Chimeric antigen receptor T cells against the IGHV4-34 B cell receptor specifically eliminate neoplastic and autoimmune B cells.
Cohen IJ, Bochi-Layec AC, Lemoine J, Jenks S, Bayat P, Kim KH, Zhao H, Ugwuanyi O, Stella F, Ghilardi G, Gabrielli G, McCuaig S, Iatrou A, Vlachonikola E, Karipidou M, Bouziani E, Espie D, Ramasubramanian R, Agathangelidis A, Bhosale A, Paruzzo L, Medico G, Kolar B, Bugrovsky R, Guruprasad P, Wang LP, Harris J, Arons E, Zhang Y, Pajarillo R, Kreiger PA, Day CP, Sahinalp SC, Wu CH, Santi A, Fulmer B, Cases M, Palmer MB, Porazzi P, Wherry EJ, Kreitman RJ, Tiacci E, Apostolidis SA, Behrens EM, Bhoj V, Sanz I, Inghirami G, Schuster SJ, Ghia P, Stamatopoulos K, Ruella M.
Cohen IJ, et al. Among authors: behrens em.
Sci Transl Med. 2026 Feb 4;18(835):eadr9382. doi: 10.1126/scitranslmed.adr9382. Epub 2026 Feb 4.
Sci Transl Med. 2026.
PMID: 41637528