van de Veerdonk FL, Zarychanski R, Lamontagne F. LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators, et al. JAMA. 2023 Nov 14;330(18):1745-1759. doi: 10.1001/jama.2023.21407. JAMA. 2023. PMID: 37877585 Free PMC article.
International Pediatric COVID-19 Severity Over the Course of the Pandemic.
Zhu Y, Almeida FJ, Baillie JK, Bowen AC, Britton PN, Brizuela ME, Buonsenso D, Burgner D, Chew KY, Chokephaibulkit K, Cohen C, Cormier SA, Crawford N, Curtis N, Farias CGA, Gilks CF, von Gottberg A, Hamer D, Jarovsky D, Jassat W, Jesus AR, Kemp LS, Khumcha B, McCallum G, Miller JE, Morello R, Munro APS, Openshaw PJM, Padmanabhan S, Phongsamart W, Reubenson G, Ritz N, Rodrigues F, Rungmaitree S, Russell F, Sáfadi MAP, Saner C, Semple MG, Prado da Silva DGB, de Sousa LMM, Diogo Moço Souza M, Spann K, Walaza S, Wolter N, Xia Y, Yeoh DK, Zar HJ, Zimmermann P, Short KR; International Severe Acute Respiratory and Emerging Infection Consortium Comprehensive Clinical Characterisation Collaboration (ISARIC4C) investigatorsPediatric Active Enhanced Disease Surveillance (PAEDS) Network group. Zhu Y, et al. Among authors: baillie jk. JAMA Pediatr. 2023 Oct 1;177(10):1073-1084. doi: 10.1001/jamapediatrics.2023.3117. JAMA Pediatr. 2023. PMID: 37603343 Free PMC article.
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry.
Griffee MJ, Bozza PT, Reyes LF, Eddington DP, Rosenberger D, Merson L, Citarella BW, Fanning JP, Alexander PMA, Fraser J, Dalton H, Cho SM; ISARIC Clinical Characterisation Group. Griffee MJ, et al. Res Pract Thromb Haemost. 2023 Jul 1;7(5):102142. doi: 10.1016/j.rpth.2023.102142. eCollection 2023 Jul. Res Pract Thromb Haemost. 2023. PMID: 37601011 Free PMC article.
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis.
Hayes AJ, Zheng X, O'Kelly J, Neyton LPA, Bochkina NA, Uings I, Liddle J, Baillie JK, Just G, Binnie M, Homer NZM, Murray TBJ, Baily J, McGuire K, Skouras C, Garden OJ, Webster SP, Iredale JP, Howie SEM, Mole DJ. Hayes AJ, et al. Among authors: baillie jk. Cell Rep. 2023 Aug 29;42(8):112763. doi: 10.1016/j.celrep.2023.112763. Epub 2023 Jul 19. Cell Rep. 2023. PMID: 37478012 Free article.
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A, Richmond A, Millar J, Russell CD, Malinauskas T, Thwaites R, Morrice K, Keating S, Maslove D, Nichol A, Semple MG, Knight J, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Begg C, Walsh T, Tenesa A, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P; GenOMICC Investigators; SCOURGE Consortium; ISARICC Investigators; 23andMe COVID-19 Team; Yang J, Ponting CP, Wilson JF, Vitart V, Abedalthagafi M, Luchessi AD, Parra EJ, Cruz R, Carracedo A, Fawkes A, Murphy L, Rowan K, Pereira AC, Law A, Fairfax B, Hendry SC, Baillie JK. Pairo-Castineira E, et al. Among authors: baillie jk. Nature. 2023 Jul;619(7971):E61. doi: 10.1038/s41586-023-06383-z. Nature. 2023. PMID: 37433877 Free PMC article. No abstract available.
Patient emergency health-care use before hospital admission for COVID-19 and long-term outcomes in Scotland: a national cohort study.
Docherty AB, Farrell J, Thorpe M, Egan C, Dunn S, Norman L, Shaw CA, Law A, Leeming G, Norris L, Brooks A, Prodan B, MacLeod R, Baxter R, Morris C, Rennie D, Oosthuyzen W, Semple MG, Baillie JK, Pius R, Seth S, Harrison EM, Lone NI. Docherty AB, et al. Among authors: baillie jk. Lancet Digit Health. 2023 Jul;5(7):e446-e457. doi: 10.1016/S2589-7500(23)00051-1. Lancet Digit Health. 2023. PMID: 37391265 Free PMC article.
HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation.
Yang H, Sun H, Brackenridge S, Zhuang X, Wing PAC, Quastel M, Walters L, Garner L, Wang B, Yao X, Felce SL, Peng Y, Moore S, Peeters BWA, Rei M, Canto Gomes J, Tomas A, Davidson A, Semple MG, Turtle LCW, Openshaw PJM, Baillie JK, Mentzer AJ, Klenerman P; ISARIC4C Investigators; Borrow P, Dong T, McKeating JA, Gillespie GM, McMichael AJ. Yang H, et al. Among authors: baillie jk. Sci Immunol. 2023 Jun 30;8(84):eabl8881. doi: 10.1126/sciimmunol.abl8881. Epub 2023 Jun 30. Sci Immunol. 2023. PMID: 37390223
Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19.
Wainstein M, Spyrison N, Dai D, Ghadimi M, Chávez-Iñiguez JS, Rizo-Topete L, Citarella BW, Merson L, Pole JD, Claure-Del Granado R, Johnson DW, Shrapnel S; ISARIC Characterization Group. Wainstein M, et al. Kidney Int Rep. 2023 May 27;8(8):1514-30. doi: 10.1016/j.ekir.2023.05.015. Online ahead of print. Kidney Int Rep. 2023. PMID: 37360820 Free PMC article.
Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial.
Pauley E, Drake TM, Griffith DM, Sigfrid L, Lone NI, Harrison EM, Baillie JK, Scott JT, Walsh TS, Semple MG, Docherty AB; ISARIC4C and RECOVER Investigators. Pauley E, et al. Among authors: baillie jk. J Intensive Care Soc. 2023 May;24(2):162-169. doi: 10.1177/17511437211052226. Epub 2021 Oct 24. J Intensive Care Soc. 2023. PMID: 37255989 Free PMC article.
Correction : Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies.
McNicholas BA, Rezoagli E, Simpkin AJ, Khanna S, Suen JY, Yeung P, Brodie D, Bassi GL, Pham T, Bellani G, Fraser JF, Laffey J; CCCC Consortium. McNicholas BA, et al. Crit Care. 2023 May 26;27(1):202. doi: 10.1186/s13054-023-04487-6. Crit Care. 2023. PMID: 37237395 Free PMC article. No abstract available.
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A, Richmond A, Millar J, Russell CD, Malinauskas T, Thwaites R, Morrice K, Keating S, Maslove D, Nichol A, Semple MG, Knight J, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Begg C, Walsh T, Tenesa A, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P; GenOMICC Investigators; SCOURGE Consortium; ISARICC Investigators; 23andMe COVID-19 Team; Yang J, Ponting CP, Wilson JF, Vitart V, Abedalthagafi M, Luchessi AD, Parra EJ, Cruz R, Carracedo A, Fawkes A, Murphy L, Rowan K, Pereira AC, Law A, Fairfax B, Hendry SC, Baillie JK. Pairo-Castineira E, et al. Among authors: baillie jk. Nature. 2023 May;617(7962):764-768. doi: 10.1038/s41586-023-06034-3. Epub 2023 May 17. Nature. 2023. PMID: 37198478 Free PMC article.
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