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A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.
Rihn SJ, Merits A, Bakshi S, Turnbull ML, Wickenhagen A, Alexander AJT, Baillie C, Brennan B, Brown F, Brunker K, Bryden SR, Burness KA, Carmichael S, Cole SJ, Cowton VM, Davies P, Davis C, De Lorenzo G, Donald CL, Dorward M, Dunlop JI, Elliott M, Fares M, da Silva Filipe A, Freitas JR, Furnon W, Gestuveo RJ, Geyer A, Giesel D, Goldfarb DM, Goodman N, Gunson R, Hastie CJ, Herder V, Hughes J, Johnson C, Johnson N, Kohl A, Kerr K, Leech H, Lello LS, Li K, Lieber G, Liu X, Lingala R, Loney C, Mair D, McElwee MJ, McFarlane S, Nichols J, Nomikou K, Orr A, Orton RJ, Palmarini M, Parr YA, Pinto RM, Raggett S, Reid E, Robertson DL, Royle J, Cameron-Ruiz N, Shepherd JG, Smollett K, Stewart DG, Stewart M, Sugrue E, Szemiel AM, Taggart A, Thomson EC, Tong L, Torrie LS, Toth R, Varjak M, Wang S, Wilkinson SG, Wyatt PG, Zusinaite E, Alessi DR, Patel AH, Zaid A, Wilson SJ, Mahalingam S. Rihn SJ, et al. Among authors: brennan b. PLoS Biol. 2021 Feb 25;19(2):e3001091. doi: 10.1371/journal.pbio.3001091. eCollection 2021 Feb. PLoS Biol. 2021. PMID: 33630831 Free PMC article.
First, we describe a facile single plasmid SARS-CoV-2 reverse genetics system that is simple to genetically manipulate and can be used to rescue infectious virus through transient transfection (without in vitro transcription or additional expression plasmids). ...
First, we describe a facile single plasmid SARS-CoV-2 reverse genetics system that is simple to genetically manipulate and can be used to re …
Development of a Reverse Genetics System for Toscana Virus (Lineage A).
Alexander AJT, Confort MP, Desloire S, Dunlop JI, Kuchi S, Sreenu VB, Mair D, Wilkie GS, Da Silva Filipe A, Brennan B, Ratinier M, Arnaud F, Kohl A. Alexander AJT, et al. Among authors: brennan b. Viruses. 2020 Apr 7;12(4):411. doi: 10.3390/v12040411. Viruses. 2020. PMID: 32272808 Free PMC article.
Toscana virus (TOSV) is a Phlebovirus in the Phenuiviridae family, order Bunyavirales, found in the countries surrounding the Mediterranean. ...Here, we determined the full sequence of the TOSV strain 1500590, a lineage A virus obtained from an infected patient (Mar …
Toscana virus (TOSV) is a Phlebovirus in the Phenuiviridae family, order Bunyavirales, found in the countries surrounding the Mediter …
Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model.
Yu KM, Park SJ, Yu MA, Kim YI, Choi Y, Jung JU, Brennan B, Choi YK. Yu KM, et al. Among authors: brennan b. Proc Natl Acad Sci U S A. 2019 Dec 9;116(52):26900-8. doi: 10.1073/pnas.1914704116. Online ahead of print. Proc Natl Acad Sci U S A. 2019. PMID: 31818942 Free PMC article.
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus classified within the Banyangvirus genus. ...Due to the recent emergence of SFTSV, there has been little time to conduct research into preventative measures aimed at com …
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus classified within the Banyang …
M Segment-Based Minigenomes and Virus-Like Particle Assays as an Approach To Assess the Potential of Tick-Borne Phlebovirus Genome Reassortment.
Rezelj VV, Mottram TJ, Hughes J, Elliott RM, Kohl A, Brennan B. Rezelj VV, et al. Among authors: brennan b. J Virol. 2019 Mar 5;93(6):e02068-18. doi: 10.1128/JVI.02068-18. Print 2019 Mar 15. J Virol. 2019. PMID: 30567991 Free PMC article.
Bunyaviruses have a tripartite negative-sense RNA genome. Due to the segmented nature of these viruses, if two closely related viruses coinfect the same host or vector cell, it is possible that RNA segments from either of the two parental viruses will be inco …
Bunyaviruses have a tripartite negative-sense RNA genome. Due to the segmented nature of these viruses, if two closely related vir
Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis.
Choi Y, Park SJ, Sun Y, Yoo JS, Pudupakam RS, Foo SS, Shin WJ, Chen SB, Tsichlis PN, Lee WJ, Lee JS, Li W, Brennan B, Choi YK, Jung JU. Choi Y, et al. Among authors: brennan b. Nat Microbiol. 2019 Mar;4(3):429-437. doi: 10.1038/s41564-018-0329-x. Epub 2019 Jan 7. Nat Microbiol. 2019. PMID: 30617349 Free PMC article.
A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus.
Allen ER, Krumm SA, Raghwani J, Halldorsson S, Elliott A, Graham VA, Koudriakova E, Harlos K, Wright D, Warimwe GM, Brennan B, Huiskonen JT, Dowall SD, Elliott RM, Pybus OG, Burton DR, Hewson R, Doores KJ, Bowden TA. Allen ER, et al. Among authors: brennan b. Cell Rep. 2018 Dec 26;25(13):3750-3758.e4. doi: 10.1016/j.celrep.2018.12.001. Cell Rep. 2018. PMID: 30590046 Free PMC article.
The Gn subcomponent of the Gn-Gc assembly that envelopes the human and animal pathogen, Rift Valley fever virus (RVFV), is a primary target of the neutralizing antibody response. ...Structural characterization revealed that these nAbs were directed to the membrane-distal d …
The Gn subcomponent of the Gn-Gc assembly that envelopes the human and animal pathogen, Rift Valley fever virus (RVFV), is a primary …
Detection, infection dynamics and small RNA response against Culex Y virus in mosquito-derived cells.
Franzke K, Leggewie M, Sreenu VB, Jansen S, Heitmann A, Welch SR, Brennan B, Elliott RM, Tannich E, Becker SC, Schnettler E. Franzke K, et al. Among authors: brennan b. J Gen Virol. 2018 Dec;99(12):1739-1745. doi: 10.1099/jgv.0.001173. Epub 2018 Nov 5. J Gen Virol. 2018. PMID: 30394867
Many insect cell lines are persistently infected with insect-specific viruses (ISV) often unrecognized by the scientific community. Considering recent findings showing the possibility of interference between arbovirus and ISV infections, it is important to pay attention to …
Many insect cell lines are persistently infected with insect-specific viruses (ISV) often unrecognized by the scientific community. C …
Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas.
Dunlop JI, Szemiel AM, Navarro A, Wilkie GS, Tong L, Modha S, Mair D, Sreenu VB, Da Silva Filipe A, Li P, Huang YS, Brennan B, Hughes J, Vanlandingham DL, Higgs S, Elliott RM, Kohl A. Dunlop JI, et al. Among authors: brennan b. PLoS Negl Trop Dis. 2018 Oct 29;12(10):e0006884. doi: 10.1371/journal.pntd.0006884. eCollection 2018 Oct. PLoS Negl Trop Dis. 2018. PMID: 30372452 Free PMC article.
Orthobunyaviruses such as Cache Valley virus (CVV) and Kairi virus (KRIV) are important animal pathogens. ...Both CVV and KRIV showed a wide in vitro cell host range, with BHK-21 cells a suitable host cell line for virus propagation and titration. To develop …
Orthobunyaviruses such as Cache Valley virus (CVV) and Kairi virus (KRIV) are important animal pathogens. ...Both CVV and KRIV …
Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20.
Feng J, Wickenhagen A, Turnbull ML, Rezelj VV, Kreher F, Tilston-Lunel NL, Slack GS, Brennan B, Koudriakova E, Shaw AE, Rihn SJ, Rice CM, Bieniasz PD, Elliott RM, Shi X, Wilson SJ. Feng J, et al. Among authors: brennan b. J Virol. 2018 Jun 13;92(13):e02140-17. doi: 10.1128/JVI.02140-17. Print 2018 Jul 1. J Virol. 2018. PMID: 29695422 Free PMC article.
Similar to the case against other viruses known to be targeted by ISG20, the antibunyaviral activity of ISG20 is dependent upon its functional RNase activity. Through use of an infectious virus-like particle (VLP) assay (based on the BUNV minigenome system), we conf …
Similar to the case against other viruses known to be targeted by ISG20, the antibunyaviral activity of ISG20 is dependent upon its f …
Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids.
Mottram TJ, Li P, Dietrich I, Shi X, Brennan B, Varjak M, Kohl A. Mottram TJ, et al. Among authors: brennan b. PLoS Negl Trop Dis. 2017 Dec 21;11(12):e0006155. doi: 10.1371/journal.pntd.0006155. eCollection 2017 Dec. PLoS Negl Trop Dis. 2017. PMID: 29267287 Free PMC article.
The RVFV genome is composed of tripartite, single stranded, negative or ambisense RNAs. The small (S) segment encodes both the nucleocapsid protein (N) and the non-structural protein (NSs). The N protein is responsible for the formation of the viral ribonucleoprotein (RNP) …
The RVFV genome is composed of tripartite, single stranded, negative or ambisense RNAs. The small (S) segment encodes both the nucleo …
Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments.
Barski M, Brennan B, Miller OK, Potter JA, Vijayakrishnan S, Bhella D, Naismith JH, Elliott RM, Schwarz-Linek U. Barski M, et al. Among authors: brennan b. Elife. 2017 Sep 15;6:e29236. doi: 10.7554/eLife.29236. Elife. 2017. PMID: 28915104 Free PMC article.
A hallmark of RVFV pathology is NSs filament formation in infected cell nuclei. Recombinant virus encoding the NSs core domain induced intranuclear filaments, suggesting it contains all essential determinants for nuclear translocation and filament formation. Mutations of k …
A hallmark of RVFV pathology is NSs filament formation in infected cell nuclei. Recombinant virus encoding the NSs core domain induce …
Mapping of Transcription Termination within the S Segment of SFTS Phlebovirus Facilitated Generation of NSs Deletant Viruses.
Brennan B, Rezelj VV, Elliott RM. Brennan B, et al. J Virol. 2017 Jul 27;91(16):e00743-17. doi: 10.1128/JVI.00743-17. Print 2017 Aug 15. J Virol. 2017. PMID: 28592543 Free PMC article.
These viruses cannot antagonize the mammalian interferon (IFN) response mounted to virus infection. The generation of NSs-lacking viruses was achieved by mapping the transcriptional termination of two S-segment-derived subgenomic mRNAs, which revealed …
These viruses cannot antagonize the mammalian interferon (IFN) response mounted to virus infection. The generation of NSs-lack …
Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins.
Rezelj VV, Li P, Chaudhary V, Elliott RM, Jin DY, Brennan B. Rezelj VV, et al. Among authors: brennan b. mSphere. 2017 Jun 28;2(3):e00234-17. doi: 10.1128/mSphere.00234-17. eCollection 2017 May-Jun. mSphere. 2017. PMID: 28680969 Free PMC article.
We studied the molecular mechanisms of IFN antagonism employed by the NSs proteins of human apathogenic Uukuniemi virus (UUKV) and those of Heartland virus (HRTV) and severe fever with thrombocytopenia syndrome virus (SFTSV), both of which cause severe diseas …
We studied the molecular mechanisms of IFN antagonism employed by the NSs proteins of human apathogenic Uukuniemi virus (UUKV) and th …
Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected.
Cumberworth SL, Barrie JA, Cunningham ME, de Figueiredo DPG, Schultz V, Wilder-Smith AJ, Brennan B, Pena LJ, Freitas de Oliveira França R, Linington C, Barnett SC, Willison HJ, Kohl A, Edgar JM. Cumberworth SL, et al. Among authors: brennan b. Acta Neuropathol Commun. 2017 Jun 23;5(1):50. doi: 10.1186/s40478-017-0450-8. Acta Neuropathol Commun. 2017. PMID: 28645311 Free PMC article.
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). ...
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral a …
RNA Interference Restricts Rift Valley Fever Virus in Multiple Insect Systems.
Dietrich I, Jansen S, Fall G, Lorenzen S, Rudolf M, Huber K, Heitmann A, Schicht S, Ndiaye EH, Watson M, Castelli I, Brennan B, Elliott RM, Diallo M, Sall AA, Failloux AB, Schnettler E, Kohl A, Becker SC. Dietrich I, et al. Among authors: brennan b. mSphere. 2017 May 3;2(3):e00090-17. doi: 10.1128/mSphere.00090-17. eCollection 2017 May-Jun. mSphere. 2017. PMID: 28497117 Free PMC article.
The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of po …
The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. …
A role for glycolipid biosynthesis in severe fever with thrombocytopenia syndrome virus entry.
Drake MJ, Brennan B, Briley K Jr, Bart SM, Sherman E, Szemiel AM, Minutillo M, Bushman FD, Bates P. Drake MJ, et al. Among authors: brennan b. PLoS Pathog. 2017 Apr 7;13(4):e1006316. doi: 10.1371/journal.ppat.1006316. eCollection 2017 Apr. PLoS Pathog. 2017. PMID: 28388693 Free PMC article.
A novel bunyavirus was recently found to cause severe febrile illness with high mortality in agricultural regions of China, Japan, and South Korea. This virus, named severe fever with thrombocytopenia syndrome virus (SFTSV), represents a new group within the Phlebov …
A novel bunyavirus was recently found to cause severe febrile illness with high mortality in agricultural regions of China, Japan, and South …
Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil.
Donald CL, Brennan B, Cumberworth SL, Rezelj VV, Clark JJ, Cordeiro MT, Freitas de Oliveira França R, Pena LJ, Wilkie GS, Da Silva Filipe A, Davis C, Hughes J, Varjak M, Selinger M, Zuvanov L, Owsianka AM, Patel AH, McLauchlan J, Lindenbach BD, Fall G, Sall AA, Biek R, Rehwinkel J, Schnettler E, Kohl A. Donald CL, et al. Among authors: brennan b. PLoS Negl Trop Dis. 2016 Oct 5;10(10):e0005048. doi: 10.1371/journal.pntd.0005048. eCollection 2016 Oct. PLoS Negl Trop Dis. 2016. PMID: 27706161 Free PMC article.
BACKGROUND: The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern. ...CONCLUSIONS/SIGNIFICANCE: The full-length genome sequence including non-codin …
BACKGROUND: The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of …
Homage to Richard M. Elliott.
Kohl A, Brennan B, Weber F. Kohl A, et al. Among authors: brennan b. Viruses. 2016 Aug 10;8(8):224. doi: 10.3390/v8080224. Viruses. 2016. PMID: 27517952 Free PMC article.
Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase.
Shi X, Botting CH, Li P, Niglas M, Brennan B, Shirran SL, Szemiel AM, Elliott RM. Shi X, et al. Among authors: brennan b. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8825-30. doi: 10.1073/pnas.1603364113. Epub 2016 Jul 20. Proc Natl Acad Sci U S A. 2016. PMID: 27439867 Free PMC article.
The M genome segment of Bunyamwera virus (BUNV)-the prototype of both the Bunyaviridae family and the Orthobunyavirus genus-encodes the glycoprotein precursor (GPC) that is proteolytically cleaved to yield two viral structural glycoproteins, Gn and Gc, and a nonstructural …
The M genome segment of Bunyamwera virus (BUNV)-the prototype of both the Bunyaviridae family and the Orthobunyavirus genus-encodes t …
Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.
Halldorsson S, Behrens AJ, Harlos K, Huiskonen JT, Elliott RM, Crispin M, Brennan B, Bowden TA. Halldorsson S, et al. Among authors: brennan b. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7154-9. doi: 10.1073/pnas.1603827113. Epub 2016 Jun 20. Proc Natl Acad Sci U S A. 2016. PMID: 27325770 Free PMC article.
An emergent viral pathogen termed severe fever with thrombocytopenia syndrome virus (SFTSV) is responsible for thousands of clinical cases and associated fatalities in China, Japan, and South Korea. ...By comparison of SFTSV Gc with that of the prefusion structure of the r …
An emergent viral pathogen termed severe fever with thrombocytopenia syndrome virus (SFTSV) is responsible for thousands of clinical …
In memoriam--Richard M. Elliott (1954-2015).
Brennan B, Weber F, Kormelink R, Schnettler E, Bouloy M, Failloux AB, Weaver SC, Fazakerley JK, Fragkoudis R, Harris M, Barr JN, Palese P, García-Sastre A, Dalziel RG, Dutia BM, Lowen AC, Steel J, Randall RE, Paul Duprex W, Rice CM, Tesh RB, Murphy FA, Ebihara H, Vasconcelos PFC, Nunes MR, Fooks AR, Smith GL, Goodfellow I, Pappu HR, Lamb RA, Paterson RG, Higgs S, Vanlandingham DL, Dietzgen RG, Stephen Lodmell J, Nichol ST, Daly J, Ullman DE, Plyusnin A, Plyusnina A, Efstathiou S, Hewson R, Tordo N, Cherry S, Boutell C, Hosie MJ, Murcia PR, Neil JC, Palmarini M, Patel AH, Willett BJ, Kohl A, McLauchlan J. Brennan B, et al. J Gen Virol. 2015 Aug;96(8):1975-1978. doi: 10.1099/jgv.0.000241. J Gen Virol. 2015. PMID: 26315040 Free PMC article. No abstract available.
Reverse genetics system for severe fever with thrombocytopenia syndrome virus.
Brennan B, Li P, Zhang S, Li A, Liang M, Li D, Elliott RM. Brennan B, et al. J Virol. 2015 Mar;89(6):3026-37. doi: 10.1128/JVI.03432-14. Epub 2014 Dec 31. J Virol. 2015. PMID: 25552716 Free PMC article.
We then generated recombinant viruses from cloned cDNAs prepared to the antigenomic RNAs both of the minimally passaged virus (HB29) and of a cell culture-adapted strain designated HB29pp. ...IMPORTANCE: SFTSV and related tick-borne phleboviruses such as Heartland …
We then generated recombinant viruses from cloned cDNAs prepared to the antigenomic RNAs both of the minimally passaged virus
Emerging phleboviruses.
Elliott RM, Brennan B. Elliott RM, et al. Among authors: brennan b. Curr Opin Virol. 2014 Apr;5(100):50-7. doi: 10.1016/j.coviro.2014.01.011. Epub 2014 Feb 28. Curr Opin Virol. 2014. PMID: 24607799 Free PMC article. Review.
The majority of bunyaviruses are vectored by arthropods and thus have the remarkable capability to replicate in hosts of disparate phylogeny. The family has provided many examples of emerging viruses including Sin Nombre and related viruses responsible for hantaviru …
The majority of bunyaviruses are vectored by arthropods and thus have the remarkable capability to replicate in hosts of disparate phylogeny …
The consequences of reconfiguring the ambisense S genome segment of Rift Valley fever virus on viral replication in mammalian and mosquito cells and for genome packaging.
Brennan B, Welch SR, Elliott RM. Brennan B, et al. PLoS Pathog. 2014 Feb 13;10(2):e1003922. doi: 10.1371/journal.ppat.1003922. eCollection 2014 Feb. PLoS Pathog. 2014. PMID: 24550727 Free PMC article.
Using reverse genetics we generated a virus, designated rMP12:S-Swap, in which the N protein is expressed from the NSs locus and NSs from the N locus within the genomic S RNA. In cells infected with rMP12:S-Swap NSs is expressed at higher levels with r …
Using reverse genetics we generated a virus, designated rMP12:S-Swap, in which the N protein is expressed from the NSs locus a …
Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase.
Brennan B, Li P, Elliott RM. Brennan B, et al. J Gen Virol. 2011 Dec;92(Pt 12):2906-2913. doi: 10.1099/vir.0.036749-0. Epub 2011 Sep 7. J Gen Virol. 2011. PMID: 21900422
The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses both transcription of viral mRNAs and replication of the tripartite …
The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein …
Creation of a recombinant Rift Valley fever virus with a two-segmented genome.
Brennan B, Welch SR, McLees A, Elliott RM. Brennan B, et al. J Virol. 2011 Oct;85(19):10310-8. doi: 10.1128/JVI.05252-11. Epub 2011 Jul 27. J Virol. 2011. PMID: 21795328 Free PMC article.
Both the NSs and NSm proteins are dispensable for virus growth in tissue culture. Using reverse genetics, we generated a recombinant virus, designated r2segMP12, containing a two-segmented genome in which the NSs coding sequence was replaced with that for the Gn and …
Both the NSs and NSm proteins are dispensable for virus growth in tissue culture. Using reverse genetics, we generated a recombinant …