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2019 11
2020 6
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Integrated Transcriptomics, Metabolomics, and Lipidomics Profiling in Rat Lung, Blood, and Serum for Assessment of Laser Printer-Emitted Nanoparticle Inhalation Exposure-Induced Disease Risks.
Guo NL, Poh TY, Pirela S, Farcas MT, Chotirmall SH, Tham WK, Adav SS, Ye Q, Wei Y, Shen S, Christiani DC, Ng KW, Thomas T, Qian Y, Demokritou P. Guo NL, et al. Int J Mol Sci. 2019 Dec 16;20(24):6348. doi: 10.3390/ijms20246348. Int J Mol Sci. 2019. PMID: 31888290 Free PMC article.
This study employed genome-wide mRNA and miRNA profiling in rat lung and blood integrated with metabolomics and lipidomics profiling in rat serum to identify biomarkers for assessing PEPs-induced disease risks. ...To the best of our knowledge, this is the fir …
This study employed genome-wide mRNA and miRNA profiling in rat lung and blood integrated with metabolomics and lipidomics pro …
LC-MS-Based Metabolomics and Lipidomics Study of High-Density-Lipoprotein-Modulated Glucose Metabolism with an apoA-I Knockout Mouse Model.
Liu J, Zhao M, Zhu Y, Wang X, Zheng L, Yin Y. Liu J, et al. J Proteome Res. 2019 Jan 4;18(1):48-56. doi: 10.1021/acs.jproteome.8b00290. Epub 2018 Dec 13. J Proteome Res. 2019. PMID: 30543107
To understand systemic metabolic changes correlated with HDL in glucose metabolism, we applied LC-MS-based metabolomics and lipidomics to detect metabolomic and lipidomic profiles of plasma from apoA-I knockout mice fed a high-fat diet. ...This study m …
To understand systemic metabolic changes correlated with HDL in glucose metabolism, we applied LC-MS-based metabolomics and lipido
Molecular Choreography of Acute Exercise.
Contrepois K, Wu S, Moneghetti KJ, Hornburg D, Ahadi S, Tsai MS, Metwally AA, Wei E, Lee-McMullen B, Quijada JV, Chen S, Christle JW, Ellenberger M, Balliu B, Taylor S, Durrant MG, Knowles DA, Choudhry H, Ashland M, Bahmani A, Enslen B, Amsallem M, Kobayashi Y, Avina M, Perelman D, Schüssler-Fiorenza Rose SM, Zhou W, Ashley EA, Montgomery SB, Chaib H, Haddad F, Snyder MP. Contrepois K, et al. Cell. 2020 May 28;181(5):1112-1130.e16. doi: 10.1016/j.cell.2020.04.043. Cell. 2020. PMID: 32470399
Acute physical activity leads to several changes in metabolic, cardiovascular, and immune pathways. Although studies have examined selected changes in these pathways, the system-wide molecular response to an acute bout of exercise has not been fully characterized. W …
Acute physical activity leads to several changes in metabolic, cardiovascular, and immune pathways. Although studies have examined se …
Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies.
Imamura F, Fretts A, Marklund M, Ardisson Korat AV, Yang WS, Lankinen M, Qureshi W, Helmer C, Chen TA, Wong K, Bassett JK, Murphy R, Tintle N, Yu CI, Brouwer IA, Chien KL, Frazier-Wood AC, Del Gobbo LC, Djoussé L, Geleijnse JM, Giles GG, de Goede J, Gudnason V, Harris WS, Hodge A, Hu F; InterAct Consortium, Koulman A, Laakso M, Lind L, Lin HJ, McKnight B, Rajaobelina K, Risérus U, Robinson JG, Samieri C, Siscovick DS, Soedamah-Muthu SS, Sotoodehnia N, Sun Q, Tsai MY, Uusitupa M, Wagenknecht LE, Wareham NJ, Wu JH, Micha R, Forouhi NG, Lemaitre RN, Mozaffarian D; Fatty Acids and Outcomes Research Consortium (FORCE). Imamura F, et al. PLoS Med. 2018 Oct 10;15(10):e1002670. doi: 10.1371/journal.pmed.1002670. eCollection 2018 Oct. PLoS Med. 2018. PMID: 30303968 Free PMC article. Clinical Trial.
BACKGROUND: We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D). ...Whereas study …
BACKGROUND: We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans- …
Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure.
Halade GV, Kain V, Tourki B, Jadapalli JK. Halade GV, et al. Metabolism. 2019 Jul;96:22-32. doi: 10.1016/j.metabol.2019.04.011. Epub 2019 Apr 15. Metabolism. 2019. PMID: 30999004
Lipoxygenase-deficient mice reduced diabetes risk biomarker 2-aminoadipic acid with profound alterations of plasma metabolic signaling of hexoses, amino acids, biogenic amines, acylcarnitines, glycerophospholipids, and sphingolipids in acute HF, thereby improved sur …
Lipoxygenase-deficient mice reduced diabetes risk biomarker 2-aminoadipic acid with profound alterations of plasma metabolic s …
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.
Lovric A, Granér M, Bjornson E, Arif M, Benfeitas R, Nyman K, Ståhlman M, Pentikäinen MO, Lundbom J, Hakkarainen A, Sirén R, Nieminen MS, Lundbom N, Lauerma K, Taskinen MR, Mardinoglu A, Boren J. Lovric A, et al. Sci Rep. 2018 Sep 21;8(1):14200. doi: 10.1038/s41598-018-31865-w. Sci Rep. 2018. PMID: 30242179 Free PMC article.
Thus, we aimed to identify and assess the predictive capability of novel potential metabolic biomarkers for ectopic fat depots in non-diabetic men with NAFLD, using the inflammation-associated proteome, lipidome and metabolome. ...Our analyses highligh …
Thus, we aimed to identify and assess the predictive capability of novel potential metabolic biomarkers for ectopic fat depots in non …
Unravelling HDL-Looking beyond the Cholesterol Surface to the Quality Within.
Kajani S, Curley S, McGillicuddy FC. Kajani S, et al. Int J Mol Sci. 2018 Jul 6;19(7):1971. doi: 10.3390/ijms19071971. Int J Mol Sci. 2018. PMID: 29986413 Free PMC article. Review.
High-density lipoprotein (HDL) particles have experienced a turbulent decade of falling from grace with widespread demotion from the most-sought-after therapeutic target to reverse cardiovascular disease (CVD), to mere biomarker status. ...The composition of HDL par …
High-density lipoprotein (HDL) particles have experienced a turbulent decade of falling from grace with widespread demotion from the most-so …
Mass Spectrometry in Advancement of Redox Precision Medicine.
Chen X, Lee J, Wu H, Tsang AW, Furdui CM. Chen X, et al. Adv Exp Med Biol. 2019;1140:327-358. doi: 10.1007/978-3-030-15950-4_19. Adv Exp Med Biol. 2019. PMID: 31347057 Review.
It is of outmost importance that cells maintain a healthy redox state by balancing the action of oxidants and antioxidants; failure to do so leads to a multitude of diseases including cancer, diabetes, fibrosis, autoimmune diseases, and cardiovascular and neurodegen …
It is of outmost importance that cells maintain a healthy redox state by balancing the action of oxidants and antioxidants; failure to do so …
Effect of Vitamin D(3) on the Postprandial Lipid Profile in Obese Patients: A Non-Targeted Lipidomics Study.
Fernández-Arroyo S, Hernández-Aguilera A, de Vries MA, Burggraaf B, van der Zwan E, Pouw N, Joven J, Cabezas MC. Fernández-Arroyo S, et al. Nutrients. 2019 May 27;11(5):1194. doi: 10.3390/nu11051194. Nutrients. 2019. PMID: 31137923 Free PMC article. Clinical Trial.
Abstract: Postprandial lipemia can lead to an accumulation of atherogenic lipoproteins in the circulation associated with systemic low-grade inflammation and an increased risk of cardiovascular disease. ...Our results suggest a turnover of sphingomyelins, probably due to a …
Abstract: Postprandial lipemia can lead to an accumulation of atherogenic lipoproteins in the circulation associated with systemic low-grade …
Exploratory lipidomics in patients with nascent Metabolic Syndrome.
Ramakrishanan N, Denna T, Devaraj S, Adams-Huet B, Jialal I. Ramakrishanan N, et al. J Diabetes Complications. 2018 Aug;32(8):791-794. doi: 10.1016/j.jdiacomp.2018.05.014. Epub 2018 May 25. J Diabetes Complications. 2018. PMID: 29895440
BACKGROUND: Metabolic Syndrome (MetS) is a cardio-metabolic cluster that confers an increased risk of developing both diabetes and atherosclerotic cardiovascular disease (ASCVD). ...Moreover, lipidomics poses as an exciting new tool that has potential to shed …
BACKGROUND: Metabolic Syndrome (MetS) is a cardio-metabolic cluster that confers an increased risk of developing both diabetes and at …
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