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1,011 results

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Unknown field was ignored: [acetyl-CoA-carboxylase]
Page 1
Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity.
Shen J, Wu W, Wang K, Wu J, Liu B, Li C, Gong Z, Hong X, Fang H, Zhang X, Xu X. Shen J, et al. mBio. 2024 May 8;15(5):e0341423. doi: 10.1128/mbio.03414-23. Epub 2024 Apr 4. mBio. 2024. PMID: 38572988 Free PMC article.
Disruption of beta-barrel results in dissociation of the tetramer into dimers in solution and decreased biotin carboxylase activity. Biotinylation of the BCCP domain further promotes BC1 and CTbeta-CTalpha interactions to form an enzymatically active ACC, whi …
Disruption of beta-barrel results in dissociation of the tetramer into dimers in solution and decreased biotin carboxylase activit …
A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis.
Levert KL, Waldrop GL, Stephens JM. Levert KL, et al. J Biol Chem. 2002 May 10;277(19):16347-50. doi: 10.1074/jbc.C200113200. Epub 2002 Mar 20. J Biol Chem. 2002. PMID: 11907024 Free article.
In this study, we observed that treatment of 3T3-L1 cells with biotin chloroacetylated at the 1' nitrogen reduced the enzymatic activity of cytosolic acetyl-CoA carboxylase and concomitantly inhibited the differentiation of 3T3-L1 cells in a dose-dependent manner. T …
In this study, we observed that treatment of 3T3-L1 cells with biotin chloroacetylated at the 1' nitrogen reduced the enzymatic ac …
Insights into the methodology of acetyl-CoA carboxylase inhibition.
Čavužić MT, Larson BA, Waldrop GL. Čavužić MT, et al. Methods Enzymol. 2024;708:67-103. doi: 10.1016/bs.mie.2024.10.017. Epub 2024 Nov 4. Methods Enzymol. 2024. PMID: 39572150
The first half reaction is catalyzed by biotin carboxylase and involves the carboxylation of the vitamin biotin which is covalently attached to the biotin carboxyl carrier protein. ...The second half will focus on inhibitors that also possess antibacterial …
The first half reaction is catalyzed by biotin carboxylase and involves the carboxylation of the vitamin biotin which is coval …
AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions.
Kido K, Yamanaka S, Nakano S, Motani K, Shinohara S, Nozawa A, Kosako H, Ito S, Sawasaki T. Kido K, et al. Elife. 2020 May 11;9:e54983. doi: 10.7554/eLife.54983. Elife. 2020. PMID: 32391793 Free PMC article.
Here, we demonstrate a novel BirA enzyme, AirID (ancestral BirA for proximity-dependent biotin identification), which was designed de novo using an ancestral enzyme reconstruction algorithm and metagenome data. ...Experiments using BioID take more than 16 hours to complete …
Here, we demonstrate a novel BirA enzyme, AirID (ancestral BirA for proximity-dependent biotin identification), which was designed de …
Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA.
Adina-Zada A, Zeczycki TN, St Maurice M, Jitrapakdee S, Cleland WW, Attwood PV. Adina-Zada A, et al. Biochem Soc Trans. 2012 Jun 1;40(3):567-72. doi: 10.1042/BST20120041. Biochem Soc Trans. 2012. PMID: 22616868 Review.
The activity of the biotin-dependent enzyme pyruvate carboxylase from many organisms is highly regulated by the allosteric activator acetyl-CoA. ...However, it is apparent that acetyl-CoA binding does not induce the observed asymmetrical tetramer conformation …
The activity of the biotin-dependent enzyme pyruvate carboxylase from many organisms is highly regulated by the allosteric …
Regulation of acetyl-CoA carboxylase.
Kim KH. Kim KH. Curr Top Cell Regul. 1983;22:143-76. doi: 10.1016/b978-0-12-152822-5.50009-9. Curr Top Cell Regul. 1983. PMID: 6135568 Review. No abstract available.
"Pyruvate Carboxylase, Structure and Function".
Valle M. Valle M. Subcell Biochem. 2017;83:291-322. doi: 10.1007/978-3-319-46503-6_11. Subcell Biochem. 2017. PMID: 28271481 Review.
This large enzyme is multifunctional, and each subunit contains two active sites that catalyze two consecutive reactions that lead to the carboxylation of pyruvate into oxaloacetate, and a binding site for acetyl-CoA, an allosteric regulator of the enzyme. Pyruvate carboxy …
This large enzyme is multifunctional, and each subunit contains two active sites that catalyze two consecutive reactions that lead to …
Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate-regulated by interaction of PII with the biotin carboxyl carrier subunit.
Feria Bourrellier AB, Valot B, Guillot A, Ambard-Bretteville F, Vidal J, Hodges M. Feria Bourrellier AB, et al. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):502-7. doi: 10.1073/pnas.0910097107. Epub 2009 Dec 14. Proc Natl Acad Sci U S A. 2010. PMID: 20018655 Free PMC article.
Mass spectroscopy of SDS/PAGE-resolved protein bands identified the biotin carboxyl carrier protein subunits of the plastidial acetyl-CoA carboxylase (ACCase) and three other proteins containing a similar biotin/lipoyl-binding motif as putative PII targets. ...In in …
Mass spectroscopy of SDS/PAGE-resolved protein bands identified the biotin carboxyl carrier protein subunits of the plastidial acetyl …
Proximity Labeling in Plants.
Xu SL, Shrestha R, Karunadasa SS, Xie PQ. Xu SL, et al. Annu Rev Plant Biol. 2023 May 22;74:285-312. doi: 10.1146/annurev-arplant-070522-052132. Epub 2023 Feb 28. Annu Rev Plant Biol. 2023. PMID: 36854476 Free PMC article. Review.
PL-MS has revolutionized the way we perform proteomics by overcoming several hurdles imposed by traditional technology, such as biochemical fractionation and affinity purification mass spectrometry. In this review, we focus on biotin ligase-based PL-MS applications …
PL-MS has revolutionized the way we perform proteomics by overcoming several hurdles imposed by traditional technology, such as biochemical …
Deficient acetyl CoA carboxylase activity in multiple carboxylase deficiency.
Feldman GL, Wolf B. Feldman GL, et al. Clin Chim Acta. 1981 Apr 9;111(2-3):147-51. doi: 10.1016/0009-8981(81)90181-9. Clin Chim Acta. 1981. PMID: 6112081
Multiple carboxylase deficiency has previously been characterized by deficient activity of three biotin-dependent enzymes: propionyl CoA carboxylase, pyruvate carboxylase and beta-methylcrotonyl CoA carboxylase. ...Furthermore, ACC activity increased six- to …
Multiple carboxylase deficiency has previously been characterized by deficient activity of three biotin-dependent enzymes: pro …
1,011 results