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67 results

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Page 1
BrdU/EdU dual labeling to determine the cell-cycle dynamics of defined cellular subpopulations.
Harris L, Zalucki O, Piper M. Harris L, et al. J Mol Histol. 2018 Jun;49(3):229-234. doi: 10.1007/s10735-018-9761-8. Epub 2018 Feb 14. J Mol Histol. 2018. PMID: 29445897
The advantage of this protocol over cumulative labeling approaches is that only a single time-point is required for measurement. An additional benefit of this protocol over existing dual-analog approaches (CldU/IdU) is the antibody-free detection of EdU and the acid-free d …
The advantage of this protocol over cumulative labeling approaches is that only a single time-point is required for measurement. An addition …
Ambient temperature influences the neural benefits of exercise.
Maynard ME, Chung C, Comer A, Nelson K, Tran J, Werries N, Barton EA, Spinetta M, Leasure JL. Maynard ME, et al. Behav Brain Res. 2016 Feb 15;299:27-31. doi: 10.1016/j.bbr.2015.11.017. Epub 2015 Nov 30. Behav Brain Res. 2016. PMID: 26608539
Many of the neural benefits of exercise require weeks to manifest. It would be useful to accelerate onset of exercise-driven plastic changes, such as increased hippocampal neurogenesis. Exercise represents a significant challenge to the brain because it produces hea …
Many of the neural benefits of exercise require weeks to manifest. It would be useful to accelerate onset of exercise-driven plastic …
Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia.
Fujiwara R, Haag M, Schaeffeler E, Nies AT, Zanger UM, Schwab M. Fujiwara R, et al. Hepatology. 2018 Apr;67(4):1609-1619. doi: 10.1002/hep.29599. Epub 2018 Mar 2. Hepatology. 2018. PMID: 29059457 Review.
Accumulation of bilirubin in the brain leads to the onset of irreversible brain damage, termed kernicterus. Breastfeeding is one of the most significant factors that increase the risk of developing kernicterus in infants. Why does this most natural way of feeding in …
Accumulation of bilirubin in the brain leads to the onset of irreversible brain damage, termed kernicterus. Breastfeeding is o …
The Metabolic Map into the Pathomechanism and Treatment of PGM1-CDG.
Radenkovic S, Bird MJ, Emmerzaal TL, Wong SY, Felgueira C, Stiers KM, Sabbagh L, Himmelreich N, Poschet G, Windmolders P, Verheijen J, Witters P, Altassan R, Honzik T, Eminoglu TF, James PM, Edmondson AC, Hertecant J, Kozicz T, Thiel C, Vermeersch P, Cassiman D, Beamer L, Morava E, Ghesquière B. Radenkovic S, et al. Am J Hum Genet. 2019 May 2;104(5):835-846. doi: 10.1016/j.ajhg.2019.03.003. Epub 2019 Apr 11. Am J Hum Genet. 2019. PMID: 30982613 Free PMC article.
The disease and treatment mechanisms, however, have remained largely elusive. Here, we confirm the clinical benefit of galactose supplementation in PGM1-CDG-affected individuals and obtain significant insights into the functional and biochemical regulation of glycosylation …
The disease and treatment mechanisms, however, have remained largely elusive. Here, we confirm the clinical benefit of galactose supp …
Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury.
Chauhan NB, Gatto R. Chauhan NB, et al. Brain Res. 2010 Nov 11;1360:177-92. doi: 10.1016/j.brainres.2010.09.010. Epub 2010 Sep 15. Brain Res. 2010. PMID: 20833152
Simvastatin and recombinant human erythropoietin (rhEpo) are implicated as potential therapeutic candidates for traumatic brain injury (TBI). Prominent effects of simvastatin include its anti-inflammatory, neurotrophic and neuroregenerative actions studied in various model …
Simvastatin and recombinant human erythropoietin (rhEpo) are implicated as potential therapeutic candidates for traumatic brain injur …
Souvenaid in the management of mild cognitive impairment: an expert consensus opinion.
Cummings J, Passmore P, McGuinness B, Mok V, Chen C, Engelborghs S, Woodward M, Manzano S, Garcia-Ribas G, Cappa S, Bertolucci P, Chu LW. Cummings J, et al. Alzheimers Res Ther. 2019 Aug 17;11(1):73. doi: 10.1186/s13195-019-0528-6. Alzheimers Res Ther. 2019. PMID: 31421681 Free PMC article.
Souvenaid is a once-daily drink containing a mixture of precursors and cofactors (long-chain omega-3 fatty acids, uridine, choline, B vitamins, vitamin C, vitamin E, and selenium), which was developed to support the formation and function of neuronal membranes and synapses …
Souvenaid is a once-daily drink containing a mixture of precursors and cofactors (long-chain omega-3 fatty acids, uridine, choline, B …
Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet.
Perez-Pardo P, Dodiya HB, Broersen LM, Douna H, van Wijk N, Lopes da Silva S, Garssen J, Keshavarzian A, Kraneveld AD. Perez-Pardo P, et al. Nutr Neurosci. 2018 Jul;21(6):391-402. doi: 10.1080/1028415X.2017.1294555. Epub 2017 Mar 9. Nutr Neurosci. 2018. PMID: 28276272 Free article.
The 'dual-hit' hypothesis of PD speculates that a putative pathogen enters the brain via two routes: the olfactory system and the GI system. Here, we investigated (1) whether local exposures of the neurotoxin rotenone in the gut or the brain of mice could induce PD- …
The 'dual-hit' hypothesis of PD speculates that a putative pathogen enters the brain via two routes: the olfactory system and the GI …
O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.
Yuzwa SA, Vocadlo DJ. Yuzwa SA, et al. Chem Soc Rev. 2014 Oct 7;43(19):6839-58. doi: 10.1039/c4cs00038b. Epub 2014 Apr 24. Chem Soc Rev. 2014. PMID: 24759912 Review.
Within the brains of AD patients O-GlcNAc levels have been found to be decreased and aggregates of tau appear to lack O-GlcNAc entirely. Accordingly, glucose hypometabolism within the brain may result in disruption of the normal functions of O-GlcNAc within the b …
Within the brains of AD patients O-GlcNAc levels have been found to be decreased and aggregates of tau appear to lack O-GlcNAc entire …
Differentiation and neurological benefit of the mesenchymal stem cells transplanted into the rat brain following intracerebral hemorrhage.
Zhang H, Huang Z, Xu Y, Zhang S. Zhang H, et al. Neurol Res. 2006 Jan;28(1):104-12. doi: 10.1179/016164106X91960. Neurol Res. 2006. PMID: 16464372
We generated the ICH model by injecting collagenase VII into rat brain. Subsequently, 5-bromo-2-deoxyuridine (BrdU)-labeled mesenchymal stem cells were delivered into the brain through carotid artery, cervical vein or lateral ventricle. ...Collectively, our study in …
We generated the ICH model by injecting collagenase VII into rat brain. Subsequently, 5-bromo-2-deoxyuridine (BrdU)-labeled mesenchym …
67 results