Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1964 1
1970 2
1971 1
1972 1
1973 2
1974 3
1975 1
1976 3
1979 2
1980 1
1981 1
1983 2
1984 1
1985 1
1986 1
1987 2
1988 1
1989 1
1990 2
1992 1
1993 3
1995 2
1996 1
1997 2
1998 1
1999 1
2004 1
2005 1
2006 2
2010 1
2011 2
2012 1
2013 1
2014 4
2015 5
2016 2
2017 5
2018 4
2019 7
2020 9
2021 5
2022 4
2023 8
2024 7
2025 6
2026 5

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

110 results

Results by year

Filters applied: . Clear all
Page 1
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer.
Cappellesso F, Orban MP, Shirgaonkar N, Berardi E, Serneels J, Neveu MA, Di Molfetta D, Piccapane F, Caroppo R, Debellis L, Ostyn T, Joudiou N, Mignion L, Richiardone E, Jordan BF, Gallez B, Corbet C, Roskams T, DasGupta R, Tejpar S, Di Matteo M, Taverna D, Reshkin SJ, Topal B, Virga F, Mazzone M. Cappellesso F, et al. Nat Cancer. 2022 Dec;3(12):1464-1483. doi: 10.1038/s43018-022-00470-2. Epub 2022 Dec 15. Nat Cancer. 2022. PMID: 36522548 Free PMC article.
By single-cell RNA-sequencing analysis in individuals with pancreatic ductal adenocarcinoma (PDAC), we reveal solute carrier family 4 member 4 (SLC4A4) as the most abundant bicarbonate transporter, predominantly expressed by epithelial ductal cells. Functionally, SLC4A4 in …
By single-cell RNA-sequencing analysis in individuals with pancreatic ductal adenocarcinoma (PDAC), we reveal solute carrier family 4 member …
Primary biliary cholangitis: pathogenesis and therapeutic opportunities.
Gulamhusein AF, Hirschfield GM. Gulamhusein AF, et al. Nat Rev Gastroenterol Hepatol. 2020 Feb;17(2):93-110. doi: 10.1038/s41575-019-0226-7. Epub 2019 Dec 9. Nat Rev Gastroenterol Hepatol. 2020. PMID: 31819247 Review.
Patients are benefiting from pharmacological agonists of farnesoid X receptor and peroxisome proliferator-activated receptors. Immunotherapy remains a challenge, with a lack of target definition, pleiotropic immune pathways and an interplay between hepatic immune responses …
Patients are benefiting from pharmacological agonists of farnesoid X receptor and peroxisome proliferator-activated receptors. Immunother …
Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism.
Ding B, Zheng P, Tan J, Chen H, Meng Q, Li J, Li X, Han D, Li Z, Ma X, Ma P, Lin J. Ding B, et al. Angew Chem Int Ed Engl. 2023 Oct 2;62(40):e202307706. doi: 10.1002/anie.202307706. Epub 2023 Aug 29. Angew Chem Int Ed Engl. 2023. PMID: 37587061
Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, a simple and drug-free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO(3) …
Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive …
Acid affairs in anti-tumour immunity.
Cappellesso F, Mazzone M, Virga F. Cappellesso F, et al. Cancer Cell Int. 2024 Oct 27;24(1):354. doi: 10.1186/s12935-024-03520-0. Cancer Cell Int. 2024. PMID: 39465367 Free PMC article. Review.
Generally, acidity and lactate dampen the anti-tumour response of both innate and adaptive immune cells favouring tumour progression and reducing the response to immunotherapy. In this review, we summarize the current knowledge on the functional, metabolic and epigenetic e …
Generally, acidity and lactate dampen the anti-tumour response of both innate and adaptive immune cells favouring tumour progression and red …
Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors.
Knopf P, Stowbur D, Hoffmann SHL, Hermann N, Maurer A, Bucher V, Poxleitner M, Tako B, Sonanini D, Krishnamachary B, Sinharay S, Fehrenbacher B, Gonzalez-Menendez I, Reckmann F, Bomze D, Flatz L, Kramer D, Schaller M, Forchhammer S, Bhujwalla ZM, Quintanilla-Martinez L, Schulze-Osthoff K, Pagel MD, Fransen MF, Röcken M, Martins AF, Pichler BJ, Ghoreschi K, Kneilling M. Knopf P, et al. Mol Cancer. 2023 Dec 15;22(1):207. doi: 10.1186/s12943-023-01900-0. Mol Cancer. 2023. PMID: 38102680 Free PMC article.
In vivo studies fully validated our in vitro findings and revealed that neutralizing the acidic extracellular tumor pH by sodium bicarbonate treatment suppresses IFN-gamma-induced PD-L1 expression and promotes immune cell infiltration in responsive tumors and thus reduces …
In vivo studies fully validated our in vitro findings and revealed that neutralizing the acidic extracellular tumor pH by sodium bicarbon …
Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity.
Zhao J, Hu S, Qi Z, Xu X, Long X, Huang A, Liu J, Cheng P. Zhao J, et al. J Immunother Cancer. 2024 Dec 4;12(12):e009768. doi: 10.1136/jitc-2024-009768. J Immunother Cancer. 2024. PMID: 39631851 Free PMC article.
BACKGROUND: Although immunotherapy can reinvigorate immune cells to clear tumors, the response rates are poor in some patients. ...Moreover, changes in the calmodulin-dependent protein kinase II (CaMKII)/cyclic AMP activates-responsive element-binding proteins (CREB) and p …
BACKGROUND: Although immunotherapy can reinvigorate immune cells to clear tumors, the response rates are poor in some patients. ...Mo …
Microenvironmental alkalization promotes the therapeutic effects of MSLN-CAR-T cells.
Wu M, Mao L, Zhai X, Liu J, Wang J, Li L, Duan J, Wang J, Lin S, Li J, Yu S. Wu M, et al. J Immunother Cancer. 2024 Oct 21;12(10):e009510. doi: 10.1136/jitc-2024-009510. J Immunother Cancer. 2024. PMID: 39433427 Free PMC article.
Unfortunately, the curative effects of current clinical therapies, including surgery, radiotherapy, chemotherapy and immunotherapy, are still limited in patients with TNBC. In this study, we showed that the heterogeneous expression at the protein level and subcellular loca …
Unfortunately, the curative effects of current clinical therapies, including surgery, radiotherapy, chemotherapy and immunotherapy, a …
Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer.
Kay EJ, Zanivan S. Kay EJ, et al. Mol Oncol. 2023 Apr;17(4):541-544. doi: 10.1002/1878-0261.13400. Epub 2023 Mar 4. Mol Oncol. 2023. PMID: 36807529 Free PMC article.
Bicarbonate transport is a pre-existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import i …
Bicarbonate transport is a pre-existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. …
Can we cure primary biliary cholangitis?
Trivedi PJ, Hirschfield GM, Eric Gershwin M. Trivedi PJ, et al. Curr Opin Immunol. 2026 Jun;100:102786. doi: 10.1016/j.coi.2026.102786. Epub 2026 May 14. Curr Opin Immunol. 2026. PMID: 42134016 Free article. Review.
In so doing, we highlight the potential role of regulatory T-cell modulation, nanoparticle-based antigen-specific tolerance, and epigenetic factors such as miRNA dysregulation, silencing bicarbonate transporters. We go on to discuss relevant concepts from autoimmune diseas …
In so doing, we highlight the potential role of regulatory T-cell modulation, nanoparticle-based antigen-specific tolerance, and epigenetic …
Durvalumab-induced diabetic ketoacidosis followed by hypothyroidism.
Patel S, Chin V, Greenfield JR. Patel S, et al. Endocrinol Diabetes Metab Case Rep. 2019 Jan 1;2019:19-0098. doi: 10.1530/EDM-19-0098. Epub 2019 Dec 12. Endocrinol Diabetes Metab Case Rep. 2019. PMID: 31829972 Free PMC article.
On admission, she was in severe diabetic ketoacidosis with venous glucose: 20.1 mmol/L, pH: 7.14, bicarbonate 11.2 mmol/L and serum beta hydroxybutyrate: >8.0 mmol/L. She had no personal or family history of diabetes or autoimmune disease. ...Regular blood glucose level …
On admission, she was in severe diabetic ketoacidosis with venous glucose: 20.1 mmol/L, pH: 7.14, bicarbonate 11.2 mmol/L and serum b …
110 results