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122 results

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Page 1
Bifemelane enhances high K(+)-evoked release of glutamate from mossy fiber synaptosomes of guinea-pig hippocampus.
Ueda M, Fujii T, Kuraishi Y, Satoh M. Ueda M, et al. Eur J Pharmacol. 1992 Aug 25;219(2):271-7. doi: 10.1016/0014-2999(92)90305-n. Eur J Pharmacol. 1992. PMID: 1358642
We have shown that bifemelane augments long-term potentiation in the mossy fiber-CA3 system, but not in the Schaffer collateral-CA1 system. To elucidate the mechanism of action of bifemelane in relation to pathway-specific augmentation of long-term potentiation, we …
We have shown that bifemelane augments long-term potentiation in the mossy fiber-CA3 system, but not in the Schaffer collateral-CA1 s …
Bifemelane protects cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.
Akaike A, Maeda T, Kume T, Kaneko S. Akaike A, et al. Jpn J Pharmacol. 1998 Mar;76(3):313-6. doi: 10.1254/jjp.76.313. Jpn J Pharmacol. 1998. PMID: 9593226 Free article.
Glutamate cytotoxicity was reduced by exposing cultures to bifemelane at concentrations of 1-10 microM for 24 hr prior to glutamate exposure. In contrast, glutamate cytotoxicity was not affected by adding bifemelane to the glutamate-containing-medium without pretrea …
Glutamate cytotoxicity was reduced by exposing cultures to bifemelane at concentrations of 1-10 microM for 24 hr prior to glutamate e …
Treatment with bifemelane for optic nerve damage following high intraocular pressure in rat eyes.
Adachi M, Takahashi K, Yuge K, Nishikawa M, Miki H, Uyama M. Adachi M, et al. Eur J Ophthalmol. 1996 Oct-Dec;6(4):415-20. doi: 10.1177/112067219600600413. Eur J Ophthalmol. 1996. PMID: 8997585
The axon count was 93.4 +/- 7.9 for the bifemelane treated group, and 79.2 +/- 6.4 for the controls. The axon count in the treated group was significantly higher. These results suggest that bifemelane, which prevents cerebral nerve cell damage from ischemia, can red …
The axon count was 93.4 +/- 7.9 for the bifemelane treated group, and 79.2 +/- 6.4 for the controls. The axon count in the treated gr …
Bifemelane hydrochloride protects against cytotoxicity of hydrogen peroxide on cultured rat neuroblastoma cell line.
Miyazaki I, Iwata-Ichikawa E, Asanuma M, Iida M, Ogawa N. Miyazaki I, et al. Neurochem Res. 1999 Jul;24(7):857-60. doi: 10.1023/a:1020953913490. Neurochem Res. 1999. PMID: 10403625
B50 cells were treated with 5 or 10 microM bifemelane for 2 days followed by treatment with 75 microM or 100 microM H2O2. H2O2 cytotoxicity was reduced by pretreatment with bifemelane. We also examined the effect of bifemelane on lipid peroxide formation in B …
B50 cells were treated with 5 or 10 microM bifemelane for 2 days followed by treatment with 75 microM or 100 microM H2O2. H2O2 cytoto …
Bifemelane induces translocation of protein kinase C in the CA3, but not the CA1, region of guinea-pig hippocampus.
Fujii T, Kuraishi Y, Okada T, Satoh M. Fujii T, et al. Can J Physiol Pharmacol. 1990 Mar;68(3):413-8. doi: 10.1139/y90-058. Can J Physiol Pharmacol. 1990. PMID: 2322898
These observations suggest that bifemelane acts directly on the hippocampus to induce translocation of protein kinase C in the CA3 region. Such an effect may be associated with the bifemelane-induced augmentation of the long-term potentiation in this region of the b …
These observations suggest that bifemelane acts directly on the hippocampus to induce translocation of protein kinase C in the CA3 re …
Bifemelane hydrochloride reduces plasma beta-endorphin-like immunoreactivity levels in rats.
Mitsuma T, Hirooka Y, Yuasa K, Nogimori T. Mitsuma T, et al. Exp Clin Endocrinol. 1990 Aug;95(3):301-5. doi: 10.1055/s-0029-1210969. Exp Clin Endocrinol. 1990. PMID: 2245819
The effect of bifemelane hydrochloride on plasma beta-endorphin-like immunoreactivity (beta-En-LI) levels in rats was studied. ...The beta-En-LI release in vitro from the anterior pituitary was inhibited with the addition of bifemelane hydrochloride. The findings su …
The effect of bifemelane hydrochloride on plasma beta-endorphin-like immunoreactivity (beta-En-LI) levels in rats was studied. ...The …
A novel effect of bifemelane, a nootropic drug, on intracellular Ca2+ levels in rat cerebral astrocytes.
Yoshida Y, Nakane A, Morita M, Kudo Y. Yoshida Y, et al. J Pharmacol Sci. 2006 Feb;100(2):126-32. doi: 10.1254/jphs.fp0050926. Epub 2006 Feb 11. J Pharmacol Sci. 2006. PMID: 16474207 Free article.
We investigated the effects of bifemelane, a nootropic drug, on the intracellular calcium concentration ([Ca2+]i) in rat cerebral astrocytes using a Ca2+ imaging device. ...Although the detail mechanisms of action of the drug are still unknown, bifemelane will be pr …
We investigated the effects of bifemelane, a nootropic drug, on the intracellular calcium concentration ([Ca2+]i) in rat cerebral ast …
Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced changes in brain monoamines and their metabolites in gerbils.
Haba K, Ogawa N, Asanuma M, Hirata H, Mori A. Haba K, et al. J Neural Transm Gen Sect. 1992;88(3):187-98. doi: 10.1007/BF01244732. J Neural Transm Gen Sect. 1992. PMID: 1384558
Bifemelane hydrochloride (bifemelane), idebenone and indeloxazine hydrochloride (indeloxazine) are used clinically to reduce apathy and other emotional disturbances in patients with cerebrovascular disease. ...In the present study, the effects of treatment with b …
Bifemelane hydrochloride (bifemelane), idebenone and indeloxazine hydrochloride (indeloxazine) are used clinically to reduce a …
Potential antidepressive properties of amantadine, memantine and bifemelane.
Moryl E, Danysz W, Quack G. Moryl E, et al. Pharmacol Toxicol. 1993 Jun;72(6):394-7. doi: 10.1111/j.1600-0773.1993.tb01351.x. Pharmacol Toxicol. 1993. PMID: 8361950
In the former test amantadine and bifemelane but not memantine were effective. In the forced swim test all three agents produced antidepressive-like activity (decreased immobility time), but in case of bifemelane it was less pronounced. ...We suggested that amantadi …
In the former test amantadine and bifemelane but not memantine were effective. In the forced swim test all three agents produced anti …
Bifemelane in the treatment of central retinal artery or vein obstruction.
Hirayama Y, Matsunaga N, Tashiro J, Amemiya T, Iwasaki M. Hirayama Y, et al. Clin Ther. 1990 May-Jun;12(3):230-5. Clin Ther. 1990. PMID: 2379227
Patients with retinal artery or vein obstruction received 150 mg of bifemelane hydrochloride daily for 1 to 11 months and other treatment (urokinase, steroid hormone, hyperbaric oxygen, or laser photocoagulation) or the latter without bifemelane. ...It is concluded …
Patients with retinal artery or vein obstruction received 150 mg of bifemelane hydrochloride daily for 1 to 11 months and other treat …
122 results