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Biotin Interference in Assays for Thyroid Hormones, Thyrotropin and Thyroglobulin.
Ylli D, Soldin SJ, Stolze B, Wei B, Nigussie G, Nguyen H, Mendu DR, Mete M, Wu D, Gomes-Lima CJ, Klubo-Gwiezdzinska J, Burman KD, Wartofsky L. Ylli D, et al. Thyroid. 2021 Aug;31(8):1160-1170. doi: 10.1089/thy.2020.0866. Epub 2021 May 26. Thyroid. 2021. PMID: 34042535 Free PMC article.
Background: Biotin has been reported to interfere with several commonly used laboratory assays resulting in misleading values and possible erroneous diagnosis and treatment. This report describes a prospective study of possible biotin interference …
Background: Biotin has been reported to interfere with several commonly used laboratory assays resulting in misleading …
Interferences With Thyroid Function Immunoassays: Clinical Implications and Detection Algorithm.
Favresse J, Burlacu MC, Maiter D, Gruson D. Favresse J, et al. Endocr Rev. 2018 Oct 1;39(5):830-850. doi: 10.1210/er.2018-00119. Endocr Rev. 2018. PMID: 29982406 Free article. Review.
Automated immunoassays used to evaluate thyroid function are vulnerable to different types of interference that can affect clinical decisions. This review provides a detailed overview of the six main types of interference known to affect measurements of th …
Automated immunoassays used to evaluate thyroid function are vulnerable to different types of interference that can affect cli …
Assessment of biotin interference in thyroid function tests.
Zhang Y, Wang R, Dong Y, Huang G, Ji B, Wang Q. Zhang Y, et al. Medicine (Baltimore). 2020 Feb;99(9):e19232. doi: 10.1097/MD.0000000000019232. Medicine (Baltimore). 2020. PMID: 32118725 Free PMC article.
The aim of the study was to systematically characterize the interference of biotin on thyroid function tests and biotin washout periods.Ten healthy adults were recruited with administration of 5 and 10 mg/d biotin for 7 days. ...Interference …
The aim of the study was to systematically characterize the interference of biotin on thyroid function tests and bio …
Approach to the Patient With Raised Thyroid Hormones and Nonsuppressed TSH.
Moran C, Schoenmakers N, Halsall D, Oddy S, Lyons G, van den Berg S, Gurnell M, Chatterjee K. Moran C, et al. J Clin Endocrinol Metab. 2024 Mar 15;109(4):1094-1108. doi: 10.1210/clinem/dgad681. J Clin Endocrinol Metab. 2024. PMID: 37988295 Free PMC article.
Measurement of free thyroid hormones (THs) and thyrotropin (TSH) using automated immunoassays is central to the diagnosis of thyroid dysfunction. ...Different types of analytical interference (eg, abnormal thyroid hormone binding proteins, antibodies t …
Measurement of free thyroid hormones (THs) and thyrotropin (TSH) using automated immunoassays is central to the diagnosis of thyro …
Significant Interference of Biotin in Thyroid Function Tests Using Beckman Analyzer: How to Identify such Interferences?
McBride M, Dasgupta A. McBride M, et al. Ann Clin Lab Sci. 2023 Jan;53(1):130-133. Ann Clin Lab Sci. 2023. PMID: 36889777
OBJECTIVE: Biotin in elevated concentration interferes with biotin-based immunoassays. We studied biotin interferences in TSH, FT4, FT3, total T4, total T3 and thyroglobulin assays both in vitro and in vivo using Beckman DXI800 analyzer. …
OBJECTIVE: Biotin in elevated concentration interferes with biotin-based immunoassays. We studied biotin inte …
Immunoassay design and biotin interference.
Dasgupta A. Dasgupta A. Adv Clin Chem. 2022;109:165-183. doi: 10.1016/bs.acc.2022.03.005. Epub 2022 May 5. Adv Clin Chem. 2022. PMID: 35953126 Review.
Nevertheless, biotin use remains widespread for growing healthy hair and nail. Unfortunately, the use/overuse of supplemental biotin may interfere with immunoassays that incorporate biotinylated antibody in assay design. ...In contrast, biotin s …
Nevertheless, biotin use remains widespread for growing healthy hair and nail. Unfortunately, the use/overuse of supplemental biot …
Biotin interference in routine clinical immunoassays.
Chiu KC, Jhan JR, Yan HN, Liao YC, Lu WH, Lee KY, Cheng LY, Yeh CK, Lee YF, Kuo CH, Chung KP, Chien TI. Chiu KC, et al. Pract Lab Med. 2025 May 1;45:e00472. doi: 10.1016/j.plabm.2025.e00472. eCollection 2025 Jul. Pract Lab Med. 2025. PMID: 40417451 Free PMC article.
BACKGROUND: Laboratory examinations play a crucial role in medical diagnostics and treatment, necessitating the identification of interference factors to ensure accurate results. Biotin, a common dietary supplement, can interfere with immunoassays utilizing …
BACKGROUND: Laboratory examinations play a crucial role in medical diagnostics and treatment, necessitating the identification of interfe …
Technical Note: Approach to Identify and Eliminate Biotin Interference in Thyroid Function Tests Using Beckman DXI 800 Analyzer by Taking Advantage of Assay Harmonization with Alinity i Analyzer.
McBride M, Dasgupta A. McBride M, et al. Ann Clin Lab Sci. 2023 May;53(3):482-484. Ann Clin Lab Sci. 2023. PMID: 37437939
OBJECTIVE: We reported significant interference of biotin in FT3 and FT4 assays using Beckman DXI 800 analyzer. Recently we acquired Alinity i analyzer where TSH, FT3 and FT4 assays are not biotin based. We hypothesized that if thyroid fu …
OBJECTIVE: We reported significant interference of biotin in FT3 and FT4 assays using Beckman DXI 800 analyzer. Recentl …
Assay of Thyroid Hormone and Related Substances.
Spencer CA. Spencer CA. 2025 Jul 3. In: Feingold KR, Adler RA, Ahmed SF, Anawalt B, Blackman MR, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hamilton E, Hofland J, Jan de Beur S, Kalra S, Kaltsas G, Kapoor N, Kim M, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. 2025 Jul 3. In: Feingold KR, Adler RA, Ahmed SF, Anawalt B, Blackman MR, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hamilton E, Hofland J, Jan de Beur S, Kalra S, Kaltsas G, Kapoor N, Kim M, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 25905337 Free Books & Documents. Review.
This chapter reviews how improvements in the sensitivity and specificity of thyroid tests [total and free thyroid hormones (T4 and T3), TSH, thyroid autoantibodies (TRAb, TPOAb, and TgAb) and thyroglobulin (Tg)] have advanced the detection and treatment of …
This chapter reviews how improvements in the sensitivity and specificity of thyroid tests [total and free thyroid hormones (T4 …
The biotin interference within interference suppressed immunoassays.
Kabiri P, Weiskirchen R, van Helden J. Kabiri P, et al. J Clin Lab Anal. 2021 Sep;35(9):e23940. doi: 10.1002/jcla.23940. Epub 2021 Aug 4. J Clin Lab Anal. 2021. PMID: 34346119 Free PMC article.
In the first experiment 59 interference suppressed immunoassays of the manufacturer Roche Diagnostics were examined regarding their sensitivity to a biotin interference. In the second experiment the pharmacokinetic of biotin was examined by supplementi …
In the first experiment 59 interference suppressed immunoassays of the manufacturer Roche Diagnostics were examined regarding their s …
73 results