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Trans-resveratrol enriched maternal diet protects the immature hippocampus from perinatal asphyxia in rats.
Isac S, Panaitescu AM, Spataru A, Iesanu M, Totan A, Udriste A, Cucu N, Peltecu G, Zagrean L, Zagrean AM. Isac S, et al. Neurosci Lett. 2017 Jul 13;653:308-313. doi: 10.1016/j.neulet.2017.06.003. Epub 2017 Jun 6. Neurosci Lett. 2017. PMID: 28595952
Hypoxic-ischemic encephalopathy secondary to PA affects especially vulnerable brain areas such as hippocampus and is a leading cause of neonatal morbidity. The purpose of this study is to identify new epigenetic mechanisms of brain inflammation and injury related to …
Hypoxic-ischemic encephalopathy secondary to PA affects especially vulnerable brain areas such as hippocampus and is a leading cause …
Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence.
Socała K, Żmudzka E, Lustyk K, Zagaja M, Brighenti V, Costa AM, Andres-Mach M, Pytka K, Martinelli I, Mandrioli J, Pellati F, Biagini G, Wlaź P. Socała K, et al. Phytother Res. 2024 Mar;38(3):1400-1461. doi: 10.1002/ptr.8101. Epub 2024 Jan 17. Phytother Res. 2024. PMID: 38232725 Review.
This review is a comprehensive summary of the current state of research on stilbenes in several neuropsychiatric and neurological disorders such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, and neurodegenerative disord …
This review is a comprehensive summary of the current state of research on stilbenes in several neuropsychiatric and neurological disorders …
Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women.
Thaung Zaw JJ, Howe PRC, Wong RHX. Thaung Zaw JJ, et al. Nutrients. 2020 Mar 20;12(3):828. doi: 10.3390/nu12030828. Nutrients. 2020. PMID: 32244933 Free PMC article.
We have since undertaken a larger, longer term study to confirm these benefits. Postmenopausal women aged 45-85 years (n = 129) were randomized to take placebo or 75 mg trans-resveratrol twice daily for 12 months. ...
We have since undertaken a larger, longer term study to confirm these benefits. Postmenopausal women aged 45-85 years (n = 129) were …
Neuroprotective Effect of Maternal Resveratrol Supplementation in a Rat Model of Neonatal Hypoxia-Ischemia.
Dumont U, Sanchez S, Repond C, Beauvieux MC, Chateil JF, Pellerin L, Bouzier-Sore AK, Roumes H. Dumont U, et al. Front Neurosci. 2021 Jan 15;14:616824. doi: 10.3389/fnins.2020.616824. eCollection 2020. Front Neurosci. 2021. PMID: 33519368 Free PMC article.
To decipher the molecular mechanisms of this neuroprotection, RT-qPCR and Western blots were also performed on pup brain samples. Data clearly indicated that when pregnant and/or breastfeeding females were supplemented with resveratrol, hypoxic-ischemic offspring brain …
To decipher the molecular mechanisms of this neuroprotection, RT-qPCR and Western blots were also performed on pup brain samples. Dat …
Differential responses of Trans-Resveratrol on proliferation of neural progenitor cells and aged rat hippocampal neurogenesis.
Kumar V, Pandey A, Jahan S, Shukla RK, Kumar D, Srivastava A, Singh S, Rajpurohit CS, Yadav S, Khanna VK, Pant AB. Kumar V, et al. Sci Rep. 2016 Jun 23;6:28142. doi: 10.1038/srep28142. Sci Rep. 2016. PMID: 27334554 Free PMC article.
The plethora of literature has supported the potential benefits of Resveratrol (RV) as a life-extending as well as an anticancer compound. However, these two functional discrepancies resulted at different concentration ranges. Likewise, the role of Resveratrol on adult neu …
The plethora of literature has supported the potential benefits of Resveratrol (RV) as a life-extending as well as an anticancer comp …
A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression.
Navarro G, Martínez-Pinilla E, Sánchez-Melgar A, Ortiz R, Noé V, Martín M, Ciudad C, Franco R. Navarro G, et al. PLoS One. 2017 Apr 25;12(4):e0176067. doi: 10.1371/journal.pone.0176067. eCollection 2017. PLoS One. 2017. PMID: 28441400 Free PMC article.
Data from a functional genomics study were retrieved with the aim to find differentially expressed genes that may be involved in the benefits provided by trans-resveratrol. Genes that showed a significantly different expression (p<0.05, cut-off of a two-fold change) in …
Data from a functional genomics study were retrieved with the aim to find differentially expressed genes that may be involved in the bene …
Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus.
Wong RH, Nealon RS, Scholey A, Howe PR. Wong RH, et al. Nutr Metab Cardiovasc Dis. 2016 May;26(5):393-9. doi: 10.1016/j.numecd.2016.03.003. Epub 2016 Mar 14. Nutr Metab Cardiovasc Dis. 2016. PMID: 27105868 Clinical Trial.
BACKGROUND AND AIMS: Progressive microvascular dysfunction in type 2 diabetes mellitus (T2DM) may impair the ability of cerebral vessels to supply blood to brain regions during local metabolic demand, thereby increasing risks of dementia. Having previously demonstrated tha …
BACKGROUND AND AIMS: Progressive microvascular dysfunction in type 2 diabetes mellitus (T2DM) may impair the ability of cerebral vessels to …