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beta-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition.
Charbonney E, Speight P, Masszi A, Nakano H, Kapus A. Charbonney E, et al. Mol Biol Cell. 2011 Dec;22(23):4472-85. doi: 10.1091/mbc.E11-04-0335. Epub 2011 Sep 30. Mol Biol Cell. 2011. PMID: 21965288 Free PMC article.
Accordingly, beta-catenin down-regulation disrupts the SRF/MRTF complex. Second, beta-catenin maintains the stability of MRTF by suppressing the Smad3-mediated recruitment of glycogen synthase kinase-3beta to MRTF, an event that ot …
Accordingly, beta-catenin down-regulation disrupts the SRF/MRTF complex. Second, beta-catenin maintains t …
Differential topical susceptibility to TGFbeta in intact and injured regions of the epithelium: key role in myofibroblast transition.
Speight P, Nakano H, Kelley TJ, Hinz B, Kapus A. Speight P, et al. Mol Biol Cell. 2013 Nov;24(21):3326-36. doi: 10.1091/mbc.E13-04-0220. Epub 2013 Sep 4. Mol Biol Cell. 2013. PMID: 24006486 Free PMC article.
Induction of epithelial-myofibroblast transition (EMyT), a robust fibrogenic phenotype change hallmarked by alpha-smooth muscle actin (SMA) expression, requires transforming growth factor-beta1 (TGFbeta) and the absence/uncoupling of intracellular cont …
Induction of epithelial-myofibroblast transition (EMyT), a robust fibrogenic phenotype change hallmarked by alpha-smoot …
How do your contacts (or their absence) shape your fate?
Charbonney E, Speight P, Kapus A. Charbonney E, et al. Tissue Barriers. 2013 Jan 1;1(1):e23699. doi: 10.4161/tisb.23699. Tissue Barriers. 2013. PMID: 24665378 Free PMC article.
Searching for molecular mechanisms underlying the synergy between contact injury and TGFbeta, we found that an interplay among three multifunctional transcriptional (co)activators, the junction component beta-catenin, the TGFbeta receptor target Smad3, …
Searching for molecular mechanisms underlying the synergy between contact injury and TGFbeta, we found that an interplay among three multifu …