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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 5
1946 23
1947 13
1948 4
1949 11
1950 41
1951 38
1952 48
1953 41
1954 45
1955 38
1956 47
1957 48
1958 38
1959 48
1960 38
1961 67
1962 82
1963 189
1964 269
1965 136
1966 175
1967 172
1968 257
1969 221
1970 284
1971 282
1972 322
1973 293
1974 341
1975 340
1976 317
1977 315
1978 328
1979 463
1980 419
1981 415
1982 532
1983 502
1984 525
1985 542
1986 553
1987 469
1988 533
1989 492
1990 574
1991 474
1992 495
1993 514
1994 539
1995 573
1996 584
1997 639
1998 658
1999 845
2000 843
2001 909
2002 941
2003 1144
2004 1221
2005 1440
2006 1746
2007 1891
2008 2019
2009 2082
2010 2145
2011 2161
2012 2539
2013 2673
2014 2800
2015 2831
2016 2872
2017 2852
2018 2905
2019 2822
2020 3168
2021 3392
2022 3157
2023 3064
2024 1553

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63,887 results

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Page 1
Depression and Mania in Bipolar Disorder.
Tondo L, Vázquez GH, Baldessarini RJ. Tondo L, et al. Curr Neuropharmacol. 2017 Apr;15(3):353-358. doi: 10.2174/1570159X14666160606210811. Curr Neuropharmacol. 2017. PMID: 28503106 Free PMC article. Review.
BACKGROUND: Episode duration, recurrence rates, and time spent in manic and depressive phases of bipolar disorder (BD) is not well defined for subtypes of the disorder. ...CONCLUSIONS: Subtypes of BD patients differed little in episode-duration, which was con …
BACKGROUND: Episode duration, recurrence rates, and time spent in manic and depressive phases of bipolar disorder (BD) is not …
Bipolar depression: the clinical characteristics and unmet needs of a complex disorder.
McIntyre RS, Calabrese JR. McIntyre RS, et al. Curr Med Res Opin. 2019 Nov;35(11):1993-2005. doi: 10.1080/03007995.2019.1636017. Epub 2019 Aug 5. Curr Med Res Opin. 2019. PMID: 31311335 Review.
Methods: We identified articles relevant to our narrative review using a multistep search of the literature and applying terms that were relevant to bipolar depression or bipolar disorder. Results: Bipolar depression accounts for the majo …
Methods: We identified articles relevant to our narrative review using a multistep search of the literature and applying terms that were rel …
Psychotic Depression: Diagnosis, Differential Diagnosis, and Treatment.
Dubovsky SL, Ghosh BM, Serotte JC, Cranwell V. Dubovsky SL, et al. Psychother Psychosom. 2021;90(3):160-177. doi: 10.1159/000511348. Epub 2020 Nov 9. Psychother Psychosom. 2021. PMID: 33166960 Free article. Review.
Psychotic depression was initially considered to be at one end of a continuum of severity of major depression. ...There is inadequate information about maintenance treatment of unipolar psychotic depression and acute and chronic treatment of psychotic bipo
Psychotic depression was initially considered to be at one end of a continuum of severity of major depression. ...There is ina …
Lithium in bipolar depression: A review of the evidence.
Riedinger MA, van der Wee NJA, Giltay EJ, de Leeuw M. Riedinger MA, et al. Hum Psychopharmacol. 2023 Sep;38(5):e2881. doi: 10.1002/hup.2881. Epub 2023 Oct 3. Hum Psychopharmacol. 2023. PMID: 37789577 Review.
BACKGROUND: Lithium is widely used as treatment of acute mania and as prophylactic therapy for bipolar disorder. International and national guidelines also consider lithium as a possible treatment of acute bipolar depression. Research on the use of lit …
BACKGROUND: Lithium is widely used as treatment of acute mania and as prophylactic therapy for bipolar disorder. International …
[Bipolar depression, a challenge diagnostic and treatmentwise].
Straszek SP, Licht RW, Nielsen RE, Vinberg M. Straszek SP, et al. Ugeskr Laeger. 2022 Apr 4;184(14):V10210821. Ugeskr Laeger. 2022. PMID: 35410656 Free article. Review. Danish.
This narrative review addresses the challenges of how to identify and treat bipolar depression. Bipolar depression, i.e. depressive episode(s) as part of bipolar disorder, can be differentiated from unipolar depression only through …
This narrative review addresses the challenges of how to identify and treat bipolar depression. Bipolar depression
Cariprazine for the treatment of bipolar depression: a review.
Ragguett RM, McIntyre RS. Ragguett RM, et al. Expert Rev Neurother. 2019 Apr;19(4):317-323. doi: 10.1080/14737175.2019.1580571. Epub 2019 Feb 20. Expert Rev Neurother. 2019. PMID: 30753085 Review.
Depressive symptoms and episodes dominate the course of bipolar disorder. The morbidity of bipolar disorder is disproportionately mediated by depressive symptoms; economic costs of bipolar disorder are also disproportionately due to unrem …
Depressive symptoms and episodes dominate the course of bipolar disorder. The morbidity of bipolar disorder is d …
Bipolar Depression: A Historical Perspective of the Current Concept, with a Focus on Future Research.
Martino DJ, Valerio MP. Martino DJ, et al. Harv Rev Psychiatry. 2021 Sep-Oct 01;29(5):351-360. doi: 10.1097/HRP.0000000000000309. Harv Rev Psychiatry. 2021. PMID: 34310532 Review.
The aim of this narrative review is to trace the origin of the concept of bipolar depression and to expose some of its limitations. Bipolar depression is a broad clinical construct including experiences ranging from traditional melancholic and psychoti …
The aim of this narrative review is to trace the origin of the concept of bipolar depression and to expose some of its limitat …
Old Age Bipolar Disorder-Epidemiology, Aetiology and Treatment.
Arnold I, Dehning J, Grunze A, Hausmann A. Arnold I, et al. Medicina (Kaunas). 2021 Jun 8;57(6):587. doi: 10.3390/medicina57060587. Medicina (Kaunas). 2021. PMID: 34201098 Free PMC article. Review.
We conducted a Medline literature search from 1970-2021 using the MeSH terms "bipolar disorder" and "aged" or "geriatric" or "elderly". The additional literature was retrieved by examining cross references and by a hand search in textbooks. With sparse data on the t …
We conducted a Medline literature search from 1970-2021 using the MeSH terms "bipolar disorder" and "aged" or "geriatric" or " …
Bipolar postpartum depression: An update and recommendations.
Sharma V, Doobay M, Baczynski C. Sharma V, et al. J Affect Disord. 2017 Sep;219:105-111. doi: 10.1016/j.jad.2017.05.014. Epub 2017 May 11. J Affect Disord. 2017. PMID: 28535448 Review.
In the absence of controlled treatment data, preference should be given to drugs normally indicated for bipolar depression including lithium, quetiapine and lamotrigine. Although antidepressants have been studied in combination with mood stabilizers in bipolar
In the absence of controlled treatment data, preference should be given to drugs normally indicated for bipolar depression inc …
Use of "Lights" for Bipolar Depression.
Sit D, Haigh S. Sit D, et al. Curr Psychiatry Rep. 2019 May 22;21(6):45. doi: 10.1007/s11920-019-1025-0. Curr Psychiatry Rep. 2019. PMID: 31119407 Review.
PURPOSE: In this review, we will review the background and diagnosis of bipolar disorder (BD); describe the efficacy data and potential circadian and neural mechanisms underlying the effects of bright light for bipolar depression; and discuss the imple …
PURPOSE: In this review, we will review the background and diagnosis of bipolar disorder (BD); describe the efficacy data and …
Cariprazine in Bipolar Depression and Mania: State of the Art.
Mazza M, Marano G, Traversi G, Carocci V, Romano B, Janiri L. Mazza M, et al. CNS Neurol Disord Drug Targets. 2018;17(10):723-727. doi: 10.2174/1871527317666180828120256. CNS Neurol Disord Drug Targets. 2018. PMID: 30152291 Review.
This review is a comprehensive and thorough summary of the most important findings on cariprazine use in bipolar mania and depression. Pharmacokinetics, pharmacogenetics, tolerability and safety adverse effects are discussed in this paper. ...Cariprazine represents …
This review is a comprehensive and thorough summary of the most important findings on cariprazine use in bipolar mania and depress
Treating bipolar depression with esketamine: Safety and effectiveness data from a naturalistic multicentric study on esketamine in bipolar versus unipolar treatment-resistant depression.
Martinotti G, Dell'Osso B, Di Lorenzo G, Maina G, Bertolino A, Clerici M, Barlati S, Rosso G, Di Nicola M, Marcatili M, d'Andrea G, Cavallotto C, Chiappini S, De Filippis S, Nicolò G, De Fazio P, Andriola I, Zanardi R, Nucifora D, Di Mauro S, Bassetti R, Pettorruso M, McIntyre RS, Sensi SL, di Giannantonio M, Vita A; REAL-ESK Study Group. Martinotti G, et al. Bipolar Disord. 2023 May;25(3):233-244. doi: 10.1111/bdi.13296. Epub 2023 Jan 18. Bipolar Disord. 2023. PMID: 36636839 Free article.
BACKGROUND: Bipolar depression accounts for most of the disease duration in type I and type II bipolar disorder (BD), with few treatment options, often poorly tolerated. Many individuals do not respond to first-line therapeutic options, resulting in tr …
BACKGROUND: Bipolar depression accounts for most of the disease duration in type I and type II bipolar disorder
Is it depression or is it bipolar depression?
Rolin D, Whelan J, Montano CB. Rolin D, et al. J Am Assoc Nurse Pract. 2020 Oct;32(10):703-713. doi: 10.1097/JXX.0000000000000499. J Am Assoc Nurse Pract. 2020. PMID: 33017361
Although bipolar disorder is characterized by manic, hypomanic, and depressive episodes, the most common and debilitating symptomatic presentation is depression. ...Relevant information for this review was identified through a multistep literature search of P …
Although bipolar disorder is characterized by manic, hypomanic, and depressive episodes, the most common and debilitating symp …
Bipolar depression: Managing patients with second generation antipsychotics.
Avery LM, Drayton SJ. Avery LM, et al. Int J Psychiatry Med. 2016;51(2):145-59. doi: 10.1177/0091217416636576. Int J Psychiatry Med. 2016. PMID: 27079776 Review.
Bipolar affective disorder is a debilitating illness that manifests as cyclical episodes of mood elevation and depression, but the treatment of the depressive episodes (i.e., bipolar depression) differs considerably from the treatment of major d
Bipolar affective disorder is a debilitating illness that manifests as cyclical episodes of mood elevation and depression
Treatment-resistant bipolar depression.
Sachs GS. Sachs GS. Psychiatr Clin North Am. 1996 Jun;19(2):215-36. doi: 10.1016/s0193-953x(05)70285-9. Psychiatr Clin North Am. 1996. PMID: 8827187 Review.
Patients with treatment-resistant bipolar depression require careful management, which takes into account the life-threatening potential of their depression and the risk of iatrogenic mania. Because there are few data specific to treatment of bipolar
Patients with treatment-resistant bipolar depression require careful management, which takes into account the life-threatening …
Bipolar depression: management options.
Malhi GS, Mitchell PB, Salim S. Malhi GS, et al. CNS Drugs. 2003;17(1):9-25. doi: 10.2165/00023210-200317010-00002. CNS Drugs. 2003. PMID: 12467490 Review.
Bipolar depression is the predominant abnormal mood state in bipolar disorder. However, despite the key pertinence of this phase of the condition, the focus of research and indeed of clinical interest in the management of bipolar disorder
Bipolar depression is the predominant abnormal mood state in bipolar disorder. However, despite the key pertinen
Treatment of bipolar depression.
Berk M, Berk L, Davey CG, Moylan S, Giorlando F, Singh AB, Kalra H, Dodd S, Malhi GS. Berk M, et al. Med J Aust. 2013 Sep 16;199(S6):S32-5. doi: 10.5694/mja12.10611. Med J Aust. 2013. PMID: 25370283 Review.
Depression is usually the predominant phase in bipolar disorder, causes the most psychosocial disability, and carries significant risk of suicide. The management of bipolar depression is relatively under-studied and poses significant challenges
Depression is usually the predominant phase in bipolar disorder, causes the most psychosocial disability, and carries s
Efficacy of Ketamine in bipolar depression: focus on anhedonia.
Gałuszko-Węgielnik M, Wiglusz MS, Słupski J, Szałach Ł, Włodarczk A, Górska N, Szarmach J, Jakuszkowiak-Wojten K, Wilkowska A, Cubała WJ. Gałuszko-Węgielnik M, et al. Psychiatr Danub. 2019 Sep;31(Suppl 3):554-560. Psychiatr Danub. 2019. PMID: 31488790 Review.
Bipolar depression (BD) is among the most severe psychiatric disorders. A significant number of patients do not achieve an entirely symptom-free state and experience residual sub-syndromal depression. Most of the treatment options approved for bipolar
Bipolar depression (BD) is among the most severe psychiatric disorders. A significant number of patients do not achieve an ent
Treating Circadian Rhythm Disruption in Bipolar Disorder.
Gold AK, Kinrys G. Gold AK, et al. Curr Psychiatry Rep. 2019 Mar 2;21(3):14. doi: 10.1007/s11920-019-1001-8. Curr Psychiatry Rep. 2019. PMID: 30826893 Free PMC article. Review.
PURPOSE OF REVIEW: Disruptions in circadian rhythms are believed to underlie the illness course of bipolar disorder (BD). This review evaluates recent studies on the treatment of circadian dysfunction in BD. RECENT FINDINGS: Targeted social rhythm therapy may be use …
PURPOSE OF REVIEW: Disruptions in circadian rhythms are believed to underlie the illness course of bipolar disorder (BD). This …
Bipolar depression: overview and commentary.
Baldessarini RJ, Vieta E, Calabrese JR, Tohen M, Bowden CL. Baldessarini RJ, et al. Harv Rev Psychiatry. 2010 May-Jun;18(3):143-57. doi: 10.3109/10673221003747955. Harv Rev Psychiatry. 2010. PMID: 20415631 Review.
In bipolar depression, antidepressant responses often are unsatisfactory, and these agents probably are overused. Emerging treatments, including several anticonvulsant and modern antipsychotic drugs, as well as lithium-alone or in selected combinations-are partially …
In bipolar depression, antidepressant responses often are unsatisfactory, and these agents probably are overused. Emerging tre …
Integrated pathophysiology of schizophrenia, major depression, and bipolar disorder as monoamine axon disorder.
Nakamura S. Nakamura S. Front Biosci (Schol Ed). 2022 Jan 24;14(1):4. doi: 10.31083/j.fbs1401004. Front Biosci (Schol Ed). 2022. PMID: 35320915 Free article. Review.
Together, based on accumulating data from animal and human studies, the pathophysiology of schizophrenia, major depression, and bipolar disorder is summarized as follows: The degeneration of monoamine axons is associated with the negative and cognitive sympto …
Together, based on accumulating data from animal and human studies, the pathophysiology of schizophrenia, major depression, and bi
Bipolar depression in pediatric populations : epidemiology and management.
Cosgrove VE, Roybal D, Chang KD. Cosgrove VE, et al. Paediatr Drugs. 2013 Apr;15(2):83-91. doi: 10.1007/s40272-013-0022-8. Paediatr Drugs. 2013. PMID: 23529869 Review.
Depression in children and adolescents with bipolar disorder is more commonly observed than mania or hypomania, and is associated with significant functional disability in multiple environmental realms. ...This article provides a brief overview of the epidemi
Depression in children and adolescents with bipolar disorder is more commonly observed than mania or hypomania, and is
Treatment of Bipolar Depression: Evolving Recommendations.
Post RM. Post RM. Psychiatr Clin North Am. 2016 Mar;39(1):11-33. doi: 10.1016/j.psc.2015.09.001. Psychiatr Clin North Am. 2016. PMID: 26876316 Review.
Bipolar depression is the most common and difficult-to-treat phase of bipolar disorder. ...Many of the drugs discussed here are graded provisionally for the strength of the findings in the literature, safety and tolerability, and likely utility of use
Bipolar depression is the most common and difficult-to-treat phase of bipolar disorder. ...Many of the drugs dis
Bipolar depression: the real challenge.
Hirschfeld RM. Hirschfeld RM. Eur Neuropsychopharmacol. 2004 May;14 Suppl 2:S83-8. doi: 10.1016/j.euroneuro.2004.03.001. Eur Neuropsychopharmacol. 2004. PMID: 15142612 Review.
Current treatments for bipolar disorder have focused on mania, yet symptoms of bipolar depression occur more frequently, last longer, are more disruptive and are associated with greater risk of suicide than mania. ...These facts emphasise the importanc …
Current treatments for bipolar disorder have focused on mania, yet symptoms of bipolar depression occur more fre …
Antidepressants in bipolar depression.
Vieta E. Vieta E. Acta Psychiatr Scand. 2008 Nov;118(5):335-6. doi: 10.1111/j.1600-0447.2008.01233.x. Acta Psychiatr Scand. 2008. PMID: 18855837 No abstract available.
Bipolar Depression and Cognitive Impairment: Shared Mechanisms and New Treatment Avenues.
Depp CA, Dev S, Eyler LT. Depp CA, et al. Psychiatr Clin North Am. 2016 Mar;39(1):95-109. doi: 10.1016/j.psc.2015.09.004. Epub 2015 Dec 11. Psychiatr Clin North Am. 2016. PMID: 26876321 Free PMC article. Review.
Depression and cognitive impairment are pervasive and highly disabling aspects of bipolar disorder. ...Novel treatment avenues at the intersection of bipolar depression and cognitive impairment target inflammation directly or indirectly health b
Depression and cognitive impairment are pervasive and highly disabling aspects of bipolar disorder. ...Novel treatment
Arketamine for bipolar depression: Open-label, dose-escalation, pilot study.
Bandeira ID, Leal GC, Correia-Melo FS, Souza-Marques B, Silva SS, Lins-Silva DH, Mello RP, Vieira F, Dorea-Bandeira I, Faria-Guimarães D, Carneiro B, Caliman-Fontes AT, Kapczinski F, Miranda-Scippa Â, Lacerda ALT, Quarantini LC. Bandeira ID, et al. J Psychiatr Res. 2023 Aug;164:229-234. doi: 10.1016/j.jpsychires.2023.06.028. Epub 2023 Jun 23. J Psychiatr Res. 2023. PMID: 37385001 Clinical Trial.
There are significantly fewer options for the treatment of bipolar depression than major depressive disorder, with an urgent need for alternative therapies. ...To the best of our knowledge, this pilot trial is the first to test the feasibility and safety of t …
There are significantly fewer options for the treatment of bipolar depression than major depressive disorder, with an u …
Bipolar depression: phenomenological overview and clinical characteristics.
Mitchell PB, Malhi GS. Mitchell PB, et al. Bipolar Disord. 2004 Dec;6(6):530-9. doi: 10.1111/j.1399-5618.2004.00137.x. Bipolar Disord. 2004. PMID: 15541069 Review.
OBJECTIVES: There has been increasing interest in the depressed phase of bipolar disorder (bipolar depression). This paper aims to review the clinical characteristics of bipolar depression, focusing upon its prevalence and phenomenology, …
OBJECTIVES: There has been increasing interest in the depressed phase of bipolar disorder (bipolar depression). …
Lumateperone (Caplyta) for bipolar depression.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2022 Aug 8;64(1656):126-128. Med Lett Drugs Ther. 2022. PMID: 35921078 No abstract available.
Quetiapine monotherapy for bipolar depression.
Janicak PG, Rado JT. Janicak PG, et al. Expert Opin Pharmacother. 2011 Jul;12(10):1643-51. doi: 10.1517/14656566.2011.585461. Epub 2011 May 24. Expert Opin Pharmacother. 2011. PMID: 21609188 Review.
INTRODUCTION: Depression, in the context of bipolar disorder, is more prevalent than hypomania or mania and accounts for most of the disability. Furthermore, the treatment of bipolar depression is more complicated than the treatment of unipolar …
INTRODUCTION: Depression, in the context of bipolar disorder, is more prevalent than hypomania or mania and accounts fo …
Bipolar depression: a new role for atypical antipsychotics?
Keck PE Jr. Keck PE Jr. Bipolar Disord. 2005;7 Suppl 4:34-40. doi: 10.1111/j.1399-5618.2005.00213.x. Bipolar Disord. 2005. PMID: 15948765 Review.
Bipolar depression, the most common phase of bipolar disorder, causes significant morbidity and mortality. ...Thus there is a major unmet need for effective, well-tolerated agents for the treatment of bipolar depression. The atypical anti
Bipolar depression, the most common phase of bipolar disorder, causes significant morbidity and mortality. ...Th
Bipolar depression: issues in diagnosis and treatment.
Thase ME. Thase ME. Harv Rev Psychiatry. 2005 Sep-Oct;13(5):257-71. doi: 10.1080/10673220500326425. Harv Rev Psychiatry. 2005. PMID: 16251165 Review.
Although bipolar affective disorder is defined by the history of manic or hypomanic episodes, depression is arguably a more important facet of the illness. ...Distinguishing features of bipolar depression include earlier age of onset, a family h …
Although bipolar affective disorder is defined by the history of manic or hypomanic episodes, depression is arguably a …
Zonisamide for bipolar depression.
Wilson MS, Findling RL. Wilson MS, et al. Expert Opin Pharmacother. 2007 Jan;8(1):111-3. doi: 10.1517/14656566.8.1.111. Expert Opin Pharmacother. 2007. PMID: 17163811 Review.
In addition to effectiveness and tolerability, bipolar depression research has sought agents that do not induce cycling or mania. ...Until further research is available, zonisamide is not recommended as a first-line treatment for bipolar depression....
In addition to effectiveness and tolerability, bipolar depression research has sought agents that do not induce cycling or man …
The use of antidepressants in bipolar disorder patients with depression.
Bowden CL, Singh V. Bowden CL, et al. Expert Opin Pharmacother. 2016;17(1):17-25. doi: 10.1517/14656566.2016.1104299. Epub 2015 Oct 19. Expert Opin Pharmacother. 2016. PMID: 26479314 Review.
INTRODUCTION: The proportion of time that bipolar patients experience depressive symptoms and clinical states, with associated psychosocial impairment and elevated risk of suicide, is significantly greater than the time spent in manic/hypomanic forms of bipolar diso …
INTRODUCTION: The proportion of time that bipolar patients experience depressive symptoms and clinical states, with associated psycho …
Bipolar depression: specific treatments.
Potter WZ. Potter WZ. J Clin Psychiatry. 1998;59 Suppl 18:30-6. J Clin Psychiatry. 1998. PMID: 9840196 Review.
From the perspective of pharmacologic treatment, bipolar depression is considered in this article as belonging to a spectrum of affective disorders. Insufficient controlled data permit only general recommendations for treatment of the spectrum of affective disorders …
From the perspective of pharmacologic treatment, bipolar depression is considered in this article as belonging to a spectrum o …
Bipolar depression and suicidal ideation: Moderators and mediators of a complex relationship.
Kamali M, Reilly-Harrington NA, Chang WC, McInnis M, McElroy SL, Ketter TA, Shelton RC, Deckersbach T, Tohen M, Kocsis JH, Calabrese JR, Gao K, Thase ME, Bowden CL, Kinrys G, Bobo WV, Brody BD, Sylvia LG, Rabideau DJ, Nierenberg AA. Kamali M, et al. J Affect Disord. 2019 Dec 1;259:164-172. doi: 10.1016/j.jad.2019.08.032. Epub 2019 Aug 19. J Affect Disord. 2019. PMID: 31445343 Clinical Trial.
INTRODUCTION: Not all patients with bipolar depression have suicidal ideation (SI). This study examines some factors that link bipolar depression to SI. ...Severity of depression and SI were assessed with the Bipolar Inventory of Symptoms …
INTRODUCTION: Not all patients with bipolar depression have suicidal ideation (SI). This study examines some factors that link …
[Bipolar depression].
Leboyer M, Llorca PM. Leboyer M, et al. Encephale. 2011 Dec;37 Suppl 3:S161-2. doi: 10.1016/S0013-7006(11)70045-8. Encephale. 2011. PMID: 22212867 French. No abstract available.
Bipolar depression: treatment options.
Yatham LN, Kusumakar V, Parikh SV, Haslam DR, Matte R, Sharma V, Kennedy S. Yatham LN, et al. Can J Psychiatry. 1997 Aug;42 Suppl 2:87S-91S. Can J Psychiatry. 1997. PMID: 9288441 Review.
OBJECTIVE: To review studies on treatments for bipolar depression and make recommendations for practising clinicians treating patients with bipolar depression. METHOD: Studies that examined various treatments for bipolar depression were e …
OBJECTIVE: To review studies on treatments for bipolar depression and make recommendations for practising clinicians treating …
Bipolar depression: diagnostic and treatment considerations.
Thase ME. Thase ME. Dev Psychopathol. 2006 Fall;18(4):1213-30. doi: 10.1017/S0954579406060585. Dev Psychopathol. 2006. PMID: 17064435 Review.
Bipolar affective disorder is a recurrent, disabling, and potentially lethal illness that typically begins early in life. ...Unfortunately, the correct diagnosis is often not made until there has been a treatment-emergent affective switch. There are no treatments sp
Bipolar affective disorder is a recurrent, disabling, and potentially lethal illness that typically begins early in life. ...U
Bipolar depression in children and adolescents.
DeFilippis MS, Wagner KD. DeFilippis MS, et al. CNS Spectr. 2013 Aug;18(4):209-13. doi: 10.1017/S1092852913000217. Epub 2013 Apr 10. CNS Spectr. 2013. PMID: 23570693 Review.
Children and adolescents with bipolar disorder may have depression as the presenting mood state. ...Evidence-based treatments are needed to guide clinicians' treatment decisions for youth with bipolar depression. This article reviews the prevale …
Children and adolescents with bipolar disorder may have depression as the presenting mood state. ...Evidence-based trea …
Treatment of bipolar depression.
Musetti L, Del Grande C, Marazziti D, Dell'Osso L. Musetti L, et al. CNS Spectr. 2013 Aug;18(4):177-87. doi: 10.1017/S1092852912001009. Epub 2013 Feb 8. CNS Spectr. 2013. PMID: 23391164 Review.
However, the treatment of bipolar depression has been poorly investigated in comparison with that of manic episodes and unipolar major depressive disorder. ...In this article, we review available treatment options for bipolar depression, and we …
However, the treatment of bipolar depression has been poorly investigated in comparison with that of manic episodes and unipol …
Agmatine as a potential therapeutic intervention in bipolar depression: the preclinical landscape.
Watts D, Pfaffenseller B, Wollenhaupt-Aguiar B, Paul Géa L, Cardoso TA, Kapczinski F. Watts D, et al. Expert Opin Ther Targets. 2019 Apr;23(4):327-339. doi: 10.1080/14728222.2019.1581764. Epub 2019 Feb 22. Expert Opin Ther Targets. 2019. PMID: 30764678 Review.
Present antidepressant treatments are only helpful in a quarter of patients with bipolar depression, and new strategies are warranted. Increasing evidence suggests that accelerated polyamine metabolism is associated with the pathophysiology of depression. ... …
Present antidepressant treatments are only helpful in a quarter of patients with bipolar depression, and new strategies are wa …
Animal models of recurrent or bipolar depression.
Kato T, Kasahara T, Kubota-Sakashita M, Kato TM, Nakajima K. Kato T, et al. Neuroscience. 2016 May 3;321:189-196. doi: 10.1016/j.neuroscience.2015.08.016. Epub 2015 Aug 8. Neuroscience. 2016. PMID: 26265551 Free article. Review.
Animal models of mental disorders should ideally have construct, face, and predictive validity, but current animal models do not always satisfy these validity criteria. Additionally, animal models of depression rely mainly on stress-induced behavioral changes. These stress …
Animal models of mental disorders should ideally have construct, face, and predictive validity, but current animal models do not always sati …
Diagnosis, Epidemiology and Management of Mixed States in Bipolar Disorder.
Fagiolini A, Coluccia A, Maina G, Forgione RN, Goracci A, Cuomo A, Young AH. Fagiolini A, et al. CNS Drugs. 2015 Sep;29(9):725-40. doi: 10.1007/s40263-015-0275-6. CNS Drugs. 2015. PMID: 26369921 Free article. Review.
Approximately 40% of patients with bipolar disorder experience mixed episodes, defined as a manic state with depressive features, or manic symptoms in a patient with bipolar depression. ...Targeted, specific treatments developed through a greater under …
Approximately 40% of patients with bipolar disorder experience mixed episodes, defined as a manic state with depressive featur …
Consequences of misdiagnosis: inaccurate treatment and poor patient outcomes in bipolar disorder.
Nasrallah HA. Nasrallah HA. J Clin Psychiatry. 2015 Oct;76(10):e1328. doi: 10.4088/JCP.14016tx2c. J Clin Psychiatry. 2015. PMID: 26528666 Free article. Review.
Bipolar depression is difficult to diagnose and is often mistaken for unipolar depression. ...An accurate diagnosis and appropriate treatment of bipolar disorder are necessary to prevent this chain of potentially disastrous events....
Bipolar depression is difficult to diagnose and is often mistaken for unipolar depression. ...An accurate diagnosis and
Treatment of bipolar depression.
Dubovsky SL. Dubovsky SL. Psychiatr Clin North Am. 2005 Jun;28(2):349-70, vii. doi: 10.1016/j.psc.2005.02.003. Psychiatr Clin North Am. 2005. PMID: 15826736 Review.
This article discusses current practices in the treatment of bipolar depression. In the absence of more definitive research, the treatment of bipolar depression is guided by clinical experience and expert opinion, and sometimes by marketing and popular …
This article discusses current practices in the treatment of bipolar depression. In the absence of more definitive research, t …
[The differential diagnosis of unipolar and bipolar depression based on EEG signals].
Galkin SA, Bokhan NA. Galkin SA, et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(11):51-56. doi: 10.17116/jnevro202212211151. Zh Nevrol Psikhiatr Im S S Korsakova. 2022. PMID: 36440777 Review. Russian.
The relevance of timely detection and differential diagnosis of depressive disorder and bipolar affective disorder (BD) is beyond doubt. In complex differential diagnostic cases, clinicians can come to the aid of objective research methods, such as electroenc …
The relevance of timely detection and differential diagnosis of depressive disorder and bipolar affective disorder (BD) …
The treatment of bipolar depression.
Compton MT, Nemeroff CB. Compton MT, et al. J Clin Psychiatry. 2000;61 Suppl 9:57-67. J Clin Psychiatry. 2000. PMID: 10826663 Review.
BACKGROUND: The treatment of bipolar depression represents a relatively understudied area in clinical psychiatry. ...Search terms included bipolar depression, antidepressants, and bipolar disorder. Only publications in English are reviewe …
BACKGROUND: The treatment of bipolar depression represents a relatively understudied area in clinical psychiatry. ...Search te …
The impact of bipolar depression.
Post RM. Post RM. J Clin Psychiatry. 2005;66 Suppl 5:5-10. J Clin Psychiatry. 2005. PMID: 16038596 Review.
Bipolar disorder is a chronic, intermittent illness that is associated with high morbidity and mortality. ...Although bipolar disorder consists of recurring episodes of mania and depression, patients spend more time depressed than manic. ...
Bipolar disorder is a chronic, intermittent illness that is associated with high morbidity and mortality. ...Although bipol
STEP-BD and bipolar depression: what have we learned?
Thase ME. Thase ME. Curr Psychiatry Rep. 2007 Dec;9(6):497-503. doi: 10.1007/s11920-007-0068-9. Curr Psychiatry Rep. 2007. PMID: 18221631 Review.
This article summarizes recent findings from the STEP-BD project pertaining to bipolar depression treatment. Highlighted are four papers that report, in turn, a large, randomized controlled trial of adjunctive antidepressants; a large, randomized controlled trial of …
This article summarizes recent findings from the STEP-BD project pertaining to bipolar depression treatment. Highlighted are f …
Diagnostic guidelines for bipolar depression: a probabilistic approach.
Mitchell PB, Goodwin GM, Johnson GF, Hirschfeld RM. Mitchell PB, et al. Bipolar Disord. 2008 Feb;10(1 Pt 2):144-52. doi: 10.1111/j.1399-5618.2007.00559.x. Bipolar Disord. 2008. PMID: 18199233 Review.
RESULTS: There are no pathognomonic characteristics of bipolar I depression compared to unipolar depressive disorder. There are, however, replicated findings of clinical characteristics that are more common in both bipolar I depression and unipo …
RESULTS: There are no pathognomonic characteristics of bipolar I depression compared to unipolar depressive disorder. T …
Burden of bipolar depression: impact of disorder and medications on quality of life.
Michalak EE, Murray G, Young AH, Lam RW. Michalak EE, et al. CNS Drugs. 2008;22(5):389-406. doi: 10.2165/00023210-200822050-00003. CNS Drugs. 2008. PMID: 18399708 Review.
Although the manic or hypomanic episodes define the disorder, recent research has shown that depressive symptoms predominate over manic symptoms in the majority of patients, and that bipolar depression accounts for much of the significant morbidity and mortal …
Although the manic or hypomanic episodes define the disorder, recent research has shown that depressive symptoms predominate over man …
Diagnosis and treatment of postpartum bipolar depression.
Kelly E, Sharma V. Kelly E, et al. Expert Rev Neurother. 2010 Jul;10(7):1045-51. doi: 10.1586/ern.10.81. Expert Rev Neurother. 2010. PMID: 20586688 Review.
Research into postpartum mood disorders has focused primarily on major depressive disorder, and has overlooked the study of bipolar disorder, particularly bipolar II disorder and bipolar disorder not otherwise specified. ...The mos …
Research into postpartum mood disorders has focused primarily on major depressive disorder, and has overlooked the study of bipola
Efficacy of electroconvulsive therapy in bipolar versus unipolar major depression: a meta-analysis.
Dierckx B, Heijnen WT, van den Broek WW, Birkenhäger TK. Dierckx B, et al. Bipolar Disord. 2012 Mar;14(2):146-50. doi: 10.1111/j.1399-5618.2012.00997.x. Bipolar Disord. 2012. PMID: 22420590 Review.
In bipolar depression, response to treatment with antidepressants is disappointing. ...This analysis shows similar efficacy of ECT in patients with unipolar and bipolar depression (OR = 1.08, 95% CI: 0.75-1.57). CONCLUSION: ECT appears to be equally ef …
In bipolar depression, response to treatment with antidepressants is disappointing. ...This analysis shows similar efficacy of …
Efficacy of Ketamine in Bipolar Depression: Systematic Review and Meta-analysis.
Parsaik AK, Singh B, Khosh-Chashm D, Mascarenhas SS. Parsaik AK, et al. J Psychiatr Pract. 2015 Nov;21(6):427-35. doi: 10.1097/PRA.0000000000000106. J Psychiatr Pract. 2015. Retraction in: J Psychiatr Pract. 2018 Jul;24(4):307. doi: 10.1097/PRA.0000000000000324. PMID: 26554325 Retracted. Review.
OBJECTIVE: To consolidate the evidence from the literature to evaluate the role of ketamine in the treatment of bipolar depression. METHODS: Major databases, including MEDLINE, EMBASE, Cochrane, and Scopus, were searched through October 2014, for studies reporting t …
OBJECTIVE: To consolidate the evidence from the literature to evaluate the role of ketamine in the treatment of bipolar depression
Distinctions between bipolar and unipolar depression.
Cuellar AK, Johnson SL, Winters R. Cuellar AK, et al. Clin Psychol Rev. 2005 May;25(3):307-39. doi: 10.1016/j.cpr.2004.12.002. Clin Psychol Rev. 2005. PMID: 15792852 Free PMC article. Review.
This is a review of the studies comparing unipolar and bipolar depression, with focus on the course, symptomatology, neurobiology, and psychosocial literatures. ...The current nomenclature of bipolar and unipolar disorders has resulted in research that compar …
This is a review of the studies comparing unipolar and bipolar depression, with focus on the course, symptomatology, neurobiol …
Effective agents in treating bipolar depression.
Nierenberg AA. Nierenberg AA. J Clin Psychiatry. 2008 Oct 15;69(10):e29. doi: 10.4088/jcp.1008e29. J Clin Psychiatry. 2008. PMID: 19192432 Review.
Despite the prevalence of depression in bipolar disorder, evidence suggests that antidepressants are not likely to benefit most patients. Lithium has long been the first-line treatment for bipolar disorder, but it is not the most effective agent …
Despite the prevalence of depression in bipolar disorder, evidence suggests that antidepressants are not likely to bene …
Treatment options for acute depression in bipolar disorder.
Bauer M, Ritter P, Grunze H, Pfennig A. Bauer M, et al. Bipolar Disord. 2012 May;14 Suppl 2:37-50. doi: 10.1111/j.1399-5618.2012.00991.x. Bipolar Disord. 2012. PMID: 22510035 Review.
OBJECTIVE: The burden of depression represents the most debilitating dimension for the majority of patients with bipolar disorder and dominates the long-term course of the illness. ...RESULTS: Overall, the number of suitably controlled studies for the treatme …
OBJECTIVE: The burden of depression represents the most debilitating dimension for the majority of patients with bipolar di
The Influence of Trauma, Life Events, and Social Relationships on Bipolar Depression.
Johnson SL, Cuellar AK, Gershon A. Johnson SL, et al. Psychiatr Clin North Am. 2016 Mar;39(1):87-94. doi: 10.1016/j.psc.2015.09.003. Epub 2015 Dec 22. Psychiatr Clin North Am. 2016. PMID: 26876320 Free PMC article. Review.
A growing body of research suggests that the social environment exerts a powerful influence on the course of bipolar depression. This article reviews longitudinal research to suggest that trauma, negative life events, social support deficits, and family difficulties …
A growing body of research suggests that the social environment exerts a powerful influence on the course of bipolar depression
Rate of switch from bipolar depression into mania after morning light therapy: A historical review.
Benedetti F. Benedetti F. Psychiatry Res. 2018 Mar;261:351-356. doi: 10.1016/j.psychres.2018.01.013. Epub 2018 Jan 9. Psychiatry Res. 2018. PMID: 29348073 Review.
Light therapy (LT) is efficacious for bipolar depression with effect sizes equivalent to those in antidepressant pharmacotherapy trials. Patients with bipolar disorder (BD) show a 15-40% rate of manic switches during antidepressant drug treatment. ...
Light therapy (LT) is efficacious for bipolar depression with effect sizes equivalent to those in antidepressant pharmacothera …
Bipolar depression: a review of randomised clinical trials.
Goodnick PJ. Goodnick PJ. Expert Opin Pharmacother. 2007 Jan;8(1):13-21. doi: 10.1517/14656566.8.1.13. Expert Opin Pharmacother. 2007. PMID: 17163803 Review.
Randomised, controlled trials have been completed in the study of the response of bipolar depression to lithium, antiepileptic drugs, antidepressants (particularly the selective serotonin re-uptake inhibitors) and a few miscellaneous agents including pramipexole. .. …
Randomised, controlled trials have been completed in the study of the response of bipolar depression to lithium, antiepileptic …
Antidepressant chronotherapeutics for bipolar depression.
Benedetti F. Benedetti F. Dialogues Clin Neurosci. 2012 Dec;14(4):401-11. doi: 10.31887/DCNS.2012.14.4/fbenedetti. Dialogues Clin Neurosci. 2012. PMID: 23393416 Free PMC article. Review.
The antidepressant effects of chronotherapeutics are evident in difficult-to-treat conditions such as bipolar depression, which has been associated with extremely low success rates of antidepressant drugs in naturalistic settings and with stable antidepressant respo …
The antidepressant effects of chronotherapeutics are evident in difficult-to-treat conditions such as bipolar depression, whic …
Challenges in the management of bipolar depression.
Suppes T, Kelly DI, Perla JM. Suppes T, et al. J Clin Psychiatry. 2005;66 Suppl 5:11-6. J Clin Psychiatry. 2005. PMID: 16038597 Review.
Bipolar depression has started to receive more attention in clinical trials only relatively recently, despite the fact that patients spend more time in the depressed phase than in the manic phase of bipolar disorder. ...Untreated or inappropriately tre
Bipolar depression has started to receive more attention in clinical trials only relatively recently, despite the fact that pa
Pharmacotherapy of depression and mixed states in bipolar disorder.
Montgomery SA, Schatzberg AF, Guelfi JD, Kasper S, Nemeroff C, Swann A, Zajecka J. Montgomery SA, et al. J Affect Disord. 2000 Sep;59 Suppl 1:S39-S56. doi: 10.1016/s0165-0327(00)00178-6. J Affect Disord. 2000. PMID: 11121826 Review.
The treatment of bipolar depression requires the resolution of depression and the establishment of mood stability. ...There is little evidence for long-term benefits of antidepressive agents in bipolar disorder, and some evidence that they may d …
The treatment of bipolar depression requires the resolution of depression and the establishment of mood stability. ...T …
Treatment of bipolar depression: an update.
Fountoulakis KN, Grunze H, Panagiotidis P, Kaprinis G. Fountoulakis KN, et al. J Affect Disord. 2008 Jul;109(1-2):21-34. doi: 10.1016/j.jad.2007.10.016. Epub 2007 Nov 26. J Affect Disord. 2008. PMID: 18037498 Review.
This article attempts to summarize the current status of our knowledge and practice in the acute treatment and prophylaxis of bipolar depression. For prophylactic treatment, our knowledge about lithium firmly supports its usefulness against bipolar depress
This article attempts to summarize the current status of our knowledge and practice in the acute treatment and prophylaxis of bipolar
Strategies to reduce misdiagnosis of bipolar depression.
Bowden CL. Bowden CL. Psychiatr Serv. 2001 Jan;52(1):51-5. doi: 10.1176/appi.ps.52.1.51. Psychiatr Serv. 2001. PMID: 11141528 Review.
Research over the past decade indicates that the prevalence of bipolar disorder is similar to that of major depression. The author discusses complexities in the diagnosis of bipolar disorder, especially in distinguishing bipolar from unip …
Research over the past decade indicates that the prevalence of bipolar disorder is similar to that of major depression. …
Bipolar depression: focus on phenomenology.
Akiskal HS. Akiskal HS. J Affect Disord. 2005 Feb;84(2-3):105-6. doi: 10.1016/j.jad.2004.12.002. J Affect Disord. 2005. PMID: 15708406 No abstract available.
Bipolar disorder.
Mitchell PB. Mitchell PB. Aust Fam Physician. 2013 Sep;42(9):616-9. Aust Fam Physician. 2013. PMID: 24024220 Free article.
General practitioners are central in the management of patients with bipolar disorder. OBJECTIVE: To update clinicians on the recognition, diagnosis and management of bipolar disorder in light of recent research. DISCUSSION: There is growing concern ab …
General practitioners are central in the management of patients with bipolar disorder. OBJECTIVE: To update clinicians on the …
The importance of anxiety in both major depression and bipolar disorder.
Goldberg D, Fawcett J. Goldberg D, et al. Depress Anxiety. 2012 Jun;29(6):471-8. doi: 10.1002/da.21939. Epub 2012 May 2. Depress Anxiety. 2012. PMID: 22553107 Review.
Both anxiety diagnoses and anxious symptoms are more common in both unipolar and bipolar depression. This paper explores the relationship between anxious symptoms and GAD with both unipolar and bipolar depression. METHOD: MDD and bipolar diso
Both anxiety diagnoses and anxious symptoms are more common in both unipolar and bipolar depression. This paper explores the r …
Bipolar depression: criteria for treatment selection, definition of refractoriness, and treatment options.
Yatham LN, Calabrese JR, Kusumakar V. Yatham LN, et al. Bipolar Disord. 2003 Apr;5(2):85-97. doi: 10.1034/j.1399-5618.2003.00019.x. Bipolar Disord. 2003. PMID: 12680897 Review.
OBJECTIVE: This paper reviews controlled studies of bipolar depression, outlines criteria for choosing treatment, defines refractoriness in bipolar depression, and provides options for treatment of refractory bipolar depression. ...RESULT …
OBJECTIVE: This paper reviews controlled studies of bipolar depression, outlines criteria for choosing treatment, defines refr …
Bipolar disorder: Diagnosis, treatment and future directions.
Lane NM, Smith DJ. Lane NM, et al. J R Coll Physicians Edinb. 2023 Sep;53(3):192-196. doi: 10.1177/14782715231197577. Epub 2023 Aug 30. J R Coll Physicians Edinb. 2023. PMID: 37649414 Review.
Bipolar disorder is a relatively common mental illness, characterised by recurrent episodes of mania (or hypomania) and major depression, and associated with a significant burden of morbidity and premature mortality. ...This short review provides an up-to-dat
Bipolar disorder is a relatively common mental illness, characterised by recurrent episodes of mania (or hypomania) and major
Reevaluating therapies for bipolar depression.
Grunze H. Grunze H. J Clin Psychiatry. 2005;66 Suppl 5:17-25. J Clin Psychiatry. 2005. PMID: 16038598 Review.
The most commonly employed pharmacotherapies for bipolar depression include antidepressants, lithium, and anticonvulsants, such as lamotrigine, valproate, and carbamazepine. ...However, some treatment guidelines still caution that antidepressant exposure should be m …
The most commonly employed pharmacotherapies for bipolar depression include antidepressants, lithium, and anticonvulsants, suc …
New treatment guidelines for acute bipolar depression: a systematic review.
Nivoli AM, Colom F, Murru A, Pacchiarotti I, Castro-Loli P, González-Pinto A, Fountoulakis KN, Vieta E. Nivoli AM, et al. J Affect Disord. 2011 Mar;129(1-3):14-26. doi: 10.1016/j.jad.2010.05.018. Epub 2010 Jun 9. J Affect Disord. 2011. PMID: 20538341 Review.
INTRODUCTION: Bipolar depression poses a great burden on patients and their families due to its duration, associated functional impairment, and limited treatment options. ...Lamotrigine has become a highly controversial option. CONCLUSION: The management of bipol
INTRODUCTION: Bipolar depression poses a great burden on patients and their families due to its duration, associated functiona …
The dark side of bipolarity: detecting bipolar depression in its pleomorphic expressions.
Akiskal HS. Akiskal HS. J Affect Disord. 2005 Feb;84(2-3):107-15. doi: 10.1016/j.jad.2004.06.003. J Affect Disord. 2005. PMID: 15708407 Review.
Thus, mania occurs in 1% of the population at large; bipolar depression afflicts at least 5 times more people. Much of the new literature on this subject has emphasized its high prevalence, morbidity, and mortality. There has been relatively less attention paid to t …
Thus, mania occurs in 1% of the population at large; bipolar depression afflicts at least 5 times more people. Much of the new …
Olfactory markers for depression: Differences between bipolar and unipolar patients.
Kazour F, Richa S, Abi Char C, Surget A, Elhage W, Atanasova B. Kazour F, et al. PLoS One. 2020 Aug 13;15(8):e0237565. doi: 10.1371/journal.pone.0237565. eCollection 2020. PLoS One. 2020. PMID: 32791517 Free PMC article.
Hedonic rating of pleasant odors may distinguish bipolar depression from unipolar depression during periods of decompensation and phases of remission. Olfactory assessment may be useful to screen unipolar and bipolar depression, leading to possi …
Hedonic rating of pleasant odors may distinguish bipolar depression from unipolar depression during periods of decompen …
The role of atypical antipsychotics in bipolar depression and anxiety disorders.
McIntyre R, Katzman M. McIntyre R, et al. Bipolar Disord. 2003;5 Suppl 2:20-35. doi: 10.1111/j.1399-2406.2003.00061.x. Bipolar Disord. 2003. PMID: 14700010 Review.
Bipolar disorder is a complex condition that includes symptoms of mania, depression, and often anxiety. Diagnosing and treating bipolar depression is challenging, with the disorder often being diagnosed as unipolar depression. ...
Bipolar disorder is a complex condition that includes symptoms of mania, depression, and often anxiety. Diagnosing and
Bipolar depression in primary care: a hidden threat.
Lewis FT. Lewis FT. J Am Osteopath Assoc. 2004 Jun;104(6 Suppl 6):S9-14. J Am Osteopath Assoc. 2004. PMID: 15222640 Review.
With the recent awareness of the bipolar spectrum, the interest and concern of physicians regarding the depressive side of bipolar disorder has emerged. Depression is the modal phase of bipolar disorder, as well as the phase that imparts …
With the recent awareness of the bipolar spectrum, the interest and concern of physicians regarding the depressive side of bipolar
Recognition, diagnosis and treatment of postpartum bipolar depression.
Pope CJ, Sharma V, Mazmanian D. Pope CJ, et al. Expert Rev Neurother. 2014 Jan;14(1):19-28. doi: 10.1586/14737175.2014.846219. Epub 2013 Nov 26. Expert Rev Neurother. 2014. PMID: 24308278 Review.
Bipolar disorder is a serious and often chronic disorder characterized by episodes of depression, hypomania, mania or mixed states that affects many individuals worldwide, and is a leading cause of years of 'healthy' life lost as a result of disability
Bipolar disorder is a serious and often chronic disorder characterized by episodes of depression, hypomania, man
Use of adjunctive stimulants in adult bipolar depression.
Dell'Osso B, Ketter TA. Dell'Osso B, et al. Int J Neuropsychopharmacol. 2013 Feb;16(1):55-68. doi: 10.1017/S1461145712000326. Epub 2012 Apr 13. Int J Neuropsychopharmacol. 2013. PMID: 22717304 Free article. Review.
Bipolar depression represents a high priority research field, due to its pervasiveness, and high economic and personal (suicidality, impaired function, quality of life) costs, and the limited evidence base to inform therapeutics. ...Moreover, the use of antidepressa
Bipolar depression represents a high priority research field, due to its pervasiveness, and high economic and personal (suicid
Neurosurgical treatment of bipolar depression: defining treatment resistance and identifying surgical targets.
Lipsman N, McIntyre RS, Giacobbe P, Torres C, Kennedy SH, Lozano AM. Lipsman N, et al. Bipolar Disord. 2010 Nov;12(7):691-701. doi: 10.1111/j.1399-5618.2010.00868.x. Bipolar Disord. 2010. PMID: 21040286 Review.
OBJECTIVES: Bipolar disorder (BD) is a complex psychiatric disorder that is often underrecognized, misdiagnosed, and challenging to detect. ...Herein, we provide the rationale for employing DBS as an alternative treatment avenue in individuals with bipolar
OBJECTIVES: Bipolar disorder (BD) is a complex psychiatric disorder that is often underrecognized, misdiagnosed, and ch …
Bipolar depression: an overview.
Oral ET, Vahip S. Oral ET, et al. IDrugs. 2004 Sep;7(9):846-50. IDrugs. 2004. PMID: 15470602 Review.
Although the treatment of bipolar depression remains an understudied area, new data from randomized, controlled trials and naturalistic studies have expanded the range of treatments available. ...Guidelines for the acute treatment of bipolar depression
Although the treatment of bipolar depression remains an understudied area, new data from randomized, controlled trials and nat …
Clinical highlights in bipolar depression: focus on atypical antipsychotics.
Calabrese JR, Elhaj O, Gajwani P, Gao K. Calabrese JR, et al. J Clin Psychiatry. 2005;66 Suppl 5:26-33. J Clin Psychiatry. 2005. PMID: 16038599 Review.
Despite the considerable burden of bipolar depression, the treatment of this debilitating phase of bipolar disorder is suboptimally addressed by currently available pharmacologic options. ...Evidence of antidepressant efficacy for some of the atypical …
Despite the considerable burden of bipolar depression, the treatment of this debilitating phase of bipolar disorder
Treatment of acute bipolar depression: a review of the literature.
Srisurapanont M, Yatham LN, Zis AP. Srisurapanont M, et al. Can J Psychiatry. 1995 Nov;40(9):533-44. doi: 10.1177/070674379504000906. Can J Psychiatry. 1995. PMID: 8574989 Review.
OBJECTIVE: Our goal was to ascertain the efficacy of various antidepressant treatments for acute bipolar depression. METHOD: English articles that reported on the efficacy of antidepressant treatments in bipolar depression were located by computerized …
OBJECTIVE: Our goal was to ascertain the efficacy of various antidepressant treatments for acute bipolar depression. METHOD: E …
Are there subtypes of bipolar depression?
Perich T, Hadzi-Pavlovic D, Frankland A, Breakspear M, Loo C, Roberts G, Holmes-Preston E, Mitchell PB. Perich T, et al. Acta Psychiatr Scand. 2016 Sep;134(3):260-7. doi: 10.1111/acps.12615. Epub 2016 Jun 20. Acta Psychiatr Scand. 2016. PMID: 27324550
OBJECTIVE: To investigate for subtypes of bipolar depression using latent class analysis (LCA). METHOD: Participants were recruited through a bipolar disorder (BD) clinic. ...CONCLUSION: Our study suggests the existence of two or three distinct classes …
OBJECTIVE: To investigate for subtypes of bipolar depression using latent class analysis (LCA). METHOD: Participants were recr …
Metabolic syndrome in bipolar disorder: a review with a focus on bipolar depression.
McElroy SL, Keck PE Jr. McElroy SL, et al. J Clin Psychiatry. 2014 Jan;75(1):46-61. doi: 10.4088/JCP.13r08634. J Clin Psychiatry. 2014. PMID: 24502861 Review.
OBJECTIVE: To perform a detailed, qualitative review of existing literature on the co-occurrence of bipolar disorder and metabolic syndrome, the impact of metabolic dysregulation on patients with bipolar disorder, and treatment considerations, with a f …
OBJECTIVE: To perform a detailed, qualitative review of existing literature on the co-occurrence of bipolar disorder and metab …
Medicating mood with maintenance in mind: bipolar depression pharmacotherapy.
Malhi GS, Adams D, Berk M. Malhi GS, et al. Bipolar Disord. 2009 Jun;11 Suppl 2:55-76. doi: 10.1111/j.1399-5618.2009.00711.x. Bipolar Disord. 2009. PMID: 19538686 Review.
OBJECTIVES: Bipolar depression is a core feature of bipolar disorder, a phase in which many patients spend the majority of time and one that confers a significant degree of burden and risk. ...CONCLUSIONS: There has been a tendency for research trials …
OBJECTIVES: Bipolar depression is a core feature of bipolar disorder, a phase in which many patients spend the m …
Light therapy in the treatment of patients with bipolar depression: A meta-analytic study.
Tseng PT, Chen YW, Tu KY, Chung W, Wang HY, Wu CK, Lin PY. Tseng PT, et al. Eur Neuropsychopharmacol. 2016 Jun;26(6):1037-47. doi: 10.1016/j.euroneuro.2016.03.001. Epub 2016 Mar 9. Eur Neuropsychopharmacol. 2016. PMID: 26993616 Review.
Light therapy (LT) has been widely used in the treatment of seasonal affective disorder. Recently some evidence indicated that LT may play a role in bipolar depression, either as monotherapy or in combination with total sleep deprivation (TSD). However, the s …
Light therapy (LT) has been widely used in the treatment of seasonal affective disorder. Recently some evidence indicated that LT may …
Unipolar depression/bipolar depression: connections and controversies.
Mondimore FM. Mondimore FM. Int Rev Psychiatry. 2005 Feb;17(1):39-47. doi: 10.1080/09540260500068216. Int Rev Psychiatry. 2005. PMID: 16194769 Review.
The modern dichotomous divide between unipolar and bipolar depressive disorders derives from several monographs that appeared in the mid-twentieth century. Studies of illness course and differing symptomatic profiles in unipolar and bipolar illness support this inte …
The modern dichotomous divide between unipolar and bipolar depressive disorders derives from several monographs that appeared in the …
Scale matters: the need for a Bipolar Depression Rating Scale (BDRS).
Berk M, Malhi GS, Mitchell PB, Cahill CM, Carman AC, Hadzi-Pavlovic D, Hawkins MT, Tohen M. Berk M, et al. Acta Psychiatr Scand Suppl. 2004;(422):39-45. doi: 10.1111/j.1600-0447.2004.00412.x. Acta Psychiatr Scand Suppl. 2004. PMID: 15330937 Review.
OBJECTIVE: To briefly review the clinical and biological distinctions between unipolar and bipolar depression critiquing in particular currently available depression rating scales and discuss the need for a new observer-rated scale tailored to bipolar
OBJECTIVE: To briefly review the clinical and biological distinctions between unipolar and bipolar depression critiquing in pa …
Differential effects of unipolar versus bipolar depression on episodic memory updating.
Dongaonkar B, Hupbach A, Nadel L, Chattarji S. Dongaonkar B, et al. Neurobiol Learn Mem. 2019 May;161:158-168. doi: 10.1016/j.nlm.2019.04.008. Epub 2019 Apr 17. Neurobiol Learn Mem. 2019. PMID: 31004802
Since such dynamic memory processes remain largely unexplored in psychiatric disorders, we examined the impact of depression on episodic memory updating. Unipolar and bipolar depression patients, and age/education matched controls, first learned a set of obje …
Since such dynamic memory processes remain largely unexplored in psychiatric disorders, we examined the impact of depression on episo …
[Bipolar depression in childhood and adolescence].
Birkle S, Holtmann M. Birkle S, et al. Prax Kinderpsychol Kinderpsychiatr. 2014;63(3):219-36. Prax Kinderpsychol Kinderpsychiatr. 2014. PMID: 24707769 Review. German.
This review gives an overview of the epidemiology, etiology, diagnosis, course and the treatment of bipolar depression in children and adolescents as well as existing problems for clinical practice. Usually it takes a longer period until affected patients with bi
This review gives an overview of the epidemiology, etiology, diagnosis, course and the treatment of bipolar depression in chil …
Bipolar depression: prototypically melancholic in its clinical features.
Parker G, McCraw S, Hadzi-Pavlovic D, Hong M, Barrett M. Parker G, et al. J Affect Disord. 2013 May;147(1-3):331-7. doi: 10.1016/j.jad.2012.11.035. Epub 2012 Dec 20. J Affect Disord. 2013. PMID: 23261138
BACKGROUND: Numerous studies have considered whether bipolar depression is phenomenologically similar or different to unipolar depression. While there have been some relatively consistent individual features identified, no clear clinical phenotype has been de …
BACKGROUND: Numerous studies have considered whether bipolar depression is phenomenologically similar or different to unipolar …
ECNP consensus meeting. Bipolar depression. Nice, March 2007.
Goodwin GM, Anderson I, Arango C, Bowden CL, Henry C, Mitchell PB, Nolen WA, Vieta E, Wittchen HU. Goodwin GM, et al. Eur Neuropsychopharmacol. 2008 Jul;18(7):535-49. doi: 10.1016/j.euroneuro.2008.03.003. Epub 2008 May 23. Eur Neuropsychopharmacol. 2008. PMID: 18501566 Review.
A broad diagnosis of bipolar disorder risks confounding with other childhood psychopathology and has less predictive value for bipolar disorder in adulthood than the conservative definition. ...TREATMENT STUDIES IN BIPOLAR DEPRESSION: Mon …
A broad diagnosis of bipolar disorder risks confounding with other childhood psychopathology and has less predictive value for …
Bipolar Disorder and Inflammation.
Rosenblat JD, McIntyre RS. Rosenblat JD, et al. Psychiatr Clin North Am. 2016 Mar;39(1):125-37. doi: 10.1016/j.psc.2015.09.006. Epub 2015 Dec 10. Psychiatr Clin North Am. 2016. PMID: 26876323 Review.
The pathophysiology of bipolar disorder (BD) remains poorly understood. Current psychopharmacologic treatments are often poorly tolerated and carry high rates of treatment resistance. ...
The pathophysiology of bipolar disorder (BD) remains poorly understood. Current psychopharmacologic treatments are often poorl …
Unrecognized bipolar disorder in patients with depression managed in primary care: A systematic review and meta-analysis.
Daveney J, Panagioti M, Waheed W, Esmail A. Daveney J, et al. Gen Hosp Psychiatry. 2019 May-Jun;58:71-76. doi: 10.1016/j.genhosppsych.2019.03.006. Epub 2019 Mar 27. Gen Hosp Psychiatry. 2019. PMID: 30933689
There is some evidence that unrecognized bipolar disorder is prevalent amongst patients with depression in primary care which can lead to non-optimal treatment. ...CONCLUSION: Over 3 in 20 patients with depression have unrecognized bipolar di
There is some evidence that unrecognized bipolar disorder is prevalent amongst patients with depression in primary care …
Atypical Antipsychotics in the Treatment of Acute Bipolar Depression with Mixed Features: A Systematic Review and Exploratory Meta-Analysis of Placebo-Controlled Clinical Trials.
Fornaro M, Stubbs B, De Berardis D, Perna G, Valchera A, Veronese N, Solmi M, Ganança L. Fornaro M, et al. Int J Mol Sci. 2016 Feb 16;17(2):241. doi: 10.3390/ijms17020241. Int J Mol Sci. 2016. PMID: 26891297 Free PMC article. Review.
Evidence supporting the use of second generation antipsychotics (SGAs) in the treatment of acute depression with mixed features (MFs) associated with bipolar disorder (BD) is scarce and equivocal. Therefore, we conducted a systematic review and preliminary me …
Evidence supporting the use of second generation antipsychotics (SGAs) in the treatment of acute depression with mixed features (MFs) …
Treatment strategies for bipolar depression.
Bowden CL. Bowden CL. J Clin Psychiatry. 2010 May;71(5):e10. doi: 10.4088/JCP.8125tx2c. J Clin Psychiatry. 2010. PMID: 20492847 Review.
Resolving acute bipolar mood episodes is only one part of an overall strategy for treating bipolar disorder. ...General strategies for treating patients with bipolar disorder include continuing the acute pharmacotherapeutic regimen into the main …
Resolving acute bipolar mood episodes is only one part of an overall strategy for treating bipolar disorder. ...General …
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