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A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.
Prager N, Bickett K, French N, Marcovici G. Prager N, et al. J Altern Complement Med. 2002 Apr;8(2):143-52. doi: 10.1089/acm.2002.8.143. J Altern Complement Med. 2002. PMID: 12006122 Clinical Trial.
Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic hyperplasia (BPH). ...OBJECTIVES: …
Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the en …
Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats.
Sasidharan S, Kp S, Bhaumik A, Kanti Das S, Nair J H. Sasidharan S, et al. Res Rep Urol. 2022 May 26;14:225-239. doi: 10.2147/RRU.S365598. eCollection 2022. Res Rep Urol. 2022. PMID: 35651598 Free PMC article.
The seed extracts exhibited a potent inhibitory effect on dihydrotestosterone (DHT) in serum and prostate. In addition, the PSA level in the serum showed a noteworthy decrease in comparison with the BPH group. ...Finally, liquid chromatography quadrupole time-of-flight mas …
The seed extracts exhibited a potent inhibitory effect on dihydrotestosterone (DHT) in serum and prostate. In addition, the PSA level …
Pharmacological Effects of the Lipidosterolic Extract from Kigelia africana Fruits in Experimental Benign Prostatic Hyperplasia Induced by Testosterone in Sprague Dawley Rats.
Occhiuto C, Santoro G, Tranchida PQ, Bono G, Occhiuto F. Occhiuto C, et al. J Exp Pharmacol. 2023 Feb 5;15:41-50. doi: 10.2147/JEP.S383699. eCollection 2023. J Exp Pharmacol. 2023. PMID: 36776546 Free PMC article.
METHODS: BPH was induced in experimental groups by daily subcutaneous injections of testosterone propionate (TP) for four weeks. beta-sitosterol (beta-s) was used as positive control. On day 28, the animals were sacrificed by cervical dislocation after anesth …
METHODS: BPH was induced in experimental groups by daily subcutaneous injections of testosterone propionate (TP) for four weeks. beta …