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2014 1
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Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing.
Dhaliwal S, Rybak I, Ellis SR, Notay M, Trivedi M, Burney W, Vaughn AR, Nguyen M, Reiter P, Bosanac S, Yan H, Foolad N, Sivamani RK. Dhaliwal S, et al. Br J Dermatol. 2019 Feb;180(2):289-296. doi: 10.1111/bjd.16918. Epub 2018 Sep 21. Br J Dermatol. 2019. PMID: 29947134 Free article. Clinical Trial.
The retinol users reported more facial skin scaling and stinging. CONCLUSIONS: Our study demonstrates that bakuchiol is comparable with retinol in its ability to improve photoageing and is better tolerated than retinol. Bakuchiol is promi …
The retinol users reported more facial skin scaling and stinging. CONCLUSIONS: Our study demonstrates that bakuchiol is …
Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects.
Chaudhuri RK, Bojanowski K. Chaudhuri RK, et al. Int J Cosmet Sci. 2014 Jun;36(3):221-30. doi: 10.1111/ics.12117. Epub 2014 Mar 6. Int J Cosmet Sci. 2014. PMID: 24471735
OBJECTIVE: The study was undertaken to compare the skin care related activities of retinol and bakuchiol, a potential alternative to retinoids. ...We present evidence that bakuchiol, having no structural resemblance to retinoids, can function as a func …
OBJECTIVE: The study was undertaken to compare the skin care related activities of retinol and bakuchiol, a potential a …
Applications of bakuchiol in dermatology: Systematic review of the literature.
Puyana C, Chandan N, Tsoukas M. Puyana C, et al. J Cosmet Dermatol. 2022 Dec;21(12):6636-6643. doi: 10.1111/jocd.15420. Epub 2022 Oct 31. J Cosmet Dermatol. 2022. PMID: 36176207
RESULTS: Thirty articles matched our search terms ["Bakuchiol" and "Dermatology"] or ["Bakuchiol" and "Skin"] of which one did not meet inclusion criteria, 16 were pre-clinical studies, seven clinical studies, three commentaries, two narrative reviews, …
RESULTS: Thirty articles matched our search terms ["Bakuchiol" and "Dermatology"] or ["Bakuchiol" and "Skin"] of which one did …
Cosmeceuticals for antiaging: a systematic review of safety and efficacy.
Lau M, Mineroff Gollogly J, Wang JY, Jagdeo J. Lau M, et al. Arch Dermatol Res. 2024 May 17;316(5):173. doi: 10.1007/s00403-024-02908-2. Arch Dermatol Res. 2024. PMID: 38758222
After screening of titles, abstracts, and full text, 32 studies involving 1236 patients met inclusion criteria, including 20 randomized controlled trials (RCTs) and 12 non-randomized open-label clinical trials for Vitamin C, Retinol, Bakuchiol, Tetrahydrojasm …
After screening of titles, abstracts, and full text, 32 studies involving 1236 patients met inclusion criteria, including 20 randomiz …
Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing - Experimental evidence for a holistic treatment approach.
Bluemke A, Ring AP, Immeyer J, Hoff A, Eisenberg T, Gerwat W, Meyer F, Breitkreutz S, Klinger LM, Brandner JM, Sandig G, Seifert M, Segger D, Rippke F, Schweiger D. Bluemke A, et al. Int J Cosmet Sci. 2022 Jun;44(3):377-393. doi: 10.1111/ics.12784. Epub 2022 Jun 9. Int J Cosmet Sci. 2022. PMID: 35514037 Free PMC article.
RESULTS: In contrast to retinol, bakuchiol demonstrated high antioxidative efficacy. Levels of PGE2 and MIF were significantly decreased by both bakuchiol and retinol. Bakuchiol but not retinol significantly increased FGF7 protein levels. …
RESULTS: In contrast to retinol, bakuchiol demonstrated high antioxidative efficacy. Levels of PGE2 and MIF were significantly …
Silybum marianum Extract: A Highly Effective Natural Alternative to Retinoids to Prevent Skin Aging Without Side Effects.
Boira C, Chapuis E, Lapierre L, Tiguemounine J, Scandolera A, Reynaud R. Boira C, et al. J Cosmet Dermatol. 2025 Jan;24(1):e16613. doi: 10.1111/jocd.16613. Epub 2024 Dec 18. J Cosmet Dermatol. 2025. PMID: 39692756 Free PMC article. Clinical Trial.
BACKGROUND: Vitamin A, or retinol, is one of the most effective antiaging molecules, but it presents issues with photo-sensitivity and irritation. ...OBJECTIVE: Here, we present a Silibum marianum extract (SME) as a retinol-like ingredient providing bo …
BACKGROUND: Vitamin A, or retinol, is one of the most effective antiaging molecules, but it presents issues with photo- …
Comparison of Quantification Using UV-Vis, NMR, and HPLC Methods of Retinol-Like Bakuchiol Present in Cosmetic Products.
Grzelecka M, Siudem P, Tyburc N, Triyasmono L, Holzgrabe U, Paradowska K. Grzelecka M, et al. Int J Mol Sci. 2025 Jul 10;26(14):6638. doi: 10.3390/ijms26146638. Int J Mol Sci. 2025. PMID: 40724887 Free PMC article.
From the point of view of the bioactive compound, it is also essential to develop a method for rapid quality control of cosmetic preparations containing bakuchiol. The aim of this study was to apply and compare methods for the quantification of bakuchiol in c …
From the point of view of the bioactive compound, it is also essential to develop a method for rapid quality control of cosmetic preparation …
Cutaneous delivery and biodistribution of a lipophilic natural product - bakuchiol: Comparing nanocarrier performance.
Syafitri E, Kalia YN. Syafitri E, et al. Int J Pharm. 2025 Aug 20;681:125886. doi: 10.1016/j.ijpharm.2025.125886. Epub 2025 Jun 23. Int J Pharm. 2025. PMID: 40562285 Free article.
Bakuchiol (BAK) is a natural bioactive agent described as a functional analogue of retinol that acts through the same cellular pathways. Its lipophilicity (log K(o/w) 6.1) and oily state at ambient temperature pose significant challenges in formulation development. …
Bakuchiol (BAK) is a natural bioactive agent described as a functional analogue of retinol that acts through the same cellular …
In a Preliminary Study on Human Subjects, a Cosmetic Cream Containing a Harungana madagascariensis Plant Extract Induces Similar Anti-Aging Effects to a Retinol-Containing Cream.
Gibielle C, Bousseksou L, Guéhenneux S, Vié K. Gibielle C, et al. Clin Cosmet Investig Dermatol. 2023 Apr 19;16:1051-1058. doi: 10.2147/CCID.S401290. eCollection 2023. Clin Cosmet Investig Dermatol. 2023. PMID: 37155516 Free PMC article.
Yet, their use can result in adverse reactions. Even bakuchiol, a natural functional analog, can lead to contact dermatitis. We previously showed that a Harungana madagascariensis (Lam. ex Poir.) plant extract (HME) presents retinol-like properties in vitro. ...Futu …
Yet, their use can result in adverse reactions. Even bakuchiol, a natural functional analog, can lead to contact dermatitis. We previ …
Bakuchiol: From structural mimicry to systems-level skin biology.
Chaudhuri RK. Chaudhuri RK. Int J Cosmet Sci. 2026 Jun 22. doi: 10.1111/ics.70116. Online ahead of print. Int J Cosmet Sci. 2026. PMID: 42332430 Review.
Bakuchiol was initially introduced as a functional alternative to retinol based on its ability to modulate gene expression associated with skin aging. ...Collectively, these findings position bakuchiol not merely as a retinol alternative, but as a syst …
Bakuchiol was initially introduced as a functional alternative to retinol based on its ability to modulate gene expression ass …
20 results