Metabolic and transcriptional effects of bazedoxifene/conjugated estrogens in a model of obesity-associated breast cancer risk.
Giles ED, Cook KL, Jenschke RM, Corleto KA, Landrock D, Mahmood TN, Sanchez KE, Levin A, Hursting SD, Kimler BF, Komm BS, Fabian CJ.
Giles ED, et al.
JCI Insight. 2025 Mar 6;10(8):e182694. doi: 10.1172/jci.insight.182694. eCollection 2025 Apr 22.
JCI Insight. 2025.
PMID: 40048260
Free PMC article.
Tamoxifen may also induce or worsen insulin resistance and hypertriglyceridemia, especially in women with obesity. The combination of bazedoxifene and conjugated estrogens (BZA/CE) reduces vasomotor symptoms and is currently undergoing evaluation for breast c …
Tamoxifen may also induce or worsen insulin resistance and hypertriglyceridemia, especially in women with obesity. The combination of baz …