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Discovery of the oncogenic MDM2, a direct binding target of berberine and a potential therapeutic, in multiple myeloma.
Li C, Su R, Wang X, Huang G, Liu Y, Yang J, Yin Z, Gu C, Fei J. Li C, et al. Funct Integr Genomics. 2022 Oct;22(5):1031-1041. doi: 10.1007/s10142-022-00880-6. Epub 2022 Jul 7. Funct Integr Genomics. 2022. PMID: 35794284
Recent studies have suggested the potency of berberine (BBR) for multiple cancer treatments, including multiple myeloma (MM). ...
Recent studies have suggested the potency of berberine (BBR) for multiple cancer treatments, including multiple myel …
Active Components of Traditional Chinese Medicinal Material for Multiple Myeloma: Current Evidence and Future Directions.
Yu CC, Li Y, Cheng ZJ, Wang X, Mao W, Zhang YW. Yu CC, et al. Front Pharmacol. 2022 Jan 27;13:818179. doi: 10.3389/fphar.2022.818179. eCollection 2022. Front Pharmacol. 2022. PMID: 35153791 Free PMC article. Review.
Multiple myeloma (MM) is a hematological malignancy characterized by clonal expansion of plasma cells in bone marrow, leading to the overproduction of monoclonal immunoglobulins. ...Despite improvement in the survival of MM patients with use of myeloma-target …
Multiple myeloma (MM) is a hematological malignancy characterized by clonal expansion of plasma cells in bone marrow, leading …
Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1.
Gu C, Yin Z, Nie H, Liu Y, Yang J, Huang G, Shen J, Chen L, Fei J. Gu C, et al. BMC Biol. 2020 Mar 25;18(1):33. doi: 10.1186/s12915-020-00766-8. BMC Biol. 2020. PMID: 32213189 Free PMC article.
BACKGROUND: Current therapies for multiple myeloma (MM) are associated with toxicity and resistance, highlighting the need for novel effective therapeutics. Berberine (BBR), a botanical alkaloid derived from several Berberis medicinal plants, has exhibited an …
BACKGROUND: Current therapies for multiple myeloma (MM) are associated with toxicity and resistance, highlighting the need for …
Signal pathways, diseases, and functions associated with the miR-19a/92a cluster and the use of berberine to modulate the expression of this cluster in multiple myeloma cells.
Yin Z, Yang J, Ning R, Liu Y, Feng M, Gu C, Fei J, Li Y. Yin Z, et al. J Biochem Mol Toxicol. 2018 Jun;32(6):e22057. doi: 10.1002/jbt.22057. Epub 2018 Apr 24. J Biochem Mol Toxicol. 2018. PMID: 29687521
BACKGROUND: Berberine downregulated miR-19a/92a cluster expression in multiple myeloma (MM) cells. METHODS: The cell viability of MM cells after berberine treatment was measured by CCK8 assay. qRT-PCR assay validated miR-19a/92a expression in multip …
BACKGROUND: Berberine downregulated miR-19a/92a cluster expression in multiple myeloma (MM) cells. METHODS: The cell vi …
Regulatory effects of berberine on microRNome in Cancer and other conditions.
Ayati SH, Fazeli B, Momtazi-Borojeni AA, Cicero AFG, Pirro M, Sahebkar A. Ayati SH, et al. Crit Rev Oncol Hematol. 2017 Aug;116:147-158. doi: 10.1016/j.critrevonc.2017.05.008. Epub 2017 Jun 13. Crit Rev Oncol Hematol. 2017. PMID: 28693796 Review.
Berberine (BBR) is an isoquinoline alkaloid found in different plant families such as Berberidaceae, Ranunculaceae, and Papaveraceae. ...Here, we reviewed the target miRs of BBR and the relevance of their modulation for the potential treatment of serious human diseases lik …
Berberine (BBR) is an isoquinoline alkaloid found in different plant families such as Berberidaceae, Ranunculaceae, and Papaveraceae. …
[Study of the effects in vitro of berberine combined with bortezomib on multiple myeloma cell line U266 cells].
Tian Y, Li LH, Yang GZ, Chen WM. Tian Y, et al. Zhonghua Xue Ye Xue Za Zhi. 2016 Nov 14;37(11):976-981. doi: 10.3760/cma.j.issn.0253-2727.2016.11.010. Zhonghua Xue Ye Xue Za Zhi. 2016. PMID: 27995884 Free PMC article. Chinese.
Objective: To investigate the effects of berberine in combination with bortezomib on proliferation and apoptosis of multiple myeloma (MM) cell line. Methods: MM cell line U266 cells were treated with berberine and/or bortezomib. The effects of berbe …
Objective: To investigate the effects of berberine in combination with bortezomib on proliferation and apoptosis of multiple …
Integrative analysis of signaling pathways and diseases associated with the miR-106b/25 cluster and their function study in berberine-induced multiple myeloma cells.
Gu C, Li T, Yin Z, Chen S, Fei J, Shen J, Zhang Y. Gu C, et al. Funct Integr Genomics. 2017 May;17(2-3):253-262. doi: 10.1007/s10142-016-0519-7. Epub 2016 Sep 19. Funct Integr Genomics. 2017. PMID: 27647143
Berberine (BBR), a traditional Chinese herbal medicine compound, has emerged as a novel class of anti-tumor agent. Our previous microRNA (miRNA) microarray demonstrated that miR-106b/25 was significantly down-regulated in BBR-treated multiple myeloma (MM) cel …
Berberine (BBR), a traditional Chinese herbal medicine compound, has emerged as a novel class of anti-tumor agent. Our previous micro …
Systematic analysis of berberine-induced signaling pathway between miRNA clusters and mRNAs and identification of mir-99a 125b cluster function by seed-targeting inhibitors in multiple myeloma cells.
Feng M, Luo X, Gu C, Li Y, Zhu X, Fei J. Feng M, et al. RNA Biol. 2015;12(1):82-91. doi: 10.1080/15476286.2015.1017219. RNA Biol. 2015. PMID: 25826415 Free PMC article.
BACKGROUND: Berberine (BBR) is a natural alkaloid derived from a traditional Chinese herbal medicine. ...Meanwhile, both BBR and seed-targeting t-anti-mir-99a 125b cluster LNAs significantly induced apoptosis, G2-phase cell cycle arrest and colony inhibition. CONCLUSIONS: …
BACKGROUND: Berberine (BBR) is a natural alkaloid derived from a traditional Chinese herbal medicine. ...Meanwhile, both BBR and seed …
Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberine.
Luo X, Gu J, Zhu R, Feng M, Zhu X, Li Y, Fei J. Luo X, et al. BMC Syst Biol. 2014 Jul 7;8:82. doi: 10.1186/1752-0509-8-82. BMC Syst Biol. 2014. PMID: 25000828 Free PMC article.
Furthermore, both berberine and seed-targeting anti-miR-21 oligonucleotide induced apoptosis, G2-phase cell cycle arrest and colony inhibition in multiple myeloma cell lines. Depletion of PDCD4 by short interfering RNA could rescue berberine-induced cy …
Furthermore, both berberine and seed-targeting anti-miR-21 oligonucleotide induced apoptosis, G2-phase cell cycle arrest and colony i …
Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter.
Qing Y, Hu H, Liu Y, Feng T, Meng W, Jiang L, Sun Y, Yao Y. Qing Y, et al. Cell Biol Int. 2014 May;38(5):563-70. doi: 10.1002/cbin.10206. Cell Biol Int. 2014. PMID: 24843889
Berberine has multiple pharmacological activities, such as anti-oxidative, anti-inflammation and anticancer activity. It reduces the proliferation and induces apoptosis in the multiple myeloma cell line, U266. Here we explored the detailed mechanism by …
Berberine has multiple pharmacological activities, such as anti-oxidative, anti-inflammation and anticancer activity. It reduc …
13 results