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Page 1
Enzymology of vertebrate carotenoid oxygenases.
Harrison EH, Kopec RE. Harrison EH, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov;1865(11):158653. doi: 10.1016/j.bbalip.2020.158653. Epub 2020 Feb 5. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32035229 Free PMC article. Review.
This review focuses on the two that function as carotenoid oxygenases. beta-Carotene 15,15'-dioxygenase (BCO1) catalyzes the oxidative cleavage of the central 15,15' carbon-carbon double of beta-carotene bond by addition of molecular oxygen. The …
This review focuses on the two that function as carotenoid oxygenases. beta-Carotene 15,15'-dioxygenase (BCO1) catalyze …
beta-Carotene Oxygenase 1 Activity Modulates Circulating Cholesterol Concentrations in Mice and Humans.
Amengual J, Coronel J, Marques C, Aradillas-García C, Morales JMV, Andrade FCD, Erdman JW, Teran-Garcia M. Amengual J, et al. J Nutr. 2020 Aug 1;150(8):2023-2030. doi: 10.1093/jn/nxaa143. J Nutr. 2020. PMID: 32433733 Free PMC article.
OBJECTIVE: The objective of this study was to determine the impact of dietary beta-carotene and the activity of beta-carotene oxygenase 1 (BCO1), which is the enzyme responsible for the conversion of beta-carotene to vita …
OBJECTIVE: The objective of this study was to determine the impact of dietary beta-carotene and the activity of beta- …
Molecular and dietary regulation of beta,beta-carotene 15,15'-monooxygenase 1 (BCMO1).
Lietz G, Lange J, Rimbach G. Lietz G, et al. Arch Biochem Biophys. 2010 Oct 1;502(1):8-16. doi: 10.1016/j.abb.2010.06.032. Epub 2010 Jul 1. Arch Biochem Biophys. 2010. PMID: 20599666 Review.
beta,beta-Carotene 15,15'-monooxygenase-1 (BCMO1) is a key enzyme in vitamin A metabolism in mammals. ...Detailed knowledge about BCMO1 regulation as well as genetic variations causing variable cleavage activities may provide a background …
beta,beta-Carotene 15,15'-monooxygenase-1 (BCMO1) is a key enzyme in vitamin A metabolism in mammals. ... …
A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption.
Widjaja-Adhi MA, Lobo GP, Golczak M, Von Lintig J. Widjaja-Adhi MA, et al. Hum Mol Genet. 2015 Jun 1;24(11):3206-19. doi: 10.1093/hmg/ddv072. Epub 2015 Feb 20. Hum Mol Genet. 2015. PMID: 25701869 Free PMC article.
Genome-wide studies have associated common genetic polymorphisms in the BCO1 gene with this variability. The BCO1 gene encodes an enzyme that is expressed in the intestine and converts provitamin A carotenoids to vitamin A-aldehyde. ...In …
Genome-wide studies have associated common genetic polymorphisms in the BCO1 gene with this variability. The BCO1 …
Provitamin A metabolism and functions in mammalian biology.
von Lintig J. von Lintig J. Am J Clin Nutr. 2012 Nov;96(5):1234S-44S. doi: 10.3945/ajcn.112.034629. Epub 2012 Oct 10. Am J Clin Nutr. 2012. PMID: 23053549 Free PMC article. Review.
Provitamin A carotenoids such as beta-carotene are the major source for retinoids (vitamin A and its derivatives) in the human diet. ...Studies in knockout mouse models showed that intestinal beta-carotene absorption and conversion …
Provitamin A carotenoids such as beta-carotene are the major source for retinoids (vitamin A and its derivatives …
Decoding Hypercarotenemia: Integrating Pathophysiology, Clinical Recognition, and Precision Management.
Wang Z, Xu J, Xu G, Sha Y, Wang K, Chen G. Wang Z, et al. Cureus. 2025 Oct 13;17(10):e94519. doi: 10.7759/cureus.94519. eCollection 2025 Oct. Cureus. 2025. PMID: 41246777 Free PMC article. Review.
This comprehensive review synthesizes current understanding of hypercarotenemia pathophysiology through systematic literature analysis encompassing molecular mechanisms, epidemiological trends, clinical phenotypes, and therapeutic interventions, with particular emphasis on gen …
This comprehensive review synthesizes current understanding of hypercarotenemia pathophysiology through systematic literature analysis encom …
Identification of key genes and relevant genetic variants regulating muscle color in chicken using a multi-omics approach.
Men L, Yu Y, Cai R, Liu X, Wang Y, Chen Z, Zhao G, Wen J, Li H, Cui H. Men L, et al. Genomics. 2025 Nov;117(6):111105. doi: 10.1016/j.ygeno.2025.111105. Epub 2025 Sep 22. Genomics. 2025. PMID: 40992513 Free article.
Also, the relevant single-nucleotide polymorphism (SNP) rs315311588 identified among the SNPs present in the 10 introns of BCO1, was found to reduce the expression level of BCO1 and increase the breast muscle meat color b*. Moreover, the multi-omics results r …
Also, the relevant single-nucleotide polymorphism (SNP) rs315311588 identified among the SNPs present in the 10 introns of BCO1 …
SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana.
Graßmann S, Pivovarova-Ramich O, Henze A, Raila J, Ampem Amoako Y, King Nyamekye R, Bedu-Addo G, Mockenhaupt FP, Schulze MB, Danquah I. Graßmann S, et al. Nutrients. 2020 Jun 16;12(6):1786. doi: 10.3390/nu12061786. Nutrients. 2020. PMID: 32560166 Free PMC article.
In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs. ...Previously, adolescents in rural Ghana have shown high total plasma carotenoid concentrations, while 36% had a …
In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food forti …
Two common single nucleotide polymorphisms in the gene encoding beta-carotene 15,15'-monoxygenase alter beta-carotene metabolism in female volunteers.
Leung WC, Hessel S, Méplan C, Flint J, Oberhauser V, Tourniaire F, Hesketh JE, von Lintig J, Lietz G. Leung WC, et al. FASEB J. 2009 Apr;23(4):1041-53. doi: 10.1096/fj.08-121962. Epub 2008 Dec 22. FASEB J. 2009. PMID: 19103647
The key enzyme responsible for beta-carotene conversion into retinal is beta-carotene 15,15'-monoxygenase (BCMO1). Since it has been reported that the conversion of beta-carotene into vitamin A is highly variab …
The key enzyme responsible for beta-carotene conversion into retinal is beta-carotene 15,15'-monoxygenase …