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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 3
2007 2
2008 5
2009 8
2010 14
2011 16
2012 14
2013 13
2014 21
2015 19
2016 27
2017 36
2018 31
2019 27
2020 31
2021 32
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2023 23
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333 results

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Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway.
Zhu X, Bian H, Wang L, Sun X, Xu X, Yan H, Xia M, Chang X, Lu Y, Li Y, Xia P, Li X, Gao X. Zhu X, et al. Free Radic Biol Med. 2019 Sep;141:192-204. doi: 10.1016/j.freeradbiomed.2019.06.019. Epub 2019 Jun 18. Free Radic Biol Med. 2019. PMID: 31226399
Mechanistically, BBR promoted the phosphorylation of AMP-activated protein kinase (AMPK) and sterol regulatory element-binding protein-1c (SREBP-1c) in HepG2 cells and the liver of HFD-fed mice. ...CONCLUSION: BBR reduces liver TG synthesis and …
Mechanistically, BBR promoted the phosphorylation of AMP-activated protein kinase (AMPK) and sterol regulatory e …
AMPK and its Activator Berberine in the Treatment of Neurodegenerative Diseases.
Qin S, Tang H, Li W, Gong Y, Li S, Huang J, Fang Y, Yuan W, Liu Y, Wang S, Guo Y, Guo Y, Xu Z. Qin S, et al. Curr Pharm Des. 2020;26(39):5054-5066. doi: 10.2174/1381612826666200523172334. Curr Pharm Des. 2020. PMID: 32445451 Review.
Here, we summarized that the energy sensor adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), and its agonist berberine can combat the common underlying pathological events of neurodegeneration, including oxidative stress, neuroin …
Here, we summarized that the energy sensor adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), and …
Berberine modulates deacetylation of PPARgamma to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway.
Xu Y, Yu T, Ma G, Zheng L, Jiang X, Yang F, Wang Z, Li N, He Z, Song X, Wen D, Kong J, Yu Y, Cao L. Xu Y, et al. Int J Biol Sci. 2021 Jul 25;17(12):3173-3187. doi: 10.7150/ijbs.62556. eCollection 2021. Int J Biol Sci. 2021. PMID: 34421358 Free PMC article.
We have further demonstrated that berberine activated energy metabolic sensing pathway AMPK/SIRT1 axis to increase the level of PPARgamma deacetylation, which leads to promoting adipose tissue remodeling and increasing the expression of the thermogenic protein …
We have further demonstrated that berberine activated energy metabolic sensing pathway AMPK/SIRT1 axis to increase the level o …
The effect of Berberine on weight loss in order to prevent obesity: A systematic review.
Ilyas Z, Perna S, Al-Thawadi S, Alalwan TA, Riva A, Petrangolini G, Gasparri C, Infantino V, Peroni G, Rondanelli M. Ilyas Z, et al. Biomed Pharmacother. 2020 Jul;127:110137. doi: 10.1016/j.biopha.2020.110137. Epub 2020 Apr 27. Biomed Pharmacother. 2020. PMID: 32353823 Free article.
As a result of this review, we summarized the effects of Berberine in different models and the related mechanism of actions. In preclinical models, Berberine demonstrates that it affects gut microbiota by reducing diversity of microbes starting at a dosage of 100 mg …
As a result of this review, we summarized the effects of Berberine in different models and the related mechanism of actions. In precl …
AMPK, Mitochondrial Function, and Cardiovascular Disease.
Wu S, Zou MH. Wu S, et al. Int J Mol Sci. 2020 Jul 15;21(14):4987. doi: 10.3390/ijms21144987. Int J Mol Sci. 2020. PMID: 32679729 Free PMC article. Review.
Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine triphosphate levels in response to energetic and/or cellular stress. ...The functions of AMPK …
Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous catabolic and anabolic signaling pathways to …
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics.
Feng X, Sureda A, Jafari S, Memariani Z, Tewari D, Annunziata G, Barrea L, Hassan STS, Šmejkal K, Malaník M, Sychrová A, Barreca D, Ziberna L, Mahomoodally MF, Zengin G, Xu S, Nabavi SM, Shen AZ. Feng X, et al. Theranostics. 2019 Mar 16;9(7):1923-1951. doi: 10.7150/thno.30787. eCollection 2019. Theranostics. 2019. PMID: 31037148 Free PMC article. Review.
Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is an eminent component of traditional Chinese and Ayurvedic medicine for more than 2000 years. ...Re …
Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to develop new pha …
Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation by downregulating galectin-3 via the NF-kappaB and AMPK signaling pathways.
Pei C, Zhang Y, Wang P, Zhang B, Fang L, Liu B, Meng S. Pei C, et al. Phytother Res. 2019 Feb;33(2):294-308. doi: 10.1002/ptr.6217. Epub 2018 Nov 6. Phytother Res. 2019. PMID: 30402951 Free PMC article. Clinical Trial.
Overexpression of galectin-3 intervened the inhibitory effect of BBR on macrophage activation. BBR activated phospho-AMPK and inhibited phospho-NF-kappaB p65 nuclear translocation. AMPK inhibition and NF-kappaB activation abolished the inhibitory effects of BBR on g …
Overexpression of galectin-3 intervened the inhibitory effect of BBR on macrophage activation. BBR activated phospho-AMPK and inhibit …
Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity.
DiNicolantonio JJ, McCarty MF, Assanga SI, Lujan LL, O'Keefe JH. DiNicolantonio JJ, et al. Open Heart. 2022 Mar;9(1):e001801. doi: 10.1136/openhrt-2021-001801. Open Heart. 2022. PMID: 35301252 Free PMC article. Review.
A deficit of the latter appears to mediate the endothelial toxicity of the SARS-CoV-2 spike protein. Ferulic acid also enhances the activation of AMP-activated kinase (AMPK) by increasing expression and activity of its activating kinase LKB1-whereas …
A deficit of the latter appears to mediate the endothelial toxicity of the SARS-CoV-2 spike protein. Ferulic acid also enhances the a …
Berberine ameliorates collagen-induced arthritis in mice by restoring macrophage polarization via AMPK/mTORC1 pathway switching glycolytic reprogramming.
Cheng JW, Yu Y, Zong SY, Cai WW, Wang Y, Song YN, Xian H, Wei F. Cheng JW, et al. Int Immunopharmacol. 2023 Nov;124(Pt B):111024. doi: 10.1016/j.intimp.2023.111024. Epub 2023 Oct 10. Int Immunopharmacol. 2023. PMID: 37827054
Previously, we demonstrated that the anti-arthritis effect of berberine (BBR) in rats with adjuvant-induced arthritis (AA) may be related to AMP-activated protein kinase (AMPK) activation (a key regulator in the biological energy metabolism), an …
Previously, we demonstrated that the anti-arthritis effect of berberine (BBR) in rats with adjuvant-induced arthritis (AA) may be rel …
Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1.
Ren G, Ding YW, Wang LL, Jiang JD. Ren G, et al. Front Pharmacol. 2023 Apr 18;14:1148611. doi: 10.3389/fphar.2023.1148611. eCollection 2023. Front Pharmacol. 2023. PMID: 37144221 Free PMC article.
Aim: AMPK is the key regulatory kinase mediating the effect of berberine (BBR) and metformin on metabolic improvement. ...And overexpression of UHRF1 abolished the effect of BBR on AMPK activation. Conclusion: BBR activated lysosomal AMPK as dependent …
Aim: AMPK is the key regulatory kinase mediating the effect of berberine (BBR) and metformin on metabolic improvement. ...And …
333 results