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The use of beta-sitosterol for the treatment of prostate cancer and benign prostatic hyperplasia.
Macoska JA. Macoska JA. Am J Clin Exp Urol. 2023 Dec 15;11(6):467-480. eCollection 2023. Am J Clin Exp Urol. 2023. PMID: 38148931 Free PMC article. Review.
By weight, however, plant sterols make up an abundant ingredient component, with saw palmetto extract or its primary component, beta-sitosterol, often comprising the most abundant sterol. Saw palmetto extract/beta-sitosterol has been shown to promote a …
By weight, however, plant sterols make up an abundant ingredient component, with saw palmetto extract or its primary component, beta- …
Beta-Sitosterol Alters Collagen Distribution in Prostate Fibroblasts.
D'Arcy Q, Sarna-McCarthy M, Bowen D, Soto FO, Zarringhalam K, Macoska JA. D'Arcy Q, et al. J Diet Suppl. 2024;21(3):313-326. doi: 10.1080/19390211.2023.2276943. Epub 2023 Nov 7. J Diet Suppl. 2024. PMID: 37933457 Free article.
In terms of prostate health, previous work almost exclusively focused on the effects of beta-sitosterol on prostatic epithelium, with little attention paid to the effects on prostatic stroma. ...To address whether beta-sitosterol m …
In terms of prostate health, previous work almost exclusively focused on the effects of beta-sitosterol on prostatic …
Benign Prostatic Hyperplasia: Rapid Evidence Review.
Arnold MJ, Gaillardetz A, Ohiokpehai J. Arnold MJ, et al. Am Fam Physician. 2023 Jun;107(6):613-622. Am Fam Physician. 2023. PMID: 37327163 Free article.
Lower urinary tract symptoms from benign prostatic hyperplasia affect 25% of U.S. men, nearly one-half of whom have at least moderate symptoms. ...Although saw palmetto is not effective, the herbal treatments Pygeum africanum and beta-sitosterol may be effect …
Lower urinary tract symptoms from benign prostatic hyperplasia affect 25% of U.S. men, nearly one-half of whom have at least moderate …
Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer.
Cicero AFG, Allkanjari O, Busetto GM, Cai T, Larganà G, Magri V, Perletti G, Robustelli Della Cuna FS, Russo GI, Stamatiou K, Trinchieri A, Vitalone A. Cicero AFG, et al. Arch Ital Urol Androl. 2019 Oct 2;91(3). doi: 10.4081/aiua.2019.3.139. Arch Ital Urol Androl. 2019. PMID: 31577095 Free article. Review.
Medicinal plants, in the form of plant parts or extracts of them, are commonly used for the treatment of prostate diseases such as benign hypertrophy, prostatitis and chronic pelvic pain syndrome. ...Pollen extracts significantly improve symptoms, pain, and quality …
Medicinal plants, in the form of plant parts or extracts of them, are commonly used for the treatment of prostate diseases such as be …
Multifunctional roles and pharmacological potential of beta-sitosterol: Emerging evidence toward clinical applications.
Khan Z, Nath N, Rauf A, Emran TB, Mitra S, Islam F, Chandran D, Barua J, Khandaker MU, Idris AM, Wilairatana P, Thiruvengadam M. Khan Z, et al. Chem Biol Interact. 2022 Sep 25;365:110117. doi: 10.1016/j.cbi.2022.110117. Epub 2022 Aug 19. Chem Biol Interact. 2022. PMID: 35995256 Review.
To offset the low efficacy of beta-sitosterol, designing beta-sitosterol delivery for "cancer cell-specific" therapy holds great potential. Delivery of beta-sitosterol via liposomes is a demonstration that has shown great promise. But fur …
To offset the low efficacy of beta-sitosterol, designing beta-sitosterol delivery for "cancer cell-specific" the …
Pine-Extracted Phytosterol beta-Sitosterol (APOPROSTAT( ) Forte) Inhibits Both Human Prostate Smooth Muscle Contraction and Prostate Stromal Cell Growth, Without Cytotoxic Effects: A Mechanistic Link to Clinical Efficacy in LUTS/BPH.
Tamalunas A, Schierholz F, Poth H, Vigodski V, Brandstetter M, Ciotkowska A, Rutz B, Hu S, Stadelmeier LF, Schulz H, Ledderose S, Rogenhofer N, Kolben T, Stief CG, Hennenberg M. Tamalunas A, et al. Pharmaceuticals (Basel). 2025 Dec 6;18(12):1864. doi: 10.3390/ph18121864. Pharmaceuticals (Basel). 2025. PMID: 41471353 Free PMC article.
Introduction: Medical treatment of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) targets prostate smooth muscle tone for rapid relieve of symptoms and prostate size to prevent disease progression. ...Thus, we investigate …
Introduction: Medical treatment of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) targets pr …
Molecular Mechanism of beta-Sitosterol and its Derivatives in Tumor Progression.
Bao X, Zhang Y, Zhang H, Xia L. Bao X, et al. Front Oncol. 2022 Jun 8;12:926975. doi: 10.3389/fonc.2022.926975. eCollection 2022. Front Oncol. 2022. PMID: 35756648 Free PMC article. Review.
beta-Sitosterol (SIT), a white powdery organic substance with a molecular formula of C(29)H(50)O, is one of the most abundant naturally occurring phytosterols in plants. ...In addition, SIT exerts an anti-tumor effect on multiple malignant tumors such as breast, gas …
beta-Sitosterol (SIT), a white powdery organic substance with a molecular formula of C(29)H(50)O, is one of the most abundant …
beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review.
Wilt TJ, MacDonald R, Ishani A. Wilt TJ, et al. BJU Int. 1999 Jun;83(9):976-83. doi: 10.1046/j.1464-410x.1999.00026.x. BJU Int. 1999. PMID: 10368239
Three studies used nonglucosidic beta-sitosterols and one used a preparation that contained only beta-sitosterol-beta-d-glucoside. Compared with placebo, beta-sitosterol improved urinary symptom scores and flow measures. ...The WMD for peak urin …
Three studies used nonglucosidic beta-sitosterols and one used a preparation that contained only beta-sitosterol-beta-d …
Network pharmacology and experimental validation to explore the role and potential mechanism of Liuwei Dihuang Decoction in prostate cancer.
Zhan X, Li H, Jin J, Ju X, Gao J, Chen X, Yuan F, Gu J, Xu D, Ju G. Zhan X, et al. BMC Complement Med Ther. 2024 Jul 26;24(1):284. doi: 10.1186/s12906-024-04572-5. BMC Complement Med Ther. 2024. PMID: 39061044 Free PMC article.
Molecular docking results showed that quercetin, kaempferol, beta-sitosterol and other main active ingredients of LWDHD treatment for PCa were combined with core proteins MAPK1 and AKT1 well. ...The PI3K/AKT signaling pathway may be a central pathway of LWDHD to inh …
Molecular docking results showed that quercetin, kaempferol, beta-sitosterol and other main active ingredients of LWDHD treatm …
Aspects of beta-sitosterol's Pharmacology, Nutrition and Analysis.
Dwivedi J, Wal P, Sachan P, Dwivedi M, Gunjal SD, Wasnik U, Singhai A. Dwivedi J, et al. Curr Pharm Biotechnol. 2025;26(14):2234-2256. doi: 10.2174/0113892010313844240905055119. Curr Pharm Biotechnol. 2025. PMID: 39318007 Review.
Experimental research on beta-sitosterol provides unequivocal evidence that phytosterol can be supplemented with other methods to combat serious illnesses. Such a high potential identifies this substance as a noteworthy medication for the future based on its composi …
Experimental research on beta-sitosterol provides unequivocal evidence that phytosterol can be supplemented with other methods …
150 results