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Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells.
Wilson A, Kamel W, Davies K, De Laurent ZR, Arif R, Clarke AT, Bell-Sakyi L, Lamont D, Demyanenko Y, Noerenberg M, Kohl A, Mohammed S, Castello A, Brennan B. Wilson A, et al. Among authors: brennan b. PLoS Pathog. 2025 Aug 4;21(8):e1013393. doi: 10.1371/journal.ppat.1013393. eCollection 2025 Aug. PLoS Pathog. 2025. PMID: 40758761 Free PMC article.
Cellular RNA-binding proteins (RBPs) are pivotal for the viral lifecycle, mediating key host-virus interactions that promote or repress virus infection. While these interactions have been largely studied in the vertebrate host, no comprehensive analyses of protein-R …
Cellular RNA-binding proteins (RBPs) are pivotal for the viral lifecycle, mediating key host-virus interactions that promote or repre …
From prototype to outbreak: conserved pathogenesis of Oropouche virus in a novel murine pregnancy model highlights its public health implications.
Gunter KB, Bowen JM, Clarke AT, McFarlane M, Omoga DCA, Pozuelos S, Rogers LM, Aronoff DM, Vornhagen J, Brennan B, Tilston NL. Gunter KB, et al. Among authors: brennan b. bioRxiv [Preprint]. 2025 Aug 2:2025.08.02.668287. doi: 10.1101/2025.08.02.668287. bioRxiv. 2025. PMID: 40766593 Free PMC article. Preprint.
Oropouche virus (OROV) is an emerging orthobunyavirus responsible for widespread outbreaks across South and Central America. ...
Oropouche virus (OROV) is an emerging orthobunyavirus responsible for widespread outbreaks across South and Central America. ...
Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors.
Petit MJ, Flory C, Gu Q, Fares M, Lamont D, Score A, Davies K, Bell-Sakyi L, Scaturro P, Brennan B, Kohl A. Petit MJ, et al. Among authors: brennan b. Nat Commun. 2025 May 21;16(1):4732. doi: 10.1038/s41467-025-59565-w. Nat Commun. 2025. PMID: 40399277 Free PMC article.
However, the cellular interactions between arboviruses and ticks, especially for negative-strand RNA viruses, remain largely unexplored. Here, we employ a proteomics informed by transcriptomics approach to elucidate the cellular response of the Rhipicephalus microplus-deri …
However, the cellular interactions between arboviruses and ticks, especially for negative-strand RNA viruses, remain largely unexplor …
The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs.
Reuter M, Parry RH, McFarlane M, Gestuveo RJ, Arif R, Khromykh AA, Brennan B, Varjak M, Castello A, Redecke L, Schnettler E, Kohl A. Reuter M, et al. Among authors: brennan b. RNA. 2025 Apr 16;31(5):679-691. doi: 10.1261/rna.080149.124. RNA. 2025. PMID: 39947927 Free PMC article.
It is initiated by the detection of viral long double-stranded RNA (dsRNA) by the RNase III enzyme Dicer 2 (Dcr2), which is processed into predominantly 21 nt virus-derived small interfering RNAs (vsiRNAs) that are taken up by the Argonaute 2 (Ago2) protein to target viral …
It is initiated by the detection of viral long double-stranded RNA (dsRNA) by the RNase III enzyme Dicer 2 (Dcr2), which is processed into p …
The catalytic tetrad of Aedes aegypti argonaute 2 is critical for the antiviral activity of the exogenous siRNA pathway.
Dummunee K, Parry RH, Redecke L, Varjak M, Brennan B, Kohl A, McFarlane M. Dummunee K, et al. Among authors: brennan b. J Biol Chem. 2025 Apr;301(4):108332. doi: 10.1016/j.jbc.2025.108332. Epub 2025 Feb 19. J Biol Chem. 2025. PMID: 39984048 Free PMC article.
Viruses transmitted by biting arthropods, arboviruses, pose a significant global health and economic threat. ...Effective control of arbovirus transmission often relies on targeting the vectors, making it crucial to understand the interactions between the virus and …
Viruses transmitted by biting arthropods, arboviruses, pose a significant global health and economic threat. ...Effective control of …
Characterisation of the antiviral RNA interference response to Toscana virus in sand fly cells.
Alexander AJT, Salvemini M, Sreenu VB, Hughes J, Telleria EL, Ratinier M, Arnaud F, Volf P, Brennan B, Varjak M, Kohl A. Alexander AJT, et al. Among authors: brennan b. PLoS Pathog. 2023 Mar 30;19(3):e1011283. doi: 10.1371/journal.ppat.1011283. eCollection 2023 Mar. PLoS Pathog. 2023. PMID: 36996243 Free PMC article.
Toscana virus (TOSV) (Bunyavirales, Phenuiviridae, Phlebovirus, Toscana phlebovirus) and other related human pathogenic arboviruses are transmitted by phlebotomine sand flies. ...Following TOSV infection, distinctive 21 nucleotide virus-derived small interfering RNA …
Toscana virus (TOSV) (Bunyavirales, Phenuiviridae, Phlebovirus, Toscana phlebovirus) and other related human pathogenic arboviruses a …
Immunogenicity of a Candidate Live Attenuated Vaccine for Rift Valley Fever Virus with a Two-Segmented Genome.
Ayers VB, Huang YS, Dunlop JI, Kohl A, Brennan B, Higgs S, Vanlandingham DL. Ayers VB, et al. Among authors: brennan b. Viral Immunol. 2023 Jan;36(1):33-40. doi: 10.1089/vim.2022.0104. Epub 2022 Nov 18. Viral Immunol. 2023. PMID: 36399689 Free PMC article.
Rift Valley fever virus (RVFV) is an emerging arbovirus that affects both ruminants and humans. RVFV causes severe and recurrent outbreaks in Africa and the Arabian Peninsula with a significant risk for emergence into new locations. ...
Rift Valley fever virus (RVFV) is an emerging arbovirus that affects both ruminants and humans. RVFV causes severe and recurrent outb …
Virus-host interactions during tick-borne bunyavirus infection.
Fares M, Brennan B. Fares M, et al. Among authors: brennan b. Curr Opin Virol. 2022 Dec;57:101278. doi: 10.1016/j.coviro.2022.101278. Epub 2022 Nov 11. Curr Opin Virol. 2022. PMID: 36375406 Free article. Review.
The Bunyavirales order is the largest grouping of RNA viruses, comprising emerging and re-emerging human, plant and animal pathogens. Bunyaviruses have a global distribution and many members of the order are transmitted by arthropods. ...In this short review, we summarise …
The Bunyavirales order is the largest grouping of RNA viruses, comprising emerging and re-emerging human, plant and animal pathogens. …
Replication Kinetics of a Candidate Live-Attenuated Vaccine for Cache Valley Virus in Aedes albopictus.
Ayers VB, Huang YS, Dunlop JI, Kohl A, Brennan B, Higgs S, Vanlandingham DL. Ayers VB, et al. Among authors: brennan b. Vector Borne Zoonotic Dis. 2022 Nov;22(11):553-558. doi: 10.1089/vbz.2022.0053. Vector Borne Zoonotic Dis. 2022. PMID: 36354965 Free PMC article.
Background: The emergence or re-emergence of several orthobunyaviruses (order: Bunyavirales; family: Peribunyaviridae), including Cache Valley virus (CVV) and Oropouche virus, warrants the development and evaluation of candidate live-attenuated vaccines (LAVs). ...I …
Background: The emergence or re-emergence of several orthobunyaviruses (order: Bunyavirales; family: Peribunyaviridae), including Cache Vall …
An outbreak of Rift Valley fever among peri-urban dairy cattle in northern Tanzania.
de Glanville WA, Allan KJ, Nyarobi JM, Thomas KM, Lankester F, Kibona TJ, Claxton JR, Brennan B, Carter RW, Crump JA, Halliday JEB, Ladbury G, Mmbaga BT, Mramba F, Nyasebwa OM, Rubach MP, Rostal MK, Sanka P, Swai ES, Szemiel AM, Willett BJ, Cleaveland S. de Glanville WA, et al. Among authors: brennan b. Trans R Soc Trop Med Hyg. 2022 Nov 1;116(11):1082-1090. doi: 10.1093/trstmh/trac076. Trans R Soc Trop Med Hyg. 2022. PMID: 36040309 Free PMC article.
METHODS: Samples collected between 2017 and 2019 from livestock suffering abortion across northern Tanzania were retrospectively tested for evidence of RVF virus infection using serology and reverse transcription quantitative polymerase chain reaction (RT-qPCR). ...Genotyp …
METHODS: Samples collected between 2017 and 2019 from livestock suffering abortion across northern Tanzania were retrospectively tested for …
Exploration of immunological responses underpinning severe fever with thrombocytopenia syndrome virus infection reveals IL-6 as a therapeutic target in an immunocompromised mouse model.
Bryden SR, Dunlop JI, Clarke AT, Fares M, Pingen M, Wu Y, Willett BJ, Patel AH, Gao GF, Kohl A, Brennan B. Bryden SR, et al. Among authors: brennan b. PNAS Nexus. 2022 Mar 10;1(1):pgac024. doi: 10.1093/pnasnexus/pgac024. eCollection 2022 Mar. PNAS Nexus. 2022. PMID: 35529317 Free PMC article.
Dabie bandavirus (previously severe fever with thrombocytopenia syndrome virus; SFTSV), is an emerging tick-borne bunyavirus responsible for severe fever with thrombocytopenia syndrome (SFTS), a disease with high case fatality that is characterized by high fever, thrombocy …
Dabie bandavirus (previously severe fever with thrombocytopenia syndrome virus; SFTSV), is an emerging tick-borne bunyavirus responsi …
A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.
Rihn SJ, Merits A, Bakshi S, Turnbull ML, Wickenhagen A, Alexander AJT, Baillie C, Brennan B, Brown F, Brunker K, Bryden SR, Burness KA, Carmichael S, Cole SJ, Cowton VM, Davies P, Davis C, De Lorenzo G, Donald CL, Dorward M, Dunlop JI, Elliott M, Fares M, da Silva Filipe A, Freitas JR, Furnon W, Gestuveo RJ, Geyer A, Giesel D, Goldfarb DM, Goodman N, Gunson R, Hastie CJ, Herder V, Hughes J, Johnson C, Johnson N, Kohl A, Kerr K, Leech H, Lello LS, Li K, Lieber G, Liu X, Lingala R, Loney C, Mair D, McElwee MJ, McFarlane S, Nichols J, Nomikou K, Orr A, Orton RJ, Palmarini M, Parr YA, Pinto RM, Raggett S, Reid E, Robertson DL, Royle J, Cameron-Ruiz N, Shepherd JG, Smollett K, Stewart DG, Stewart M, Sugrue E, Szemiel AM, Taggart A, Thomson EC, Tong L, Torrie LS, Toth R, Varjak M, Wang S, Wilkinson SG, Wyatt PG, Zusinaite E, Alessi DR, Patel AH, Zaid A, Wilson SJ, Mahalingam S. Rihn SJ, et al. Among authors: brennan b. PLoS Biol. 2021 Feb 25;19(2):e3001091. doi: 10.1371/journal.pbio.3001091. eCollection 2021 Feb. PLoS Biol. 2021. PMID: 33630831 Free PMC article.
First, we describe a facile single plasmid SARS-CoV-2 reverse genetics system that is simple to genetically manipulate and can be used to rescue infectious virus through transient transfection (without in vitro transcription or additional expression plasmids). ...
First, we describe a facile single plasmid SARS-CoV-2 reverse genetics system that is simple to genetically manipulate and can be used to re …
Development of a Reverse Genetics System for Toscana Virus (Lineage A).
Alexander AJT, Confort MP, Desloire S, Dunlop JI, Kuchi S, Sreenu VB, Mair D, Wilkie GS, Da Silva Filipe A, Brennan B, Ratinier M, Arnaud F, Kohl A. Alexander AJT, et al. Among authors: brennan b. Viruses. 2020 Apr 7;12(4):411. doi: 10.3390/v12040411. Viruses. 2020. PMID: 32272808 Free PMC article.
Toscana virus (TOSV) is a Phlebovirus in the Phenuiviridae family, order Bunyavirales, found in the countries surrounding the Mediterranean. ...Here, we determined the full sequence of the TOSV strain 1500590, a lineage A virus obtained from an infected patient (Mar …
Toscana virus (TOSV) is a Phlebovirus in the Phenuiviridae family, order Bunyavirales, found in the countries surrounding the Mediter …
Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model.
Yu KM, Park SJ, Yu MA, Kim YI, Choi Y, Jung JU, Brennan B, Choi YK. Yu KM, et al. Among authors: brennan b. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26900-26908. doi: 10.1073/pnas.1914704116. Epub 2019 Dec 9. Proc Natl Acad Sci U S A. 2019. PMID: 31818942 Free PMC article.
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus classified within the Banyangvirus genus. ...Here, we report 2 attenuated recombinant SFTS viruses that induce a humoral immune response in immunized ferrets and …
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus classified within the Banyang …
M Segment-Based Minigenomes and Virus-Like Particle Assays as an Approach To Assess the Potential of Tick-Borne Phlebovirus Genome Reassortment.
Rezelj VV, Mottram TJ, Hughes J, Elliott RM, Kohl A, Brennan B. Rezelj VV, et al. Among authors: brennan b. J Virol. 2019 Mar 5;93(6):e02068-18. doi: 10.1128/JVI.02068-18. Print 2019 Mar 15. J Virol. 2019. PMID: 30567991 Free PMC article.
Bunyaviruses have a tripartite negative-sense RNA genome. Due to the segmented nature of these viruses, if two closely related viruses coinfect the same host or vector cell, it is possible that RNA segments from either of the two parental viruses will be inco …
Bunyaviruses have a tripartite negative-sense RNA genome. Due to the segmented nature of these viruses, if two closely related vir …
A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus.
Allen ER, Krumm SA, Raghwani J, Halldorsson S, Elliott A, Graham VA, Koudriakova E, Harlos K, Wright D, Warimwe GM, Brennan B, Huiskonen JT, Dowall SD, Elliott RM, Pybus OG, Burton DR, Hewson R, Doores KJ, Bowden TA. Allen ER, et al. Among authors: brennan b. Cell Rep. 2018 Dec 26;25(13):3750-3758.e4. doi: 10.1016/j.celrep.2018.12.001. Cell Rep. 2018. PMID: 30590046 Free PMC article.
The Gn subcomponent of the Gn-Gc assembly that envelopes the human and animal pathogen, Rift Valley fever virus (RVFV), is a primary target of the neutralizing antibody response. To better understand the molecular basis for immune recognition, we raised a class of neutrali …
The Gn subcomponent of the Gn-Gc assembly that envelopes the human and animal pathogen, Rift Valley fever virus (RVFV), is a primary …
Detection, infection dynamics and small RNA response against Culex Y virus in mosquito-derived cells.
Franzke K, Leggewie M, Sreenu VB, Jansen S, Heitmann A, Welch SR, Brennan B, Elliott RM, Tannich E, Becker SC, Schnettler E. Franzke K, et al. Among authors: brennan b. J Gen Virol. 2018 Dec;99(12):1739-1745. doi: 10.1099/jgv.0.001173. Epub 2018 Nov 5. J Gen Virol. 2018. PMID: 30394867
Many insect cell lines are persistently infected with insect-specific viruses (ISV) often unrecognized by the scientific community. Considering recent findings showing the possibility of interference between arbovirus and ISV infections, it is important to pay attention to …
Many insect cell lines are persistently infected with insect-specific viruses (ISV) often unrecognized by the scientific community. C …
Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas.
Dunlop JI, Szemiel AM, Navarro A, Wilkie GS, Tong L, Modha S, Mair D, Sreenu VB, Da Silva Filipe A, Li P, Huang YS, Brennan B, Hughes J, Vanlandingham DL, Higgs S, Elliott RM, Kohl A. Dunlop JI, et al. Among authors: brennan b. PLoS Negl Trop Dis. 2018 Oct 29;12(10):e0006884. doi: 10.1371/journal.pntd.0006884. eCollection 2018 Oct. PLoS Negl Trop Dis. 2018. PMID: 30372452 Free PMC article.
Both CVV and KRIV showed a wide in vitro cell host range, with BHK-21 cells a suitable host cell line for virus propagation and titration. To develop attenuated viruses, the open reading frames of the NSs proteins were disrupted. The recombinant viruses with …
Both CVV and KRIV showed a wide in vitro cell host range, with BHK-21 cells a suitable host cell line for virus propagation and titra …
Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20.
Feng J, Wickenhagen A, Turnbull ML, Rezelj VV, Kreher F, Tilston-Lunel NL, Slack GS, Brennan B, Koudriakova E, Shaw AE, Rihn SJ, Rice CM, Bieniasz PD, Elliott RM, Shi X, Wilson SJ. Feng J, et al. Among authors: brennan b. J Virol. 2018 Jun 13;92(13):e02140-17. doi: 10.1128/JVI.02140-17. Print 2018 Jul 1. J Virol. 2018. PMID: 29695422 Free PMC article.
Similar to the case against other viruses known to be targeted by ISG20, the antibunyaviral activity of ISG20 is dependent upon its functional RNase activity. Through use of an infectious virus-like particle (VLP) assay (based on the BUNV minigenome system), we conf …
Similar to the case against other viruses known to be targeted by ISG20, the antibunyaviral activity of ISG20 is dependent upon its f …
Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids.
Mottram TJ, Li P, Dietrich I, Shi X, Brennan B, Varjak M, Kohl A. Mottram TJ, et al. Among authors: brennan b. PLoS Negl Trop Dis. 2017 Dec 21;11(12):e0006155. doi: 10.1371/journal.pntd.0006155. eCollection 2017 Dec. PLoS Negl Trop Dis. 2017. PMID: 29267287 Free PMC article.
The N protein is responsible for the formation of the viral ribonucleoprotein (RNP) complexes, which are essential in the virus life cycle and for the transcription and replication of the viral genome. There is currently limited knowledge surrounding the roles of the RVFV …
The N protein is responsible for the formation of the viral ribonucleoprotein (RNP) complexes, which are essential in the virus life …
Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments.
Barski M, Brennan B, Miller OK, Potter JA, Vijayakrishnan S, Bhella D, Naismith JH, Elliott RM, Schwarz-Linek U. Barski M, et al. Among authors: brennan b. Elife. 2017 Sep 15;6:e29236. doi: 10.7554/eLife.29236. Elife. 2017. PMID: 28915104 Free PMC article.
A hallmark of RVFV pathology is NSs filament formation in infected cell nuclei. Recombinant virus encoding the NSs core domain induced intranuclear filaments, suggesting it contains all essential determinants for nuclear translocation and filament formation. Mutations of k …
A hallmark of RVFV pathology is NSs filament formation in infected cell nuclei. Recombinant virus encoding the NSs core domain induce …
Mapping of Transcription Termination within the S Segment of SFTS Phlebovirus Facilitated Generation of NSs Deletant Viruses.
Brennan B, Rezelj VV, Elliott RM. Brennan B, et al. J Virol. 2017 Jul 27;91(16):e00743-17. doi: 10.1128/JVI.00743-17. Print 2017 Aug 15. J Virol. 2017. PMID: 28592543 Free PMC article.
These viruses cannot antagonize the mammalian interferon (IFN) response mounted to virus infection. The generation of NSs-lacking viruses was achieved by mapping the transcriptional termination of two S-segment-derived subgenomic mRNAs, which revealed that tr …
These viruses cannot antagonize the mammalian interferon (IFN) response mounted to virus infection. The generation of NSs-lack …
Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins.
Rezelj VV, Li P, Chaudhary V, Elliott RM, Jin DY, Brennan B. Rezelj VV, et al. Among authors: brennan b. mSphere. 2017 Jun 28;2(3):e00234-17. doi: 10.1128/mSphere.00234-17. eCollection 2017 May-Jun. mSphere. 2017. PMID: 28680969 Free PMC article.
We studied the molecular mechanisms of IFN antagonism employed by the NSs proteins of human apathogenic Uukuniemi virus (UUKV) and those of Heartland virus (HRTV) and severe fever with thrombocytopenia syndrome virus (SFTSV), both of which cause severe diseas …
We studied the molecular mechanisms of IFN antagonism employed by the NSs proteins of human apathogenic Uukuniemi virus (UUKV) and th …
Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected.
Cumberworth SL, Barrie JA, Cunningham ME, de Figueiredo DPG, Schultz V, Wilder-Smith AJ, Brennan B, Pena LJ, Freitas de Oliveira França R, Linington C, Barnett SC, Willison HJ, Kohl A, Edgar JM. Cumberworth SL, et al. Among authors: brennan b. Acta Neuropathol Commun. 2017 Jun 23;5(1):50. doi: 10.1186/s40478-017-0450-8. Acta Neuropathol Commun. 2017. PMID: 28645311 Free PMC article.
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). ...
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral a …
RNA Interference Restricts Rift Valley Fever Virus in Multiple Insect Systems.
Dietrich I, Jansen S, Fall G, Lorenzen S, Rudolf M, Huber K, Heitmann A, Schicht S, Ndiaye EH, Watson M, Castelli I, Brennan B, Elliott RM, Diallo M, Sall AA, Failloux AB, Schnettler E, Kohl A, Becker SC. Dietrich I, et al. Among authors: brennan b. mSphere. 2017 May 3;2(3):e00090-17. doi: 10.1128/mSphere.00090-17. eCollection 2017 May-Jun. mSphere. 2017. PMID: 28497117 Free PMC article.
The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of po …
The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. …
A role for glycolipid biosynthesis in severe fever with thrombocytopenia syndrome virus entry.
Drake MJ, Brennan B, Briley K Jr, Bart SM, Sherman E, Szemiel AM, Minutillo M, Bushman FD, Bates P. Drake MJ, et al. Among authors: brennan b. PLoS Pathog. 2017 Apr 7;13(4):e1006316. doi: 10.1371/journal.ppat.1006316. eCollection 2017 Apr. PLoS Pathog. 2017. PMID: 28388693 Free PMC article.
A novel bunyavirus was recently found to cause severe febrile illness with high mortality in agricultural regions of China, Japan, and South Korea. This virus, named severe fever with thrombocytopenia syndrome virus (SFTSV), represents a new group within the Phlebov …
A novel bunyavirus was recently found to cause severe febrile illness with high mortality in agricultural regions of China, Japan, and South …
Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil.
Donald CL, Brennan B, Cumberworth SL, Rezelj VV, Clark JJ, Cordeiro MT, Freitas de Oliveira França R, Pena LJ, Wilkie GS, Da Silva Filipe A, Davis C, Hughes J, Varjak M, Selinger M, Zuvanov L, Owsianka AM, Patel AH, McLauchlan J, Lindenbach BD, Fall G, Sall AA, Biek R, Rehwinkel J, Schnettler E, Kohl A. Donald CL, et al. Among authors: brennan b. PLoS Negl Trop Dis. 2016 Oct 5;10(10):e0005048. doi: 10.1371/journal.pntd.0005048. eCollection 2016 Oct. PLoS Negl Trop Dis. 2016. PMID: 27706161 Free PMC article.
BACKGROUND: The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern. ...CONCLUSIONS/SIGNIFICANCE: The full-length genome sequence including non-codin …
BACKGROUND: The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of …
Homage to Richard M. Elliott.
Kohl A, Brennan B, Weber F. Kohl A, et al. Among authors: brennan b. Viruses. 2016 Aug 10;8(8):224. doi: 10.3390/v8080224. Viruses. 2016. PMID: 27517952 Free PMC article.
Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase.
Shi X, Botting CH, Li P, Niglas M, Brennan B, Shirran SL, Szemiel AM, Elliott RM. Shi X, et al. Among authors: brennan b. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8825-30. doi: 10.1073/pnas.1603364113. Epub 2016 Jul 20. Proc Natl Acad Sci U S A. 2016. PMID: 27439867 Free PMC article.
The M genome segment of Bunyamwera virus (BUNV)-the prototype of both the Bunyaviridae family and the Orthobunyavirus genus-encodes the glycoprotein precursor (GPC) that is proteolytically cleaved to yield two viral structural glycoproteins, Gn and Gc, and a nonstructural …
The M genome segment of Bunyamwera virus (BUNV)-the prototype of both the Bunyaviridae family and the Orthobunyavirus genus-encodes t …
Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.
Halldorsson S, Behrens AJ, Harlos K, Huiskonen JT, Elliott RM, Crispin M, Brennan B, Bowden TA. Halldorsson S, et al. Among authors: brennan b. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7154-9. doi: 10.1073/pnas.1603827113. Epub 2016 Jun 20. Proc Natl Acad Sci U S A. 2016. PMID: 27325770 Free PMC article.
An emergent viral pathogen termed severe fever with thrombocytopenia syndrome virus (SFTSV) is responsible for thousands of clinical cases and associated fatalities in China, Japan, and South Korea. ...By comparison of SFTSV Gc with that of the prefusion structure of the r …
An emergent viral pathogen termed severe fever with thrombocytopenia syndrome virus (SFTSV) is responsible for thousands of clinical …
In memoriam--Richard M. Elliott (1954-2015).
Brennan B, Weber F, Kormelink R, Schnettler E, Bouloy M, Failloux AB, Weaver SC, Fazakerley JK, Fragkoudis R, Harris M, Barr JN, Palese P, García-Sastre A, Dalziel RG, Dutia BM, Lowen AC, Steel J, Randall RE, Paul Duprex W, Rice CM, Tesh RB, Murphy FA, Ebihara H, Vasconcelos PFC, Nunes MR, Fooks AR, Smith GL, Goodfellow I, Pappu HR, Lamb RA, Paterson RG, Higgs S, Vanlandingham DL, Dietzgen RG, Stephen Lodmell J, Nichol ST, Daly J, Ullman DE, Plyusnin A, Plyusnina A, Efstathiou S, Hewson R, Tordo N, Cherry S, Boutell C, Hosie MJ, Murcia PR, Neil JC, Palmarini M, Patel AH, Willett BJ, Kohl A, McLauchlan J. Brennan B, et al. J Gen Virol. 2015 Aug;96(8):1975-1978. doi: 10.1099/jgv.0.000241. J Gen Virol. 2015. PMID: 26315040 Free PMC article. No abstract available.
Reverse genetics system for severe fever with thrombocytopenia syndrome virus.
Brennan B, Li P, Zhang S, Li A, Liang M, Li D, Elliott RM. Brennan B, et al. J Virol. 2015 Mar;89(6):3026-37. doi: 10.1128/JVI.03432-14. Epub 2014 Dec 31. J Virol. 2015. PMID: 25552716 Free PMC article.
Phylogenetic analysis of the viral genome showed that SFTS virus represents a new lineage within the Phlebovirus genus, distinct from the existing sandfly fever and Uukuniemi virus groups, in the family Bunyaviridae. ...IMPORTANCE: SFTSV and related tick-borne phleb …
Phylogenetic analysis of the viral genome showed that SFTS virus represents a new lineage within the Phlebovirus genus, distinct from …
Emerging phleboviruses.
Elliott RM, Brennan B. Elliott RM, et al. Among authors: brennan b. Curr Opin Virol. 2014 Apr;5(100):50-7. doi: 10.1016/j.coviro.2014.01.011. Epub 2014 Feb 28. Curr Opin Virol. 2014. PMID: 24607799 Free PMC article. Review.
The family has provided many examples of emerging viruses including Sin Nombre and related viruses responsible for hantavirus cardiopulmonary syndrome in the Americas, first identified in 1993, and Schmallenberg virus which emerged in Europe in 2011, causing …
The family has provided many examples of emerging viruses including Sin Nombre and related viruses responsible for hantavirus …
The consequences of reconfiguring the ambisense S genome segment of Rift Valley fever virus on viral replication in mammalian and mosquito cells and for genome packaging.
Brennan B, Welch SR, Elliott RM. Brennan B, et al. PLoS Pathog. 2014 Feb 13;10(2):e1003922. doi: 10.1371/journal.ppat.1003922. eCollection 2014 Feb. PLoS Pathog. 2014. PMID: 24550727 Free PMC article.
Rift Valley fever virus (RVFV, family Bunyaviridae) is a mosquito-borne pathogen of both livestock and humans, found primarily in Sub-Saharan Africa and the Arabian Peninsula. ...In cells infected with rMP12:S-Swap NSs is expressed at higher levels with respect to N than i …
Rift Valley fever virus (RVFV, family Bunyaviridae) is a mosquito-borne pathogen of both livestock and humans, found primarily in Sub …
Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase.
Brennan B, Li P, Elliott RM. Brennan B, et al. J Gen Virol. 2011 Dec;92(Pt 12):2906-2913. doi: 10.1099/vir.0.036749-0. Epub 2011 Sep 7. J Gen Virol. 2011. PMID: 21900422 Free article.
The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses both transcription of viral mRNAs and replication of the tripartite …
The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein …
Creation of a recombinant Rift Valley fever virus with a two-segmented genome.
Brennan B, Welch SR, McLees A, Elliott RM. Brennan B, et al. J Virol. 2011 Oct;85(19):10310-8. doi: 10.1128/JVI.05252-11. Epub 2011 Jul 27. J Virol. 2011. PMID: 21795328 Free PMC article.
Both the NSs and NSm proteins are dispensable for virus growth in tissue culture. Using reverse genetics, we generated a recombinant virus, designated r2segMP12, containing a two-segmented genome in which the NSs coding sequence was replaced with that for the Gn and …
Both the NSs and NSm proteins are dispensable for virus growth in tissue culture. Using reverse genetics, we generated a recombinant …