bdnf - Search Results

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2025	7

1

BDNF as a Promising Therapeutic Agent in Parkinson's Disease.

Palasz E, Wysocka A, Gasiorowska A, Chalimoniuk M, Niewiadomski W, Niewiadomska G. Palasz E, et al. Int J Mol Sci. 2020 Feb 10;21(3):1170. doi: 10.3390/ijms21031170. Int J Mol Sci. 2020. PMID: 32050617 Free PMC article. Review.

Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration. ...Direct delivery of exogenous BDNF into the patient's brain did not relieve the symptoms of disease, nor did attempts to enhance BDNF expres …

Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration. ...Direct delive …

2

BDNF - a key transducer of antidepressant effects.

Björkholm C, Monteggia LM. Björkholm C, et al. Neuropharmacology. 2016 Mar;102:72-9. doi: 10.1016/j.neuropharm.2015.10.034. Epub 2015 Nov 11. Neuropharmacology. 2016. PMID: 26519901 Free PMC article. Review.

Here, we review accumulating evidence that the neurotrophin brain-derived neurotrophic factor (BDNF) serves as a transducer, acting as the link between the antidepressant drug and the neuroplastic changes that result in the improvement of the de …

Here, we review accumulating evidence that the neurotrophin brain-derived neurotrophic factor (BDNF) serv …

3

BDNF and its signaling in cancer.

Malekan M, Nezamabadi SS, Samami E, Mohebalizadeh M, Saghazadeh A, Rezaei N. Malekan M, et al. J Cancer Res Clin Oncol. 2023 Jun;149(6):2621-2636. doi: 10.1007/s00432-022-04365-8. Epub 2022 Sep 29. J Cancer Res Clin Oncol. 2023. PMID: 36173463 Review.

PURPOSE: Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophic factors that can potentially increase cancer cell growth, survival, proliferation, anoikis, and migration by tyrosine kinase receptors TrkB and the p7 …

PURPOSE: Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophic factors th …

4

Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression.

Zhang K, Wang F, Zhai M, He M, Hu Y, Feng L, Li Y, Yang J, Wu C. Zhang K, et al. Theranostics. 2023 Jan 22;13(3):1059-1075. doi: 10.7150/thno.81067. eCollection 2023. Theranostics. 2023. PMID: 36793868 Free PMC article.

Results: Chronic CORT induces depressive-like behaviors and decreases the expression of neuronal brain-derived neurotrophic factor (BDNF) in the dentate gyrus (DG) of the hippocampus in mice. ...Furthermore, chronic CORT induces hyperactive neur …

Results: Chronic CORT induces depressive-like behaviors and decreases the expression of neuronal brain-derived neurotrophic …

5

Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions.

Walsh JJ, Tschakovsky ME. Walsh JJ, et al. Appl Physiol Nutr Metab. 2018 Nov;43(11):1095-1104. doi: 10.1139/apnm-2018-0192. Epub 2018 May 18. Appl Physiol Nutr Metab. 2018. PMID: 29775542 Review.

Acute bouts of exercise transiently improve cognitive function, while long-term exercise training stimulates brain plasticity, improves brain function, and helps to stave off neurological disease. The action of brain-derived neurotrophic factor (BDN …

Acute bouts of exercise transiently improve cognitive function, while long-term exercise training stimulates brain plasticity, improves brai …

6

Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations.

Erdogan MA, Gurbuz O, Bozkurt MF, Erbas O. Erdogan MA, et al. Neurochem Res. 2024 Apr;49(4):1034-1048. doi: 10.1007/s11064-023-04089-2. Epub 2024 Jan 10. Neurochem Res. 2024. PMID: 38198049 Free PMC article.

This study aimed to investigate the gene expression of WNT, brain-derived neurotrophic factor (BDNF) levels, specific cytokines, m-TOR expression, neuropathology, and autism-related neurobehavioral outcomes in a rat model. ...Our findings reveal …

This study aimed to investigate the gene expression of WNT, brain-derived neurotrophic factor (BDNF) leve …

7

NGF and BDNF in pediatrics syndromes.

Ferraguti G, Terracina S, Micangeli G, Lucarelli M, Tarani L, Ceccanti M, Spaziani M, D'Orazi V, Petrella C, Fiore M. Ferraguti G, et al. Neurosci Biobehav Rev. 2023 Feb;145:105015. doi: 10.1016/j.neubiorev.2022.105015. Epub 2022 Dec 21. Neurosci Biobehav Rev. 2023. PMID: 36563920 Review.

Neurotrophins (NTs) as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) play multiple roles in different settings including neuronal development, function and survival in both the peripheral and the central nervous s …

Neurotrophins (NTs) as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) play …

8

Metabolic homeostasis via BDNF and its receptors.

Podyma B, Parekh K, Güler AD, Deppmann CD. Podyma B, et al. Trends Endocrinol Metab. 2021 Jul;32(7):488-499. doi: 10.1016/j.tem.2021.04.005. Epub 2021 May 4. Trends Endocrinol Metab. 2021. PMID: 33958275 Free PMC article. Review.

These signals include conserved meal and adipocyte cues such as glucose and leptin, respectively, in addition to more novel players including brain-derived neurotrophic factor (BDNF). In particular, BDNF's two receptors, tropomyosin relat …

These signals include conserved meal and adipocyte cues such as glucose and leptin, respectively, in addition to more novel players includin …

9

Mechanisms Controlling the Expression and Secretion of BDNF.

Arévalo JC, Deogracias R. Arévalo JC, et al. Biomolecules. 2023 May 2;13(5):789. doi: 10.3390/biom13050789. Biomolecules. 2023. PMID: 37238659 Free PMC article. Review.

Brain-derived nerve factor (BDNF), through TrkB receptor activation, is an important modulator for many different physiological and pathological functions in the nervous system. ...In this review we summarize the new advances regarding the molecular pl …

Brain-derived nerve factor (BDNF), through TrkB receptor activation, is an important modulator for many differen …

10

BDNF Propeptide: A Novel Modulator of Synaptic Plasticity.

Kojima M, Mizui T. Kojima M, et al. Vitam Horm. 2017;104:19-28. doi: 10.1016/bs.vh.2016.11.006. Epub 2017 Jan 25. Vitam Horm. 2017. PMID: 28215295 Review.

One of the most characterized neurotrophic factors is brain-derived neurotrophic factor (BDNF), which regulates neuronal survival and differentiation, and functions in activity-dependent plasticity processes such as long-term potentiation …

One of the most characterized neurotrophic factors is brain-derived neurotrophic factor (BDNF), wh …

11

BDNF and memory processing.

Bekinschtein P, Cammarota M, Medina JH. Bekinschtein P, et al. Neuropharmacology. 2014 Jan;76 Pt C:677-83. doi: 10.1016/j.neuropharm.2013.04.024. Epub 2013 May 18. Neuropharmacology. 2014. PMID: 23688925 Review.

Brain-derived neurotrophic factor has emerged as one of the most important molecules involved in memory. ...However, regulation of BDNF expression is very complex as well as its modes of action. Here we describe the latest research carried out o …

Brain-derived neurotrophic factor has emerged as one of the most important molecules involved in memory. ...Howe …

12

Challenges of BDNF-based therapies: From common to rare diseases.

Miranda-Lourenço C, Ribeiro-Rodrigues L, Fonseca-Gomes J, Tanqueiro SR, Belo RF, Ferreira CB, Rei N, Ferreira-Manso M, de Almeida-Borlido C, Costa-Coelho T, Freitas CF, Zavalko S, Mouro FM, Sebastião AM, Xapelli S, Rodrigues TM, Diógenes MJ. Miranda-Lourenço C, et al. Pharmacol Res. 2020 Dec;162:105281. doi: 10.1016/j.phrs.2020.105281. Epub 2020 Nov 5. Pharmacol Res. 2020. PMID: 33161136 Review.

Brain-derived neurotrophic factor (BDNF) possesses diverse biological functions which are mediated by the activation of two main classes of receptors, the tropomyosin-related kinase (Trk) B and the p75 neurotrophin receptor (p75(NTR)). ...We des …

Brain-derived neurotrophic factor (BDNF) possesses diverse biological functions which are mediated by the …

13

Hippocampal BDNF in physiological conditions and social isolation.

Zaletel I, Filipović D, Puškaš N. Zaletel I, et al. Rev Neurosci. 2017 Jul 26;28(6):675-692. doi: 10.1515/revneuro-2016-0072. Rev Neurosci. 2017. PMID: 28593903 Review.

Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. ...Since BDNF levels are age depe …

Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF …

14

BDNF, endurance activity, and mechanisms underlying the evolution of hominin brains.

Hill T, Polk JD. Hill T, et al. Am J Phys Anthropol. 2019 Jan;168 Suppl 67:47-62. doi: 10.1002/ajpa.23762. Epub 2018 Dec 21. Am J Phys Anthropol. 2019. PMID: 30575024 Review.

According to this hypothesis, selection for aerobic capacity increased the activity of various signaling molecules, including those involved in brain growth. One key molecule is brain-derived neurotrophic factor (BDNF), a protein that regulates …

According to this hypothesis, selection for aerobic capacity increased the activity of various signaling molecules, including those involved …

15

Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review.

Zelada MI, Garrido V, Liberona A, Jones N, Zúñiga K, Silva H, Nieto RR. Zelada MI, et al. Int J Mol Sci. 2023 Sep 30;24(19):14810. doi: 10.3390/ijms241914810. Int J Mol Sci. 2023. PMID: 37834258 Free PMC article. Review.

Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MDD). ...Finally, we reviewed the evidence that relates peripheral levels of BDNF and BDNF polymorphisms with the development an …

Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MD …

16

BDNF Modulation by microRNAs: An Update on the Experimental Evidence.

De Assis GG, Murawska-Ciałowicz E. De Assis GG, et al. Cells. 2024 May 20;13(10):880. doi: 10.3390/cells13100880. Cells. 2024. PMID: 38786102 Free PMC article. Review.

MicroRNAs can interfere with protein function by suppressing their messenger RNA translation or the synthesis of its related factors. The function of brain-derived neurotrophic factor (BDNF) is essential to the proper formation and function of t …

MicroRNAs can interfere with protein function by suppressing their messenger RNA translation or the synthesis of its related factors. The fu …

17

BDNF: New Views of an Old Player in Traumatic Brain Injury.

Giesler LP, Mychasiuk R, Shultz SR, McDonald SJ. Giesler LP, et al. Neuroscientist. 2024 Oct;30(5):560-573. doi: 10.1177/10738584231164918. Epub 2023 Apr 17. Neuroscientist. 2024. PMID: 37067029 Free PMC article. Review.

Traumatic brain injury is a common health problem affecting millions of people each year. BDNF has been investigated in the context of traumatic brain injury due to its crucial role in maintaining brain homeostasis. ...We also review studies investigating the role of BD …

Traumatic brain injury is a common health problem affecting millions of people each year. BDNF has been investigated in the context o …

18

Microglia and BDNF at the crossroads of stressor related disorders: Towards a unique trophic phenotype.

Prowse N, Hayley S. Prowse N, et al. Neurosci Biobehav Rev. 2021 Dec;131:135-163. doi: 10.1016/j.neubiorev.2021.09.018. Epub 2021 Sep 16. Neurosci Biobehav Rev. 2021. PMID: 34537262 Free article. Review.

Recent studies do suggest that microglia can modulate neuronal plasticity, possibly through brain derived neurotrophic factor (BDNF). This is particularly important given the link between BDNF and neuropsychiatric and neurodegenerative pa …

Recent studies do suggest that microglia can modulate neuronal plasticity, possibly through brain derived neurotrophic …

19

Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters.

You H, Lu B. You H, et al. Biomolecules. 2023 Apr 6;13(4):655. doi: 10.3390/biom13040655. Biomolecules. 2023. PMID: 37189402 Free PMC article. Review.

The gene encoding brain-derived neurotrophic factor (Bdnf) consists of nine non-coding exons driven by unique promoters, leading to the expression of nine Bdnf transcripts that play different roles in various brain regions and physiologic …

The gene encoding brain-derived neurotrophic factor (Bdnf) consists of nine non-coding exons driven by un …

20

BDNF at the synapse: why location matters.

Song M, Martinowich K, Lee FS. Song M, et al. Mol Psychiatry. 2017 Oct;22(10):1370-1375. doi: 10.1038/mp.2017.144. Epub 2017 Jul 25. Mol Psychiatry. 2017. PMID: 28937692 Free PMC article.

Such efforts have led to a detailed understanding on the molecular mechanisms of neurotrophic factor signaling. One member, brain-derived neurotrophic factor (BDNF) has drawn much attention due to its pleiotropic roles in the centr …

Such efforts have led to a detailed understanding on the molecular mechanisms of neurotrophic factor signaling. One member, …

21

Early Life Stress Affects Bdnf Regulation: A Role for Exercise Interventions.

Campbell TS, Donoghue KM, Ghosh U, Nelson CM, Roth TL. Campbell TS, et al. Int J Mol Sci. 2022 Oct 3;23(19):11729. doi: 10.3390/ijms231911729. Int J Mol Sci. 2022. PMID: 36233029 Free PMC article. Review.

This result occurs in part to disruptions in Brain derived neurotrophic factor (Bdnf) gene regulation, which plays a vital role in early neural programming and brain health in adulthood. A potential treatment mechanism to reverse the effects of …

This result occurs in part to disruptions in Brain derived neurotrophic factor (Bdnf) gene regulation, wh …

22

The role of BDNF in the pathophysiology and treatment of schizophrenia.

Favalli G, Li J, Belmonte-de-Abreu P, Wong AH, Daskalakis ZJ. Favalli G, et al. J Psychiatr Res. 2012 Jan;46(1):1-11. doi: 10.1016/j.jpsychires.2011.09.022. Epub 2011 Oct 26. J Psychiatr Res. 2012. PMID: 22030467 Review.

Brain derived neurotrophic factor (BDNF) has been associated with the pathophysiology of schizophrenia (SCZ). ...In this manuscript we review existing knowledge relating the function of BDNF to synaptic transmission and neural plasticity …

Brain derived neurotrophic factor (BDNF) has been associated with the pathophysiology of schizophrenia (S …

23

BDNF Expression in Cortical GABAergic Interneurons.

Barreda Tomás FJ, Turko P, Heilmann H, Trimbuch T, Yanagawa Y, Vida I, Münster-Wandowski A. Barreda Tomás FJ, et al. Int J Mol Sci. 2020 Feb 25;21(5):1567. doi: 10.3390/ijms21051567. Int J Mol Sci. 2020. PMID: 32106593 Free PMC article.

Brain-derived neurotrophic factor (BDNF) is a major neuronal growth factor that is widely expressed in the central nervous system. It is synthesized as a glycosylated precursor protein, (pro)BDNF and post-translationally converted …

Brain-derived neurotrophic factor (BDNF) is a major neuronal growth factor that is widely expresse …

24

BDNF: a neuromodulator in nociceptive pathways?

Pezet S, Malcangio M, McMahon SB. Pezet S, et al. Brain Res Brain Res Rev. 2002 Oct;40(1-3):240-9. doi: 10.1016/s0165-0173(02)00206-0. Brain Res Brain Res Rev. 2002. PMID: 12589922 Review.

During development, brain-derived neurotrophic factor (BDNF) supports the survival of certain neuronal population in central and peripheral nervous system. ...In addition, behavioural data indicate that antagonism of BDNF attenuates the s …

During development, brain-derived neurotrophic factor (BDNF) supports the survival of certain neuronal po …

25

Engineered BDNF producing cells as a potential treatment for neurologic disease.

Deng P, Anderson JD, Yu AS, Annett G, Fink KD, Nolta JA. Deng P, et al. Expert Opin Biol Ther. 2016 Aug;16(8):1025-33. doi: 10.1080/14712598.2016.1183641. Epub 2016 May 21. Expert Opin Biol Ther. 2016. PMID: 27159050 Free PMC article. Review.

INTRODUCTION: Brain-derived neurotrophic factor (BDNF) has been implicated in wide range of neurological diseases and injury. ...The use of MSC as a delivery platform for BDNF holds great promise for clinical advancement of neurotrophi …

INTRODUCTION: Brain-derived neurotrophic factor (BDNF) has been implicated in wide range of neurological …

26

Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review).

Xie Z, Xu X, Cao W, He L, Kou C, He J, Guo Y, Yue M, Mo S. Xie Z, et al. Int J Oncol. 2023 Feb;62(2):30. doi: 10.3892/ijo.2023.5478. Epub 2023 Jan 12. Int J Oncol. 2023. PMID: 36633145 Review.

MicroRNA (miRNA), a non-coding single-stranded RNA molecule with a length of 21-25 nucleotides transcripts, has been identified to play important roles in tumorigenesis and shows great potential applications in cancer diagnosis, prognosis and therapy. Brain derived …

MicroRNA (miRNA), a non-coding single-stranded RNA molecule with a length of 21-25 nucleotides transcripts, has been identified to play impo …

27

Transcript specificity in BDNF-regulated protein synthesis.

Ruiz CR, Shi J, Meffert MK. Ruiz CR, et al. Neuropharmacology. 2014 Jan;76 Pt C(0 0):657-63. doi: 10.1016/j.neuropharm.2013.05.004. Epub 2013 May 22. Neuropharmacology. 2014. PMID: 23707639 Free PMC article. Review.

Brain-derived neurotrophic factor (BDNF) is a critical activity-dependent modulator of gene expression, which can regulate both transcription and translation. Several functions of BDNF, including the induction of dendrite outgrowth and lo …

Brain-derived neurotrophic factor (BDNF) is a critical activity-dependent modulator of gene expression, w …

28

Effects of antipsychotics on the BDNF in schizophrenia.

Huang TL. Huang TL. Curr Med Chem. 2013;20(3):345-50. doi: 10.2174/092986713804870729. Curr Med Chem. 2013. PMID: 23157625 Review.

Brain-derived neurotropic factor (BDNF) is involved in the development of the brain, and likely influences the neuroplasticity in schizophrenia. ...Therefore, BDNF is a candidate gene for schizophrenia. In past decades, the blood (serum or plasm …

Brain-derived neurotropic factor (BDNF) is involved in the development of the brain, and likely influences the n …

29

Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review.

Treble-Barna A, Heinsberg LW, Stec Z, Breazeale S, Davis TS, Kesbhat AA, Chattopadhyay A, VonVille HM, Ketchum AM, Yeates KO, Kochanek PM, Weeks DE, Conley YP. Treble-Barna A, et al. Neurosci Biobehav Rev. 2023 Apr;147:105078. doi: 10.1016/j.neubiorev.2023.105078. Epub 2023 Feb 9. Neurosci Biobehav Rev. 2023. PMID: 36764636 Free PMC article. Review.

Epigenomic modifications of the brain-derived neurotrophic factor (BDNF) gene have been postulated to underlie the pathogenesis of neurodevelopmental, psychiatric, and neurological conditions. This systematic review summarizes current evidence i …

Epigenomic modifications of the brain-derived neurotrophic factor (BDNF) gene have been postulated to und …

30

The emerging role of the BDNF-TrkB signaling pathway in the modulation of pain perception.

Cappoli N, Tabolacci E, Aceto P, Dello Russo C. Cappoli N, et al. J Neuroimmunol. 2020 Dec 15;349:577406. doi: 10.1016/j.jneuroim.2020.577406. Epub 2020 Sep 24. J Neuroimmunol. 2020. PMID: 33002723 Review.

The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain transmission both in peripheral and central nervous system (CNS). ...Moreover, BDNF polymorphisms can interfere with BDNF role in pain perception. In …

The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain transmission both in per …

31

BDNF: the career of a multifaceted neurotrophin in spinal cord injury.

Weishaupt N, Blesch A, Fouad K. Weishaupt N, et al. Exp Neurol. 2012 Dec;238(2):254-64. doi: 10.1016/j.expneurol.2012.09.001. Epub 2012 Sep 12. Exp Neurol. 2012. PMID: 22982152 Review.

Brain-derived neurotrophic factor (BDNF) has been identified as a potent promoter of neurite growth, a finding that has led to an ongoing exploration of this neurotrophin as a potential treatment for spinal cord injury. ...In addition, neuronal …

Brain-derived neurotrophic factor (BDNF) has been identified as a potent promoter of neurite growth, a fi …

32

BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis.

Zheleznyakova GY, Cao H, Schiöth HB. Zheleznyakova GY, et al. Behav Brain Funct. 2016 Jun 6;12(1):17. doi: 10.1186/s12993-016-0101-4. Behav Brain Funct. 2016. PMID: 27267954 Free PMC article. Review.

Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous …

Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and functi …

33

Comparative Genomics of the BDNF Gene, Non-Canonical Modes of Transcriptional Regulation, and Neurological Disease.

Keifer J. Keifer J. Mol Neurobiol. 2021 Jun;58(6):2851-2861. doi: 10.1007/s12035-021-02306-z. Epub 2021 Jan 30. Mol Neurobiol. 2021. PMID: 33517560 Review.

Many activity-inducible genes generate transcripts by alternative splicing that have an unknown physiological or behavioral function. One such gene codes for the protein brain-derived neurotrophic factor (BDNF). BDNF is a neurotrophin who …

Many activity-inducible genes generate transcripts by alternative splicing that have an unknown physiological or behavioral function. One su …

34

The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF.

Miao Z, Wang Y, Sun Z. Miao Z, et al. Int J Mol Sci. 2020 Feb 18;21(4):1375. doi: 10.3390/ijms21041375. Int J Mol Sci. 2020. PMID: 32085670 Free PMC article. Review.

Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays an important role in multiple stress-related mental disorders. ...Moreover, epigenetic regulation of BDNF, including DNA methylation, his …

Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays an i …

35

Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation.

Lima Giacobbo B, Doorduin J, Klein HC, Dierckx RAJO, Bromberg E, de Vries EFJ. Lima Giacobbo B, et al. Mol Neurobiol. 2019 May;56(5):3295-3312. doi: 10.1007/s12035-018-1283-6. Epub 2018 Aug 17. Mol Neurobiol. 2019. PMID: 30117106 Free PMC article. Review.

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the healthy and diseased brain. ...Patients with psychiatric and neurodegenerative disorders often have reduced BDNF concentrations in their blood and br …

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the healthy and dise …

36

A MicroRNA-BDNF Negative Feedback Signaling Loop in Brain: Implications for Alzheimer's Disease.

Keifer J, Zheng Z, Ambigapathy G. Keifer J, et al. Microrna. 2015;4(2):101-8. doi: 10.2174/2211536604666150813152620. Microrna. 2015. PMID: 26456533 Review.

Accumulating data indicate there is a regulatory negative feedback loop between one ubiquitous neurotrophin, brain-derived neurotrophic factor (BDNF), and miRNAs. That is, while BDNF treatment stimulates neuronal miRNA expression, miRNAs …

Accumulating data indicate there is a regulatory negative feedback loop between one ubiquitous neurotrophin, brain-derived …

37

BDNF.

McAllister AK. McAllister AK. Curr Biol. 2002 Apr 30;12(9):R310. doi: 10.1016/s0960-9822(02)00825-4. Curr Biol. 2002. PMID: 12007428 Free article. No abstract available.

38

BDNF gene hydroxymethylation in hippocampus related to neuroinflammation-induced depression-like behaviors in mice.

Zhao T, Piao LH, Li DP, Xu SH, Wang SY, Yuan HB, Zhang CX. Zhao T, et al. J Affect Disord. 2023 Feb 15;323:723-730. doi: 10.1016/j.jad.2022.12.035. Epub 2022 Dec 16. J Affect Disord. 2023. PMID: 36529411

The microglial activation and cellular 5-hmC localization in the hippocampus were confirmed by immunostaining. The transcripts of Tets and BDNF were examined by qPCR method. The global 5-hmC levels and enrichment of 5-hmC in BDNF gene in the hippocampus were analyze …

The microglial activation and cellular 5-hmC localization in the hippocampus were confirmed by immunostaining. The transcripts of Tets and …

39

Neurotrophins and Their Receptors: BDNF's Role in GABAergic Neurodevelopment and Disease.

Hernández-Del Caño C, Varela-Andrés N, Cebrián-León A, Deogracias R. Hernández-Del Caño C, et al. Int J Mol Sci. 2024 Jul 30;25(15):8312. doi: 10.3390/ijms25158312. Int J Mol Sci. 2024. PMID: 39125882 Free PMC article. Review.

Neurotrophins and their receptors are distinctly expressed during brain development and play crucial roles in the formation, survival, and function of neurons in the nervous system. Among these molecules, brain-derived neurotrophic factor (BDNF) …

Neurotrophins and their receptors are distinctly expressed during brain development and play crucial roles in the formation, survival, and f …

40

Emerging Insights into the Role of BDNF on Health and Disease in Periphery.

Ichimura-Shimizu M, Kurrey K, Miyata M, Dezawa T, Tsuneyama K, Kojima M. Ichimura-Shimizu M, et al. Biomolecules. 2024 Apr 5;14(4):444. doi: 10.3390/biom14040444. Biomolecules. 2024. PMID: 38672461 Free PMC article. Review.

Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. ...Interestingly, BDNF is also expressed in the hypothalamus in appetite and energy metabolism. Previous repor …

Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth …

41

Pro-BDNF Knockout Causes Abnormal Motor Behaviours and Early Death in Mice.

Li H, Lin LY, Zhang Y, Lim Y, Rahman M, Beck A, Al-Hawwas M, Feng S, Bobrovskaya L, Zhou XF. Li H, et al. Neuroscience. 2020 Jul 1;438:145-157. doi: 10.1016/j.neuroscience.2020.05.007. Epub 2020 May 13. Neuroscience. 2020. PMID: 32413397

Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family, best characterized for its survival and differentiative effects in the central nervous system. Pro-BDNF, known as the precursor of BDNF, is believed t …

Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family, best characterized for i …

42

Altering BDNF expression by genetics and/or environment: impact for emotional and depression-like behaviour in laboratory mice.

Chourbaji S, Brandwein C, Gass P. Chourbaji S, et al. Neurosci Biobehav Rev. 2011 Jan;35(3):599-611. doi: 10.1016/j.neubiorev.2010.07.003. Epub 2010 Jul 17. Neurosci Biobehav Rev. 2011. PMID: 20621121 Review.

According to the "neurotrophin hypothesis", brain-derived neurotrophic factor (BDNF) is an important candidate gene in depression. Moreover, environmental stress is known to represent a risk factor in the pathophysiology and treatment of …

According to the "neurotrophin hypothesis", brain-derived neurotrophic factor (BDNF) is an important cand …

43

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy.

Notaras M, Hill R, van den Buuse M. Notaras M, et al. Mol Psychiatry. 2015 Aug;20(8):916-30. doi: 10.1038/mp.2015.27. Epub 2015 Mar 31. Mol Psychiatry. 2015. PMID: 25824305 Review.

Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development, differentiation and plasticity in both the developing and adult brain. A single-nucleotide polymorphism in the proregion of BDNF, termed the Val66Met pol …

Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development, differentiation and …

44

Epigenetic regulation of the BDNF gene: implications for psychiatric disorders.

Boulle F, van den Hove DL, Jakob SB, Rutten BP, Hamon M, van Os J, Lesch KP, Lanfumey L, Steinbusch HW, Kenis G. Boulle F, et al. Mol Psychiatry. 2012 Jun;17(6):584-96. doi: 10.1038/mp.2011.107. Epub 2011 Sep 6. Mol Psychiatry. 2012. PMID: 21894152 Review.

Abnormal brain-derived neurotrophic factor (BDNF) signaling seems to have a central role in the course and development of various neurological and psychiatric disorders. In addition, positive effects of psychotropic drugs are known to activate …

Abnormal brain-derived neurotrophic factor (BDNF) signaling seems to have a central role in the course an …

45

Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications.

Post RM. Post RM. J Psychiatr Res. 2007 Dec;41(12):979-90. doi: 10.1016/j.jpsychires.2006.09.009. Epub 2007 Jan 18. J Psychiatr Res. 2007. PMID: 17239400 Review.

A number of lines of converging evidence suggest that brain-derived neurotrophic factor (BDNF) may play a role in the onset and treatment of bipolar disorder. ...All the primary antidepressant modalities, as well as the mood stabilizers lithium …

A number of lines of converging evidence suggest that brain-derived neurotrophic factor (BDNF) may play a …

46

The metabotrophic NGF and BDNF: an emerging concept.

Chaldakov G. Chaldakov G. Arch Ital Biol. 2011 Jun;149(2):257-63. doi: 10.4449/aib.v149i2.1366. Arch Ital Biol. 2011. PMID: 21701997 Review.

The field of neurotrophins, particularly, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), has witnessed a number of breakthroughs in recent years. There is evidence now that NGF and BDNF mediate multiple bio …

The field of neurotrophins, particularly, nerve growth factor (NGF) and brain-derived neurotrophic factor …

47

Smilagenin induces expression and epigenetic remodeling of BDNF in alzheimer's disease.

Yang S, Fan L, Zhang R, Song C, Shi J, Wang J, Zhang P, Wang H, Zhang Y. Yang S, et al. Phytomedicine. 2023 Sep;118:154956. doi: 10.1016/j.phymed.2023.154956. Epub 2023 Jul 17. Phytomedicine. 2023. PMID: 37499345

We previously found that SMI significantly increased brain-derived neurotrophic factor (BDNF) expression in Abeta-intoxicated SH-SY5Y cells. ...Furthermore, chromatin immunoprecipitation results showed that SMI could increase the levels of H3AC …

We previously found that SMI significantly increased brain-derived neurotrophic factor (BDNF) expression …

48

Is altered BDNF biosynthesis a general feature in patients with cognitive dysfunctions?

Carlino D, De Vanna M, Tongiorgi E. Carlino D, et al. Neuroscientist. 2013 Aug;19(4):345-53. doi: 10.1177/1073858412469444. Epub 2012 Dec 14. Neuroscientist. 2013. PMID: 23242909 Review.

In the attempt to define new clinical biomarkers, current research trends aim at the identification of common molecular features in these pathologies rather than searching for differences. Brain-derived neurotrophic factor (BDNF) has attracted g …

In the attempt to define new clinical biomarkers, current research trends aim at the identification of common molecular features in these pa …

49

Differential Regulation of the BDNF Gene in Cortical and Hippocampal Neurons.

Esvald EE, Tuvikene J, Moistus A, Rannaste K, Kõomägi S, Timmusk T. Esvald EE, et al. J Neurosci. 2022 Dec 7;42(49):9110-9128. doi: 10.1523/JNEUROSCI.2535-21.2022. Epub 2022 Oct 31. J Neurosci. 2022. PMID: 36316156 Free PMC article.

Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin that supports the survival, differentiation, and signaling of various neuronal populations. ...Together, our data reveal complicated brain region-specific fine-tuning of …

Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin that supports the survival, d …

50

Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements.

Ibarra IL, Ratnu VS, Gordillo L, Hwang IY, Mariani L, Weinand K, Hammarén HM, Heck J, Bulyk ML, Savitski MM, Zaugg JB, Noh KM. Ibarra IL, et al. Mol Syst Biol. 2022 Aug;18(8):e10473. doi: 10.15252/msb.202110473. Mol Syst Biol. 2022. PMID: 35996956 Free PMC article.

Neuronal stimulation induced by the brain-derived neurotrophic factor (BDNF) triggers gene expression, which is crucial for neuronal survival, differentiation, synaptic plasticity, memory formation, and neurocognitive health. ...Here, using temp …

Neuronal stimulation induced by the brain-derived neurotrophic factor (BDNF) triggers gene expression, wh …

51

BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1.

Rosa JG, Hamel K, Soles A, Sheeler C, Borgenheimer E, Gilliat S, Sbrocco K, Ghanoum F, Handler HP, Forster C, Rainwater O, Cvetanovic M. Rosa JG, et al. Neurobiol Dis. 2023 Mar;178:106023. doi: 10.1016/j.nbd.2023.106023. Epub 2023 Jan 29. Neurobiol Dis. 2023. PMID: 36724861 Free PMC article.

There are no disease-modifying treatments or cures for SCA1. Brain-derived neurotrophic factor (BDNF) plays important role in cerebellar physiology and has shown therapeutic potential for cerebellar pathology in the transgenic mouse model of SCA …

There are no disease-modifying treatments or cures for SCA1. Brain-derived neurotrophic factor (BDNF) pla …

52

Regulation of Satiety by Bdnf-e2-Expressing Neurons through TrkB Activation in Ventromedial Hypothalamus.

Chu P, Guo W, You H, Lu B. Chu P, et al. Biomolecules. 2023 May 11;13(5):822. doi: 10.3390/biom13050822. Biomolecules. 2023. PMID: 37238691 Free PMC article.

The transcripts for Bdnf (brain-derived neurotrophic factor), driven by different promoters, are expressed in different brain regions to control different body functions. Specific promoter(s) that regulates energy balance remain unclear. We show …

The transcripts for Bdnf (brain-derived neurotrophic factor), driven by different promoters, are expresse …

53

Brain derived neurotrophic factor (BDNF) and suicidal behavior: A review of studies from Asian countries.

Sonal A, Raghavan V. Sonal A, et al. Asian J Psychiatr. 2018 Mar;33:128-132. doi: 10.1016/j.ajp.2018.03.004. Epub 2018 Mar 2. Asian J Psychiatr. 2018. PMID: 29525506 Review.

The biological basis of suicide and suicidal behavior is actively researched. Recently, the role of Brain Derived Neurotropic Factor (BDNF) in suicidal behavior has gained attention and significant results are observed. In this review, we aimed to focu …

The biological basis of suicide and suicidal behavior is actively researched. Recently, the role of Brain Derived Neurotropic …

54

A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review.

Notaras M, Hill R, van den Buuse M. Notaras M, et al. Neurosci Biobehav Rev. 2015 Apr;51:15-30. doi: 10.1016/j.neubiorev.2014.12.016. Epub 2015 Jan 3. Neurosci Biobehav Rev. 2015. PMID: 25562189 Review.

Schizophrenia is believed to arise from complex gene-environment interactions. Brain-derived neurotrophic factor (BDNF) is involved in neuronal development, differentiation and plasticity. ...Here we provide a comprehensive review of the relatio …

Schizophrenia is believed to arise from complex gene-environment interactions. Brain-derived neurotrophic factor …

55

Measurement methods of BDNF levels in major depression: a qualitative systematic review of clinical trials.

Teche SP, Nuernberg GL, Sordi AO, de Souza LH, Remy L, Ceresér KM, Rocha NS. Teche SP, et al. Psychiatr Q. 2013 Dec;84(4):485-97. doi: 10.1007/s11126-013-9261-7. Psychiatr Q. 2013. PMID: 23564563 Review.

There is evidence that the brain-derived neurotrophic factor (BDNF) has implications for the pathophysiology of major depressive disorders (MDD). ...Trials used different methods to evaluate BDNF levels: most of them verified serum BDN …

There is evidence that the brain-derived neurotrophic factor (BDNF) has implications for the pathophysiol …

56

Potential therapeutic uses of BDNF in neurological and psychiatric disorders.

Nagahara AH, Tuszynski MH. Nagahara AH, et al. Nat Rev Drug Discov. 2011 Mar;10(3):209-19. doi: 10.1038/nrd3366. Nat Rev Drug Discov. 2011. PMID: 21358740 Review.

The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are actively produced and trafficked in multiple regions in the adult brain, where they influence neuronal activ …

The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related ki …

57

Peripheral brain derived neurotrophic factor (BDNF) in bulimia nervosa: a systematic review.

Phillips K, Keane K, Wolfe BE. Phillips K, et al. Arch Psychiatr Nurs. 2014 Apr;28(2):108-13. doi: 10.1016/j.apnu.2013.11.006. Epub 2013 Nov 23. Arch Psychiatr Nurs. 2014. PMID: 24673784 Review.

While multifaceted etiology is likely, several neurobiological factors may play a role. Brain derived neurotrophic factor (BDNF), a potential biomarker linked to eating and weight disorders, is one factor of recent investigation. ...Key t …

While multifaceted etiology is likely, several neurobiological factors may play a role. Brain derived neurotrophic f …

58

Exercise-induced BDNF promotes PPARdelta-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery.

Chan WS, Ng CF, Pang BPS, Hang M, Tse MCL, Iu ECY, Ooi XC, Yang X, Kim JK, Lee CW, Chan CB. Chan WS, et al. Sci Signal. 2024 Mar 19;17(828):eadh2783. doi: 10.1126/scisignal.adh2783. Epub 2024 Mar 19. Sci Signal. 2024. PMID: 38502732 Free PMC article.

Post-exercise recovery is essential to resolve metabolic perturbations and promote long-term cellular remodeling in response to exercise. Here, we report that muscle-generated brain-derived neurotrophic factor (BDNF) elicits post-exercise recove …

Post-exercise recovery is essential to resolve metabolic perturbations and promote long-term cellular remodeling in response to exercise. He …

59

BDNF produced by cerebral microglia promotes cortical plasticity and pain hypersensitivity after peripheral nerve injury.

Huang L, Jin J, Chen K, You S, Zhang H, Sideris A, Norcini M, Recio-Pinto E, Wang J, Gan WB, Yang G. Huang L, et al. PLoS Biol. 2021 Jul 22;19(7):e3001337. doi: 10.1371/journal.pbio.3001337. eCollection 2021 Jul. PLoS Biol. 2021. PMID: 34292944 Free PMC article.

Following peripheral nerve injury, microglia in the S1 maintain ramified morphology and normal density but up-regulate the mRNA expression of brain-derived neurotrophic factor (BDNF). Using in vivo two-photon imaging and Cx3cr1CreER;Bdnfflox mic …

Following peripheral nerve injury, microglia in the S1 maintain ramified morphology and normal density but up-regulate the mRNA expression o …

60

The evolution of BDNF is defined by strict purifying selection and prodomain spatial coevolution, but what does it mean for human brain disease?

Lucaci AG, Notaras MJ, Kosakovsky Pond SL, Colak D. Lucaci AG, et al. Transl Psychiatry. 2022 Jun 22;12(1):258. doi: 10.1038/s41398-022-02021-w. Transl Psychiatry. 2022. PMID: 35732627 Free PMC article.

Brain-Derived Neurotrophic Factor (BDNF) is an essential mediator of brain assembly, development, and maturation. ...To better understand the role of BDNF in disease, we sought to define the evolution of BDNF within Mammalia. We co …

Brain-Derived Neurotrophic Factor (BDNF) is an essential mediator of brain assembly, development, and mat …

61

New insights in the biology of BDNF synthesis and release: implications in CNS function.

Greenberg ME, Xu B, Lu B, Hempstead BL. Greenberg ME, et al. J Neurosci. 2009 Oct 14;29(41):12764-7. doi: 10.1523/JNEUROSCI.3566-09.2009. J Neurosci. 2009. PMID: 19828787 Free PMC article. Review.

BDNF has pleiotropic effects on neuronal development and synaptic plasticity that underlie circuit formation and cognitive function. Recent breakthroughs reveal that neuronal activity regulates BDNF cell biology, including Bdnf transcription, dendritic target …

BDNF has pleiotropic effects on neuronal development and synaptic plasticity that underlie circuit formation and cognitive function. …

62

Early macrophage-mediated Bdnf expression in white adipose tissue during high-fat diet feeding.

Sakata K, Kobayashi T, Yokokura S, Fukuchi M. Sakata K, et al. Biochem Biophys Res Commun. 2023 Dec 17;686:149163. doi: 10.1016/j.bbrc.2023.149163. Epub 2023 Oct 31. Biochem Biophys Res Commun. 2023. PMID: 37924667

The expression of brain-derived neurotrophic factor (BDNF) is observed not only in the brain, but also in peripheral tissues including white adipose tissues (WATs). ...In mice on a 2-week HFD, the induction of Bdnf expression in WATs was …

The expression of brain-derived neurotrophic factor (BDNF) is observed not only in the brain, but also in …

63

Neurotrophic Factors in Mouse Models of Autism Spectrum Disorder: Focus on BDNF and IGF-1.

Reim D, Schmeisser MJ. Reim D, et al. Adv Anat Embryol Cell Biol. 2017;224:121-134. doi: 10.1007/978-3-319-52498-6_7. Adv Anat Embryol Cell Biol. 2017. PMID: 28551754 Review.

As most of this work has investigated the role of brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) in ASD formation, we focus on these two molecules in this review. We start with reviewing findings on n …

As most of this work has investigated the role of brain-derived neurotrophic factor (BDNF) and insulin-li …

64

[Brain-Derived Neurotrophic Factor (BDNF): role of this neurotrophin in cardiovascular physiopathology].

Lorgis L, Amoureux S, Vergely C, Zeller M, Cottin Y, Rochette L. Lorgis L, et al. Ann Cardiol Angeiol (Paris). 2009 Apr;58(2):99-103. doi: 10.1016/j.ancard.2008.11.001. Epub 2008 Dec 3. Ann Cardiol Angeiol (Paris). 2009. PMID: 19281964 Review. French.

Neurotrophic-factors research is dominated by neurotrophins (NT): a family of polypeptides which includes molecules such as Nerve Growth Factor (NGF) and the Brain-Derived Neurotrophic Factor (BDNF). ...Thus, investigations of this …

Neurotrophic-factors research is dominated by neurotrophins (NT): a family of polypeptides which includes molecules such as Nerve Gro …

65

A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder.

Hing B, Sathyaputri L, Potash JB. Hing B, et al. Am J Med Genet B Neuropsychiatr Genet. 2018 Mar;177(2):143-167. doi: 10.1002/ajmg.b.32616. Epub 2017 Dec 15. Am J Med Genet B Neuropsychiatr Genet. 2018. PMID: 29243873 Review.

A gene potentially important to this disorder is the brain derived neurotrophic factor (BDNF) as it is involved in processes controlling neuroplasticity. ...We will also describe epigenetic processes that mediate this change in BDNF expre …

A gene potentially important to this disorder is the brain derived neurotrophic factor (BDNF) as it is in …

66

Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice.

Xie X, Houtz J, Liao GY, Chen Y, Xu B. Xie X, et al. Endocrinology. 2023 Jan 9;164(3):bqad008. doi: 10.1210/endocr/bqad008. Endocrinology. 2023. PMID: 36631165 Free PMC article.

In this study we investigated the role of brain-derived neurotrophic factor (BDNF) in the control of dietary fat intake in a mouse model that mimics the common human Val-to-Met (Val66Met) polymorphism that impairs BDNF release via the reg …

In this study we investigated the role of brain-derived neurotrophic factor (BDNF) in the control of diet …

67

Novel BDNF-regulatory microRNAs in neurodegenerative disorders pathogenesis: An in silico study.

Khani-Habibabadi F, Askari S, Zahiri J, Javan M, Behmanesh M. Khani-Habibabadi F, et al. Comput Biol Chem. 2019 Dec;83:107153. doi: 10.1016/j.compbiolchem.2019.107153. Epub 2019 Nov 2. Comput Biol Chem. 2019. PMID: 31751881

Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor with various roles in the central nervous system neurogenesis, neuroprotection, and axonal guide. ...Analyzed data led to introduce 5 newly reported miRNAs that coul …

Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor with various roles in the …

68

Human cerebral endothelial cells are a potential source for bioactive BDNF.

Bayas A, Hummel V, Kallmann BA, Karch C, Toyka KV, Rieckmann P. Bayas A, et al. Cytokine. 2002 Jul 21;19(2):55-8. doi: 10.1006/cyto.2002.0892. Cytokine. 2002. PMID: 12182839 Review.

Inflammatory stimuli within the central nervous system may not only induce tissue damage but may also convey neuroprotection. It has been shown that brain derived neurotrophic factor (BDNF) is a neuroprotective candidate. Here we show that BD …

Inflammatory stimuli within the central nervous system may not only induce tissue damage but may also convey neuroprotection. It has been sh …

69

A role for BDNF in mechanosensation.

Carroll P, Lewin GR, Koltzenburg M, Toyka KV, Thoenen H. Carroll P, et al. Nat Neurosci. 1998 May;1(1):42-6. doi: 10.1038/242. Nat Neurosci. 1998. PMID: 10195107

Brain-derived neurotrophic factor (BDNF) is a survival factor for certain sensory neurons during development. ...Postnatal treatment of BDNF +/- mice with recombinant BDNF completely rescued the mechanosensitivity deficit. . …

Brain-derived neurotrophic factor (BDNF) is a survival factor for certain sensory neurons during d …

70

BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues.

Stenz L, Zewdie S, Laforge-Escarra T, Prados J, La Harpe R, Dayer A, Paoloni-Giacobino A, Perroud N, Aubry JM. Stenz L, et al. Neurosci Res. 2015 Feb;91:1-7. doi: 10.1016/j.neures.2014.10.003. Epub 2014 Oct 17. Neurosci Res. 2015. PMID: 25450314

Several psychiatric disorders have been associated with CpG methylation changes in CG rich promoters of the brain-derived neurotrophic factor (BDNF) mainly by extracting DNA from peripheral blood cells. ...In the hippocampus, BDNF promote …

Several psychiatric disorders have been associated with CpG methylation changes in CG rich promoters of the brain-derived n …

71

BDNF rs6265 Met carriers with alcohol use disorder show greater age-related decline of N-acetylaspartate in left dorsolateral prefrontal cortex.

Durazzo TC, McNerney MW, Hansen AM, Gu M, Sacchet MD, Padula CB. Durazzo TC, et al. Drug Alcohol Depend. 2023 Jul 1;248:109901. doi: 10.1016/j.drugalcdep.2023.109901. Epub 2023 Apr 28. Drug Alcohol Depend. 2023. PMID: 37146499

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is implicated in neuronal and glial cell growth and differentiation, synaptic plasticity, and apoptotic mechanisms. A single-nucleotide polymorphism of the BDNF rs6265 gene may contribu …

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is implicated in neuronal and glial cell growth and …

72

Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin.

Leger C, Quirié A, Méloux A, Fontanier E, Chaney R, Basset C, Lemaire S, Garnier P, Prigent-Tessier A. Leger C, et al. Int J Mol Sci. 2024 Jan 19;25(2):1213. doi: 10.3390/ijms25021213. Int J Mol Sci. 2024. PMID: 38279218 Free PMC article.

The positive effects of physical exercise (EX) are well known to be mediated by cerebral BDNF (brain-derived neurotrophic factor), a neurotrophin involved in learning and memory, the expression of which could be induced by circulating irisin, a …

The positive effects of physical exercise (EX) are well known to be mediated by cerebral BDNF (brain-derived neurotr …

73

Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models.

Ge X, Zheng M, Hu M, Fang X, Geng D, Liu S, Wang L, Zhang J, Guan L, Zheng P, Xie Y, Pan W, Zhou M, Zhou L, Tang R, Zheng K, Yu Y, Huang XF. Ge X, et al. J Clin Invest. 2023 Feb 15;133(4):e154612. doi: 10.1172/JCI154612. J Clin Invest. 2023. PMID: 36787221 Free PMC article.

At single-cell resolution, we confirmed that QA impaired neurons, altered the dendritic spine's intracellular signal, and reduced brain-derived neurotrophic factor (BDNF) levels. Using Caenorhabditis elegans models, QA induced dopaminergic and g …

At single-cell resolution, we confirmed that QA impaired neurons, altered the dendritic spine's intracellular signal, and reduced brain …

74

BDNF specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance.

Fujimura M, Unoki T. Fujimura M, et al. Environ Toxicol. 2024 May;39(5):3149-3159. doi: 10.1002/tox.24174. Epub 2024 Feb 7. Environ Toxicol. 2024. PMID: 38323385

In our previous study using cultured rat neurons, we performed a comprehensive gene expression analysis and found that the brain-derived neurotrophic factor (BDNF), a neurotrophin (NT), was specifically expressed in HiNs. Therefore, to elucidate …

In our previous study using cultured rat neurons, we performed a comprehensive gene expression analysis and found that the brain-d …

75

The BDNF Val66Met Polymorphism, Regular Exercise, and Cognition: A Systematic Review.

Liu T, Li H, Colton JP, Ge S, Li C. Liu T, et al. West J Nurs Res. 2020 Aug;42(8):660-673. doi: 10.1177/0193945920907308. Epub 2020 Feb 20. West J Nurs Res. 2020. PMID: 32075548

The purpose of this study was to synthesize research evidence from studies on the relationships among the BDNF Val66Met polymorphism, regular exercise, and cognition in human subjects. PubMed, CINAHL, and Web of Science were searched systematically. ...Compelling evidence …

The purpose of this study was to synthesize research evidence from studies on the relationships among the BDNF Val66Met polymorphism, …

76

The expanding role of BDNF: a therapeutic target for Alzheimer's disease?

Fumagalli F, Racagni G, Riva MA. Fumagalli F, et al. Pharmacogenomics J. 2006 Jan-Feb;6(1):8-15. doi: 10.1038/sj.tpj.6500337. Pharmacogenomics J. 2006. PMID: 16314887 Review.

This review will focus on different pharmacological interventions that are currently in use or drugs under development, narrowing the therapeutic agents to those that interfere with the expression of the trophic factor brain-derived neurotrophic fac …

This review will focus on different pharmacological interventions that are currently in use or drugs under development, narrowing the therap …

77

BDNF blood serum linkage with BDNF gene polymorphism (rs6265) in thyroid pathology patients in the West-Ukrainian population.

Kamyshna II, Pavlovych LB, Sydorchuk LP, Malyk IV, Kamyshnyi AM. Kamyshna II, et al. Endocr Regul. 2021 Dec 7;55(4):193-203. doi: 10.2478/enr-2021-0021. Endocr Regul. 2021. PMID: 34879183 Free article.

Objective. Brain-derived neurotrophic factor (BDNF) is identified as an important growth factor involved in learning and memory. ...The analysis of the correlation between BDNF levels and the levels of thyroid-stimulating hormone ( …

Objective. Brain-derived neurotrophic factor (BDNF) is identified as an important growth factor in …

78

Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory neural network activity in mice in vitro.

Bouvier J, Autran S, Fortin G, Champagnat J, Thoby-Brisson M. Bouvier J, et al. J Physiol Paris. 2006 Nov-Dec;100(5-6):290-6. doi: 10.1016/j.jphysparis.2007.05.008. Epub 2007 Jun 8. J Physiol Paris. 2006. PMID: 17628454 Review.

In humans, several pathologies are associated with disturbances of the respiratory control, some of them including alteration in the brain-derived neurotrophic factor (BDNF) signalling pathway. BDNF has long been known as a neurotrophi …

In humans, several pathologies are associated with disturbances of the respiratory control, some of them including alteration in the brai …

79

High throughput assay for compounds that boost BDNF expression in neurons.

Liao GY, Xu H, Shumate J, Scampavia L, Spicer T, Xu B. Liao GY, et al. SLAS Discov. 2023 Apr;28(3):88-94. doi: 10.1016/j.slasd.2023.02.005. Epub 2023 Feb 25. SLAS Discov. 2023. PMID: 36842668 Free PMC article.

Deficiencies in brain-derived neurotrophic factor (BDNF) have been linked to several brain disorders, making compounds that can boost neuronal BDNF synthesis attractive as potential therapeutics. ...BDNF-NLuc protein appears to fun …

Deficiencies in brain-derived neurotrophic factor (BDNF) have been linked to several brain disorders, mak …

80

[Construction and expression of BDNF gene overexpression lentiviral vector].

Zhong J, Shi JC, Zhang Q, Meng JF, Zhang QQ, Li JG. Zhong J, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2022 Sep;38(5):397-400. doi: 10.12047/j.cjap.6280.2022.074. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2022. PMID: 37088740 Free article. Chinese.

81

Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning.

Petzold A, Psotta L, Brigadski T, Endres T, Lessmann V. Petzold A, et al. Neurobiol Learn Mem. 2015 Apr;120:52-60. doi: 10.1016/j.nlm.2015.02.009. Epub 2015 Feb 24. Neurobiol Learn Mem. 2015. PMID: 25724412

Brain-derived neurotrophic factor (BDNF) is a crucial mediator of neural plasticity and, consequently, of memory formation. In hippocampus-dependent learning tasks BDNF also seems to play an essential role. However, there are conflicting …

Brain-derived neurotrophic factor (BDNF) is a crucial mediator of neural plasticity and, consequently, of …

82

BDNF genotype Val66Met interacts with acute plasma BDNF levels to predict fear extinction and recall.

Ney LJ, Matthews A, Nicholson E, Zuj D, Ken Hsu CM, Steward T, Graham B, Harrison B, Nichols D, Felmingham K. Ney LJ, et al. Behav Res Ther. 2021 Oct;145:103942. doi: 10.1016/j.brat.2021.103942. Epub 2021 Jul 30. Behav Res Ther. 2021. PMID: 34340176

Brain-derived neurotropic factor (BDNF) is a potent regulator of memory processes and is believed to influence the consolidation of fear extinction memories. No previous human study has tested the effect of unstimulated BDNF on fear extinction r …

Brain-derived neurotropic factor (BDNF) is a potent regulator of memory processes and is believed to influence t …

83

A subpopulation of Bdnf-e1-expressing glutamatergic neurons in the lateral hypothalamus critical for thermogenesis control.

You H, Chu P, Guo W, Lu B. You H, et al. Mol Metab. 2020 Jan;31:109-123. doi: 10.1016/j.molmet.2019.11.013. Epub 2019 Nov 22. Mol Metab. 2020. PMID: 31918913 Free PMC article.

OBJECTIVE: Brown adipose tissue (BAT)-mediated thermogenesis plays a key role in energy homeostasis and the maintenance of body temperature. Previous work suggests that brain-derived neurotrophic factor (BDNF) is involved in BAT thermogenesis, b …

OBJECTIVE: Brown adipose tissue (BAT)-mediated thermogenesis plays a key role in energy homeostasis and the maintenance of body temperature. …

84

A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.

Meng P, Zhang X, Liu TT, Liu J, Luo Y, Xie MX, Yang H, Fang R, Guo DW, Zhong ZY, Wang YH, Ge JW. Meng P, et al. BMC Complement Med Ther. 2023 Jun 15;23(1):198. doi: 10.1186/s12906-023-04000-0. BMC Complement Med Ther. 2023. PMID: 37322430 Free PMC article.

Meanwhile, XYS could increase the expression of PSD-95, SYN in the CA1, CA3 regions of hippocampal by regulating the BDNF/trkB/PI3K signal axis. CONCLUSION: The possible mechanism on synapse of XYS in depression was successfully predicted. BDNF/trkB/PI3K signal axis …

Meanwhile, XYS could increase the expression of PSD-95, SYN in the CA1, CA3 regions of hippocampal by regulating the BDNF/trkB/PI3K s …

85

Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer's Disease.

Piancatelli D, Aureli A, Sebastiani P, Colanardi A, Del Beato T, Del Cane L, Sucapane P, Marini C, Di Loreto S. Piancatelli D, et al. Int J Mol Sci. 2022 Nov 23;23(23):14599. doi: 10.3390/ijms232314599. Int J Mol Sci. 2022. PMID: 36498925 Free PMC article.

Brain-derived neurotrophic factor (BDNF) has a protective role in Alzheimer's disease (AD). ...Patients with BDNFVal/Val homozygous also had significantly lower circulating BDNF compared with controls (p = 0.010). Moreover, lower BDNF …

Brain-derived neurotrophic factor (BDNF) has a protective role in Alzheimer's disease (AD). ...Patients w …

86

Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): a systematic review of experimental studies in the elderly.

Coelho FG, Gobbi S, Andreatto CA, Corazza DI, Pedroso RV, Santos-Galduróz RF. Coelho FG, et al. Arch Gerontol Geriatr. 2013 Jan-Feb;56(1):10-5. doi: 10.1016/j.archger.2012.06.003. Epub 2012 Jun 29. Arch Gerontol Geriatr. 2013. PMID: 22749404 Review.

Five out of six studies reported a significantly higher BDNF response to aerobic acute exercise and to aerobic or strength training program in healthy elderly and elderly with different pathologies. CONCLUSION: It was not possible to establish a recommendation protocol for …

Five out of six studies reported a significantly higher BDNF response to aerobic acute exercise and to aerobic or strength training p …

87

Neurohemodynamic correlates of BDNF gene expression in schizophrenia patients with working memory deficits: A functional MRI study.

Selvaraj S, Shivakumar V, Kavya PV, Mullapudi T, Bhalerao G, Sreeraj VS, Suhas S, Dinakaran D, Parlikar R, Chhabra H, Narayanaswamy JC, Debnath M, Rao NP, Muralidharan K, Venkatasubramanian G. Selvaraj S, et al. Asian J Psychiatr. 2022 Nov;77:103261. doi: 10.1016/j.ajp.2022.103261. Epub 2022 Sep 17. Asian J Psychiatr. 2022. PMID: 36181754

INTRODUCTION: Brain-derived neurotrophic factor (BDNF) is involved in neuroplasticity underlying cognitive deficits, including working memory deficits (WMD), in schizophrenia. ...CONCLUSION: We found a significant positive association between …

INTRODUCTION: Brain-derived neurotrophic factor (BDNF) is involved in neuroplasticity underlying cognitiv …

88

Longitudinal Changes in BDNF and MMP-9 Protein Plasma Levels in Children after Cochlear Implantation.

Matusiak M, Oziębło D, Ołdak M, Rejmak E, Kaczmarek L, Skarżyński H. Matusiak M, et al. Int J Mol Sci. 2023 Feb 13;24(4):3714. doi: 10.3390/ijms24043714. Int J Mol Sci. 2023. PMID: 36835126 Free PMC article.

In this longitudinal study, a cohort of 59 implanted children were divided into two subgroups according to their ages at implantation-below or above 1 year old-and the plasma levels of matrix metalloproteinase-9 (MMP-9), brain-derived neurotrophic factor …

In this longitudinal study, a cohort of 59 implanted children were divided into two subgroups according to their ages at implantation-below …

89

Cerebellar BDNF Promotes Exploration and Seeking for Novelty.

Laricchiuta D, Andolina D, Angelucci F, Gelfo F, Berretta E, Puglisi-Allegra S, Petrosini L. Laricchiuta D, et al. Int J Neuropsychopharmacol. 2018 May 1;21(5):485-498. doi: 10.1093/ijnp/pyy015. Int J Neuropsychopharmacol. 2018. PMID: 29471437 Free PMC article.

To verify the effects of the acute increase of brain derived neurotrophic factor, balancing and avoiding mice were bilaterally brain derived neurotrophic factor-infused in the cortical cerebellar regions. ...CONCLUSIONS: Cer …

To verify the effects of the acute increase of brain derived neurotrophic factor, balancing and avoiding mice we …

90

BDNF Val66Met polymorphism and protein levels in amniotic fluid.

Cattaneo A, Bocchio-Chiavetto L, Zanardini R, Marchina E, Bellotti D, Milanesi E, Moraschi S, Calabrese F, Barlati S, Riva MA, Gennarelli M. Cattaneo A, et al. BMC Neurosci. 2010 Feb 8;11:16. doi: 10.1186/1471-2202-11-16. BMC Neurosci. 2010. PMID: 20141627 Free PMC article.

BACKGROUND: Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin which plays survival- and growth-promoting activity in neuronal cells and it is involved in cellular plasticity mechanisms as it controls activity dependent synaptic transmis …

BACKGROUND: Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin which plays survival- and growth-p …

91

BDNF is required for the normal development of taste neurons in vivo.

Zhang C, Brandemihl A, Lau D, Lawton A, Oakley B. Zhang C, et al. Neuroreport. 1997 Mar 3;8(4):1013-7. doi: 10.1097/00001756-199703030-00039. Neuroreport. 1997. PMID: 9141083

This prompted the evaluation of null mutant mice corresponding to the three neurotrophin ligands for tyrosine kinase receptor B (TrkB): brain-derived neurotrophic factor (BDNF), neurotrophin (NT)3, NT4. The vallate gustatory epithelium of nt3-/- …

This prompted the evaluation of null mutant mice corresponding to the three neurotrophin ligands for tyrosine kinase receptor B (TrkB): b …

92

Kynurenine pathway is altered in BDNF Val66Met knock-in mice: Effect of physical exercise.

Ieraci A, Beggiato S, Ferraro L, Barbieri SS, Popoli M. Ieraci A, et al. Brain Behav Immun. 2020 Oct;89:440-450. doi: 10.1016/j.bbi.2020.07.031. Epub 2020 Jul 26. Brain Behav Immun. 2020. PMID: 32726686

The Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism has been correlated with increased predisposition to develop cognitive and psychiatric disorders, and with a reduced response to some therapeutic treatments. ...The aim of the pr …

The Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism has been correlated with increased pre …

93

BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function.

Spencer JL, Waters EM, Milner TA, Lee FS, McEwen BS. Spencer JL, et al. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4395-400. doi: 10.1073/pnas.0915105107. Epub 2010 Feb 8. Proc Natl Acad Sci U S A. 2010. PMID: 20142488 Free PMC article.

We tested whether the common human variant BDNF Val66Met interacts with estradiol in the control of hippocampal function in cycling female mice homozygous for the wild-type Val or BDNF Met variant. BDNF Met increased anxiety behavior, impaired memory, and inc …

We tested whether the common human variant BDNF Val66Met interacts with estradiol in the control of hippocampal function in cycling f …

94

Longitudinal associations between BDNF promoter methylation and late-life depression.

Kang HJ, Kim JM, Bae KY, Kim SW, Shin IS, Kim HR, Shin MG, Yoon JS. Kang HJ, et al. Neurobiol Aging. 2015 Apr;36(4):1764.e1-1764.e7. doi: 10.1016/j.neurobiolaging.2014.12.035. Epub 2015 Jan 6. Neurobiol Aging. 2015. PMID: 25648279

Reduced brain-derived neurotrophic factor (BDNF) function has been suggested as a risk factor for late-life depression. BDNF secretion is influenced by epigenetic (DNA promoter methylation) and genetic (val66met polymorphism) profi …

Reduced brain-derived neurotrophic factor (BDNF) function has been suggested as a risk factor for …

95

Development of mature BDNF-specific sandwich ELISA.

Lim Y, Zhong JH, Zhou XF. Lim Y, et al. J Neurochem. 2015 Jul;134(1):75-85. doi: 10.1111/jnc.13108. Epub 2015 Apr 21. J Neurochem. 2015. PMID: 25824396 Free article.

Mature brain-derived neurotrophic factor (mBDNF) plays a vital role in the nervous system, whereas proBDNF elicits neurodegeneration and neuronal apoptosis. ...This new ELISA will be useful for the measurement of mBDNF levels with high specificity in v …

Mature brain-derived neurotrophic factor (mBDNF) plays a vital role in the nervous system, whereas proBDNF elici …

96

The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity.

Goldfield GS, Cameron JD, Sigal RJ, Kenny GP, Prud'homme D, Ngu M, Alberga AS, Doucette S, Goldfield DB, Tulloch H, Thai H, Simas KR, Walsh J. Goldfield GS, et al. Physiol Rep. 2024 Jul;12(13):e16140. doi: 10.14814/phy2.16140. Physiol Rep. 2024. PMID: 38997217 Free PMC article.

The brain derived-neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF, and is associated with obesity and some psychiatric disorders, but its relationship to health-related quality of life (HRQoL) remains un …

The brain derived-neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF …

97

Molecular and Functional Characterization of BDNF-Overexpressing Human Retinal Pigment Epithelial Cells Established by Sleeping Beauty Transposon-Mediated Gene Transfer.

Mattern L, Otten K, Miskey C, Fuest M, Izsvák Z, Ivics Z, Walter P, Thumann G, Johnen S. Mattern L, et al. Int J Mol Sci. 2022 Oct 26;23(21):12982. doi: 10.3390/ijms232112982. Int J Mol Sci. 2022. PMID: 36361771 Free PMC article.

We present a treatment option for dry AMD that transfers the brain-derived neurotrophic factor (BDNF) gene into retinal pigment epithelial (RPE) cells by electroporation using the plasmid-based Sleeping Beauty (SB) transposon system. ...BDNF …

We present a treatment option for dry AMD that transfers the brain-derived neurotrophic factor (BDNF) gen …

98

Changes in BDNF Concentration in Men after Foam Roller Massage.

Murawska-Ciałowicz E, Ciałowicz M, Rosłanowski A, Kaczmarek A, Ratajczak-Wielgomas K, Kmiecik A, Partyńska A, Dzięgiel P, Andrzejewski W. Murawska-Ciałowicz E, et al. Cells. 2024 Sep 17;13(18):1564. doi: 10.3390/cells13181564. Cells. 2024. PMID: 39329748 Free PMC article.

The purpose of our study was to analyze the effect of roller massage on BDNF levels in men undergoing self-massage 4x/week/7 weeks. The control group consisted of men who did not perform self-massage. ...After the first week of self-massage, an increase in BDNF conc …

The purpose of our study was to analyze the effect of roller massage on BDNF levels in men undergoing self-massage 4x/week/7 weeks. T …

99

Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB.

Franks H, Wang R, Li M, Wang B, Wildmann A, Ortyl T, O'Brien S, Young D, Liao FF, Sakata K. Franks H, et al. J Neurochem. 2023 Apr;165(2):131-148. doi: 10.1111/jnc.15707. Epub 2022 Nov 17. J Neurochem. 2023. PMID: 36227087 Free PMC article.

Heat shock factor 1 (HSF1) is a master stress-responsive transcriptional factor, protecting cells from death. ...Here, we investigated its direct regulation of the brain-derived neurotrophic factor (BDNF) gene (Bdnf) in resp …

Heat shock factor 1 (HSF1) is a master stress-responsive transcriptional factor, protecting cells from death. ...Here, we inve …

100

Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity.

Gudasheva TA, Konstantinopolsky MA, Tarasiuk AV, Kolik LG, Seredenin SB. Gudasheva TA, et al. Dokl Biochem Biophys. 2019 Mar;485(1):123-125. doi: 10.1134/S1607672919020121. Epub 2019 Jun 14. Dokl Biochem Biophys. 2019. PMID: 31201630

Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. ...In this study, we established that GSB-106 also e …

Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) lo …

101

Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats.

Cheng S, Xu J, Wang W, Wang R, Li H, Jiang Z, Liu D, Pan F. Cheng S, et al. Psychopharmacology (Berl). 2023 Apr;240(4):837-851. doi: 10.1007/s00213-023-06325-7. Epub 2023 Feb 2. Psychopharmacology (Berl). 2023. PMID: 36725696

More importantly, mGluR5 expression is often accompanied by alterations in brain-derived neurotrophic factor (BDNF). Furthermore, BDNF/tropomyosin-associated kinase B (TrkB) signaling plays multiple roles, including roles in neuroplastici …

More importantly, mGluR5 expression is often accompanied by alterations in brain-derived neurotrophic factor ( …

102

BDNF Binds Its Pro-Peptide with High Affinity and the Common Val66Met Polymorphism Attenuates the Interaction.

Uegaki K, Kumanogoh H, Mizui T, Hirokawa T, Ishikawa Y, Kojima M. Uegaki K, et al. Int J Mol Sci. 2017 May 12;18(5):1042. doi: 10.3390/ijms18051042. Int J Mol Sci. 2017. PMID: 28498321 Free PMC article.

In the present study, we investigated the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (BDNF), which promotes neuronal survival, differentiation and synaptic plasticity. The BDNF pro-peptide is a post-processing produc …

In the present study, we investigated the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (B …

103

A "deficient environment" in prenatal life may compromise systems important for cognitive function by affecting BDNF in the hippocampus.

Gomez-Pinilla F, Vaynman S. Gomez-Pinilla F, et al. Exp Neurol. 2005 Apr;192(2):235-43. doi: 10.1016/j.expneurol.2004.12.001. Exp Neurol. 2005. PMID: 15755541 Review.

These structural changes are accompanied by a disruption in the normal expression pattern of brain-derived neurotrophic factor (BDNF) and its cognate tyrosine kinase B (TrkB) receptor. ...These findings have implications for disorders that invol …

These structural changes are accompanied by a disruption in the normal expression pattern of brain-derived neurotrophic …

104

BDNF, but not NT-4, is necessary for normal development of Meissner corpuscles.

González-Martínez T, Fariñas I, Del Valle ME, Feito J, Germanà G, Cobo J, Vega JA. González-Martínez T, et al. Neurosci Lett. 2005 Mar 22;377(1):12-5. doi: 10.1016/j.neulet.2004.11.078. Epub 2004 Dec 19. Neurosci Lett. 2005. PMID: 15722178

All wild-type animals as well as NT-4(-/-) animals and BDNF and NT4 heterozygous animals have Meissner corpuscles that are normal in number and size. However, Meissner corpuscles are absent the BDNF(-/-) mice. These results suggest that BDNF is the only TrkB …

All wild-type animals as well as NT-4(-/-) animals and BDNF and NT4 heterozygous animals have Meissner corpuscles that are normal in …

105

BDNF Val66Met moderates episodic memory decline and tau biomarker increases in early sporadic Alzheimer's disease.

Thomson D, Rosenich E, Maruff P, Lim YY; Alzheimer’s Disease Neuroimaging Initiative. Thomson D, et al. Arch Clin Neuropsychol. 2024 Aug 24;39(6):683-691. doi: 10.1093/arclin/acae014. Arch Clin Neuropsychol. 2024. PMID: 38454193 Free PMC article.

OBJECTIVE: Allelic variation in the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been shown to moderate rates of cognitive decline in preclinical sporadic Alzheimer's disease (AD; i.e., Abeta + older adults), and pre-sympto …

OBJECTIVE: Allelic variation in the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has be …

106

Follicular fluid exosomes inhibit BDNF expression and promote the secretion of chemokines in granulosa cells by delivering miR-10b-5p.

Yuan C, Cao M, Chen L, Zhao Y, Chen X, Shen C, Li C, Zhou X. Yuan C, et al. Theriogenology. 2023 Mar 15;199:86-94. doi: 10.1016/j.theriogenology.2023.01.013. Epub 2023 Jan 16. Theriogenology. 2023. PMID: 36709652

The results showed that, when compared to the controls, the expression of the chemokines CCL2 and CXCL8 was significantly increased, whereas the expression of brain-derived neurotrophic factor (BDNF) was significantly decreased. The miRNA expres …

The results showed that, when compared to the controls, the expression of the chemokines CCL2 and CXCL8 was significantly increased, whereas …

107

Gastrodin promotes the regeneration of peripheral nerves by regulating miR-497/BDNF axis.

Yongguang L, Xiaowei W, Huichao Y, Yanxiang Z. Yongguang L, et al. BMC Complement Med Ther. 2022 Feb 18;22(1):45. doi: 10.1186/s12906-021-03483-z. BMC Complement Med Ther. 2022. PMID: 35177060 Free PMC article.

Dual-luciferase reporter gene assays were applied to verify the binding site between miR-497 and brain-derived neurotrophic factor (BDNF) 3'UTR. MiR-497 expression was probed by quantitative real-time polymerase chain reaction (qRT-PCR). ...GAS …

Dual-luciferase reporter gene assays were applied to verify the binding site between miR-497 and brain-derived neurotrophic …

108

Effects of Tail Pinch on BDNF and trkB Expression in the Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats.

Serra MP, Sanna F, Boi M, Trucas M, Fernández-Teruel A, Corda MG, Giorgi O, Quartu M. Serra MP, et al. Int J Mol Sci. 2023 May 30;24(11):9498. doi: 10.3390/ijms24119498. Int J Mol Sci. 2023. PMID: 37298449 Free PMC article.

In this article, we describe the effects of tail pinch (TP), a mild acute stressor, on the levels of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor B (trkB) proteins in the hippocampus (HC) of the outbred Roman High- ( …

In this article, we describe the effects of tail pinch (TP), a mild acute stressor, on the levels of brain-derived neurotro …

109

Brain-derived neurotrophic factor and schizophrenia.

Di Carlo P, Punzi G, Ursini G. Di Carlo P, et al. Psychiatr Genet. 2019 Oct;29(5):200-210. doi: 10.1097/YPG.0000000000000237. Psychiatr Genet. 2019. PMID: 31465000 Free PMC article. Review.

The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the central nervous system. ...A deeper understanding of bra …

The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes neuronal p …

110

The miR-195-3p/BDNF axis is a promising therapeutic for heart failure.

Yao L, Gong X, Liu Y, Hao K, Jiang J, Luo Z. Yao L, et al. Int J Cardiol. 2024 Jul 1;406:131991. doi: 10.1016/j.ijcard.2024.131991. Epub 2024 Mar 22. Int J Cardiol. 2024. PMID: 38521509 No abstract available.

111

BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skin.

Botchkarev VA, Botchkareva NV, Lommatzsch M, Peters EM, Lewin GR, Subramaniam A, Braun A, Renz H, Paus R. Botchkarev VA, et al. Eur J Neurosci. 1998 Oct;10(10):3276-83. doi: 10.1046/j.1460-9568.1998.00365.x. Eur J Neurosci. 1998. PMID: 9786221

Here, we have investigated the sympathetic innervation of back skin in mice overexpressing brain-derived neurotrophic factor (BDNF) under the alpha-myosin heavy-chain promoter, as well as in BDNF knockout (-/-) mice. ...This suggests that …

Here, we have investigated the sympathetic innervation of back skin in mice overexpressing brain-derived neurotrophic …

112

The effect of acute crocin on behavioral changes and BDNF expression level in socially isolated rats.

Kamaei AK, Hosseini SF, Teimourparsaei P, Payamani M, Vaseghi S. Kamaei AK, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun;397(6):3929-3944. doi: 10.1007/s00210-023-02843-5. Epub 2023 Nov 21. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37987792

Real-time PCR was used to assess BDNF hippocampal expression level. The results showed that social isolation decreased anxiety- and depressive-like behavior, pain threshold, and BDNF expression, and induced OCD-like behavior and hyperlocomotion. ...It can be suggest …

Real-time PCR was used to assess BDNF hippocampal expression level. The results showed that social isolation decreased anxiety- and d …

113

Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of beta-glucan on chronic stress-induced depression-like behaviors in mice.

Zhao C, Shi R, Lu X, Yang R, Chen Z, Chen B, Hu W, Ren J, Peng J, Zhu T, Zhu H, Huang C. Zhao C, et al. Eur J Pharmacol. 2024 Feb 5;964:176288. doi: 10.1016/j.ejphar.2023.176288. Epub 2023 Dec 23. Eur J Pharmacol. 2024. PMID: 38142848

Our results showed that a single injection of beta-glucan one day before stress exposure dose-dependently prevented the depression-like behaviors triggered by chronic unpredictable stress (CUS), which peaked at 20 mg/kg and prevented the impairment of hippocampal brain- …

Our results showed that a single injection of beta-glucan one day before stress exposure dose-dependently prevented the depression-like beha …

114

BDNF gene can Be activated by Ca2+ signals without involvement of de novo AP-1 synthesis.

Sano K, Nanba H, Tabuchi A, Tsuchiya T, Tsuda M. Sano K, et al. Biochem Biophys Res Commun. 1996 Dec 24;229(3):788-93. doi: 10.1006/bbrc.1996.1881. Biochem Biophys Res Commun. 1996. PMID: 8954973

Although stimulation of N-methyl-D-aspartate receptors or voltage-dependent calcium channels induces both the activation of c-fos and brain-derived neurotrophic factor (BDNF) genes, it is not certain how the activation of these genes is related. …

Although stimulation of N-methyl-D-aspartate receptors or voltage-dependent calcium channels induces both the activation of c-fos and bra …

115

Endoplasmic reticulum stress in the livers of BDNF heterozygous knockout mice.

Cırrık S, Hacioglu G, Abidin İ, Aydın-Abidin S, Noyan T. Cırrık S, et al. Arch Physiol Biochem. 2019 Oct;125(4):378-386. doi: 10.1080/13813455.2018.1489850. Epub 2018 Jul 24. Arch Physiol Biochem. 2019. PMID: 30039987

Context: Involvement of endoplasmic reticulum (ER) stress and brain-derived neurotrophic factor (BDNF) in hepatic lipid metabolism has been reported previously. ...Animals were divided into four groups; WT, WT + Tm, BDNF((+/-)), and BD …

Context: Involvement of endoplasmic reticulum (ER) stress and brain-derived neurotrophic factor (BDNF) in …

116

Eucommia Leaf Extract Induces BDNF Production in Rat Hypothalamus and Enhances Lipid Metabolism and Aerobic Glycolysis in Rat Liver.

Oikawa H, Miyazaki S, Kurata R, Hattori M, Hayashi N, Kawaguchi N, Hirata T, Ueda T, Fujikawa T. Oikawa H, et al. Curr Mol Pharmacol. 2021;14(2):234-244. doi: 10.2174/1874467213666200505094631. Curr Mol Pharmacol. 2021. PMID: 32368990

BACKGROUND: Mutations in the brain-derived neurotrophic factor (BDNF) gene and its receptor, tyrosine receptor kinase B (TrkB), have been reported to cause severe obesity in rodents. ...In addition, in rat hypothalamus, significant elevations in …

BACKGROUND: Mutations in the brain-derived neurotrophic factor (BDNF) gene and its receptor, tyrosine rec …

117

BDNF-GFP containing secretory granules are localized in the vicinity of synaptic junctions of cultured cortical neurons.

Haubensak W, Narz F, Heumann R, Lessmann V. Haubensak W, et al. J Cell Sci. 1998 Jun;111 ( Pt 11):1483-93. doi: 10.1242/jcs.111.11.1483. J Cell Sci. 1998. PMID: 9580557

The protein family of mammalian neurotrophins, comprising nerve-growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 and -4/5 (NT-3, NT-4/5), supports the survival and the phenotype of neurons from the central as …

The protein family of mammalian neurotrophins, comprising nerve-growth factor (NGF), brain-derived neurotrophic …

118

Serum brain-derived neurotrophic factor (BDNF) at rest and after acute aerobic exercise in major depressive disorder.

Kallies G, Rapp MA, Fydrich T, Fehm L, Tschorn M, Terán C, Schwefel M, Pietrek A, Henze R, Hellweg R, Ströhle A, Heinzel S, Heissel A. Kallies G, et al. Psychoneuroendocrinology. 2019 Apr;102:212-215. doi: 10.1016/j.psyneuen.2018.12.015. Epub 2018 Dec 14. Psychoneuroendocrinology. 2019. PMID: 30583245

Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect …

Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in …

119

Effects of BDNF Val66Met polymorphisms on brain structures and behaviors in adolescents with conduct disorder.

Jiang Y, Ming Q, Gao Y, Dong D, Sun X, Zhang X, Situ W, Yao S, Rao H. Jiang Y, et al. Eur Child Adolesc Psychiatry. 2020 Apr;29(4):479-488. doi: 10.1007/s00787-019-01363-z. Epub 2019 Jul 1. Eur Child Adolesc Psychiatry. 2020. PMID: 31264106

Accumulating evidence suggests that neural abnormalities in conduct disorder (CD) may be subject to genetic influences, but few imaging studies have taken genetic variants into consideration. The Val66Met polymorphism of brain-derived neurotrophic factor …

Accumulating evidence suggests that neural abnormalities in conduct disorder (CD) may be subject to genetic influences, but few imaging stud …

120

YTHDF2 as a Mediator in BDNF-Induced Proliferation of Porcine Follicular Granulosa Cells.

Liu K, Zhou X, Li C, Shen C, He G, Chen T, Cao M, Chen X, Zhang B, Chen L. Liu K, et al. Int J Mol Sci. 2024 Feb 16;25(4):2343. doi: 10.3390/ijms25042343. Int J Mol Sci. 2024. PMID: 38397033 Free PMC article.

In female mammals, the proliferation and apoptosis of granulosa cells (GCs) are critical in determining the fate of follicles and are influenced by various factors, including brain-derived neurotrophic factor (BDNF). Previous research has shown …

In female mammals, the proliferation and apoptosis of granulosa cells (GCs) are critical in determining the fate of follicles and are influe …

121

BDNF Val66Met polymorphism and serum concentrations of BDNF with smoking in Thai males.

Suriyaprom K, Tungtrongchitr R, Thawnashom K, Pimainog Y. Suriyaprom K, et al. Genet Mol Res. 2013 Oct 24;12(4):4925-33. doi: 10.4238/2013.October.24.3. Genet Mol Res. 2013. PMID: 24301752 Free article.

Many studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in the reward system of addiction, and that nicotine may induce alterations in BDNF gene expression and its protein level within the mesocorticolimbic s …

Many studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in the reward syste …

122

Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory.

Jaehne EJ, Kent JN, Antolasic EJ, Wright BJ, Spiers JG, Creutzberg KC, De Rosa F, Riva MA, Sortwell CE, Collier TJ, van den Buuse M. Jaehne EJ, et al. Transl Psychiatry. 2022 Mar 7;12(1):93. doi: 10.1038/s41398-022-01858-5. Transl Psychiatry. 2022. PMID: 35256586 Free PMC article.

The common brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced activity-dependent BDNF release and increased risk for anxiety disorders and PTSD. ...There were no changes in open-field locomotor activ …

The common brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced acti …

123

BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons.

Frank L, Ventimiglia R, Anderson K, Lindsay RM, Rudge JS. Frank L, et al. Eur J Neurosci. 1996 Jun;8(6):1220-30. doi: 10.1111/j.1460-9568.1996.tb01290.x. Eur J Neurosci. 1996. PMID: 8752592

Regulation of Trk receptors by their ligands, the neurotrophins, was investigated in dissociated cultures of embryonic day 18 rat hippocampal neurons. Cultures were exposed to brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) or NT …

Regulation of Trk receptors by their ligands, the neurotrophins, was investigated in dissociated cultures of embryonic day 18 rat hippocampa …

124

Individual differences and knockout in zebrafish reveal similar cognitive effects of BDNF between teleosts and mammals.

Lucon-Xiccato T, Montalbano G, Gatto E, Frigato E, D'Aniello S, Bertolucci C. Lucon-Xiccato T, et al. Proc Biol Sci. 2022 Dec 21;289(1989):20222036. doi: 10.1098/rspb.2022.2036. Epub 2022 Dec 21. Proc Biol Sci. 2022. PMID: 36541170 Free PMC article.

We tested this hypothesis by assessing the effects of the brain-derived neurotrophic factor (BDNF), which is critical for mammalian cognitive functioning, on fish's cognitive abilities. We found that individual differences in zebrafish's learnin …

We tested this hypothesis by assessing the effects of the brain-derived neurotrophic factor (BDNF), which …

125

Maternal supply of BDNF to mouse fetal brain through the placenta.

Kodomari I, Wada E, Nakamura S, Wada K. Kodomari I, et al. Neurochem Int. 2009 Feb;54(2):95-8. doi: 10.1016/j.neuint.2008.11.005. Epub 2008 Dec 9. Neurochem Int. 2009. PMID: 19114070

In the present study, we tested permeation of maternal brain-derived neurotrophic factor (BDNF) to fetuses, using BDNF-gene deficient mice and exogenous BDNF administration. At embryonic day 13.5 (E13.5)-14.5, BDNF protein c …

In the present study, we tested permeation of maternal brain-derived neurotrophic factor (BDNF) to fetuse …

126

Chronic exposure to imipramine induces a switch from depression-like to mania-like behavior in female serotonin transporter knockout rats: Role of BDNF signaling in the infralimbic cortex.

Sadighi M, Mai L, Xu Y, Boillot M, Targa G, Mottarlini F, Brambilla P, Gass P, Caffino L, Fumagalli F, Homberg JR. Sadighi M, et al. J Affect Disord. 2024 Apr 15;351:128-142. doi: 10.1016/j.jad.2024.01.186. Epub 2024 Jan 26. J Affect Disord. 2024. PMID: 38280571 Free article.

METHODS: To investigate the potential neuronal pathways, serotonin transporter knockout (SERT KO) rats, an experimental model of female BD patients, were subjected to a battery of behavioral tests under chronic treatment of the antidepressant imipramine. In addition, the expressi …

METHODS: To investigate the potential neuronal pathways, serotonin transporter knockout (SERT KO) rats, an experimental model of female BD p …

127

Brain-derived neurotrophic factor knock-out mice develop non-alcoholic steatohepatitis.

Ichimura-Shimizu M, Kojima M, Suzuki S, Miyata M, Osaki Y, Matsui K, Mizui T, Tsuneyama K. Ichimura-Shimizu M, et al. J Pathol. 2023 Dec;261(4):465-476. doi: 10.1002/path.6204. Epub 2023 Oct 2. J Pathol. 2023. PMID: 37781961

While brain-derived neurotrophic factor (BDNF), which is a growth factor associated with cognitive improvement and the alleviation of depression symptoms, is known to regulate food intake and body weight, the role of BDNF in periph …

While brain-derived neurotrophic factor (BDNF), which is a growth factor associated with cognitive …

128

Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer's Disease.

Wu CC, Lien CC, Hou WH, Chiang PM, Tsai KJ. Wu CC, et al. Sci Rep. 2016 Jun 6;6:27358. doi: 10.1038/srep27358. Sci Rep. 2016. PMID: 27264956 Free PMC article.

Stem cell-based therapy is a potential treatment for neurodegenerative diseases, but its application to Alzheimer's disease (AD) remains limited. Brain-derived neurotrophic factor (BDNF) is critical in the pathogenesis and treatment of AD. Here, …

Stem cell-based therapy is a potential treatment for neurodegenerative diseases, but its application to Alzheimer's disease (AD) remains lim …

129

Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance.

Sakata K, Martinowich K, Woo NH, Schloesser RJ, Jimenez DV, Ji Y, Shen L, Lu B. Sakata K, et al. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15103-8. doi: 10.1073/pnas.1222872110. Epub 2013 Aug 26. Proc Natl Acad Sci U S A. 2013. PMID: 23980178 Free PMC article.

Activity-dependent gene transcription, including that of the brain-derived neurotrophic factor (Bdnf) gene, has been implicated in various cognitive functions. ...Here, we show that disruption of activity-dependent BDNF expression impairs …

Activity-dependent gene transcription, including that of the brain-derived neurotrophic factor (Bdnf) gen …

130

Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses.

Zakharenko SS, Patterson SL, Dragatsis I, Zeitlin SO, Siegelbaum SA, Kandel ER, Morozov A. Zakharenko SS, et al. Neuron. 2003 Sep 11;39(6):975-90. doi: 10.1016/s0896-6273(03)00543-9. Neuron. 2003. PMID: 12971897 Free article.

Brain-derived neurotrophic factor (BDNF) has been implicated in several forms of long-term potentiation (LTP) at different hippocampal synapses. ...BDNF-dependent forms of LTP also require activation of L-type voltage-gated calcium channe …

Brain-derived neurotrophic factor (BDNF) has been implicated in several forms of long-term potentiation ( …

131

SRF and SRF Cofactor mRNA Expression Is Differentially Regulated by BDNF Stimulation in Cortical Neurons.

Ihara D, Miyata T, Fukuchi M, Tsuda M, Tabuchi A. Ihara D, et al. Biol Pharm Bull. 2023 Apr 1;46(4):636-639. doi: 10.1248/bpb.b22-00825. Epub 2023 Feb 18. Biol Pharm Bull. 2023. PMID: 36801840 Free article.

Serum response factor (SRF) is a transcription factor that plays essential roles in multiple brain functions in concert with SRF cofactors such as ternary complex factor (TCF) and megakaryoblastic leukemia (MKL)/myocardin-related transcription factor ( …

Serum response factor (SRF) is a transcription factor that plays essential roles in multiple brain functions in concert with S …

132

Azadiradione up-regulates the expression of parvalbumin and BDNF via Ube3a.

Jana S, Giri B, Das S, Manna A, Mandal SC, Ranjan Jana N. Jana S, et al. Gene. 2024 Mar 1;897:148081. doi: 10.1016/j.gene.2023.148081. Epub 2023 Dec 13. Gene. 2024. PMID: 38101713

Treatment of azadiradione to HT22 hippocampal cell line and in adult mice induced the expression of Ube3a as well as two important synaptic function and plasticity regulating proteins, parvalbumin and brain-derived neurotropic factor (BDNF). Interestin …

Treatment of azadiradione to HT22 hippocampal cell line and in adult mice induced the expression of Ube3a as well as two important synaptic …

133

The BDNF-ERK/MAPK axis reduces phosphatase and actin regulator1, 2 and 3 (PHACTR1, 2 and 3) mRNA expressions in cortical neurons.

Ihara D, Oishi R, Kasahara S, Yamamoto A, Kaito M, Tabuchi A. Ihara D, et al. Drug Discov Ther. 2024 Sep 19;18(4):255-259. doi: 10.5582/ddt.2024.01048. Epub 2024 Aug 25. Drug Discov Ther. 2024. PMID: 39183043 Free article.

In this study, we focused on an important neurotrophin, brain-derived neurotrophic factor (BDNF), and examined its effect on mRNA expression of PHACTR family member in cortical neurons. ...These findings aid the elucidation of how BDNF re …

In this study, we focused on an important neurotrophin, brain-derived neurotrophic factor (BDNF), and exa …

134

Spontaneous urinary bladder regeneration after subtotal cystectomy increases YAP/WWTR1 signaling and downstream BDNF expression: Implications for smooth muscle injury responses.

Aitken KJ, Yadav P, Sidler M, Thanabalasingam T, Ahmed T, Aggarwal P, Yip ST, Jeffrey N, Jiang JX, Siebenaller A, Sotiropoulos C, Huang R, Le DMQ, Delgado-Olguin P, Bagli D. Aitken KJ, et al. PLoS One. 2023 Jul 26;18(7):e0287205. doi: 10.1371/journal.pone.0287205. eCollection 2023. PLoS One. 2023. PMID: 37494380 Free PMC article.

Rodents have the capacity for spontaneous bladder regeneration and bladder smooth muscle cell (BSMC) migration following a subtotal cystectomy (STC). YAP/WWTR1 and BDNF (Brain-derived neurotrophic factor) play crucial roles in development and re …

Rodents have the capacity for spontaneous bladder regeneration and bladder smooth muscle cell (BSMC) migration following a subtotal cystecto …

135

Characterization of endotoxin free protein production of brain-derived neurotrophic factor (BDNF) for the study of Parkinson model in SH-SY5Y differentiated cells.

Saisawang C, Priewkhiew S, Wongsantichon J, Reamtong O, Nopparat C, Mukda S, Ketterman AJ, Govitrapong P. Saisawang C, et al. Protein Expr Purif. 2023 Mar;203:106212. doi: 10.1016/j.pep.2022.106212. Epub 2022 Dec 5. Protein Expr Purif. 2023. PMID: 36481372

The cellular differentiation process begins with retinoic acid incubation, followed by incubation with brain-derived neurotrophic factor (BDNF), a recombinant protein produced in E. coli cells. ...The expression of DCX and MAP-2 in differentiate …

The cellular differentiation process begins with retinoic acid incubation, followed by incubation with brain-derived neurot …

136

Increased Methylation of Brain-Derived Neurotrophic Factor (BDNF) Is Related to Emotionally Unstable Personality Disorder and Severity of Suicide Attempt in Women.

Jamshidi E, Boström AED, Wilczek A, Nilsonne Å, Åsberg M, Jokinen J. Jamshidi E, et al. Cells. 2023 Jan 17;12(3):350. doi: 10.3390/cells12030350. Cells. 2023. PMID: 36766691 Free PMC article.

Brain-derived neurotrophic factor (BDNF) has previously been associated with the pathogenesis of both emotionally unstable personality disorder (EUPD) and suicidal behavior. ...Further studies investigating epigenetic and genetic effects of B …

Brain-derived neurotrophic factor (BDNF) has previously been associated with the pathogenesis of both emo …

137

Association of serum BDNF levels and the BDNF Val66Met polymorphism with the sleep pattern in healthy young adults.

Saitoh K, Furihata R, Kaneko Y, Suzuki M, Takahashi S, Uchiyama M. Saitoh K, et al. PLoS One. 2018 Jun 26;13(6):e0199765. doi: 10.1371/journal.pone.0199765. eCollection 2018. PLoS One. 2018. PMID: 29944703 Free PMC article. Clinical Trial.

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is widely expressed in the brain and plays an important role in neuronal maintenance, plasticity, and neurogenesis. ...STUDY OBJECTIVES: To elucidate whether the serum BDNF levels and …

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is widely expressed in the brain and plays an import …

138

Neuroblasts migration under control of reactive astrocyte-derived BDNF: a promising therapy in late neurogenesis after traumatic brain injury.

Wu N, Sun X, Zhou C, Yan J, Cheng C. Wu N, et al. Stem Cell Res Ther. 2023 Jan 5;14(1):2. doi: 10.1186/s13287-022-03232-0. Stem Cell Res Ther. 2023. PMID: 36600294 Free PMC article.

Neurogenesis has provided therapeutic options for treating TBI. Brain derived neurotrophic factor (BDNF) plays a key role in neuroblasts migration. We aimed to investigate to the key regulating principle of BDNF in endogenous neuroblasts …

Neurogenesis has provided therapeutic options for treating TBI. Brain derived neurotrophic factor (BDNF) …

139

Generation of three induced pluripotent stem cell lines carrying different variants of the BDNF (Val66Met) polymorphism.

Horschitz S, Frank J, Koch P. Horschitz S, et al. Stem Cell Res. 2023 Feb;66:102989. doi: 10.1016/j.scr.2022.102989. Epub 2022 Dec 5. Stem Cell Res. 2023. PMID: 36473250 Free article.

Brain-derived neurotrophic factor (BDNF) has been implicated in a multitude of neurodevelopmental processes including neuronal differentiation, axonal outgrowth, synaptic plasticity, or survival. One human-specific single nucleotide polymorphism …

Brain-derived neurotrophic factor (BDNF) has been implicated in a multitude of neurodevelopmental process …

140

An Imbalance in the Pro/mature BDNF Ratio Occurs in Multiple Brain Regions During Normal Ageing in Wild-Type Mice.

Cade S, Zhou XF, Bobrovskaya L. Cade S, et al. J Mol Neurosci. 2023 Jun;73(6):469-484. doi: 10.1007/s12031-023-02131-0. Epub 2023 Jun 14. J Mol Neurosci. 2023. PMID: 37314606 Free PMC article.

The main aim of this study was to determine how precursor brain-derived neurotrophic factor changes relative to its mature isoform with normal brain ageing in wild type mice. ...Relative amounts of precursor brain-derived neurotrophic …

The main aim of this study was to determine how precursor brain-derived neurotrophic factor changes relative to …

141

Acute exercise modulates BDNF and pro-BDNF protein content in immune cells.

Brunelli A, Dimauro I, Sgrò P, Emerenziani GP, Magi F, Baldari C, Guidetti L, Di Luigi L, Parisi P, Caporossi D. Brunelli A, et al. Med Sci Sports Exerc. 2012 Oct;44(10):1871-80. doi: 10.1249/MSS.0b013e31825ab69b. Med Sci Sports Exerc. 2012. PMID: 22543740

PURPOSE: Although several studies have shown that immune cells stimulated by in vitro stress are capable to produce neurotrophins, there is still no evidence whether physiological stress, such as exercise, can modulate the in vivo levels of brain-derived neurotro …

PURPOSE: Although several studies have shown that immune cells stimulated by in vitro stress are capable to produce neurotrophins, there is …

142

Brain-Derived Neurotrophic Factor (BDNF) in the Frontal Cortex Enhances Social Interest in the BTBR Mouse Model of Autism.

Kaminskaya YP, Ilchibaeva TV, Shcherbakova AI, Allayarova ER, Popova NK, Naumenko VS, Tsybko AS. Kaminskaya YP, et al. Biochemistry (Mosc). 2024 Aug;89(8):1509-1518. doi: 10.1134/S0006297924080091. Biochemistry (Mosc). 2024. PMID: 39245458

A large body of evidence implies the involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of autism spectrum disorders (ASDs). A deficiency of BDNF in the hippocampus and frontal cortex of BTBR mice (a model of auti …

A large body of evidence implies the involvement of brain-derived neurotrophic factor (BDNF) in the patho …

143

Acute Normobaric Hypoxia Lowers Executive Functions among Young Men despite Increase of BDNF Concentration.

Chroboczek M, Kujach S, Łuszczyk M, Grzywacz T, Soya H, Laskowski R. Chroboczek M, et al. Int J Environ Res Public Health. 2022 Aug 30;19(17):10802. doi: 10.3390/ijerph191710802. Int J Environ Res Public Health. 2022. PMID: 36078520 Free PMC article.

There was a significant increase (p < 0.013) in the brain-derived neurotrophic factor (BDNF) level after NH conditions compared to the baseline, which was not seen in NOR. ...We also noted that this negative effect was associated with decreas

…

There was a significant increase (p < 0.013) in the brain-derived neurotrophic factor (BDNF) level aft

…

144

Influence of altered serum and muscle concentrations of BDNF on electrophysiological properties of spinal motoneurons in wild-type and BDNF-knockout rats.

Grzelak N, Krutki P, Bączyk M, Kaczmarek D, Mrówczyński W. Grzelak N, et al. Sci Rep. 2023 Mar 20;13(1):4571. doi: 10.1038/s41598-023-31703-8. Sci Rep. 2023. PMID: 36941445 Free PMC article.

The purpose of this study was to determine whether altered serum and/or muscle concentrations of brain-derived neurotrophic factor (BDNF) can modify the electrophysiological properties of spinal motoneurons (MNs). ...The latter two groups underw …

The purpose of this study was to determine whether altered serum and/or muscle concentrations of brain-derived neurotrophic …

145

Effects of moderate-intensity aerobic exercise on serum BDNF and motor learning in the upper-limb in patients after chronic-stroke: A randomized, controlled feasibility study with embedded health economic evaluation.

Maguire C, Betschart M, Pohl J, Primani F, Taeymans J, Hund-Georgiadis M. Maguire C, et al. NeuroRehabilitation. 2023;52(3):485-506. doi: 10.3233/NRE-220239. NeuroRehabilitation. 2023. PMID: 36806518 Clinical Trial.

BACKGROUND: Brain-derived neurotrophic factor (BDNF) promotes activity-dependent neuroplasticity and is released following aerobic-exercise. ...CLINICAL OUTCOMES: No significant changes in immediate or long-term serum-BDNF in either group …

BACKGROUND: Brain-derived neurotrophic factor (BDNF) promotes activity-dependent neuroplasticity and is r …

146

The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice.

Moffat JJ, Sakhai SA, Hoisington ZW, Ehinger Y, Ron D. Moffat JJ, et al. Psychopharmacology (Berl). 2023 Feb;240(2):303-317. doi: 10.1007/s00213-022-06305-3. Epub 2023 Jan 9. Psychopharmacology (Berl). 2023. PMID: 36622381 Free PMC article.

BACKGROUND: The brain-derived neurotrophic factor (BDNF) Valine 66 to Methionine human polymorphism results in impaired activity-dependent BDNF release and has been linked to psychiatric disorders including depression and anxiety. ...CONC …

BACKGROUND: The brain-derived neurotrophic factor (BDNF) Valine 66 to Methionine human polymorphism resul …

147

Identification of key genes involved in neural regeneration and the repairing effect of BDNF-overexpressed BMSCs on spinal cord ischemia-reperfusion injury in rats.

Yin F, Liu Z, Zhang D, Shen Z, Niu Z, Guo L. Yin F, et al. Biomed Pharmacother. 2023 Apr;160:114293. doi: 10.1016/j.biopha.2023.114293. Epub 2023 Feb 1. Biomed Pharmacother. 2023. PMID: 36736275 Free article.

Bone marrow mesenchymal stem cells (BMSCs) can repair spinal cord ischemia-reperfusion injury (SCII); however, only a few BMSCs are usually located in the injured spinal cord. Since the brain-derived neurotrophic factor (BDNF) can promote neural …

Bone marrow mesenchymal stem cells (BMSCs) can repair spinal cord ischemia-reperfusion injury (SCII); however, only a few BMSCs are usually …

148

[Research progress of BDNF and depression].

Qiao H, An SC, Xu C. Qiao H, et al. Sheng Li Ke Xue Jin Zhan. 2011 Jun;42(3):195-200. Sheng Li Ke Xue Jin Zhan. 2011. PMID: 21932517 Review. Chinese.

BDNF is widespread existed in CNS and PNS, because of its function in nerve regeneration and restoration, more and more researches focused on the effect of BDNF on neural plasticity in the development of depression and the mechanisms of antidepressant. This article …

BDNF is widespread existed in CNS and PNS, because of its function in nerve regeneration and restoration, more and more researches fo …

149

Chronic running-wheel exercise from adolescence leads to increased anxiety and depression-like phenotypes in adulthood in rats: Effects on stress markers and interaction with BDNF Val66Met genotype.

Jaehne EJ, Kent JN, Lam N, Schonfeld L, Spiers JG, Begni V, De Rosa F, Riva MA, van den Buuse M. Jaehne EJ, et al. Dev Psychobiol. 2023 Jan;65(1):e22347. doi: 10.1002/dev.22347. Dev Psychobiol. 2023. PMID: 36567651 Free article.

Exercise has been shown to be beneficial in reducing symptoms of affective disorders and to increase the expression of brain-derived neurotrophic factor (BDNF). The BDNF Val66Met polymorphism is associated with reduced activity-dependent …

Exercise has been shown to be beneficial in reducing symptoms of affective disorders and to increase the expression of brain-deriv …

150

Mutation in the TRKB Cholesterol Recognition Site that blocks Antidepressant Binding does not Influence the Basal or BDNF-Stimulated Activation of TRKB.

Biojone C, Cannarozzo C, Seiffert N, Diniz CRAF, Brunello CA, Castrén E, Casarotto P. Biojone C, et al. Cell Mol Neurobiol. 2023 Dec 17;44(1):4. doi: 10.1007/s10571-023-01438-1. Cell Mol Neurobiol. 2023. PMID: 38104054 Free PMC article.

Brain-derived neurotrophic factor (BDNF) acting upon its receptor Neurotrophic tyrosine kinase receptor 2 (NTRK2, TRKB) plays a central role in the development and maintenance of synaptic function and activity- or drug-induced plasticity. …

Brain-derived neurotrophic factor (BDNF) acting upon its receptor Neurotrophic tyrosine kinase rec …

151

The association of brain-derived neurotrophic factor with the diagnosis and treatment response in depression.

Nikolac Perkovic M, Gredicak M, Sagud M, Nedic Erjavec G, Uzun S, Pivac N. Nikolac Perkovic M, et al. Expert Rev Mol Diagn. 2023 Apr;23(4):283-296. doi: 10.1080/14737159.2023.2200937. Epub 2023 Apr 14. Expert Rev Mol Diagn. 2023. PMID: 37038358 Review.

INTRODUCTION: Recent evidence from the studies evaluating the association between brain-derived neurotrophic factor (BDNF) concentration/levels, BDNF Val66Met (rs6265) polymorphism, and major depressive disorders, referred as depression, …

INTRODUCTION: Recent evidence from the studies evaluating the association between brain-derived neurotrophic factor …

152

Brain-derived neurotrophic factor protects neurons by stimulating mitochondrial function through protein kinase A.

Swain M, K Soman S, Tapia K, Dagda RY, Dagda RK. Swain M, et al. J Neurochem. 2023 Oct;167(1):104-125. doi: 10.1111/jnc.15945. Epub 2023 Sep 9. J Neurochem. 2023. PMID: 37688457 Free PMC article.

Brain-derived neurotrophic factor (BDNF) stimulates dendrite outgrowth and synaptic plasticity by activating downstream protein kinase A (PKA) signaling. Recently, BDNF has been shown to modulate mitochondrial respiration in isolated brai …

Brain-derived neurotrophic factor (BDNF) stimulates dendrite outgrowth and synaptic plasticity by activat …

153

Endovascular Stem Cell Therapy Promotes Neuronal Remodeling to Enhance Post Stroke Recovery by Alleviating Endoplasmic Reticulum Stress Modulated by BDNF Signaling.

Kaur H, Sarmah D, Datta A, Borah A, Yavagal DR, Bhattacharya P. Kaur H, et al. Stem Cell Rev Rep. 2023 Jan;19(1):264-274. doi: 10.1007/s12015-022-10461-6. Epub 2022 Oct 17. Stem Cell Rev Rep. 2023. PMID: 36251114

BACKGROUND AND PURPOSE: The impact of increased BDNF expression in brain by endovascular delivered mesenchymal stem cells (MSCs) post stroke towards modulating endoplasmic reticulum (ER) stress mediated neuronal remodeling has not been directly studied. ...CONCLUSIONS: The …

BACKGROUND AND PURPOSE: The impact of increased BDNF expression in brain by endovascular delivered mesenchymal stem cells (MSCs) post …

154

BDNF gene transcripts in mesencephalic neurons and its differential regulation by NMDA.

Aliaga E, Rage F, Bustos G, Tapia-Arancibia L. Aliaga E, et al. Neuroreport. 1998 Jun 22;9(9):1959-62. doi: 10.1097/00001756-199806220-00008. Neuroreport. 1998. PMID: 9674574

Brain-derived neurotrophic factor (BDNF) enhances survival and protects dopaminergic neurons from neurotoxicity. ...In adult rat mesencephalon we only detected BDNF mRNAs originated from exons 1a and 1c. Quantitative RT-PCR analysis of me …

Brain-derived neurotrophic factor (BDNF) enhances survival and protects dopaminergic neurons from neuroto …

155

Central Stimulatory Effect of Kynurenic Acid on BDNF-TrkB Signaling and BER Enzymatic Activity in the Hippocampal CA1 Field in Sheep.

Roszkowicz-Ostrowska K, Młotkowska P, Kowalczyk P, Marciniak E, Barszcz M, Misztal T. Roszkowicz-Ostrowska K, et al. Int J Mol Sci. 2022 Dec 21;24(1):136. doi: 10.3390/ijms24010136. Int J Mol Sci. 2022. PMID: 36613581 Free PMC article.

Therefore, the present study tested the hypothesis that centrally acting KYNA would positively affect: (1) brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signaling and (2) selected base excision repair (BER) pathway e …

Therefore, the present study tested the hypothesis that centrally acting KYNA would positively affect: (1) brain-derived ne …

156

Long Noncoding RNA LINC00473 Ameliorates Depression-Like Behaviors in Female Mice by Acting as a Molecular Sponge to Regulate miR-497-5p/BDNF Axis.

Li B, Zhao H, Sun J. Li B, et al. Comput Math Methods Med. 2022 Aug 28;2022:4244425. doi: 10.1155/2022/4244425. eCollection 2022. Comput Math Methods Med. 2022. Retraction in: Comput Math Methods Med. 2023 Dec 6;2023:9847091. doi: 10.1155/2023/9847091. PMID: 36072768 Free PMC article. Retracted.

CUMS mice were injected with lentiviral vectors of LINC00473 (LV-LINC00473), miR-497-5p inhibitor, short hairpin- (sh-) brain-derived neurotrophic factor (sh-BDNF), or miR-497-5p mimic to evaluate depressive behaviors, including sucrose preferen …

CUMS mice were injected with lentiviral vectors of LINC00473 (LV-LINC00473), miR-497-5p inhibitor, short hairpin- (sh-) brain-deri …

157

Sevoflurane-induced POCD-associated exosomes delivered miR-584-5p regulates the growth of human microglia HMC3 cells through targeting BDNF.

Zhao J, Zhang W, Wang S, Li Z, Huang Y, Li L. Zhao J, et al. Aging (Albany NY). 2022 Nov 30;14(24):9890-9907. doi: 10.18632/aging.204398. Epub 2022 Nov 30. Aging (Albany NY). 2022. PMID: 36455873 Free PMC article.

Besides, POCD-derived exosomes and miR-584-5p mimics significantly down-regulated the expression levels of BDNF and p-TrkB, and up-regulated Caspase 3 and IL-1beta. Finally, BDNF was confirmed to be the target of miR-584-5p. CONCLUSIONS: Sevoflurane-induced POCD-ass …

Besides, POCD-derived exosomes and miR-584-5p mimics significantly down-regulated the expression levels of BDNF and p-TrkB, and up-re …

158

Association between reduced plasma BDNF concentration and MMSE scores in both chronic schizophrenia and mild cognitive impairment.

Gredicak M, Nikolac Perkovic M, Nedic Erjavec G, Uzun S, Kozumplik O, Svob Strac D, Pivac N. Gredicak M, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Aug 30;134:111086. doi: 10.1016/j.pnpbp.2024.111086. Epub 2024 Jul 11. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 39002927

Reduced brain derived neurotrophic factor (BDNF) concentration is reported to be associated with a cognitive decline in schizophrenia, depending on the stage of the disease. ...BDNF Val66Met polymorphism was not associated with the MMSE s …

Reduced brain derived neurotrophic factor (BDNF) concentration is reported to be associated with a cognit …

159

Evaluation of 5-HTTLPR (insertion/deletion) and BDNF (rs6265) genetic variations in the Slovakian individuals suffering from affective disorders.

Bednarova A, Cizmarikova M, Habalova V, Jarcuskova D. Bednarova A, et al. Gen Physiol Biophys. 2021 Sep;40(5):365-376. doi: 10.4149/gpb_2021025. Gen Physiol Biophys. 2021. PMID: 34602450

To understand risk factors of the disorders, we evaluated genetic variations of the serotonin reuptake transporter (5-HTTLPR, ins/del) and the brain-derived neurotrophic factor (BDNF, rs6265) in Slovak patients suffering from AD. ...In gene-gene …

To understand risk factors of the disorders, we evaluated genetic variations of the serotonin reuptake transporter (5-HTTLPR, ins/del) and t …

160

Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions.

Hempstead BL. Hempstead BL. Trans Am Clin Climatol Assoc. 2015;126:9-19. Trans Am Clin Climatol Assoc. 2015. PMID: 26330656 Free PMC article. Review.

Brain-derived neurotrophic factor (BDNF) is a member of a family of neurotrophins which include nerve growth factor, neurotrophin 3, and neurotrophin 4. ...More recently identified isoforms which are translated from the bdnf gene, …

Brain-derived neurotrophic factor (BDNF) is a member of a family of neurotrophins which include nerve gro …

161

Brain-derived neurotrophic factor (BDNF) downregulates mRNA levels of suppressor of cancer cell invasion (SCAI) variants in cortical neurons.

Ihara D, Mizukoshi M, Tabuchi A. Ihara D, et al. Genes Cells. 2024 Jan;29(1):99-105. doi: 10.1111/gtc.13086. Epub 2023 Nov 27. Genes Cells. 2024. PMID: 38009531 Free article.

In the present study, we hypothesized that brain-derived neurotrophic factor (BDNF), which is important for neuronal plasticity and development, might alter SCAI mRNA levels. ...Our findings provide insights into the molecular mechanism underlyi …

In the present study, we hypothesized that brain-derived neurotrophic factor (BDNF), which is important f …

162

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease.

Ding Y, Botchway BOA, Zhang Y, Liu X. Ding Y, et al. Food Funct. 2023 Jun 19;14(12):5537-5550. doi: 10.1039/d2fo03484k. Food Funct. 2023. PMID: 37279045 Review.

They have a potential role in NDs and psychosis. The brain-derived neurotrophic factor (BDNF)/tyrosine kinase receptor B (TrkB) signaling pathway is closely related to the growth, survival and differentiation of neurons. Ginsenosides exert a neu …

They have a potential role in NDs and psychosis. The brain-derived neurotrophic factor (BDNF)/tyrosine ki …

163

In silico analysis of the V66M variant of human BDNF in psychiatric disorders: An approach to precision medicine.

De Oliveira CCS, Pereira GRC, De Alcantara JYS, Antunes D, Caffarena ER, De Mesquita JF. De Oliveira CCS, et al. PLoS One. 2019 Apr 18;14(4):e0215508. doi: 10.1371/journal.pone.0215508. eCollection 2019. PLoS One. 2019. PMID: 30998730 Free PMC article.

Brain-derived neurotrophic factor (BDNF) plays an important role in neurogenesis and synapse formation. The V66M is the most prevalent BDNF mutation in humans and impairs the function and distribution of BDNF. This mutation is rela …

Brain-derived neurotrophic factor (BDNF) plays an important role in neurogenesis and synapse formation. T …

164

BDNF and epilepsy--the bad could turn out to be good.

Reibel S, Depaulis A, Larmet Y. Reibel S, et al. Trends Neurosci. 2001 Jun;24(6):318-9. doi: 10.1016/s0166-2236(00)01869-5. Trends Neurosci. 2001. PMID: 11421232 No abstract available.

165

Neurotrophin-targeted therapeutics: A gateway to cognition and more?

Nordvall G, Forsell P, Sandin J. Nordvall G, et al. Drug Discov Today. 2022 Oct;27(10):103318. doi: 10.1016/j.drudis.2022.07.003. Epub 2022 Jul 16. Drug Discov Today. 2022. PMID: 35850433 Free article. Review.

Neurotrophins, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), are small proteins expressed in the brain and peripheral tissues, which regulate several key aspects of neuronal function, including neurogenes …

Neurotrophins, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), are …

166

Ca(2+)-Permeable TRPV1 Receptor Mediates Neuroprotective Effects in a Mouse Model of Alzheimer's Disease via BDNF/CREB Signaling Pathway.

Kim J, Seo S, Park JHY, Lee KW, Kim J, Kim JC. Kim J, et al. Mol Cells. 2023 May 31;46(5):319-328. doi: 10.14348/molcells.2023.2156. Epub 2023 Apr 18. Mol Cells. 2023. PMID: 37070458 Free PMC article.

In a previous study, it was discovered that a triple-transgenic Alzheimer's disease (AD) mouse model (3xTg-AD(+/+)) has anti-AD effects. The expression of proteins in the brain-derived neurotrophic factor (BDNF)/cAMP response element binding pro …

In a previous study, it was discovered that a triple-transgenic Alzheimer's disease (AD) mouse model (3xTg-AD(+/+)) has anti-AD effects. The …

167

Decoding the neurotoxic effects of propofol: insights into the RARalpha-Snhg1-Bdnf regulatory cascade.

Xu Y, Xin X, Tao T. Xu Y, et al. Am J Physiol Cell Physiol. 2024 Jun 1;326(6):C1735-C1752. doi: 10.1152/ajpcell.00547.2023. Epub 2024 Apr 15. Am J Physiol Cell Physiol. 2024. PMID: 38618701 Free PMC article.

Insights into the role of the retinoic acid receptor-alpha, small nucleolar RNA host gene 1, and brain-derived neurotrophic factor (RARalpha-Snhg1-Bdnf) network can offer significant advancements in minimizing these effects. ...The findings draw …

Insights into the role of the retinoic acid receptor-alpha, small nucleolar RNA host gene 1, and brain-derived neurotrophic …

168

PPARalpha is involved in high-fat diet-induced risk avoidance impairment via the regulation of hippocampal BDNF.

Zhu XY, Luo J, Wei XJ, Pan LH, Xu XF, Hu LB, Dong YB, Jiang YK, Dong FY, Xu L, Xu LM, Liu AM, Zhang XQ. Zhu XY, et al. Food Funct. 2023 Jul 17;14(14):6541-6553. doi: 10.1039/d3fo01636f. Food Funct. 2023. PMID: 37381721

Moreover, biochemical analysis suggested that the decreased levels of the brain-derived neurotrophic factor (BDNF) in the hippocampus might contribute to risk avoidance impairment induced by a HFD. These results indicated that PPARalpha is invol …

Moreover, biochemical analysis suggested that the decreased levels of the brain-derived neurotrophic factor ( …

169

The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface.

Turovsky YA, Gureev AP, Vitkalova IY, Popov VN, Vakhtin AA. Turovsky YA, et al. J Integr Neurosci. 2021 Jun 30;20(2):287-296. doi: 10.31083/j.jin2002028. J Integr Neurosci. 2021. PMID: 34258927 Free article.

We found that carriers of the G/G genotype of the rs6265 polymorphism (BDNF gene) demonstrated the best results in video-oculographic interface mastery. In contrast, carriers of the A/A genotype were characterized by large standard deviations in the average amplitude of ey …

We found that carriers of the G/G genotype of the rs6265 polymorphism (BDNF gene) demonstrated the best results in video-oculographic …

170

Brain-derived neurotrophic factor: findings in schizophrenia.

Buckley PF, Pillai A, Howell KR. Buckley PF, et al. Curr Opin Psychiatry. 2011 Mar;24(2):122-7. doi: 10.1097/YCO.0b013e3283436eb7. Curr Opin Psychiatry. 2011. PMID: 21248641 Review.

PURPOSE OF REVIEW: To review the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity related to schizophrenia and the recent findings that have been reported on the status of BDNF in patients with schizophrenia and its ass …

PURPOSE OF REVIEW: To review the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity rela …

171

Procyanidins Extracted from the Lotus Seedpod Ameliorate Cognitive Impairment through CREB-BDNF Pathway Mediated LTP in APP/PS1 Transgenic Mice.

Wang Z, Li X, Ren X, Zhao S, Chen W, Fan C, Xu Y, Pi X, Zhang Y, Wang T, Rong S. Wang Z, et al. Curr Pharm Biotechnol. 2023;24(12):1560-1567. doi: 10.2174/1389201024666230209142145. Curr Pharm Biotechnol. 2023. PMID: 36757040

The Morris water maze test was used to assess learning and memory function, the long-term potentiation (LTP) was measured, and the expressions of Abeta, pCREB/CREB and BDNF were quantified by western blot. RESULTS: LSPC significantly ameliorated cognitive dysfunction, redu …

The Morris water maze test was used to assess learning and memory function, the long-term potentiation (LTP) was measured, and the expressio …

172

Neuroticism, depressive symptoms, and serum BDNF.

Terracciano A, Lobina M, Piras MG, Mulas A, Cannas A, Meirelles O, Sutin AR, Zonderman AB, Uda M, Crisponi L, Schlessinger D. Terracciano A, et al. Psychosom Med. 2011 Oct;73(8):638-42. doi: 10.1097/PSY.0b013e3182306a4f. Epub 2011 Sep 23. Psychosom Med. 2011. PMID: 21949427 Free PMC article.

OBJECTIVE: Animal models and clinical studies suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of depression. ...The association of serum BDNF with neuroticism was independent of depressive symptoms …

OBJECTIVE: Animal models and clinical studies suggest that brain-derived neurotrophic factor (BDNF) is in …

173

Embryonic stem cells stably expressing BDNF-GFP exhibit a BDNF-release-dependent enhancement of neuronal differentiation.

Leschik J, Eckenstaler R, Nieweg K, Lichtenecker P, Brigadski T, Gottmann K, Lessmann V, Lutz B. Leschik J, et al. J Cell Sci. 2013 Nov 1;126(Pt 21):5062-73. doi: 10.1242/jcs.135384. Epub 2013 Aug 28. J Cell Sci. 2013. PMID: 23986480

Brain-derived neurotrophic factor (BDNF) is known to be a crucial regulator of neuronal survival and synaptic plasticity in the mammalian brain. ...Thus, our study describes the generation of ESCs stably overexpressing BDNF-GFP, which are …

Brain-derived neurotrophic factor (BDNF) is known to be a crucial regulator of neuronal survival and syna …

174

Evaluating the effect of BDNF Val66Met polymorphism on complex formation with HAP1 and Sortilin1 via structural modeling.

Zamani M, Eslami M, Nezafat N, Hosseini SV, Ghasemi Y. Zamani M, et al. Comput Biol Chem. 2019 Feb;78:282-289. doi: 10.1016/j.compbiolchem.2018.12.010. Epub 2018 Dec 26. Comput Biol Chem. 2019. PMID: 30602138

Brain derived neurotrophic factor (BDNF) has a critical role in the neurogenesis, differentiation, survival of the neurons, regulation of the appetite, and energy homeostasis. ...Evidence suggests that the most frequent single nucleotide polymor …

Brain derived neurotrophic factor (BDNF) has a critical role in the neurogenesis, differentiation, surviv …

175

Effect of consumption of blue maize tortilla on anxiety-like behaviour, learning, memory and hippocampal BDNF expression in a chronic stress model in rats.

Aguirre López LO, Cuéllar Pérez JR, Santerre A, Moreno YS, Hernández De Anda Y, Bañuelos Pineda J. Aguirre López LO, et al. Nutr Neurosci. 2023 Nov;26(11):1058-1067. doi: 10.1080/1028415X.2022.2126757. Epub 2022 Sep 29. Nutr Neurosci. 2023. PMID: 36173025

OBJETIVES: This study was aimed to assess the effect of consuming blue maize tortillas on the anxiolytic capacity, preserve emotional memory, and the expression of brain-derived neurotrophic factor (BDNF) in rats subjected to chronic stress. MET …

OBJETIVES: This study was aimed to assess the effect of consuming blue maize tortillas on the anxiolytic capacity, preserve emotional memory …

176

BCI Improves Alcohol-Induced Cognitive and Emotional Impairments by Restoring pERK-BDNF.

Wang S, Zhang X, Zhao Y, Lv H, Li P, Zhang Z, Qiao X. Wang S, et al. J Mol Neurosci. 2024 Jun 18;74(3):59. doi: 10.1007/s12031-024-02237-z. J Mol Neurosci. 2024. PMID: 38890235

Extracellular regulated protein kinases (ERK) maintain neuronal survival, growth, and regulation of synaptic plasticity by phosphorylating specific transcription factors to regulate expression of brain-derived neurotrophic factor (BDNF). Dual-sp …

Extracellular regulated protein kinases (ERK) maintain neuronal survival, growth, and regulation of synaptic plasticity by phosphorylating s …

177

Releasing Mechanism of Neurotrophic Factors via Polysialic Acid.

Sato C. Sato C. Vitam Horm. 2017;104:89-112. doi: 10.1016/bs.vh.2016.11.004. Epub 2016 Dec 21. Vitam Horm. 2017. PMID: 28215308 Review.

Among the different types of neurotrophins, brain-derived neurotrophic factor (BDNF) is involved in various brain functions, including memory consolidation, synaptic plasticity, and adult neurogenesis, and is therefore a key molecule for underst …

Among the different types of neurotrophins, brain-derived neurotrophic factor (BDNF) is involved in vario …

178

An Integrative Review of Brain-Derived Neurotrophic Factor and Serious Cardiovascular Conditions.

Halloway S, Jung M, Yeh AY, Liu J, McAdams E, Barley M, Dorsey SG, Pressler SJ. Halloway S, et al. Nurs Res. 2020 Sep/Oct;69(5):376-390. doi: 10.1097/NNR.0000000000000454. Nurs Res. 2020. PMID: 32555009 Free PMC article. Review.

BACKGROUND: There is emerging evidence that supports a role for brain-derived neurotrophic factor (BDNF) in the risk and presence of serious cardiovascular conditions. ...OBJECTIVES: The purpose of this integrative review was to (a) evaluate …

BACKGROUND: There is emerging evidence that supports a role for brain-derived neurotrophic factor (BDNF) …

179

Brain-derived neurotrophic factor (BDNF) plasma levels in drug-naive OCD patients are lower than those in healthy people, but are not lower than those in drug-treated OCD patients.

Wang Y, Mathews CA, Li Y, Lin Z, Xiao Z. Wang Y, et al. J Affect Disord. 2011 Sep;133(1-2):305-10. doi: 10.1016/j.jad.2011.04.002. Epub 2011 May 25. J Affect Disord. 2011. PMID: 21616543

BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays an important role in neural development, and has been implicated in the development of depressive and anxiety disorders. ...Probably this treatment length is not sufficient to identify d …

BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays an important role in neural development, and h …

180

Brain-Derived Neurotrophic Factor: A Novel Dynamically Regulated Therapeutic Modulator in Neurological Disorders.

Sharma V, Singh TG, Kaur A, Mannan A, Dhiman S. Sharma V, et al. Neurochem Res. 2023 Feb;48(2):317-339. doi: 10.1007/s11064-022-03755-1. Epub 2022 Oct 29. Neurochem Res. 2023. PMID: 36308619 Review.

The growth factor brain-derived neurotrophic factor (BDNF), and its receptor tropomyosin-related kinase receptor type B (TrkB) play an active role in numerous areas of the adult brain, where they regulate the neuronal activity, function, …

The growth factor brain-derived neurotrophic factor (BDNF), and its receptor tropomyosin-related k …

181

Protective effects of BDNF overexpression bone marrow stromal cell transplantation in rat models of traumatic brain injury.

Wang Z, Yao W, Deng Q, Zhang X, Zhang J. Wang Z, et al. J Mol Neurosci. 2013 Feb;49(2):409-16. doi: 10.1007/s12031-012-9908-0. Epub 2012 Nov 11. J Mol Neurosci. 2013. PMID: 23143881

But other studies indicate that tissue replacement by this method may not be the main source of therapeutic benefit. Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) therapeutic potential may contribute to the recover …

But other studies indicate that tissue replacement by this method may not be the main source of therapeutic benefit. Neurotrophic fac …

182

The effect of miR-155-5p on long-term memory of sleep-deprived mice through the BDNF/NF-kappaB pathway.

Hou D, Zhong J, Hu Y, Yang G. Hou D, et al. Acta Neurobiol Exp (Wars). 2024 Jun 28;84(2):203-217. doi: 10.55782/ane-2024-2586. Acta Neurobiol Exp (Wars). 2024. PMID: 39087835 Free article.

The expression level of miR-155-5p was quantified via RT-qPCR. The binding between miR-155-5p and brain-derived neurotrophic factor (BDNF) was confirmed through a dual-luciferase reporter assay. ...Additionally, the BDNF/NF-kappaB pathway …

The expression level of miR-155-5p was quantified via RT-qPCR. The binding between miR-155-5p and brain-derived neurotrophi …

183

Exploring the mRNA and Plasma Protein Levels of BDNF, NT4, SIRT1, HSP27, and HSP70 in Multiple Sclerosis Patients and Healthy Controls.

Sokolowski I, Kucharska-Lusina A, Miller E, Majsterek I. Sokolowski I, et al. Int J Mol Sci. 2023 Nov 10;24(22):16176. doi: 10.3390/ijms242216176. Int J Mol Sci. 2023. PMID: 38003363 Free PMC article.

This study focuses on neuroprotective genes (BDNF, NT4/5, SIRT1, HSP70, and HSP27). Gene expression and protein levels of these markers were compared between MS patients and healthy controls. ...The results show that a 3.5-fold decrease in the gene expression of BDNF …

This study focuses on neuroprotective genes (BDNF, NT4/5, SIRT1, HSP70, and HSP27). Gene expression and protein levels of these marke …

184

Unlocking the epigenome: Stress and exercise induced Bdnf regulation in the prefrontal cortex.

Campbell TS, Donoghue K, Roth TL. Campbell TS, et al. Neurotoxicol Teratol. 2024 May-Jun;103:107353. doi: 10.1016/j.ntt.2024.107353. Epub 2024 Apr 20. Neurotoxicol Teratol. 2024. PMID: 38648864 Free article.

Aversive caregiving in early life is a risk factor for aberrant brain and behavioral development. This outcome is related to epigenetic dysregulation of the brain-derived neurotrophic factor (Bdnf) gene. The Bdnf gene encodes for …

Aversive caregiving in early life is a risk factor for aberrant brain and behavioral development. This outcome is related to epigenet …

185

Manipulation of BDNF signaling modifies the experience-dependent plasticity induced by pure tone exposure during the critical period in the primary auditory cortex.

Anomal R, de Villers-Sidani E, Merzenich MM, Panizzutti R. Anomal R, et al. PLoS One. 2013 May 21;8(5):e64208. doi: 10.1371/journal.pone.0064208. Print 2013. PLoS One. 2013. PMID: 23700463 Free PMC article.

In the visual system, the normal unfolding of critical period plasticity is strongly dependent on the elaboration of brain-derived neurotrophic factor (BDNF), which promotes the establishment of inhibition. ...Elvax resin implants filled with ei …

In the visual system, the normal unfolding of critical period plasticity is strongly dependent on the elaboration of brain-derived …

186

Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder.

Allan NP, Yamamoto BY, Kunihiro BP, Nunokawa CKL, Rubas NC, Wells RK, Umeda L, Phankitnirundorn K, Torres A, Peres R, Takahashi E, Maunakea AK. Allan NP, et al. Nutrients. 2024 May 7;16(10):1401. doi: 10.3390/nu16101401. Nutrients. 2024. PMID: 38794639 Free PMC article. Clinical Trial.

After 4 months follow up, we found that the KD led to decreased plasma levels of proinflammatory cytokines (IL-12p70 and IL-1b) and brain-derived neurotrophic factor (BDNF). Additionally, we observed changes in the gut microbiome, increased expr …

After 4 months follow up, we found that the KD led to decreased plasma levels of proinflammatory cytokines (IL-12p70 and IL-1b) and brain …

187

Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks.

Dodds CM, Henson RN, Suckling J, Miskowiak KW, Ooi C, Tait R, Soltesz F, Lawrence P, Bentley G, Maltby K, Skeggs A, Miller SR, McHugh S, Bullmore ET, Nathan PJ. Dodds CM, et al. PLoS One. 2013 Nov 11;8(11):e74133. doi: 10.1371/journal.pone.0074133. eCollection 2013. PLoS One. 2013. PMID: 24244264 Free PMC article. Clinical Trial.

It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. ...In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses d …

It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural cir …

188

Involvement of the BDNF gene in loneliness in adolescence: a report of opposite gene effects in boys and girls.

Verhagen M, van Roekel E, Engels RC. Verhagen M, et al. PLoS One. 2014 Mar 19;9(3):e92768. doi: 10.1371/journal.pone.0092768. eCollection 2014. PLoS One. 2014. PMID: 24647525 Free PMC article.

In the present study, the relation between the BDNF Val66Met polymorphism and loneliness in adolescent boys and girls was examined in a longitudinal study spanning five annual waves (N = 305). Latent growth curve modeling (LGCM) was used to examine the baseline level and t …

In the present study, the relation between the BDNF Val66Met polymorphism and loneliness in adolescent boys and girls was examined in …

189

Brain-derived neurotrophic factor in neurodegenerative diseases.

Zuccato C, Cattaneo E. Zuccato C, et al. Nat Rev Neurol. 2009 Jun;5(6):311-22. doi: 10.1038/nrneurol.2009.54. Nat Rev Neurol. 2009. PMID: 19498435 Review.

Changes in the levels and activities of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), have been described in a number of neurodegenerative disorders, including Huntington disease, Alzheimer disease and Parkinson …

Changes in the levels and activities of neurotrophic factors, such as brain-derived neurotrophic factor ( …

190

Challenges in recombinant brain-derived neurotrophic factor production.

Rodrigues ÉF, Fachin AL, Marins M, Stabeli RG, Beleboni RO. Rodrigues ÉF, et al. Trends Biotechnol. 2024 May;42(5):522-525. doi: 10.1016/j.tibtech.2023.11.003. Epub 2023 Nov 25. Trends Biotechnol. 2024. PMID: 38008688 Review.

Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. ...A suitable expression system is critical to achieve the most efficient production of bioactive and stable BD …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, …

191

Music with Different Tones Affects the Development of Brain Nerves in Mice in Early Life through BDNF and Its Downstream Pathways.

Wang J, Wang J, Wang Y, Chai Y, Li H, Miao D, Liu H, Li J, Bao J. Wang J, et al. Int J Mol Sci. 2023 May 1;24(9):8119. doi: 10.3390/ijms24098119. Int J Mol Sci. 2023. PMID: 37175826 Free PMC article.

Compared with group C, the expression levels of BDNF, TRKB, CREB, PI3K, AKT, GS3Kbeta, PLCgamma1, PKC, DAG, ERK and MAPK genes and proteins in the hippocampus and prefrontal cortex of mice in the music groups were up-regulated, suggesting that different tones of music coul …

Compared with group C, the expression levels of BDNF, TRKB, CREB, PI3K, AKT, GS3Kbeta, PLCgamma1, PKC, DAG, ERK and MAPK genes and pr …

192

Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression.

Elfving B, Plougmann PH, Müller HK, Mathé AA, Rosenberg R, Wegener G. Elfving B, et al. Int J Neuropsychopharmacol. 2010 Jun;13(5):563-72. doi: 10.1017/S1461145709990721. Epub 2009 Oct 2. Int J Neuropsychopharmacol. 2010. PMID: 19796445 Free article.

There is accumulating evidence that brain-derived neurotrophic factor (BDNF) plays a critical role in the pathophysiology of depression. ...The differential regulation of the BDNF levels in hippocampus, serum, and whole blood in FSL/FRL r …

There is accumulating evidence that brain-derived neurotrophic factor (BDNF) plays a critical role in the …

193

Ovarian hormones, genes, and the brain: the case of estradiol and the brain-derived neurotrophic factor (BDNF) gene.

Wei SM, Berman KF. Wei SM, et al. Neuropsychopharmacology. 2019 Jan;44(1):223-224. doi: 10.1038/s41386-018-0223-5. Neuropsychopharmacology. 2019. PMID: 30287883 Free PMC article. No abstract available.

194

Isoflurane preconditioning effects on brain damage induced by electromagnetic pulse radiation through epigenetic modification of BDNF gene transcription.

Tian LY, Cai CK, Zhang XJ, Sun XD. Tian LY, et al. Ann Palliat Med. 2020 Sep;9(5):3418-3427. doi: 10.21037/apm-20-1655. Ann Palliat Med. 2020. PMID: 33065792 Free article.

BACKGROUND: The effects of electromagnetic pulse (EMP) radiation on cognitive impairment have attracted much attention, but the mechanism is still unclear. Regulation of brain-derived neurotrophic factor (BDNF) gene expression has been found to …

BACKGROUND: The effects of electromagnetic pulse (EMP) radiation on cognitive impairment have attracted much attention, but the mechanism is …

195

Evidence of brain-derived neurotrophic factor in ameliorating cancer-related cognitive impairment: A systematic review of human studies.

Ng DQ, Chan D, Agrawal P, Zhao W, Xu X, Acharya M, Chan A. Ng DQ, et al. Crit Rev Oncol Hematol. 2022 Aug;176:103748. doi: 10.1016/j.critrevonc.2022.103748. Epub 2022 Jun 17. Crit Rev Oncol Hematol. 2022. PMID: 35718064 Free article. Review.

Brain-derived neurotrophic factor (BDNF) plays an essential role in neurogenesis and neuroplasticity and may be a key protein in cancer-related cognitive impairment (CRCI). ...Fourteen (54 %) studied BDNF protein levels while 15 (58 %) an …

Brain-derived neurotrophic factor (BDNF) plays an essential role in neurogenesis and neuroplasticity and …

196

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