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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
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1999 7
2000 10
2001 11
2002 25
2003 21
2004 17
2005 25
2006 17
2007 17
2008 17
2009 14
2010 20
2011 20
2012 24
2013 18
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2015 27
2016 15
2017 16
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2019 13
2020 12
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374 results

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Page 1
Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification.
Yang L, Dai R, Wu H, Cai Z, Xie N, Zhang X, Shen Y, Gong Z, Jia Y, Yu F, Zhao Y, Lin P, Ye C, Hu Y, Fu Y, Xu Q, Li Z, Kong W. Yang L, et al. Circ Res. 2022 Jan 21;130(2):213-229. doi: 10.1161/CIRCRESAHA.121.319745. Epub 2021 Dec 6. Circ Res. 2022. PMID: 34870453 Free article.
XBP1u interacted with beta-catenin to promote its ubiquitin-proteasomal degradation and thus inhibited beta-catenin/TCF (T-cell factor)-mediated Runx2 and Msx2 transcription. Knockdown of beta-catenin abolished the effect of XBP1u deficiency on vascular smoot …
XBP1u interacted with beta-catenin to promote its ubiquitin-proteasomal degradation and thus inhibited beta-catenin/TCF …
VE-Cadherin modulates beta-catenin/TCF-4 to enhance Vasculogenic Mimicry.
Delgado-Bellido D, Zamudio-Martínez E, Fernández-Cortés M, Herrera-Campos AB, Olmedo-Pelayo J, Perez CJ, Expósito J, de Álava E, Amaral AT, Valle FO, Diaz AG, Oliver FJ. Delgado-Bellido D, et al. Cell Death Dis. 2023 Feb 17;14(2):135. doi: 10.1038/s41419-023-05666-7. Cell Death Dis. 2023. PMID: 36797281 Free PMC article.
Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive cancer cells in an independent way of endothelial cells, to provide nutrients and oxygen leading to enhanced microenvironment complexity and treatment failure. In a previous study, we …
Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive cancer cells in an independent way of endothelial c …
beta-Catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation.
Danek P, Kardosova M, Janeckova L, Karkoulia E, Vanickova K, Fabisik M, Lozano-Asencio C, Benoukraf T, Tirado-Magallanes R, Zhou Q, Burocziova M, Rahmatova S, Pytlik R, Brdicka T, Tenen DG, Korinek V, Alberich-Jorda M. Danek P, et al. Blood. 2020 Nov 26;136(22):2574-2587. doi: 10.1182/blood.2019004664. Blood. 2020. PMID: 32822472 Free PMC article.
Here, we used a mouse expressing a truncated dominant negative form of the human TCF4 transcription factor (dnTCF4) that specifically abrogates beta-catenin-TCF/LEF interaction. Disruption of the beta-catenin-TCF/LEF interaction resulted …
Here, we used a mouse expressing a truncated dominant negative form of the human TCF4 transcription factor (dnTCF4) that specifically abroga …
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion.
Du L, Lee JH, Jiang H, Wang C, Wang S, Zheng Z, Shao F, Xu D, Xia Y, Li J, Zheng Y, Qian X, Li X, Kim HR, Xing D, Liu P, Lu Z, Lyu J. Du L, et al. J Exp Med. 2020 Nov 2;217(11):e20191115. doi: 10.1084/jem.20191115. J Exp Med. 2020. PMID: 32860047 Free PMC article.
Here, we show that Wnt ligand and activated EGFR induce the binding of the beta-catenin/TCF/LEF complex to the CD274 gene promoter region to induce PD-L1 expression, in which AKT activation plays an important role. beta-Catenin depletion, AKT inhibitio …
Here, we show that Wnt ligand and activated EGFR induce the binding of the beta-catenin/TCF/LEF complex to the C …
Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances.
Xue C, Chu Q, Shi Q, Zeng Y, Lu J, Li L. Xue C, et al. Signal Transduct Target Ther. 2025 Apr 4;10(1):106. doi: 10.1038/s41392-025-02142-w. Signal Transduct Target Ther. 2025. PMID: 40180907 Free PMC article. Review.
This review offers an in-depth analysis of the Wnt pathway, detailing its signal transduction mechanisms and principal components. Furthermore, the complex network of interactions between Wnt cascades and other key signaling pathways, such as Notch, Hedgehog, TGF-beta, FGF …
This review offers an in-depth analysis of the Wnt pathway, detailing its signal transduction mechanisms and principal components. Furthermo …
beta-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma.
Chen L, Huang K, Han L, Shi Z, Zhang K, Pu P, Jiang C, Kang C. Chen L, et al. Int J Oncol. 2011 Oct;39(4):883-90. doi: 10.3892/ijo.2011.1104. Epub 2011 Jun 29. Int J Oncol. 2011. PMID: 21720709
In addition, our analysis of the gene promoter of AKT1 revealed multiple putative Tcf-4 binding sites. In support of the concept that beta-catenin/Tcf-4 is a transcriptional regulator for AKT1, results from our chromatin immunoprecipitation studies and lucife …
In addition, our analysis of the gene promoter of AKT1 revealed multiple putative Tcf-4 binding sites. In support of the concept that bet …
beta-Catenin/TCF4 Complex-Mediated Induction of the NRF3 (NFE2L3) Gene in Cancer Cells.
Aono S, Hatanaka A, Hatanaka A, Gao Y, Hippo Y, Taketo MM, Waku T, Kobayashi A. Aono S, et al. Int J Mol Sci. 2019 Jul 8;20(13):3344. doi: 10.3390/ijms20133344. Int J Mol Sci. 2019. PMID: 31288376 Free PMC article.
We herein describe that NRF3 upregulation is induced by the beta-catenin/TCF4 complex in colon cancer cells. We first confirmed high NRF3 mRNA expression in human colon cancer specimens. The genome database indicated that the human NRF3 gene possesses a species-conserved W …
We herein describe that NRF3 upregulation is induced by the beta-catenin/TCF4 complex in colon cancer cells. We first confirmed high …
Crystal structure of a beta-catenin/Tcf complex.
Graham TA, Weaver C, Mao F, Kimelman D, Xu W. Graham TA, et al. Cell. 2000 Dec 8;103(6):885-96. doi: 10.1016/s0092-8674(00)00192-6. Cell. 2000. PMID: 11136974 Free article.
Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. ...
Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt …
Inhibition of beta-catenin/Tcf signaling by flavonoids.
Park S, Choi J. Park S, et al. J Cell Biochem. 2010 Aug 15;110(6):1376-85. doi: 10.1002/jcb.22654. J Cell Biochem. 2010. PMID: 20564233
We identified the inhibitory effect of various polyphenolic flavonoid compounds against beta-catenin/Tcf signaling in beta-catenin-activated cells. Genistein, kaempferol, isorhamnentin, and baicalein inhibited the transcriptional activity of beta-ca …
We identified the inhibitory effect of various polyphenolic flavonoid compounds against beta-catenin/Tcf signaling in b …
Helicobacter pylori infection promotes the formation of the beta-catenin/HIF-1alpha complex, enabling adaptive responses in gastric cancer cells.
Tapia HA, García-Navarrete C, Silva P, Lizana J, Fonfach C, Pezoa-Soto I, Flores T, Hernández N, Peña-Oyarzún D, Toledo J, Hernández-Gutiérrez S, Herrera D, Varas-Godoy M, Bravo D, Torres VA. Tapia HA, et al. FEBS J. 2025 Nov;292(21):5769-5788. doi: 10.1111/febs.70179. Epub 2025 Jul 7. FEBS J. 2025. PMID: 40622083
We observed that, despite maintaining total and nuclear levels of beta-catenin and TCF-4, bacterial infection disassembled the beta-catenin/TCF-4 complex, as shown by co-localization and co-immunoprecipitation assays. ...Thus, our results demonstrate t …
We observed that, despite maintaining total and nuclear levels of beta-catenin and TCF-4, bacterial infection disassembled the beta- …
374 results