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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 1
1968 1
1972 1
1973 2
1974 2
1976 1
1979 1
1983 1
1984 1
1985 1
1986 1
1987 1
1988 1
1991 2
1992 1
1993 3
1994 2
1995 1
1996 4
1997 3
1998 6
1999 1
2000 4
2001 2
2002 1
2004 1
2005 3
2006 2
2008 1
2009 1
2010 2
2011 1
2012 6
2013 3
2014 2
2015 1
2016 1
2017 5
2018 1
2019 3
2020 2
2021 2
2022 2
2023 1
2024 1

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84 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection: a randomized, crossover, population pharmacokinetic study in healthy adult volunteers.
Kado JH, Salman S, Henderson R, Hand R, Wyber R, Page-Sharp M, Batty K, Carapetis J, Manning L. Kado JH, et al. J Antimicrob Chemother. 2020 Oct 1;75(10):2951-2959. doi: 10.1093/jac/dkaa282. J Antimicrob Chemother. 2020. PMID: 32696033 Clinical Trial.
Simulations demonstrated that SC infusion of higher doses of benzathine penicillin G could provide therapeutic penicillin concentrations for 3 months. CONCLUSIONS: SC administration of benzathine penicillin G is safe and significantly delays penicillin absorption. . …
Simulations demonstrated that SC infusion of higher doses of benzathine penicillin G could provide therapeutic penicillin concentrati …
Interventions for the prevention of recurrent erysipelas and cellulitis.
Dalal A, Eskin-Schwartz M, Mimouni D, Ray S, Days W, Hodak E, Leibovici L, Paul M. Dalal A, et al. Cochrane Database Syst Rev. 2017 Jun 20;6(6):CD009758. doi: 10.1002/14651858.CD009758.pub2. Cochrane Database Syst Rev. 2017. PMID: 28631307 Free PMC article. Review.
In one study, around 10% of participants stopped treatment due to pain at the injection site (the active treatment group was given intramuscular injections of benzathine penicillin).None of the included studies assessed the development of antimicrobial resistance or qualit …
In one study, around 10% of participants stopped treatment due to pain at the injection site (the active treatment group was given intramusc …
Combination of Amoxicillin 3000 mg and Probenecid Versus 1500 mg Amoxicillin Monotherapy for Treating Syphilis in Patients With Human Immunodeficiency Virus: An Open-Label, Randomized, Controlled, Non-Inferiority Trial.
Ando N, Mizushima D, Omata K, Nemoto T, Inamura N, Hiramoto S, Takano M, Aoki T, Watanabe K, Uemura H, Shiojiri D, Yanagawa Y, Tanuma J, Teruya K, Kikuchi Y, Gatanaga H, Oka S. Ando N, et al. Clin Infect Dis. 2023 Sep 11;77(5):779-787. doi: 10.1093/cid/ciad278. Clin Infect Dis. 2023. PMID: 37157863 Clinical Trial.
BACKGROUND: Amoxicillin plus probenecid is an alternative to intramuscular benzathine penicillin G for treating syphilis in the United Kingdom. ...Therefore, amoxicillin monotherapy could be a good alternative to intramuscular benzathine penicillin G with fewer side …
BACKGROUND: Amoxicillin plus probenecid is an alternative to intramuscular benzathine penicillin G for treating syphilis in the Unite …
Azithromycin versus penicillin G benzathine for early syphilis.
Bai ZG, Wang B, Yang K, Tian JH, Ma B, Liu Y, Jiang L, Gai QY, He X, Li Y. Bai ZG, et al. Cochrane Database Syst Rev. 2012 Jun 13;(6):CD007270. doi: 10.1002/14651858.CD007270.pub2. Cochrane Database Syst Rev. 2012. PMID: 22696367 Review.
In this review we compared two current standards of treatment for early syphilis, benzathine benzylpenicillin (penicillin G) and azithromycin. OBJECTIVES: To evaluate the efficacy and safety of azithromycin versus benzathine penicillin (penicillin G) for earl …
In this review we compared two current standards of treatment for early syphilis, benzathine benzylpenicillin (penicillin G) a …
Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease.
Beaton A, Okello E, Rwebembera J, Grobler A, Engelman D, Alepere J, Canales L, Carapetis J, DeWyer A, Lwabi P, Mirabel M, Mocumbi AO, Murali M, Nakitto M, Ndagire E, Nunes MCP, Omara IO, Sarnacki R, Scheel A, Wilson N, Zimmerman M, Zühlke L, Karthikeyan G, Sable CA, Steer AC. Beaton A, et al. N Engl J Med. 2022 Jan 20;386(3):230-240. doi: 10.1056/NEJMoa2102074. Epub 2021 Nov 13. N Engl J Med. 2022. PMID: 34767321 Clinical Trial.
Participants were randomly assigned to receive either injections of penicillin G benzathine (also known as benzathine benzylpenicillin) every 4 weeks for 2 years or no prophylaxis. ...
Participants were randomly assigned to receive either injections of penicillin G benzathine (also known as benzathin
Oral linezolid compared with benzathine penicillin G for treatment of early syphilis in adults (Trep-AB Study) in Spain: a prospective, open-label, non-inferiority, randomised controlled trial.
Ubals M, Nadal-Baron P, Arando M, Rivero Á, Mendoza A, Descalzo Jorro V, Ouchi D, Pérez-Mañá C, Álvarez M, Alemany A, Hoyos-Mallecot Y, Nunley E, Lieberman NAP, Greninger AL, Galván-Casas C, Suñer C, G-Beiras C, Paredes R, Rodríguez-Gascón A, Canut A, García-Patos V, Farré M, Marks M, Giacani L, Vall-Mayans M, Mitjà O. Ubals M, et al. Lancet Infect Dis. 2024 Apr;24(4):404-416. doi: 10.1016/S1473-3099(23)00683-7. Epub 2024 Jan 8. Lancet Infect Dis. 2024. PMID: 38211601 Free PMC article. Clinical Trial.
We aimed to assess the efficacy of linezolid for treating early syphilis in adults compared with the standard of care benzathine penicillin G (BPG). METHODS: We did a multicentre, open-label, non-inferiority, randomised controlled trial to assess the efficacy of linezolid …
We aimed to assess the efficacy of linezolid for treating early syphilis in adults compared with the standard of care benzathine peni …
Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial.
Mitjà O, Hays R, Ipai A, Penias M, Paru R, Fagaho D, de Lazzari E, Bassat Q. Mitjà O, et al. Lancet. 2012 Jan 28;379(9813):342-7. doi: 10.1016/S0140-6736(11)61624-3. Epub 2012 Jan 11. Lancet. 2012. PMID: 22240407 Clinical Trial.
FINDINGS: We allocated 124 patients to the azithromycin group and 126 to the benzathine benzylpenicillin group. In the per-protocol analysis, after 6 months of follow-up, 106 (96%) of 110 patients in the azithromycin group were cured, compared with 105 (93%) of 113 …
FINDINGS: We allocated 124 patients to the azithromycin group and 126 to the benzathine benzylpenicillin group. In the per-pro …
Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial.
Bowen AC, Tong SY, Andrews RM, O'Meara IM, McDonald MI, Chatfield MD, Currie BJ, Carapetis JR. Bowen AC, et al. Lancet. 2014 Dec 13;384(9960):2132-40. doi: 10.1016/S0140-6736(14)60841-2. Epub 2014 Aug 26. Lancet. 2014. PMID: 25172376 Free article. Clinical Trial.
As such, we aimed to compare short-course oral co-trimoxazole with standard treatment with intramuscular benzathine benzylpenicillin in children with impetigo in a highly endemic setting. ...Adverse events occurred in 54 participants, 49 (90%) of whom received be
As such, we aimed to compare short-course oral co-trimoxazole with standard treatment with intramuscular benzathine benzylpenicill
Antibiotic treatment for newborns with congenital syphilis.
Walker GJ, Walker D, Molano Franco D, Grillo-Ardila CF. Walker GJ, et al. Cochrane Database Syst Rev. 2019 Feb 15;2(2):CD012071. doi: 10.1002/14651858.CD012071.pub2. Cochrane Database Syst Rev. 2019. PMID: 30776081 Free PMC article.
We downgraded the quality of evidence because of imprecision and risk of bias.One trial (169 participants) compared benzathine penicillin versus procaine benzylpenicillin. High- and moderate-quality evidence suggested that there were probably no differences between …
We downgraded the quality of evidence because of imprecision and risk of bias.One trial (169 participants) compared benzathine penici …
84 results