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2006 1
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249 results

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Page 1
The effect of Berberine on weight loss in order to prevent obesity: A systematic review.
Ilyas Z, Perna S, Al-Thawadi S, Alalwan TA, Riva A, Petrangolini G, Gasparri C, Infantino V, Peroni G, Rondanelli M. Ilyas Z, et al. Biomed Pharmacother. 2020 Jul;127:110137. doi: 10.1016/j.biopha.2020.110137. Epub 2020 Apr 27. Biomed Pharmacother. 2020. PMID: 32353823 Free article.
As a result of this review, we summarized the effects of Berberine in different models and the related mechanism of actions. In preclinical models, Berberine demonstrates that it affects gut microbiota by reducing diversity of microbes starting at a dosage of …
As a result of this review, we summarized the effects of Berberine in different models and the related mechanism of actions. I …
Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway.
Zhu X, Bian H, Wang L, Sun X, Xu X, Yan H, Xia M, Chang X, Lu Y, Li Y, Xia P, Li X, Gao X. Zhu X, et al. Free Radic Biol Med. 2019 Sep;141:192-204. doi: 10.1016/j.freeradbiomed.2019.06.019. Epub 2019 Jun 18. Free Radic Biol Med. 2019. PMID: 31226399
Mechanistically, BBR promoted the phosphorylation of AMP-activated protein kinase (AMPK) and sterol regulatory element-binding protein-1c (SREBP-1c) in HepG2 cells and the liver of HFD-fed mice. ...CONCLUSION: BBR reduces liver TG synthesis and …
Mechanistically, BBR promoted the phosphorylation of AMP-activated protein kinase (AMPK) and sterol regulatory e …
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics.
Feng X, Sureda A, Jafari S, Memariani Z, Tewari D, Annunziata G, Barrea L, Hassan STS, Šmejkal K, Malaník M, Sychrová A, Barreca D, Ziberna L, Mahomoodally MF, Zengin G, Xu S, Nabavi SM, Shen AZ. Feng X, et al. Theranostics. 2019 Mar 16;9(7):1923-1951. doi: 10.7150/thno.30787. eCollection 2019. Theranostics. 2019. PMID: 31037148 Free PMC article. Review.
Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is an eminent component of traditional Chinese and Ayurvedic medicine for more than 2000 years. ...Re …
Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to develop new pha …
Metformin and berberine synergistically improve NAFLD via the AMPK-SREBP1-FASN signaling pathway.
Li N, Chen QW, Gong XL, Liu F, Zhang B, Wang QS, Zhang H, Han JJ. Li N, et al. Sci Rep. 2025 Aug 11;15(1):29400. doi: 10.1038/s41598-025-15495-7. Sci Rep. 2025. PMID: 40790070 Free PMC article.
The research sought to explore the combined impact of metformin (Met) and berberine (BBR) on NAFLD, focusing on the AMPK-SREBP1-FASN pathway implicated in liver lipid regulation. ...An Adenosine 5'-monophosphate (AMP)-activated protein kinase( …
The research sought to explore the combined impact of metformin (Met) and berberine (BBR) on NAFLD, focusing on the AMPK-SREBP …
Therapeutic application of natural products: NAD+ metabolism as potential target.
Guo C, Huang Q, Wang Y, Yao Y, Li J, Chen J, Wu M, Zhang Z, E M, Qi H, Ji P, Liu Q, Zhao D, Su H, Qi W, Li X. Guo C, et al. Phytomedicine. 2023 Jun;114:154768. doi: 10.1016/j.phymed.2023.154768. Epub 2023 Mar 13. Phytomedicine. 2023. PMID: 36948143 Review.
RESULTS: We found that the natural products mainly include phenols (curcumin, cyclocurcumin, 4-hydroxybenzyl alcohol, salvianolic acid B, pterostilbene, EGCG), flavonoids (pinostrobin, apigenin, acacetin, tilianin, kaempferol, quercetin, isoliquiritigenin, luteolin, silybin, hydr …
RESULTS: We found that the natural products mainly include phenols (curcumin, cyclocurcumin, 4-hydroxybenzyl alcohol, salvianolic acid B, pt …
Kidney targeting and modulating macrophage polarization through AMPK signaling: Therapeutic mechanism of berberine in uric acid nephropathy.
Gong S, Chen J, Zheng X, Lu X, Chen M, Li J, Su Z, Liu Y, Chen J, Xie J, Xie Q, Li Y. Gong S, et al. Int Immunopharmacol. 2024 Sep 10;138:112632. doi: 10.1016/j.intimp.2024.112632. Epub 2024 Jul 9. Int Immunopharmacol. 2024. PMID: 38986300
Uric acid nephropathy (UAN), caused by a common metabolic disorder resulting from hyperuricemia (HUA), has an increasing incidence. Previous studies have shown that berberine (BBR) has clear urate-lowering and anti-inflammatory effects in UAN mice, but its mechanism …
Uric acid nephropathy (UAN), caused by a common metabolic disorder resulting from hyperuricemia (HUA), has an increasing incidence. Previous …
Berberine as a multi-target therapeutic agent for obesity: from pharmacological mechanisms to clinical evidence.
Kong Y, Yang H, Nie R, Zhang X, Zhang H, Nian X. Kong Y, et al. Eur J Med Res. 2025 Jun 12;30(1):477. doi: 10.1186/s40001-025-02738-6. Eur J Med Res. 2025. PMID: 40506769 Free PMC article. Review.
This therapeutic gap has revitalized interest in natural bioactive compounds, particularly berberine (BBR)-a benzodioxoloquinolizine alkaloid derived from Coptis chinensis and related medicinal plants. Preclinical and clinical studies demonstrate BBR's multimodal anti-obes …
This therapeutic gap has revitalized interest in natural bioactive compounds, particularly berberine (BBR)-a benzodioxoloquinolizine …
Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1.
Ren G, Ding YW, Wang LL, Jiang JD. Ren G, et al. Front Pharmacol. 2023 Apr 18;14:1148611. doi: 10.3389/fphar.2023.1148611. eCollection 2023. Front Pharmacol. 2023. PMID: 37144221 Free PMC article.
Aim: AMPK is the key regulatory kinase mediating the effect of berberine (BBR) and metformin on metabolic improvement. The present study investigated the mechanism of BBR on AMPK activation at low doses, which was different from that of metformin. ...
Aim: AMPK is the key regulatory kinase mediating the effect of berberine (BBR) and metformin on metabolic improvement. The pre …
Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation.
Wang M, Xu Z, Wang Z, Xu X, Sun Y. Wang M, et al. Transl Cancer Res. 2024 Sep 30;13(9):4593-4607. doi: 10.21037/tcr-24-668. Epub 2024 Sep 27. Transl Cancer Res. 2024. PMID: 39430861 Free PMC article.
METHODS: Several publicly available databases were used to collect the targets of berberine and SC. Protein-protein interaction (PPI) network, enrichment analyses and molecular docking were performed based on the potential targets of berberine against …
METHODS: Several publicly available databases were used to collect the targets of berberine and SC. Protein-protein int …
A spotlight on underlying the mechanism of AMPK in diabetes complications.
Behl T, Gupta A, Sehgal A, Sharma S, Singh S, Sharma N, Diaconu CC, Rahdar A, Hafeez A, Bhatia S, Al-Harrasi A, Bungau S. Behl T, et al. Inflamm Res. 2021 Sep;70(9):939-957. doi: 10.1007/s00011-021-01488-5. Epub 2021 Jul 28. Inflamm Res. 2021. PMID: 34319417 Review.
Thus, there is a great need for therapies targeting functions that can help in maintaining the homeostasis of glucose levels and improving insulin sensitivity. 5' adenosine monophosphate-activated protein kinase (AMPK) activation, by various direct and indirect fact …
Thus, there is a great need for therapies targeting functions that can help in maintaining the homeostasis of glucose levels and improving i …
249 results