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Dual-Targeted Theranostic Delivery of miRs Arrests Abdominal Aortic Aneurysm Development.
Wang X, Searle AK, Hohmann JD, Liu AL, Abraham MK, Palasubramaniam J, Lim B, Yao Y, Wallert M, Yu E, Chen YC, Peter K. Wang X, et al. Mol Ther. 2018 Apr 4;26(4):1056-1065. doi: 10.1016/j.ymthe.2018.02.010. Epub 2018 Feb 16. Mol Ther. 2018. PMID: 29525742 Free PMC article.
MicroRNA-126 was used as a therapeutic agent, based on its capability to downregulate VCAM-1 expression in endothelial cells and thereby reduces leukocyte adhesion and exerts anti-inflammatory effects. Ultrasound microbubbles were chosen as carriers, allowing both
MicroRNA-126 was used as a therapeutic agent, based on its capability to downregulate VCAM-1 expression in endothelial cells a
The potential theragnostic (diagnostic+therapeutic) application of exosomes in diverse biomedical fields.
Kim YS, Ahn JS, Kim S, Kim HJ, Kim SH, Kang JS. Kim YS, et al. Korean J Physiol Pharmacol. 2018 Mar;22(2):113-125. doi: 10.4196/kjpp.2018.22.2.113. Epub 2018 Feb 23. Korean J Physiol Pharmacol. 2018. PMID: 29520164 Free PMC article. Review.
Molecular components in exosomes have been found to be related to certain diseases and treatment responses, indicating that they may have applications in diagnosis via molecular imaging and biomarker detection. ...We also discuss their roles in
Molecular components in exosomes have been found to be related to certain diseases and treatment responses, indicating that th
Micro-RNAs in abdominal aortic aneurysms: insights from animal models and relevance to human disease.
Raffort J, Lareyre F, Clement M, Mallat Z. Raffort J, et al. Cardiovasc Res. 2016 May 15;110(2):165-77. doi: 10.1093/cvr/cvw046. Epub 2016 Mar 10. Cardiovasc Res. 2016. PMID: 26965051 Review.
Diagnosis and treatment are, respectively, based on imaging and surgical techniques. Drug-based therapies are still mostly ineffective, which highlight a real unmet need. ...However, the precise cellular and molecular pathways are still poorly understood. Recently, …
Diagnosis and treatment are, respectively, based on imaging and surgical techniques. Drug-based therapies are still mostly ineffectiv …
Long noncoding RNAs in key cellular processes involved in aortic aneurysms.
Wu ZY, Trenner M, Boon RA, Spin JM, Maegdefessel L. Wu ZY, et al. Atherosclerosis. 2020 Jan;292:112-118. doi: 10.1016/j.atherosclerosis.2019.11.013. Epub 2019 Nov 21. Atherosclerosis. 2020. PMID: 31785492 Free PMC article. Review.
Aortic aneurysm (AA) is a complex and dangerous vascular disease, featuring progressive and irreversible vessel dilatation. AA is typically detected either by screening, or identified incidentally through imaging studies. ...Some microRNAs (miRNA - a non-codi …
Aortic aneurysm (AA) is a complex and dangerous vascular disease, featuring progressive and irreversible vessel dilatation. AA is typ …
Nanotheranostics of circulating tumor cells, infections and other pathological features in vivo.
Kim JW, Galanzha EI, Zaharoff DA, Griffin RJ, Zharov VP. Kim JW, et al. Mol Pharm. 2013 Mar 4;10(3):813-30. doi: 10.1021/mp300577s. Epub 2013 Feb 25. Mol Pharm. 2013. PMID: 23379366 Free PMC article. Review.
Therefore, technologies capable of detecting circulating tumor cells (CTCs), circulating bacterial cells (CBCs), circulating endothelial cells (CECs), circulating blood clots, cancer biomarkers such as microparticles and exosomes, which contain important microRNA si …
Therefore, technologies capable of detecting circulating tumor cells (CTCs), circulating bacterial cells (CBCs), circulating endothelial cel …
Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension.
Kontaraki JE, Marketou ME, Parthenakis FI, Maragkoudakis S, Zacharis EA, Petousis S, Kochiadakis GE, Vardas PE. Kontaraki JE, et al. J Am Soc Hypertens. 2015 Oct;9(10):802-810. doi: 10.1016/j.jash.2015.07.013. Epub 2015 Aug 1. J Am Soc Hypertens. 2015. PMID: 26358152
MicroRNAs regulate several aspects of physiological and pathologic cardiac hypertrophy, and they represent promising therapeutic targets in cardiovascular disease. ...Thus, they may be related to heart hypertrophy in hypertensive patients and ar
MicroRNAs regulate several aspects of physiological and pathologic cardiac hypertrophy, and they represent promising therapeutic
Tumor Cell-Derived Microvesicles Induced Not Epithelial-Mesenchymal Transition but Apoptosis in Human Proximal Tubular (HK-2) Cells: Implications for Renal Impairment in Multiple Myeloma.
Zhao A, Kong F, Liu CJ, Yan G, Gao F, Guo H, Guo AY, Chen Z, Li Q. Zhao A, et al. Int J Mol Sci. 2017 Feb 27;18(3):513. doi: 10.3390/ijms18030513. Int J Mol Sci. 2017. PMID: 28264449 Free PMC article.
Microvesicles (MVs) are membrane vesicles and play an important role in disease progression. Here, we investigated the role of MVs derived from MM cells (MM-MVs) in RI of MM. ...Our study supports MM-MVs representing a previously undescribed factor and playing a potential …
Microvesicles (MVs) are membrane vesicles and play an important role in disease progression. Here, we investigated the role of MVs de …
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