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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1975 2
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1981 2
1982 1
1983 2
1984 4
1985 3
1986 4
1987 4
1988 6
1989 3
1990 2
1991 1
1992 4
1993 5
1994 4
1995 4
1996 8
1997 8
1998 11
1999 13
2000 6
2001 14
2002 19
2003 19
2004 15
2005 21
2006 20
2007 19
2008 26
2009 29
2010 34
2011 44
2012 32
2013 50
2014 55
2015 59
2016 81
2017 93
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2019 149
2020 179
2021 198
2022 182
2023 221
2024 299
2025 319
2026 170

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2,255 results

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Page 1
Parabacteroides distasonis promotes liver regeneration by increasing beta-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals.
Guo M, Jiang X, Ouyang H, Zhang X, Zhang S, Wang P, Bi G, Wu T, Zhou W, Liang F, Yang X, Fan S, Fang JH, Chen P, Bi H. Guo M, et al. Acta Pharm Sin B. 2025 Mar;15(3):1430-1446. doi: 10.1016/j.apsb.2025.01.024. Epub 2025 Feb 10. Acta Pharm Sin B. 2025. PMID: 40370533 Free PMC article.
Moreover, STAT3 inhibitor Stattic attenuated the promotive effects of BHB on cell proliferation and liver regeneration both in vitro and in vivo. Mechanistically, P. distasonis upregulated the expression of fatty acid oxidation-related proteins, and increased BHB le …
Moreover, STAT3 inhibitor Stattic attenuated the promotive effects of BHB on cell proliferation and liver regeneration both in vitro …
A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites.
Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, Raun SH, Zhao M, Coassolo L, Islam H, Oliveira B, Dai Y, Spaas J, Delgado-Gonzalez A, Donoso K, Alvarez-Buylla A, Franco-Montalban F, Letian A, Ward CP, Liu L, Svensson KJ, Goldberg EL, Gardner CD, Little JP, Banik SM, Xu Y, Long JZ. Moya-Garzon MD, et al. Cell. 2025 Jan 9;188(1):175-186.e20. doi: 10.1016/j.cell.2024.10.032. Epub 2024 Nov 12. Cell. 2025. PMID: 39536746 Free PMC article.
beta-Hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve the interconversion of BHB and primary energy intermediates. ...This BHB shunt pathway generates a family of anti-obesity ketone metabolites, t …
beta-Hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve the interconversi …
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. Youm YH, et al. Nat Med. 2015 Mar;21(3):263-9. doi: 10.1038/nm.3804. Epub 2015 Feb 16. Nat Med. 2015. PMID: 25686106 Free PMC article.
BHB levels are elevated by starvation, caloric restriction, high-intensity exercise, or the low-carbohydrate ketogenic diet. ...BHB reduces NLRP3 inflammasome-mediated interleukin (IL)-1beta and IL-18 production in human monocytes. ...
BHB levels are elevated by starvation, caloric restriction, high-intensity exercise, or the low-carbohydrate ketogenic diet. ...BH …
Ketone body beta-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics.
Llorente-Folch I, Düssmann H, Watters O, Connolly NMC, Prehn JHM. Llorente-Folch I, et al. Sci Rep. 2023 Nov 11;13(1):19664. doi: 10.1038/s41598-023-46776-8. Sci Rep. 2023. PMID: 37952048 Free PMC article.
Here, we studied the effects of BHB on mitochondrial energetics, both in non-stimulated conditions and during glutamate-mediated hyperexcitation. We found that glutamate-induced hyperexcitation stimulated mitochondrial respiration in cultured cortical neurons, and that thi …
Here, we studied the effects of BHB on mitochondrial energetics, both in non-stimulated conditions and during glutamate-mediated hype …
Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway.
Huang C, Wang J, Liu H, Huang R, Yan X, Song M, Tan G, Zhi F. Huang C, et al. BMC Med. 2022 Apr 15;20(1):148. doi: 10.1186/s12916-022-02352-x. BMC Med. 2022. PMID: 35422042 Free PMC article.
However, the role of BHB in intestinal inflammation has not yet been investigated. METHODS: Colonic mucosa of inflammatory bowel disease (IBD) patients and healthy controls were collected for evaluation of BHB level. ...The regulatory effectors of BHB were an …
However, the role of BHB in intestinal inflammation has not yet been investigated. METHODS: Colonic mucosa of inflammatory bowel dise …
By inhibiting pyroptosis to reduce neuroinflammation, PEG-bHb may prevent the development of secondary injury after traumatic brain injury.
Zeng Q, You G, Li W, An J, Huang Z, Zhang X, Zhou H, Xiao Y, Wang Y, Zhao L. Zeng Q, et al. Exp Neurol. 2025 Dec;394:115447. doi: 10.1016/j.expneurol.2025.115447. Epub 2025 Aug 27. Exp Neurol. 2025. PMID: 40882799 Review.
PEG-bHb exhibits the capacity to bind and release oxygen, promoting oxygen supply in hypoxic tissues. ...PEG-bHb has been shown to enhance motor, learning, and memory abilities following TBI. Thus, PEG-bHb can act as a promising candidate for TBI treatment... …
PEG-bHb exhibits the capacity to bind and release oxygen, promoting oxygen supply in hypoxic tissues. ...PEG-bHb has been show …
D-BHB supplementation before moderate-intensity exercise suppresses lipolysis and selectively blunts exercise-induced long-chain acylcarnitine increase in pilot study of patients with long-chain fatty acid oxidation disorders.
Gregor AN, Delerive P, Cuenoud B, Monnard I, Redeuil K, Harding CO, Gillingham MB. Gregor AN, et al. Mol Genet Metab. 2025 Apr;144(4):109070. doi: 10.1016/j.ymgme.2025.109070. Epub 2025 Feb 25. Mol Genet Metab. 2025. PMID: 40048912 Clinical Trial.

Mild to moderate GI symptoms were related to ingestion of D-BHB. Plasma D-BHB was increased after oral D-BHB compared to maltodextrin (p < .001) with an average concentration of 0.43 mM in the post-exercise period. During exercise, free fatty acids (p = .0

…
Mild to moderate GI symptoms were related to ingestion of D-BHB. Plasma D-BHB was increased after oral D-BHB compared t …
β-hydroxybutyrate restrains colitis-associated tumorigenesis by inhibiting HIF-1α-mediated angiogenesis.
Huang C, Tan H, Wang J, Huang L, Liu H, Shi Y, Zhong C, Weng S, Chen C, Zhao W, Lin Z, Li J, Zhi F, Zhang B. Huang C, et al. Cancer Lett. 2024 Jul 1;593:216940. doi: 10.1016/j.canlet.2024.216940. Epub 2024 May 8. Cancer Lett. 2024. PMID: 38729554
In vitro, BHB directly reduced VEGFA expression in hypoxic-treated CT26 cells by targeting transcriptional factor HIF-1alpha. ...In summary, BHB carries out anti-angiogenic activity in CAC by regulating HIF-1alpha/VEGFA signaling. ...
In vitro, BHB directly reduced VEGFA expression in hypoxic-treated CT26 cells by targeting transcriptional factor HIF-1alpha. ...In s …
β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications.
He Y, Cheng X, Zhou T, Li D, Peng J, Xu Y, Huang W. He Y, et al. Heliyon. 2023 Oct 17;9(11):e21098. doi: 10.1016/j.heliyon.2023.e21098. eCollection 2023 Nov. Heliyon. 2023. PMID: 37928021 Free PMC article. Review.
Previous studies have found that beta-Hydroxybutyrate (BHB), the main component of ketone bodies, is of physiological importance as a backup energy source during starvation or induces diabetic ketoacidosis when insulin deficiency occurs. ...This review focuses on the metab …
Previous studies have found that beta-Hydroxybutyrate (BHB), the main component of ketone bodies, is of physiological importance as a …
The Importance of BHB Testing on the Post-Mortem Diagnosis of Ketoacidosis.
Ahlström S, Ahlner J, Jönsson AK, Green H. Ahlström S, et al. Biomolecules. 2021 Dec 21;12(1):9. doi: 10.3390/biom12010009. Biomolecules. 2021. PMID: 35053157 Free PMC article.
All 2900 deaths from 2013 through 2019 in which BHB was analysed at the National Board of Forensic Medicine, and 1069 DKA, AKA, HHS, hypothermia, diabetes, alcoholism, and acidosis cases without BHB analysis were included. The prevalence of BHB-positive cases …
All 2900 deaths from 2013 through 2019 in which BHB was analysed at the National Board of Forensic Medicine, and 1069 DKA, AKA, HHS, …
2,255 results